Cardiology Research

The Department of Cardiology at Concord Hospital undertakes a wide range of research in all areas of cardiovascular medicine.

We undertake studies using data from our own patients and from patients around the country that allow us to identify ways of improving patient care. Patients with heart attacks, angina, fluid build-up related to the heart (heart failure), clots in the lungs, and heart rhythm disturbances are included in these studies.

Our Atherosclerosis and Vascular Biology laboratory research at the ANZAC Research Institute includes molecular research into how cells accumulate cholesterol to block arteries, how we can clear this cholesterol, and how clots form to cause heart attacks.

Our research into the control of the microcirculation in patients having angiograms is studying how small blood vessels contribute to the blood supply of the heart.

CONCORDANCE (ANZAC Research Institute)
– A national registry for coronary care

The CONCORDANCE registry has been designed within a comparative effectiveness research (CER) framework to collect and report data from hospitals located in geographically diverse regions of Australia. Information including patient demographics, presenting characteristics, past medical history, in-hospital management and outcomes at six months and two years are entered into a web-based database using an electronic clinical record form (eCRF). Individual hospital information is returned to the sites in a real time confidential report detailing information on key performance indicator (KPI) process measures and outcomes benchmarked against the aggregated study cohort.

The CONCORDANCE registry is a clinician-driven initiative describing clinical care for ACS patients admitted to Australian hospitals. The registry generates high quality data which is fed back to clinicians, and key stakeholders in ACS care. Using a CER approach, the registry describes the translation of randomised trial evidence into practice and provides insights into strategies that could improve care and ultimately patient outcomes.

Our Research Team

Professor David Brieger	Head of Department
Professor Leonard Kritharides	Clinician researcher
Associate Professor Andy Yong	Clinician researcher
Dr Cuneyt Ada	Interventional Research Fellow
Dr Austin Chin Chwan Ng	Clinician researcher
Associate Professor Harry Lowe	Clinician researcher
Danica Watson	Research Staff
Su Swe	Research Staff

Selected Grants

Amount awarded	Grant and project details
$10,000,000	Targeted Translation Research Accelerator (TTRA) initiative, 2022-2025 Australian Stroke and Heart Research Accelerator (ASHRA) Investigators: Chow C (CIA), Kritharides L (CI)
$7,913,500	Genentech, 2021-2023 Industry project grant. RESTORE-MI trial Investigator: Yong A (CIC)
$5,000,000	NHMRC Synergy Grant, 2019-2024 SOLVE-CHD Investigators: Redfern J (CIA), Brieger D (CIH)
$5,000,000	NHMRC Synergy Grant, 2024-2028 Solving Australia’s Hypertension Treatment Problem Investigators: Schutte A, Rodgers A, Bonner C, Schlaich M, Gnanenthiran S, Hespe C, Atkins E, Gnjidic D, Halcomb E, Stocks N
$2,727,508	NHMRC, 2022-2025 Enhancing the electronic Medical record (eMR) to BolsteR Acute Coronary syndromE care (The EMBRACE Project) Investigator: Brieger D
$1,816,175	Medical Research Future Fund (MRFF), 2020-2027 Anticoagulation for Stroke Prevention In patients with Recent Episodes of perioperative Atrial Fibrillation after noncardiac surgery - The ASPIRE-AF trial Investigators: Chow C, Hillis G, Brieger D, Sverdlov A, Atherton J, Thomas L, Lindley R, Ferguson C, Devereaux PJ, Conen D
$980,000	NSW Cardiovascular Collaborative, 2023-2027 Implementing novel approaches to transform blood pressure control Investigator: Gnanenthiran S (CIA)
$894,507	Medical Research Future Fund (MRFF), 2022-2025 QUICR Investigators: Gallagher R (CIA), Brieger D (CID)
$782,008	Medical Research Future Fund (MRFF), 2022-2025 Ethnicity and CVD Care and outcomes in NSW Investigators: Stanaway F (CIA), Kritharides L (CIC)
$250,000	George Institute NHMRC Program Seed Grant Funding, 2022-2023 Maximising the benefits of the next generation of BP measurement devices Investigator: Gnanenthiran, S
$250,000	George Institute NHMRC Program Seed Grant Funding, 2022-2023 Formative Research for Development of a Polypill-Based Implementation Strategy for Patients with Heart Failure with Reduced Ejection Fraction in Australia Investigator: Gnanenthiran, S
$150,000	National Heart Foundation Postdoctoral Fellowship, 2022-2024 Drug repurposing in cardiovascular disease: strategies to improve outcomes and accelerate drug translation Investigator: Gnanenthiran, S
$73,139	National Heart Foundation Vanguard, 2023 Mapping the platelet phenotype in elderly patients with coronary artery disease Investigators: Gnanenthiran S (CIB)

Previous Grants

Amount awarded	Grant and project details
€6,000,000	EU Horizon 2020, 2020-2022 AFFECT-EU – precision screening for atrial fibrillation Investigator: Freedman B
$760,000	NSW Ministry of Health Clinician Scientist grant, 2019-2022 Cholesterol efflux capacity in at risk populations Investigator: Kritharides L
$50,000	Abbott Vascular Project Grant, 2019-2022 Project grant for core lab activities Investigator: Yong A (CIA)

Our Publications

2023

Al-Mukhtar O, Stub D, Reid CM, Lo S, Lefkovits J, Walton A, Chew DP, Yong A, Nicholls SJ, Cox N, Peter K, Chan W. Variability in Contemporary Heparin Prescription and Activated Clotting Time Monitoring During Percutaneous Coronary Intervention: Call for Up-To-Date Evidence-Based Guidelines. Heart Lung Circ. 2023 Dec;32(12):1475-1481. doi: 10.1016/j.hlc.2023.09.020. Epub 2023 Nov 22.

Anastasius M, Thavendiranathan P, Kini A, Argulian E, Sharma S, Narula J, Lerakis S. Part 1: The Clinical Applications of Left Ventricular Myocardial Strain. Cardiol Rev. 2023 Apr 28. doi: 10.1097/CRD.0000000000000559. Epub ahead of print.

Anastasius M, Thavendiranathan P, Kini A, Argulian E, Sharma S, Narula J, Lerakis S. Part 2: The Clinical Applications of Left Ventricular Myocardial Strain. Cardiol Rev. 2023 Jun 5. doi: 10.1097/CRD.0000000000000560. Epub ahead of print.

Argha A, Celler BG, Yong A, Rubenis I, Butlin M, Avolio A. New Perspectives on Non-invasive Blood Pressure Measurement. Annu Int Conf IEEE Eng Med Biol Soc. 2023 Jul;2023:1-4. doi: 10.1109/EMBC40787.2023.10340757.

Barlow TR, Karve S, Brieger D, Lowe HC. Predicting Statin Adherence Following Hospital Discharge for Acute Coronary Syndromes: What's the Score? Heart Lung Circ. 2023 May;32(5):553-554. doi: 10.1016/j.hlc.2023.04.004.

Carson JL, Brooks MM, Chaitman BR, Alexander JH, Goodman SG, Bertolet M, Abbott JD, Cooper HA, Rao SV, Triulzi DJ, Fergusson DA, Kostis WJ, Noveck H, Simon T, Steg PG, DeFilippis AP, Goldsweig AM, Lopes RD, White H, Alsweiler C, Morton E, Hébert PC; MINT Investigators. Rationale and design for the myocardial ischemia and transfusion (MINT) randomized clinical trial. Am Heart J. 2023 Mar;257:120-129. doi: 10.1016/j.ahj.2022.11.015. Epub 2022 Nov 20.

Celler BG, Yong A, Rubenis I, Butlin M, Argha A, Rehan R, Avolio A. Accurate detection of Korotkoff sounds reveals large discrepancy between intra-arterial systolic pressure and simultaneous noninvasive measurement of blood pressure with brachial cuff sphygmomanometry. J Hypertens. 2024 May 1;42(5):873-882. doi: 10.1097/HJH.0000000000003651. Epub 2024 Jan 8.

Chan DC, Kritharides L, Watts GF. The remnant-cholesterol/CRP nexus: Trouble and strife when the fat hits the fire. Atherosclerosis. 2023 Aug;379:117169. doi: 10.1016/j.atherosclerosis.2023.06.075. Epub 2023 Jun 28.

Cheng YY, Brieger D, Bannon P, Chow V, Kritharides L, Ng ACC. Outcomes Following Triple Cardiac Valve Surgery Over 17-years: A Multicentre Population-Linkage Study. Heart Lung Circ. 2023 Feb;32(2):269-277. doi: 10.1016/j.hlc.2022.09.018. Epub 2022 Nov 5.

Cheng YY, Shu MWS, Rubenis I, Vijayarajan V, Hsu AC, Hyun K, Brieger D, Chow V, Kritharides L, Ng ACC. Trends in Isolated Mitral Valve Repair or Replacement Surgery in Australia: A Statewide Cohort Linkage Study. Heart Lung Circ. 2024 Jan;33(1):120-129. doi: 10.1016/j.hlc.2023.11.023. Epub 2023 Dec 29.

de Oliveira Costa J, Pearson SA, Brieger D, Lujic S, Shawon MSR, Jorm LR, van Gool K, Falster MO. In-hospital outcomes by insurance type among patients undergoing percutaneous coronary interventions for acute myocardial infarction in New South Wales public hospitals. Int J Equity Health. 2023 Oct 23;22(1):226. doi: 10.1186/s12939-023-02030-1.

Dong X, Strudwick M, Wang WY, Borlaug BA, van der Geest RJ, Ng AC, Delgado V, Bax JJ, Ng AC. Impact of body mass index and diabetes on myocardial fat content, interstitial fibrosis and function. Int J Cardiovasc Imaging. 2023 Feb;39(2):379-390. doi: 10.1007/s10554-022-02723-8. Epub 2022 Oct 28.

Figtree GA, Vernon ST, Harmer JA, Gray MP, Arnott C, Bachour E, Barsha G, Brieger D, Brown A, Celermajer DS, Channon KM, Chew NWS, Chong JJH, Chow CK, Cistulli PA, Ellinor PT, Grieve SM, Guzik TJ, Hagström E, Jenkins A, Jennings G, Keech AC, Kott KA, Kritharides L, Mamas MA, Mehran R, Meikle PJ, Natarajan P, Negishi K, O'Sullivan J, Patel S, Psaltis PJ, Redfern J, Steg PG, Sullivan DR, Sundström J, Vogel B, Wilson A, Wong D, Bhatt DL, Kovacic JC, Nicholls SJ; CRE for CAD Collaborators. Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors: JACC State-of-the-Art Review. J Am Coll Cardiol. 2023 Sep 26;82(13):1343-1359. doi: 10.1016/j.jacc.2023.06.045.

Gale CP, Stocken DD, Aktaa S, Reynolds C, Gilberts R, Brieger D, Carruthers K, Chew DP, Goodman SG, Fernandez C, Sharples LD, Yan AT, Fox K. Effectiveness of GRACE risk score in patients admitted to hospital with non-ST elevation acute coronary syndrome (UKGRIS): parallel group cluster randomised controlled trial. BMJ. 2023 Jun 14;381:e073843. doi: 10.1136/bmj-2022-073843.

Gnanenthiran SR, Agarwal A, Patel A. Frontiers of cardiovascular polypills: From atherosclerosis and beyond. Trends Cardiovasc Med. 2023 Apr;33(3):182-189. doi: 10.1016/j.tcm.2021.12.013. Epub 2021 Dec 30.

Gnanenthiran SR, Jha V, Salam A, Atkins E, Chow CK, Nelson MR, Rakotz M, Schlaich MP, Schutte AE, Usherwood T, Rodgers A. Wisdom of the Crowd: insights gained from comparing predicted and observed effects of blood pressure lowering strategies. J Hum Hypertens. 2023 May;37(5):422-424. doi: 10.1038/s41371-023-00816-y. Epub 2023 Apr 11.

Gnanenthiran SR, Limaye S. COVID-19 mRNA vaccines and myopericarditis. Intern Med J. 2023 Feb;53(2):172-177. doi: 10.1111/imj.15748. Epub 2022 May 28.

Gnanenthiran SR, Tan I, Atkins ER, Avolio A, Bennett B, Chapman N, Chow CK, Freed R, Gnjidic D, Hespe C, Kaur B, Liu HM, Patel A, Peiris D, Reid CM, Schlaich M, Sharman JE, Stergiou GS, Usherwood T, Gianacas C, Rodgers A, Schutte AE. Transforming blood pressure control in primary care through a novel remote decision support strategy based on wearable blood pressure monitoring: The NEXTGEN-BP randomized trial protocol. Am Heart J. 2023 Nov;265:50-58. doi: 10.1016/j.ahj.2023.07.005. Epub 2023 Jul 20.

Gnanenthiran SR, Webster R, Silva A, Maulik PK, Salam A, Selak V, Guggilla RK, Schutte AE, Patel A, Rodgers A; TRIUMPH Study Group. Reduced efficacy of blood pressure lowering drugs in the presence of diabetes mellitus-results from the TRIUMPH randomised controlled trial. Hypertens Res. 2023 Jan;46(1):128-135. doi: 10.1038/s41440-022-01051-7. Epub 2022 Oct 14.

Holmes L, Lui I, Lilburn P, Naoum C, Kritharides L, Ridley L, Morgan L. Bronchiectasis is associated with coronary artery calcification even in never smokers. Respirology. 2023 Aug;28(8):804-806. doi: 10.1111/resp.14527. Epub 2023 May 30.

Jaltotage B, Ihdayhid AR, Lan NSR, Pathan F, Patel S, Arnott C, Figtree G, Kritharides L, Shamsul Islam SM, Chow CK, Rankin JM, Nicholls SJ, Dwivedi G. Artificial Intelligence in Cardiology: An Australian Perspective. Heart Lung Circ. 2023 Aug;32(8):894-904. doi: 10.1016/j.hlc.2023.06.703. Epub 2023 Jul 26.

Koo B-K, Hwang D, Park S, Kuramitsu S, Yonetsu T, Kim CH et al. Practical application of coronary physiological assessment: Asia-Pacific expert consensus document: Part 2. JACC: Asia. 2023 Dec;3(6):825-842. Epub 2023 Sept 12. doi: 10.1016/j.jacasi.2023.07.004.

Koo BK, Lee JM, Hwang D, Park S, Shiono Y, Yonetsu T, Lee SH, Kawase Y, Ahn JM, Matsuo H, Shin ES, Hu X, Ding D, Fezzi S, Tu S, Low AF, Kubo T, Nam CW, Yong ASC, Harding SA, Xu B, Hur SH, Choo GH, Tan HC, Mullasari A, Hsieh IC, Kakuta T, Akasaka T, Wang J, Tahk SJ, Fearon WF, Escaned J, Park SJ. Practical Application of Coronary Physiologic Assessment: Asia-Pacific Expert Consensus Document: Part 1. JACC Asia. 2023 Aug 29;3(5):689-706. doi: 10.1016/j.jacasi.2023.07.003.

Krishnamurthy SN, Pocock S, Kaul P, Owen R, Goodman SG, Granger CB, Nicolau JC, Simon T, Westermann D, Yasuda S, Andersson K, Brandrup-Wognsen G, Hunt PR, Brieger DB, Cohen MG. Comparing the long-term outcomes in chronic coronary syndrome patients with prior ST-segment and non-ST-segment elevation myocardial infarction: findings from the TIGRIS registry. BMJ Open. 2023 Dec 18;13(12):e070237. doi: 10.1136/bmjopen-2022-070237.

Lin J, Pearson SA, Greenfield JR, Park KH, Havard A, Brieger D, Day RO, Falster MO, de Oliveira Costa J. Trends in use of sodium-glucose co-transporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) in Australia in the era of increased evidence of their cardiovascular benefits (2014-2022). Eur J Clin Pharmacol. 2023 Sep;79(9):1239-1248. doi: 10.1007/s00228-023-03539-8. Epub 2023 Jul 14.

Munhoz D, Collet C, Mizukami T, Yong A, Leone AM, Eftekhari A, Ko B, da Costa BR, Berry C, Collison D, Perera D, Christiansen EH, Rivero F, Zimmermann FM, Ando H, Matsuo H, Nakayama M, Escaned J, Sonck J, Sakai K, Adjedj J, Desta L, van Nunen LX, West NEJ, Fournier S, Storozhenko T, Amano T, Engstrøm T, Johnson T, Shinke T, Biscaglia S, Fearon WF, Ali Z, De Bruyne B, Johnson NP. Rationale and design of the pullback pressure gradient (PPG) global registry. Am Heart J. 2023 Nov;265:170-179. doi: 10.1016/j.ahj.2023.07.016. Epub 2023 Aug 21.

Nicolau JC, Owen R, Furtado RHM, Goodman SG, Granger CB, Cohen MG, Westermann D, Yasuda S, Simon T, Hedman K, Hunt PR, Brieger DB, Pocock SJ. Long-term outcomes among stable post-acute myocardial infarction patients living in rural versus urban areas: insights from the prospective, observational TIGRIS registry. Open Heart. 2023 Aug;10(2):e002326. doi: 10.1136/openhrt-2023-002326.

O'Hagan ET, Thiagalingam A, Lowe H, Min H, Marschner S, Jackson J, Klimis H, Kozor R, Figtree G, Kritharides L, Chow CK. Lifestyle changes and quality of life a year after attending Rapid Access Cardiology Clinics: an observational study. Intern Med J. 2023 Dec;53(12):2350-2354. doi: 10.1111/imj.16289.

Pearlman A, Amos D, Elder A, Lowe HC, Arnold R. Takotsubo Cardiomyopathy 'Clustering': A Novel Observation Associated With an Unprecedented Flooding Event. Heart Lung Circ. 2023 May;32(5):e36-e37. doi: 10.1016/j.hlc.2023.02.008.

Pennings GJ, Reddel CJ, Chen VM, Gnanenthiran SR, Kritharides L. Perspective: Collagen induced platelet activation via the GPVI receptor as a primary target of colchicine in cardiovascular disease. Front Cardiovasc Med. 2023 Jan 19;9:1104744. doi: 10.3389/fcvm.2022.1104744.

Ramponi F, Seco M, Bannon PG, Kritharides L, Qasabian R, Wilson MK, Vallely MP. Synchronous Carotid Endarterectomy and Anaortic Off-Pump Coronary Artery Bypass Surgery. Heart Lung Circ. 2023 May;32(5):645-651. doi: 10.1016/j.hlc.2023.01.014. Epub 2023 Mar 10.

Ratwatte S, Ng ACC, Hyun K, Philip R, Boroumand F, Weber C, Kritharides L, Brieger D. Pre-hospital and in-hospital ST-elevation myocardial infarction from 2008 to 2020 in Australia. Int J Cardiol Cardiovasc Risk Prev. 2023 Sep 21;19:200214. doi: 10.1016/j.ijcrp.2023.200214.

Rehan R, Beltrame J, Yong A. Insights into the invasive diagnostic challenges of coronary artery vasospasm - A systematic review. J Cardiol. 2024 Jan;83(1):8-16. doi: 10.1016/j.jjcc.2023.07.020. Epub 2023 Aug 3.

Rehan R, Yong A, Ng M, Weaver J, Puranik R. Coronary microvascular dysfunction: A review of recent progress and clinical implications. Front Cardiovasc Med. 2023 Jan 26;10:1111721. doi: 10.3389/fcvm.2023.1111721.

Schutte AE, Tan I, Gnanenthiran SR, Chan J, Kyriakoulis KG, Schlaich MP, Rodgers A, Stergiou GS. Reply to 'Inadequate study designs for the evaluation of blood pressure monitoring devices and their potential misleading conclusions'. J Hypertens. 2023 Aug 1;41(8):1349-1350. doi: 10.1097/HJH.0000000000003462.

Sritharan HP, Bhatia KS, van Gaal W, Kritharides L, Chow CK, Bhindi R. Association between pre-existing cardiovascular disease, mortality and cardiovascular outcomes in hospitalised patients with COVID-19. Front Cardiovasc Med. 2023 Jul 5;10:1224886. doi: 10.3389/fcvm.2023.1224886.

Sverdlov AL, Koczwara B, Cehic DA, Clark RA, Hunt L, Nicholls SJ, Thomas L, Thornton-Benko E, Kritharides L; Clinical Oncology Society of Australia (COSA)–Cardiac Society of Australia and New Zealand (CSANZ) Cardio-Oncology Working Group. When Cancer and Cardiovascular Disease Intersect: The Challenge and the Opportunity of Cardio-Oncology. Heart Lung Circ. 2023 Jun 13:S1443-9506(23)00510-3. doi: 10.1016/j.hlc.2023.04.301. Epub ahead of print.

Tan I, Gnanenthiran SR, Chan J, Kyriakoulis KG, Schlaich MP, Rodgers A, Stergiou GS, Schutte AE. Evaluation of the ability of a commercially available cuffless wearable device to track blood pressure changes. J Hypertens. 2023 Jun 1;41(6):1003-1010. doi: 10.1097/HJH.0000000000003428. Epub 2023 Apr 3.

Vijayarajan V, Hsu A, Cheng YY, Shu MWS, Hyun K, Sy R, Chow V, Brieger D, Kritharides L, Ng ACC. Outcomes Following Implantable Cardioverter-Defibrillator Insertion in Patients 80 Years of Age or Older: A Statewide Population Cohort Study. Can J Cardiol. 2024 Mar;40(3):389-398. doi: 10.1016/j.cjca.2023.10.019. Epub 2023 Oct 28.

Virk SA, Hyun K, Brieger D, Sy RW. Prognostic benefit of catheter ablation of atrial fibrillation in heart failure: An updated meta-analysis of randomized controlled trials. J Arrhythm. 2023 Jan 17;39(2):129-141. doi: 10.1002/joa3.12812.

Ward NC, Watts GF, Bishop W, Colquhoun D, Hamilton-Craig C, Hare DL, Kangaharan N, Kostner KM, Kritharides L, O'Brien R, Mori TA, Nestel PJ, Nicholls SJ, Psaltis PJ, Raffoul N, White HD, Sullivan DR. Australian Atherosclerosis Society Position Statement on Lipoprotein(a): Clinical and Implementation Recommendations. Heart Lung Circ. 2023 Mar;32(3):287-296. doi: 10.1016/j.hlc.2022.11.015. Epub 2023 Jan 25.

Wong CCY, Yong ASC. Quantitative Flow Ratio-Guided Revascularization: Equally Effective Between the Sexes. JACC Asia. 2023 Dec 26;4(3):213-215. doi: 10.1016/j.jacasi.2023.11.003.

Yu C, Meier S, Bestawros D, Sun D, Trieu J, Yong ASC, Wong CCY, Yiannikas J, Kritharides L, Beltrame JF, Naoum C. Role of Cardiac Magnetic Resonance Imaging and Troponin T in Definitive Diagnosis of Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA). Can J Cardiol. 2023 Jul;39(7):936-944. doi: 10.1016/j.cjca.2023.04.009. Epub 2023 Apr 18.

Yu C, Pathan S, Jeyaprakash P, Kritharides L, Pathan F, Negishi K. Cardiac magnetic relaxometry versus ejection fraction in anthracycline-related cardiac changes: a systematic review and meta-analysis. Open Heart. 2023 Jul;10(2):e002344. doi: 10.1136/openhrt-2023-002344.

2021

Allahwala UK, Ekmejian A, Mughal N, Brieger D, Nour D, Ciofani JL, et al. Impact of coronary artery bypass grafting (CABG) on coronary collaterals in patients with a chronic total occlusion (CTO). Int J Cardiovasc Imaging. 2021;37(12):3373-80.

Al-Obaidi, FR, Hutchings HA, Yong ASC, Al-Rubaiy L, Al-Farhan H, Al-Ali MH, Al-Kinani T, Al-Myahi M, Al-Kenzawi H, Al-Sudani N. Efficacy and safety outcomes of short duration antiplatelet therapy with early cessation of aspirin post percutaneous coronary intervention: a systematic review and meta-analysis. Current Cardiology Reviews 2021, 17(6): e051121190712.

Ayad M, Hyun K, D'Souza M, Redfern J, Gullick J, Ryan M, et al. Factors that influence whether patients with acute coronary syndromes undergo cardiac catheterisation. Med J Aust. 2021;214(7):310-7.

Becattini C., Maraziti G., Vinson D., Ng A.C.C., den Exter P.L., Cote B., Vanni S., Hakemi E.U., Khemasuwan D., Weekes A.J., Soares T.H., Ozsu S., Friz H.P., Erol S., Agnelli G., Jimenez D.. Right ventricle assessment in patients with pulmonary embolism at low-risk for death based on clinical models: an individual patient meta-analysis. European Heart Journal 2021; 42:3190-3199.

Benjamin EJ, Go AS, Desvigne-Nickens P, Anderson CD, Casadei B, Chen LY, Crijns H, Freedman B, Hills MT, Healey JS, Kamel H, Kim DY, Link MS, Lopes RD, Lubitz SA, McManus DD, Noseworthy PA, Perez MV, Piccini JP, Schnabel RB, Singer DE, Tieleman RG, Turakhia MP, Van Gelder IC, Cooper LS and Al-Khatib SM. Research Priorities in Atrial Fibrillation Screening: A Report From a National Heart, Lung, and Blood Institute Virtual Workshop. Circulation. 2021;143:372-388.

Bhatia KS, Sritharan HP, Chia J, Ciofani J, Nour D, Chui K, Vasanthakumar S, Jayadeva P, Kandadai D, Allahwala U, Bhagwandeen R, Brieger DB, Choong CYP, Delaney A, Dwivedi G, Harris B, Hillis G, Hudson B, Javorsky G, Jepson N, Kanagaratnam L, Kotsiou G, Lee A, Lo STH, MacIsaac AI, McQuillan BM, Ranasinghe I, Walton A, Weaver J, Wilson W, Yong A, Zhu J, van Gaal W, Kritharides L, Chow C, Bhindi R. Cardiac complications in patients hospitalised with COVID-19 in Australia. Heart Lung Circ 2021, Sep 1:S1443-9506(21)01193-8.

Bhatia KS, Sritharan HP, Ciofani J, Chia J, Allahwala UK, Chui K, Nour D, Vasanthakumar S, Khandadai D, Jayadeva P, Bhagwandeen R, Brieger D, Choong C, Delaney A, Dwivedi G, Harris B, Hillis G, Hudson B, Javorski G, Jepson N, Kanagaratnam L, Kotsiou G, Lee A, Lo ST, MacIsaac AI, McQuillan B, Ranasinghe I, Walton A, Weaver J, Wilson W, Yong ASC, Zhu J, Van Gaal W, Kritharides L, Chow CK, Bhindi R. Association of hypertension wth mortality in patients hospitalised with COVID-19. Open Heart 2021, Dec 8:e001853.

Bhatia KS, van Gaal W, Kritharides L, Chow CK, Bhindi R; AUS-COVID Investigators. The incidence of cardiac complications in patients hospitalised with COVID-19 in Australia: the AUS-COVID study. Med J Aust 2021, Sep, 215:279 Epub Aug 17.

Boriani G, Palmisano P, Malavasi VL, Fantecchi E, Vitolo M, Bonini N, Imberti JF, Valenti AC, Schnabel RB and Freedman B. Clinical Factors Associated with Atrial Fibrillation Detection on Single-Time Point Screening Using a Hand-Held Single-Lead ECG Device. Journal of clinical medicine. 2021;10.

Brieger D, Freedman B. Decoding stroke risk scores in atrial fibrillation: still more work to do. Eur Heart J. 2021;42(15):1486-8.

Carnicelli AP, Owen R, Pocock SJ, Brieger DB, Yasuda S, Nicolau JC, et al. Atrial fibrillation and clinical outcomes 1 to 3 years after myocardial infarction. Open Heart. 2021;8(2).

Cellar B, Butlin M, Tan I, Argha R, Yong ASC Alvolio A. Are Korotkoff sounds reliable markers for accurate estimation of systolic and diastolic pressure using brachial cuff sphygmomanometry? IEEE Transactions on Biomedical Engineering 2021;68(12): 3593-3601.

Chan NY, Orchard J, Agbayani MJ, Boddington D, Chao TF, Johar S, John B, Joung B, Krishinan S, Krittayaphong R, Kurokawa S, Lau CP, Lim TW, Linh PT, Long VH, Naik A, Okumura Y, Sasano T, Yan B, Raharjo SB, Hanafy DA, Yuniadi Y, Nwe N, Awan ZA, Huang H and Freedman B. 2021 Asia Pacific Heart Rhythm Society (APHRS) practice guidance on atrial fibrillation screening. Journal of Arrhythmia. 2021;38:31-49.

Cheng YY, Chow V, Brieger D, Yan TD, Kritharides L, Ng ACC. Outcomes of 16,436 patients requiring isolated aortic valve surgery: A statewide cohort study. Int J Cardiol, 2021 Mar 1;326:55-61.

Chew DP, Hyun K, Morton E, Horsfall M, Hillis GS, Chow CK, et al. Objective Risk Assessment vs Standard Care for Acute Coronary Syndromes: A Randomized Clinical Trial. JAMA Cardiol. 2021;6(3):304-13.

Ferguson C, Lowres N and Freedman B. Stroke Risk in Adults With Atrial Fibrillation According to Sex. Heart, lung & circulation. 2021;30:937-938.

Figtree G, Doyle K, Hsu MP, Freedman B. The Australian Cardiovascular Alliance (ACvA). Eur Heart J. 2021;42:8-10.

Freedman B and Lowres N. High-intensity atrial fibrillation screening to prevent stroke. Lancet. 2021;398:1465-1467.

Freedman B, Hindricks G, Banerjee A, Baranchuk A, Ching CK, Du X, Fitzsimons D, Healey JS, Ikeda T, Lobban TCA, Mbakwem A, Narasimhan C, Neubeck L, Noseworthy P, Philbin DM, Jr., Pinto FJ, Rwebembera J, Schnabel RB, Svendsen JH, Aguinaga L, Arbelo E, Bohm M, Farhan HA, Hobbs FDR, Martinez-Rubio A, Militello C, Naik N, Noubiap JJ, Perel P, Pineiro DJ, Ribeiro AL and Stepinska J. World Heart Federation Roadmap on Atrial Fibrillation - A 2020 Update. Glob Heart. 2021;16:41.

Gibbs H, Freedman B, Rosenqvist M, Virdone S, Mahmeed WA, Ambrosio G, Camm AJ, Jacobson B, Jerjes-Sanchez C, Kayani G, Oto A, Panchenko E, Ragy H, Kakkar AK and Investigators G-A. Clinical Outcomes in Asymptomatic and Symptomatic Atrial Fibrillation Presentations in GARFIELD-AF: Implications for AF Screening. The American journal of medicine. 2021;134:893-901 e11.

Giskes K, Lowres N, Li J, Orchard J, Hespe C and Freedman B. Atrial fibrillation self screening, management and guideline recommended therapy (AF SELF SMART): A protocol for atrial fibrillation self-screening in general practice. International journal of cardiology Heart & vasculature. 2021;32:100683.

Gnanenthiran SR, Agarwal, Patel A. Frontiers of Cardiovascular Polypills: From Atherosclerosis and Beyond. Trends in Cardiovascular Medicine. 2021. S1050-1738(21)00163-8 Schutte AE, Gnanenthiran SR, Rodgers A. An ISH-led prospective meta-analysis on RCTs of RAAS inhibitors in COVID-19 patients: A call for collaboration. HT News. March 2021.

Gnanenthiran SR, Borghi C, Burger D, Charchar F, Poulter NR, Schlaich M, Steckelings UM, Stergiou GS, Tomaszewski M, Unger T, Wainford RD, Williams B, Rodgers A, Schutte AE. A Prospective Meta-Analysis Protocol on Randomised Trials of Renin-Angiotensin System Inhibitors in Patients with Coronavirus Disease 2019 (COVID-19): An initiative of the International Society of Hypertension. BMJ Open. 2021. 11 (2), e043625.

Gnanenthiran SR, Gallagher M, Ridley L, Tang R, Kritharides L. Chronic occlusion of the thoracic aorta: a novel cause of pleuropericardial effusions and pancytopenia. J Vasc Surg Cases Innov Tech 2021, 7:540544.

Gwynn J, Gwynne K, Rodrigues R, Thompson S, Bolton G, Dimitropoulos Y, Dulvari N, Finlayson H, Hamilton S, Lawrence M, MacNiven R, Neubeck L, Rambaldini B, Taylor K, Wright D and Freedman B. Atrial Fibrillation in Indigenous Australians: A Multisite Screening Study Using a Single-Lead ECG Device in Aboriginal Primary Health Settings. Heart, lung & circulation. 2021;30:267-274.

Haghbayan H, Gale CP, Chew DP, Brieger D, Fox KA, Goodman SG, et al. Clinical Risk Prediction Models for the Prognosis and Management of Acute Coronary Syndromes. Eur Heart J Qual Care Clin Outcomes. 2021.

Hoskin S, Chow V, Brieger D, Kritharides L, Ng ACC. Trends in Acute Pulmonary Embolism Admission Rates and Mortality Outcomes in Australia 2002-2003 and 2017-2018: a retrospective cohort study. Thrombosis and Haemostasis 2021 Feb 28.doi: 10.1055/s-0041-1725932.

Hsu B, Korda R, Naganathan V, Lewis P, Ooi SY, Brieger D, et al. Burden of cardiovascular diseases in older adults using aged care services. Age Ageing. 2021;50(5):1845-9.

Hyun K, Negrone A, Redfern J, Atkins E, Chow C, Kilian J, et al. Gender Difference in Secondary Prevention of Cardiovascular Disease and Outcomes Following the Survival of Acute Coronary Syndrome. Heart Lung Circ. 2021;30(1):121-7.

Jiang Z, Ou C, Qian Y, Rehan R, Yong ASC. Coronary vessel segmentation using multiresolution and multiscale deep learning. Informatics in Medicine Unlocked 2021; 24:1-9.

Lee AH, Ng ACC, Yong ASC, Hyun K, Brieger D, Kritharides L, Chow V. Outcomes of 1,098 Patients Following Transcatheter Aortic Valve Implantation: A Statewide Population-Linkage Cohort Study. Heart Lung Circ. 2021 Mar 12:S1443-9506(21)00054-8.

Lowres N and Freedman B. Population screening for atrial fibrillation to prevent stroke. Lancet. 2021;398:1463-1465.

Lowres N and Freedman B. Searching for atrial fibrillation post-stroke with prolonged monitoring: Do it early, but should we be looking for something else? International journal of cardiology Heart & vasculature. 2021;34:100819.

Lowres N, Giskes K and Freedman B. Next frontier in management of atrial fibrillation. Heart (British Cardiac Society). 2021;107:767-768.

Lowres N, Suwanwela NC, Chutinet A and Freedman B. Response to letter to the editor regarding: "Atrial fibrillation prevalence and risk profile from novel community-based screening in Thailand: A prospective multi-centre study". International journal of cardiology Heart & vasculature. 2021;33:100752.

Ma M, Hyun K, D'Souza M, Chew D, Brieger D. Missed Opportunities to Initiate Oral Anticoagulant in Atrial Fibrillation: Insights from Australian Acute Coronary Syndrome Registries. Heart Lung Circ. 2021.

Malavasi VL, Zoccali C, Brandi MC, Micali G, Vitolo M, Imberti JF, Mussi C, Schnabel RB, Freedman B and Boriani G. Cognitive impairment in patients with atrial fibrillation: Implications for outcome in a cohort study. Int J Cardiol. 2021;323:83-89.

Meier S, Yu C, Raju H, Naoum C. Incidental diagnosis of arrhythmogenic right ventricular cardiomyopathy on coronary computed tomography angiography in a septuagenarian. Eur Heart J. 2021 Mar 14;42(11):1117. doi: 10.1093/eurheartj/ehaa749.

Nishi T, Murai T, Waseda K, Hirohata A, Yong ASC, Ng MKC, Amano T, Barbato E, Kakuta T, Fearon WF. Association of Microvascular Dysfunction With Clinical Outcomes in Patients with Non-flow Limiting Fractional Flow Reserve Measured after Percutaneous Coronary Intervention. International Journal of Cardiology heart & Vasculature 2021, 35:100833.

Parvaneh M, Witting PK, Ku J, Moradi T, Eroglu E, Freedman B, Sutherland GT, McCorkindale A, Guennewig B, Choowong P, Bell-Anderson K, Cooney G, Thomas SR and Eberhard J. Periodontitis induces endothelial dysfunction in mice. Sci Rep. 2021;11:14993.

Peng CQ, Lawson KD, Heffernan M, McDonnell G, Liew D, Lybrand S, Pearson SA, Cutler H, Kritharides L, Trieu K, Huynh Q, Usherwood T, Occhipinti JA. Gazing through time and beyond the health sector: insights from a system dynamics model of cardiovascular disease in Australia. PLos One 2021, Sep 30, 16:e0257760 doi:10.1371/journalpone.0257760.

Pennings G, Reddell C, Kockx M, Magda M, Chen V, Kritharides L. Rapid Platelet release of interleukin 1 b from human platelets is independent of NLRP3 and caspase. Thromb Haemost, 2021, June 25, doi:10.1055/s-0041-1731288.

Pennings GJ, Reddell CJ, Traini M, Campbell H, Chen V, Kritharides L. Colchicine inhibits ROS generation in response to glycoprotein VI stimulation. Sci Rep 2021, Jun 7, 11:11965.

Pocock S, Brieger DB, Owen R, Chen J, Cohen MG, Goodman S, et al. Health-related quality of life 1-3 years post-myocardial infarction: its impact on prognosis. Open Heart. 2021;8(1).

Rao A.C.A., Ng A.C.C., Sy R.W., Chia K.K.M., Hansen P.S., Chiha J., Kilian J., Kanagaratnam L.B.. Electrocardiographic QRS duration is influenced by body mass index and sex. IJC Heart & Vasculature 2021; 37:100884.

Ratwatte S, Hyun K, D'Souza M, Barraclough J, Chew DP, Shetty P, et al. Relation of Body Mass Index to Outcomes in Acute Coronary Syndrome. Am J Cardiol. 2021;138:11-9.

Ratwatte S, Kritharides L, Raju H. Autoadapt algorithm leading to left ventricular dyssynchrony and haemodynamic compromise. Eur Heart J Case Rep 2021, Oct, 5:ytab406.

Reddell CJ, Lau JK , Pennings GJ, Campbell H, Chen V, Kritharides L Circulating platelet-derived extracellular vesicles are decreased after remote ischemic preconditioning in patients with coronary disease: a randomized controlled trial. J Thromb Haemost 2021,19(10): 2605-2611.

Rehan R, Kempler E, McMaster K, Larnach G, Amos D, Elder A, Arnold R, Juergens C, Patel S, Weaver J, Ng M, Roy P, Yong A, Brieger D, Kritharides L, Adams M, Lowe HC. In hospital outcomes for high-risk percutaneous coronary intervention. In patients referred from a rural centre to metropolitan sites. Heart Lung Circ 2021, Aug 11:s1443-9506(21)01163-X.

Sarkies MN, Robinson S, Briffa T, Duffy SJ, Nelson M, Beltrame J, et al. Applying a framework to assess the impact of cardiovascular outcomes improvement research. Health Res Policy Syst. 2021;19(1):67.

Schnabel RB, Wallenhorst C, Engler D, Blankenberg S, Pfeiffer N, Spruenker NA, Buettner M, Michal M, Lackner KJ, Munzel T, Wild PS, Martinez C, Freedman B and Gutenberg Health Study i. Refined atrial fibrillation screening and cost-effectiveness in the German population. Heart (British Cardiac Society). 2021.

Schutte AE, Gnanenthiran SR. Towards a better understanding of why cumulative blood pressure is such a strong predictor of cardiovascular outcomes. Hypertension. 2021. 78(5):1267-1269.

Snir A, Wilson MK, Ju LA, Zhao Y, Wong S, Khor L, Naoum C, Wong K, Keech A, Celermajer DS, Ng MK. Novel Pressure-Regulated Deployment Strategy for Improving the Safety and Efficacy of Balloon-Expandable Transcatheter Aortic Valves. JACC Cardiovasc Interv. 2021 Nov 22;14(22):2503-2515. doi: 10.1016/j.jcin.2021.08.037. Epub 2021 Oct 27.

Stavrakis S, Elkholey K, Lofgren MM, Asad ZUA, Stephens LD and Freedman B. Screening for Atrial Fibrillation in American Indian Adults in a Tribal Primary Care Clinic. Journal of the American Heart Association. 2021;10:e020069.

Stocker TJ, Nühlen N, Schmermund A, Leipsic J, Grove EL, Deseive S, Bax JJ, Maurovich-Horvat P, Otton J, Hadamitzky M, Chen MY, Naoum C, Andreini D, Rubinshtein R, Massberg S, Hausleiter J. Impact of Dose Reduction Strategies on Image Quality of Coronary CTA in Real-World Clinical Practice: A Subanalysis of PROTECTION VI Registry Data. AJR Am J Roentgenol. 2021 Dec;217(6):1344-1352. doi: 10.2214/AJR.21.26007. Epub 2021 Jun 16.

Suwanwela NC, Chutinet A, Autjimanon H, Ounahachok T, Decha-Umphai C, Chockchai S, Indrabhakti S, Kijpaisalratana N, Akarathanawat W, Travanichakul S, Kitjavijitre T, Vongvasinkul P, Kanacharoen I, Bunlikitkul TO, Charnwut S, Lowres N and Freedman B. Atrial fibrillation prevalence and risk profile from novel community-based screening in Thailand: A prospective multi-centre study. International journal of cardiology Heart & vasculature. 2021;32:100709.

Tam CS, Gullick J, Saavedra A, Vernon ST, Figtree GA, Chow CK, et al. Combining structured and unstructured data in EMRs to create clinically-defined EMR-derived cohorts. BMC Med Inform Decis Mak. 2021;21(1):91.

Tan JWC, Chew DP, Brieger D, Eikelboom J, Montalescot G, Ako J, et al. 2020 Asian Pacific Society of Cardiology Consensus Recommendations on Antithrombotic Management for High-risk Chronic Coronary Syndrome. Eur Cardiol. 2021;16:e26.

Tern PJW, Ho AKH, Sultana R, Ahn Y, Almahmeed W, Brieger D, et al. Comparative overview of ST-elevation myocardial infarction epidemiology, demographics, management, and outcomes in five Asia-Pacific countries: a meta-analysis. Eur Heart J Qual Care Clin Outcomes. 2021;7(1):6-17.

Tong A, Sorrell TC, Black AJ, Caillaud C, Chrzanowski W, Li E, Martinez-Martin D, McEwan A, Wang R, Motion A, Bedoya AC, Huang J, Azizi L, Eggleton BJ; COVID-19 Sensor Research Priority-Setting Investigators. Research priorities for COVID-19 sensor technology. Nat Biotechnol. 2021 Feb;39(2):144-147.

Tong S, Bloom J, Quinn S, Nasis A, Hiew C, Roberts-Thomson P, Adams H, Sriamareswaran R, Htun R, Wilson W, Stub D, van Gaal W, Howes L, Yeap A, Yip B, Wu S, Perera P, Collins N, Yong A, Bhindi R, Whitbourn R, Lee A, Premaratne M, Asrress K, Freeman M, Amerena J, Layland J. Colchicine in Patients With Acute Coronary Syndrome: 2 Year Follow-Up of the Australian COPS Randomized Clinical Trial. Circulation 2021;144(19) 1584-1586.

Vijayaratnam PRS, Fulker D, Kim Y.C, Brandt J, Yi J, Yong ASC, Kritharides. L, Simmons A, Barber T.J. Investigating the haemodynamics of myocardial bridging. Experiments in Fluids, 2021, 62, Article 86.

Wachter R and Freedman B. Subclinical Atrial Fibrillation and the Risk of Recurrent Ischemic Stroke. Thrombosis and haemostasis. 2021;121:697-699.

Watts GF, Sullivan DR, Hare DL, Kostner KM, Horton AE, Bell DA, Brett T, Trent RJ, Poplawski NK, Martin AC, Srinivasan S, Justo RN, Chow CK, Pang J; and members of the FH Australasia Network Consensus Working Group. Essentials of a new clinical practice guidance on familial hypercholesterolaemia for physicians. Int Med J 2021, May, 51, 769-779.

Watts GF, Sullivan DR, Hare DL, Kostner KM, Horton AE, Bell DA, Brett T, Trent RJ, Poplawski NK, Martin AC, Srinivasan S, Justo RN, Chow CK, Pang J; FH Australasia Network Consensus Working Group. Integrated guidance for enhancing he care of familial hypercholesterolaemia in Australia. Heart Lung Circ 2021 Mar;30(3):324-349.

Wong C, Nishi T, Yong A, Murai T, Kakuta T, Waseda K, Amano T, Hirohata A, Barbato E, Ng M, Fearon W. Discordance between the index of microcirculatory resistance and coronary flow reserve after percutaneous coronary intervention. JACC Cardiovasc Interv 2021; 14(21): 2412-2414

Wong CCY, Ng ACC, Ada C, Chow V, Fearon WF, Ng MKC, Kritharides L, Yong ASC.A real world comparison of outcomes between fractional flow reserve-guided versus angiography-guided percutaneous coronary intervention. PLoS One 2021, Dec 16, 16:e0259662.

Yong ASC, Pargaonkar VS, Wong CCY, Javadzdegan A, Yamada R, Tanaka S, Kimura T, Rogers IS, Sen I, Kritharides L, Schnittger I, Tremmel JA. Abnormal shear stress and residence time are associated with proximal coronary atheroma in the presence of myocardial bridging. Int J Cardiol 2021, Oct, 340:7-13.

Yu C, Brazete S, Gullick J, Garcia MT, Brieger D, Kritharides L, Naoum C, Ng ACC, Lowe HC. Long-term outcomes following rapid access chest pain clinic assessment: first Australian data. Heart Lung Circ 2021, Sep, 30:1309-1313.

Yu C, Ng ACC, Ridley L, , Kritharides L, Meier S, Yiannikas J, Naoum C. Incidentally identified coronary artery calcium on non-contrast chest CT predicts major adverse cardiac events among hospital inpatients Open Heart 2021Oct, 8:e001695.

Yu C, Ng ACC, Ridley L, Anjaria M, Meier S, Yiannikas J, Kritharides L, Naoum C. Incidentally identified coronary artery calcium on non-contrast CT scan of the chest predicts major adverse cardiac events among hospital inpatients. Open Heart. 2021 Oct;8(2):e001695. doi: 10.1136/openhrt-2021-001695.

Zhang W, Chen Y, Miao C-Y, Huang Q-F, Sheng C-S, Shao S, Wang D, Xu S-K, Lei L, Zhang D, Chen Y-L, Hu L-X, Xia J-H, Ye X-F, Cheng Y-B, Wang Y, Guo Q-H, Li Y, Lowres N, Freedman B and Wang J-G. Quarterly versus annual ECG screening for atrial fibrillation in older Chinese individuals (AF-CATCH): a prospective, randomised controlled trial. The Lancet Healthy Longevity. 2021;2:e470-e478.

Zink MD, Mischke KG, Keszei AP, Rummey C, Freedman B, Neumann G, Tolksdorf A, Frank F, Wienstroer J, Kuth N, Schulz JB and Marx N. Screen-detected atrial fibrillation predicts mortality in elderly subjects. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2021;23:29-38.

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