Selected Grants
|
Amount awarded |
Grant and project details |
|---|---|
| $3,164,215 | National Health and Medical Research Council (NHMRC), 2021-25 “Overcoming Androgen Misuse and Abuse” Investigator: Handelsman |
On
Andrology Research
The Andrology group pursues basic, applied, clinical and public health research in male reproductive health, medicine, and biology.
Andrology is the medical and scientific discipline defined as the study of male reproductive health, medicine and biology. Male Reproductive Health involves the overlapping domains of Fertility, Sexuality and Androgenisation which overlap with male general health, especially regarding androgen (male hormonal) effects.
The Andrology group focuses on both the biological and clinical effects of androgens on male health, in particular men's reproductive and general health across all ages. Androgens (male hormones), the main one being testosterone, occur naturally in the body and play far-reaching roles in many body systems, particularly in male reproduction, fertility, and sexuality. They exert important influence on most non-reproductive tissues especially the prostate, cardiovascular system, bone and the brain, throughout the entire male lifespan and may also influence women's health.
The Andrology group is a collaboration of the:
- Andrology Research Laboratory at the ANZAC Research Institute where the focus is on the physiology and pharmacology of androgens in males and females, by undertaking research using liquid chromatography-mass spectrometry, laboratory bench research and experimental animal models.
- Andrology Department of Concord Hospital/Sydney Local Health District, where patient and community centred research is carried out and translated into improvements in patient care. The focus is on the therapeutic use of androgens such as to treat hormone deficiency states in adolescence and adulthood, in certain chronic diseases, for ageing men. In addition, we also study the relatively widespread misuse/overuse and abuse of androgens for many wishful or harmful non-medical reasons as well as in sports doping.
- Clinical Andrology Laboratory of Concord Hospital and NSW Health Pathology which provides semen analysis and elective sperm cryostorage services. The sperm cryostorage facility is the oldest and longest running sperm bank in Australia. It provides storage of frozen sperm for men about to undergo medical treatment (usually for cancer) which may result in temporary or permanent male infertility.
Our Research Team
| Professor David Handelsman | Head of Department |
|---|---|
| Reena Desai | Research Staff |
| Melissa McMartin | Research Staff |
| Dr Veena Jayadev | Clinical Staff |
| Dr Nandini Shankara-Narayana | Clinical Staff |
| Dr Ann Conway | Clinical Staff |
| Amanda Idan | Clinical Staff |
| Sasha Savkovic | Clinical Staff |
| Gareth Chaney | Clinical Staff |
Our Research Projects
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Physiology & Pharmacology of Androgens |
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Clinical Pharmacology of Testosterone |
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Androgen Abuse Recovery Study |
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Randomised controlled trial of testosterone vs placebo to prevent diabetes (T4DM study) |
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Randomised controlled trial of recovery of serum testosterone after 2 years of exogenous testosterone treatment (T4DM Run-Off study) |
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Randomised controlled trial of testosterone vs placebo with choice extension phase for androgen deficiency symptoms (T4ADS study) SF Mok, C Fennell, G Fraser, L Turner, AJ Conway, V Jayadev, DJ Handelsman |
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Randomised control trial of estradiol for men with advanced prostate cancer for impact on cognition, bone and fat N Russell, M Grossmann, DJ Handelsman |
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Impact and reversibility of non-prescribed androgen use on cardiac and male reproductive function N Narayana-Shankara, A Conway, V Jayadev, S Savkovic, C Fennell with C Yu, C Naoum, A Ng, L Kritharides (Cardiology, Concord Hospital), L Ridley (Radiology, Concord Hospital) |
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Urine and Serum Sex Steroid and Gonadotrophin Profiles in Testosterone-Treated Transgender and Hypogonadal and Healthy Control Men S Savkovic, S Lim, L Turner, C Fennell, G Fraser, V Jayadev, AJ Conway, DJ Handelsman |
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Detection of Testosterone Microdosing (Doping) in Women S Savkovic, DJ Handelsman in collaboration with Daniel Eichner (Salt Lake City Anti-Doping Lab) |
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Detection of Testosterone Microdosing (Doping) in Men S Savkovic, DJ Handelsman in collaboration with Catrin Goebel, J Grainger (Australian Sports Drug Testing Laboratory, National Measurement Institute) |
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Optimal Injection Interval for Testosterone Undecanoate Treatment of Hypogonadal and Transgender Men N Shankara Narayana, Lam P Ly, V Jayadev, C Fennell, S Savkovic, AJ Conway, DJ Handelsman |
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Pharmacokinetics of Recombinant and Urinary Human Chorionic Gonadotrophin in Men S Savkovic, DJ Handelsman in collaboration with Catrin Goebel, J Grainger (Australian Sports Drug Testing Laboratory, National Measurement Institute) |
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Skin Changes Following Testosterone Treatment In Adult Transgender Men: A Pilot Study With Controls S MacDonald, S Smith, V Jayadev, S Lim, A Conway, DJ Handelsman |
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Laboratory Research |
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Development of LCMS measurements for Vitamin D and its phase I and II metabolites Carl Jenkinson (EU Marie Curie Research Fellow), R Desai, DJ Handelsman |
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Steroid Mass Spectrometry: measuring steroid profiles in serum and biological samples R Desai, M McMartin (Edwards), DJ Handelsman |
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Urine and serum urine profiles in human puberty (Archer study) G Singh, R Desai, DJ Handelsman with K Steinbeck (CHW) |
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Experimental Studies of Androgen Action |
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Development of Objective Laboratory-based Method for Androgen Sensitivity K McGrath (UTS), A Heather (Univ Otago), DJ Handelsman |
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Androgens and Female Reproductive Physiology K Walters, DJ Handelsman |
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Role of Androgens in the Origin and Pathogenesis of Polycystic Ovary Syndrome K Walters, DJ Handelsman |
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Measurement of Testosterone Effects on Erythrocyte Lifespan (Humans, Mice) L Seccombe (Respiratory Medicine, Concord Hospital), M McMartin, DJ Handelsman |
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Public Health Andrology |
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Hormonal Epidemiology of Male Ageing: The Concord Health in Ageing Men Project CHAMP) B Hsu, R Cumming, D Le Couteur, MJ Seibel, DJ Handelsman and others |
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Pharmacoepidemiology of testosterone prescribing and overuse LP Ly, DJ Handelsman |
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Global Trends in Human Sperm Output: Re-analysis of Levine meta-analysis and meta-regression S Rezapour, A Azar, DJ Handelsman |
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Reproductive Effects of Novel Non-Cytotoxic and Immunotherapy Anti-cancer Drugs A Idan, C Fennell, S Savkovic, V Jayadev, N Shankara Narayana, AJ Conway, DJ Handelsman with G Long, A Menzies (Melanoma Institute of Australia) and A Anazodo (PoW Hospital) |
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Donor Colonisation of Non-Marrow Epithelia After Allogenic Bone Marrow Transplant N Shankara-Narayana, A Idan, S Savkovic, V Jayadev, AJ Conway, DJ Handelsman |
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Raine Birth Cohort: Reproductive Function at 30 years of age R Hart, DJ Handelsman |
Our Publications
2022
| Akram M, Raza Rizvi SS, Qayyum M, Handelsman DJ. A classification of genes involved in normal and delayed male puberty. Asian J Androl. 2022 Apr 29. doi: 10.4103/aja202210. Epub ahead of print. PMID: 35532554. |
| Catford SR, Halliday J, Lewis S, O'Bryan MK, Handelsman DJ, Hart RJ, McBain J, Rombauts L, Amor DJ, Saffery R, McLachlan RI. Reproductive function in men conceived with in vitro fertilization and intracytoplasmic sperm injection. Fertil Steril. 2022 Apr;117(4):727-737. doi: 10.1016/j.fertnstert.2021.12.026. Epub 2022 Feb 2. PMID: 35120745. |
| Coyle CS, Prescott M, Handelsman DJ, Walters KA, Campbell RE. Chronic androgen excess in female mice does not impact luteinizing hormone pulse frequency or putative GABAergic inputs to GnRH neurons. J Neuroendocrinol. 2022 Apr;34(4):e13110. doi: 10.1111/jne.13110. Epub 2022 Mar 10. PMID: 35267218. |
| Dai Z, Hirani V, Sahni S, Felson DT, Naganathan V, Blyth F, Le Couteur D, Handelsman D, Seibel MJ, Waite L, Kiel DP, Cumming R. Association of dietary fiber and risk of hip fracture in men from the Framingham Osteoporosis Study and the Concord Health and Ageing in Men Project. Nutr Health. 2022 Jun;28(2):229-238. doi: 10.1177/02601060211011798. Epub 2021 May 4. PMID: 33940973. |
| Gild ML, Stuart M, Clifton-Bligh RJ, Kinahan A, Handelsman DJ. Thyroid Hormone Abuse in Elite Sports: The Regulatory Challenge. J Clin Endocrinol Metab. 2022 Apr 19:dgac223. doi: 10.1210/clinem/dgac223. Epub ahead of print. PMID: 35438767. |
| Gnanenthiran SR, Ng ACC, Cumming RG, Brieger DB, le Couteur DG, Waite LM, Seibel M, Handelsman DJ, Naganathan V, Kritharides L, Blyth FM. Hemoglobin, Frailty, and Long-term Cardiovascular Events in Community-Dwelling Older Men Aged ≥ 70 Years. Can J Cardiol. 2022 Jun;38(6):745-753. doi: 10.1016/j.cjca.2022.01.024. Epub 2022 Jan 29. PMID: 35101588. |
| Handelsman DJ, Bacha F, DeBono M, Sleiman S, Janu MR. Sexually transmitted doping: The impact of urine contamination of semen. Drug Test Anal. 2022 Jun 2. doi: 10.1002/dta.3331. Epub ahead of print. PMID: 35655428. |
| Handelsman DJ, Cooper ER, Heather AK. Bioactivity of 11 keto and hydroxy androgens in yeast and mammalian host cells. J Steroid Biochem Mol Biol. 2022 Apr;218:106049. doi: 10.1016/j.jsbmb.2021.106049. Epub 2022 Jan 3. PMID: 34990809. |
| Handelsman DJ, Desai R, Conway AJ, Shankara-Narayana N, Stuckey BGA, Inder WJ, Grossmann M, Yeap BB, Jesudason D, Ly LP, Bracken K, Wittert GA. Recovery of male reproductive endocrine function after ceasing prolonged testosterone undecanoate injections. Eur J Endocrinol. 2022 Jan 28;186(3):307-318. doi: 10.1530/EJE-21-0608. PMID: 35000898. |
| Handelsman DJ. History of androgens and androgen action. Best Pract Res Clin Endocrinol Metab. 2022 Feb 24:101629. doi: 10.1016/j.beem.2022.101629. Epub ahead of print. PMID: 35277356. |
| Handelsman DJ. The Illusory Case for Treatment of an Invented Disease. Front Endocrinol (Lausanne). 2022 Jan 18;12:682620. doi: 10.3389/fendo.2021.682620. PMID: 35116001; PMCID: PMC8803734. |
| Islam RM, Bell RJ, Handelsman DJ, McNeil JJ, Nelson MR, Reid CM, Tonkin AM, Wolfe RS, Woods RL, Davis SR. Associations between blood sex steroid concentrations and risk of major adverse cardiovascular events in healthy older women in Australia: a prospective cohort substudy of the ASPREE trial. Lancet Healthy Longev. 2022 Feb;3(2):e109-e118. doi: 10.1016/S2666-7568(22)00001-0. Epub 2022 Feb 7. PMID: 35252940; PMCID: PMC8896500. |
| Jenkinson C, Desai R, McLeod MD, Wolf Mueller J, Hewison M, Handelsman DJ. Circulating Conjugated and Unconjugated Vitamin D Metabolite Measurements by Liquid Chromatography Mass Spectrometry. J Clin Endocrinol Metab. 2022 Jan 18;107(2):435-449. doi: 10.1210/clinem/dgab708. PMID: 34570174. |
| Khalatbari-Soltani S, Blyth FM, Naganathan V, Le Couteur DG, Handelsman DJ, Seibel MJ, Hirani V, Wright FAC, Waite LM, Cumming RG. Cohort Profile Update: The Concord Health and Ageing in Men Project (CHAMP). Int J Epidemiol. 2022 Feb 18;51(1):31-32h. doi: 10.1093/ije/dyab171. PMID: 34601611. |
| Khoa LD, Trieu Vy ND, Tai Loc NM, Thang LD, Anh DT, Hieu NP, Nhu GH, Tao ND, Hoang L, Handelsman DJ. Antibiotic usage in surgical sperm retrievals among IVF centers. Asian J Androl. 2022 Mar 25. doi: 10.4103/aja2021123. Epub ahead of print. PMID: 35343177. |
| Kiely KM, Khalatbari-Soltani S, Blyth FM, Naganathan V, Handelsman DJ, Waite LM, Le Couteur DG, Mortby ME, Cumming RG, Anstey KJ. Mixed Evidence of an Association between Self-Rated Hearing Difficulties and Falls: Prospective Analysis of Two Longitudinal Studies. Gerontology. 2022 May 20:1-11. doi: 10.1159/000524311. Epub ahead of print. PMID: 35598592. |
| Luong R, Ribeiro RV, Rangan A, Naganathan V, Blyth F, Waite LM, Handelsman DJ, Cumming RG, Le Couteur DG, Hirani V. Changes in dietary total and non-haem iron intake is associated with incident frailty in older men: The Concord Health and Ageing in Men Project. J Gerontol A Biol Sci Med Sci. 2022 Mar 30:glac077. doi: 10.1093/gerona/glac077. Epub ahead of print. PMID: 35352124. |
| Marriott RJ, Murray K, Flicker L, Hankey GJ, Matsumoto AM, Dwivedi G, Antonio L, Almeida OP, Bhasin S, Dobs AS, Handelsman DJ, Haring R, O'Neill TW, Ohlsson C, Orwoll ES, Vanderschueren D, Wittert GA, Wu FCW, Yeap BB. Lower serum testosterone concentrations are associated with a higher incidence of dementia in men: The UK Biobank prospective cohort study. Alzheimers Dement. 2022 Jan 3. doi: 10.1002/alz.12529. Epub ahead of print. PMID: 34978125. |
| Russell N, Allebone J, Dandash O, Hoermann R, Cheung AS, Zajac JD, Handelsman DJ, Kanaan RA, Grossmann M. Effect of estradiol on cognition in men undergoing androgen deprivation therapy: A randomized placebo-controlled trial. Clin Endocrinol (Oxf). 2022 Feb 12. doi: 10.1111/cen.14689. Epub ahead of print. PMID: 35150156. |
| Russell N, Ghasem-Zadeh A, Hoermann R, Cheung AS, Zajac JD, Shore-Lorenti C, Ebeling PR, Handelsman DJ, Grossmann M. Effects of estradiol on bone in men undergoing androgen deprivation therapy: a randomised placebo-controlled trial. Eur J Endocrinol. 2022 Jun 1:EJE-22-0227. doi: 10.1530/EJE-22-0227. Epub ahead of print. PMID: 35666800. |
| Savkovic S, Ly LP, Desai R, Howa J, Nair V, Eichner D, Handelsman DJ. Detection of testosterone microdosing in healthy females. Drug Test Anal. 2022 Apr;14(4):653-666. doi: 10.1002/dta.3202. Epub 2022 Jan 3. PMID: 34811948. |
| Shankara-Narayana N, Brooker L, Goebel C, Speers N, Handelsman DJ. Reliability of Drug History to Verify Androgen Abuse In Men. J Clin Endocrinol Metab. 2022 Jun 6:dgac348. doi: 10.1210/clinem/dgac348. Epub ahead of print. PMID: 35661889. |
| Shi H, Tsai KH, Ma D, Wang X, Desai R, Parungao RJ, Hunt NJ, Cheng YY, Zhang H, Xu Y, Simanainen U, Tan Q, Cooper MS, Handelsman DJ, Maitz PK, Wang Y. Controlled dual release of dihydrotestosterone and flutamide from polycaprolactone electrospun scaffolds accelerate burn wound healing. FASEB J. 2022 May;36(5):e22310. doi: 10.1096/fj.202101803R. PMID: 35394674. |
| Shu CC, Wright F, Naganathan V, Blyth FM, Le Couteur DG, Handelsman DJ, Stanaway FF. Does social support predict increased use of dental services in older men? Aust Dent J. 2022 Apr 3. doi: 10.1111/adj.12911. Epub ahead of print. PMID: 35373341. |
| Volckmar X, Vallejo M, Bertoldo MJ, Nguyen QN, Handelsman DJ, Chisholm O, Anazodo A. Oncofertility Information Available for Recently Approved Novel Non Cytotoxic and Immunotherapy Oncology Drugs. Clin Pharmacol Ther. 2022 Feb;111(2):382-390. doi: 10.1002/cpt.2254. Epub 2021 Apr 22. PMID: 33826770. |
| Wright FAC, Shu EC, Cumming RG, Naganathan V, Blyth FM, Hirani V, Le Couteur DG, Handelsman DJ, Seibel MJ, Waite LM, Stanaway FF. Oral health-related quality of life of older Australian men. Community Dent Oral Epidemiol. 2022 May 13. doi: 10.1111/cdoe.12754. Epub ahead of print. PMID: 35561045. |
| Wu H, Mach J, Gnjidic D, Naganathan V, Blyth FM, Waite LM, Handelsman DJ, Le Couteur DG, Hilmer SN. Comparing Effects of Polypharmacy on Inflammatory Profiles in Older Adults and Mice: Implications for Translational Ageing Research. J Gerontol A Biol Sci Med Sci. 2022 Mar 17:glac061. doi: 10.1093/gerona/glac061. Epub ahead of print. PMID: 35299251. |
| Xiong T, Rodriguez Paris V, Edwards MC, Hu Y, Cochran BJ, Rye KA, Ledger WL, Padmanabhan V, Handelsman DJ, Gilchrist RB, Walters KA. Androgen signaling in adipose tissue, but less likely skeletal muscle, mediates development of metabolic traits in a PCOS mouse model. Am J Physiol Endocrinol Metab. 2022 Jun 6. doi: 10.1152/ajpendo.00418.2021. Epub ahead of print. PMID: 35658542. |
| Xu P, Blyth FM, Naganathan V, Cumming RG, Handelsman DJ, Seibel MJ, Le Couteur DG, Waite LM, Khalatbari-Soltani S. Socioeconomic Inequalities in Elective and Nonelective Hospitalizations in Older Men. JAMA Netw Open. 2022 Apr 1;5(4):e226398. doi: 10.1001/jamanetworkopen.2022.6398. PMID: 35389499; PMCID: PMC8990350. |
| Yeap BB, Marriott RJ, Antonio L, Raj S, Dwivedi G, Reid CM, Anawalt BD, Bhasin S, Dobs AS, Handelsman DJ, Hankey GJ, Haring R, Matsumoto AM, Norman PE, O'Neill TW, Ohlsson C, Orwoll ES, Vanderschueren D, Wittert GA, Wu FCW, Murray K. Associations of Serum Testosterone and Sex Hormone-Binding Globulin With Incident Cardiovascular Events in Middle-Aged to Older Men. Ann Intern Med. 2022 Feb;175(2):159-170. doi: 10.7326/M21-0551. Epub 2021 Dec 28. PMID: 34958606. |
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Cervo MMC, Scott D, Seibel MJ, Cumming RG, Naganathan V, Blyth FM, Le Couteur DG, Handelsman DJ, Ribeiro RV, Waite LM, Hirani V. Adherence to Mediterranean diet and its associations with circulating cytokines, musculoskeletal health and incident falls in community-dwelling older men: The Concord Health and Ageing in Men Project. Clin Nutr. 2021 Dec;40(12):5753-5763. doi: 10.1016/j.clnu.2021.10.010. Epub 2021 Oct 23. PMID: 34763260. |
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Das A, Cumming R, Naganathan V, Blyth F, Couteur DGL, Handelsman DJ, Waite LM, Ribeiro RVR, Simpson SJ, Hirani V. Associations between dietary intake of total protein and sources of protein (plant vs. animal) and risk of all-cause and cause-specific mortality in older Australian men: The Concord Health and Ageing in Men Project. J Hum Nutr Diet. 2021 Nov 21. doi: 10.1111/jhn.12965. Epub ahead of print. PMID: 34806230. |
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Das A, Cumming RG, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Ribeiro RV, Waite LM, Simpson SJ, Hirani V. Changes in micronutrient intake and factors associated with this change among older Australian men: the Concord Health and Ageing in Men Project. Public Health Nutr. 2021 Oct;24(14):4454-4465. doi: 10.1017/S1368980020003249. Epub 2020 Sep 8. PMID: 32895085. |
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Das A, Cumming RG, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Ribeiro RV, Simpson SJ, Hirani V. Associations between nutrient intakes and dietary patterns with different sarcopenia definitions in older Australian men: the concord health and ageing in men project. Public Health Nutr. 2021 Oct;24(14):4490-4505. doi: 10.1017/S1368980020003547. Epub 2020 Oct 7. Erratum in: Public Health Nutr. 2021 Feb;24(2):378-383. PMID: 33023717. |
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Das A, Cumming RG, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Ribeiro RV, Simpson SJ, Hirani V. Associations between nutrient intakes and dietary patterns with different sarcopenia definitions in older Australian men: the concord health and ageing in men project - ERRATUM. Public Health Nutr. 2021 Feb;24(2):378-383. doi: 10.1017/S1368980020004528. Epub 2020 Nov 27. Erratum for: Public Health Nutr. 2020 Oct 07;:1-16. PMID: 33243306. |
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Das A, Cumming RG, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Ribeiro RVR, Simpson SJ, Hirani V. Dietary and supplemental antioxidant intake and risk of major adverse cardiovascular events in older men: The concord health and ageing in men project. Nutr Metab Cardiovasc Dis. 2021 Apr 9;31(4):1102-1112. doi: 10.1016/j.numecd.2020.11.032. Epub 2020 Dec 8. PMID: 33549432. |
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Das A, Cumming RG, Naganathan V, Ribeiro RV, Le Couteur DG, Handelsman DJ, Waite LM, Hirani V. The association between antioxidant intake, dietary pattern and depressive symptoms in older Australian men: the Concord Health and Ageing in Men Project. Eur J Nutr. 2021 Feb;60(1):443-454. doi: 10.1007/s00394-020-02255-8. Epub 2020 May 8. PMID: 32385686. |
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Handelsman DJ, Nimmagadda R, Desai R, Handelsman TD, Whittle B, Skorupskaite K, Anderson RA. Direct measurement of pregnanediol 3-glucuronide (PDG) in dried urine spots by liquid chromatography-mass spectrometry to detect ovulation. J Steroid Biochem Mol Biol. 2021 Jul;211:105900. doi: 10.1016/j.jsbmb.2021.105900. Epub 2021 Apr 17. PMID: 33872762. |
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Handelsman DJ. Androgen Misuse and Abuse. Endocr Rev. 2021 Jul 16;42(4):457-501. doi: 10.1210/endrev/bnab001. PMID: 33484556. |
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Islam RM, Bell RJ, Handelsman DJ, Robinson PJ, Wolfe R, Davis SR; ASPREE Investigator Group. Longitudinal changes over three years in sex steroid hormone levels in women aged 70 years and over. Clin Endocrinol (Oxf). 2021 Mar;94(3):443-448. doi: 10.1111/cen.14401. Epub 2021 Jan 2. PMID: 33351205; PMCID: PMC7957957. |
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Jenkinson C, Desai R, Slominski AT, Tuckey RC, Hewison M, Handelsman DJ. Simultaneous measurement of 13 circulating vitamin D3 and D2 mono and dihydroxy metabolites using liquid chromatography mass spectrometry. Clin Chem Lab Med. 2021 May 20;59(10):1642-1652. doi: 10.1515/cclm-2021-0441. PMID: 34013677; PMCID: PMC8419114. |
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Ji E, Weickert CS, Purves-Tyson T, White C, Handelsman DJ, Desai R, O'Donnell M, Liu D, Galletly C, Lenroot R, Weickert TW. Cortisol- dehydroepiandrosterone ratios are inversely associated with hippocampal and prefrontal brain volume in schizophrenia. Psychoneuroendocrinology. 2021 Jan;123:104916. doi: 10.1016/j.psyneuen.2020.104916. Epub 2020 Oct 14. PMID: 33169678. |
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Khalatbari-Soltani S, Cumming RG, Chomik R, Blyth FM, Naganathan V, Handelsman DJ, Le Couteur DG, Waite LM, Stanaway F. The association between home ownership and the health of older men: Cross-sectional analysis of the Australian Concord Health and Ageing in Men Project. Australas J Ageing. 2021 Sep;40(3):e199-e206. doi: 10.1111/ajag.12896. Epub 2021 Jan 25. PMID: 33492753. |
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Khalatbari-Soltani S, Stanaway F, Sherrington C, Blyth FM, Naganathan V, Handelsman DJ, Seibel MJ, Waite LM, Le Couteur DG, Cumming RG. The Prospective Association Between Socioeconomic Status and Falls Among Community-Dwelling Older Men. J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):1821-1828. doi: 10.1093/gerona/glab038. PMID: 33537735. |
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Le Couteur DG, Handelsman DJ, Stanaway F, Waite LM, Blyth FM, Naganathan V, Cumming RG, Hirani V. Sarcopenic Obesity and Amino Acids: Concord Health and Ageing in Men Project. J Gerontol A Biol Sci Med Sci. 2021 May 22;76(6):1000-1004. doi: 10.1093/gerona/glab076. PMID: 33709116. |
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Mesinovic J, Scott D, Seibel MJ, Cumming RG, Naganathan V, Blyth FM, Le Couteur DG, Waite LM, Handelsman DJ, Hirani V. Risk Factors for Incident Falls and Fractures in Older Men With and Without Type 2 Diabetes Mellitus: The Concord Health and Ageing in Men Project. J Gerontol A Biol Sci Med Sci. 2021 May 22;76(6):1090-1100. doi: 10.1093/gerona/glab062. PMID: 33649759. |
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Milledge K, Cumming RG, Wright FA, Naganathan V, Blyth FM, Le Couteur DG, Waite LM, Handelsman DJ, Hirani V. Associations between the composition of functional tooth units and nutrient intake in older men: the Concord Health and Ageing in Men Project. Public Health Nutr. 2021 Dec;24(18):6335-6345. doi: 10.1017/S1368980021003566. Epub 2021 Aug 20. PMID: 34412721. |
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Ng CA, Scott D, Seibel MJ, Cumming RG, Naganathan V, Blyth FM, Le Couteur DG, Waite LM, Handelsman DJ, Hirani V. Higher-Impact Physical Activity Is Associated With Maintenance of Bone Mineral Density But Not Reduced Incident Falls or Fractures in Older Men: The Concord Health and Aging in Men Project. J Bone Miner Res. 2021 Apr;36(4):662-672. doi: 10.1002/jbmr.4228. Epub 2020 Dec 23. PMID: 33278306. |
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Ng Tang Fui M, Hoermann R, Bracken K, Handelsman DJ, Inder WJ, Stuckey BGA, Yeap BB, Ghasem-Zadeh A, Robledo KP, Jesudason D, Zajac JD, Wittert GA, Grossmann M. Effect of Testosterone Treatment on Bone Microarchitecture and Bone Mineral Density in Men: A 2-Year RCT. J Clin Endocrinol Metab. 2021 Jul 13;106(8):e3143-e3158. doi: 10.1210/clinem/dgab149. Erratum in: J Clin Endocrinol Metab. 2021 Jun 16;106(7):e2855. PMID: 33693907. |
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Ni H, Schmidli R, Savkovic S, Strasser SI, Hetherington J, Desai R, Handelsman DJ. Depot Pure GnRH Antagonist for Long-term Treatment of Ovarian Hyperthecosis Monitored by Multisteroid LCMS Profiling. J Endocr Soc. 2021 Nov 8;5(12):bvab167. doi: 10.1210/jendso/bvab167. PMID: 34877444; PMCID: PMC8645162. |
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Porteous R, Haden P, Hackwell ECR, Singline A, Herde MK, Desai R, Handelsman DJ, Grattan DR, Herbison AE. Reformulation of PULSAR for Analysis of Pulsatile LH Secretion and a Revised Model of Estrogen-Negative Feedback in Mice. Endocrinology. 2021 Nov 1;162(11):bqab165. doi: 10.1210/endocr/bqab165. PMID: 34383026. |
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Rodriguez Paris V, Edwards MC, Aflatounian A, Bertoldo MJ, Ledger WL, Handelsman DJ, Gilchrist RB, Walters KA. Pathogenesis of Reproductive and Metabolic PCOS Traits in a Mouse Model. J Endocr Soc. 2021 Apr 7;5(6):bvab060. doi: 10.1210/jendso/bvab060. PMID: 34056500; PMCID: PMC8152184. |
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Russell N, Hoermann R, Cheung AS, Zajac JD, Handelsman DJ, Grossmann M. Effects of estradiol on fat in men undergoing androgen deprivation therapy: a randomized trial. Eur J Endocrinol. 2021 Nov 30;186(1):9-23. doi: 10.1530/EJE-21-0663. PMID: 34678758. |
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Scott D, Blyth F, Naganathan V, Le Couteur DG, Handelsman DJ, Seibel MJ, Waite LM, Hirani V. Prospective associations of chronic and intrusive pain with sarcopenia and physical disability amongst older Australian men: The Concord Health and Ageing in Men Project. Exp Gerontol. 2021 Oct 1;153:111501. doi: 10.1016/j.exger.2021.111501. Epub 2021 Jul 24. PMID: 34314842. |
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Shankara Narayana N, Ly LP, Jayadev V, Fennell C, Savkovic S, Conway AJ, Handelsman DJ. Optimal injection interval for testosterone undecanoate treatment of hypogonadal and transgender men. Endocr Connect. 2021 Jul 14;10(7):758-766. doi: 10.1530/EC-21-0109. PMID: 34137730; PMCID: PMC8346198. |
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Shi H, Cheer K, Simanainen U, Lesmana B, Ma D, Hew JJ, Parungao RJ, Li Z, Cooper MS, Handelsman DJ, Maitz PK, Wang Y. The contradictory role of androgens in cutaneous and major burn wound healing. Burns Trauma. 2021 Apr 20;9:tkaa046. doi: 10.1093/burnst/tkaa046. PMID: 33928173; PMCID: PMC8058007. |
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Stanaway FF, Ribeiro RV, Khalatbari-Soltani S, Cvejic E, Blyth FM, Naganathan V, Handelsman DJ, Le Couteur DG, Simpson SJ, Waite LM, Cumming RG, Hirani V. Diet quality in an ethnically diverse population of older men in Australia. Eur J Clin Nutr. 2021 Dec;75(12):1792-1800. doi: 10.1038/s41430-021-00893-7. Epub 2021 Mar 12. PMID: 33712723. |
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Sucquart IE, Nagarkar R, Edwards MC, Rodriguez Paris V, Aflatounian A, Bertoldo MJ, Campbell RE, Gilchrist RB, Begg DP, Handelsman DJ, Padmanabhan V, Anderson RA, Walters KA. Neurokinin 3 Receptor Antagonism Ameliorates Key Metabolic Features in a Hyperandrogenic PCOS Mouse Model. Endocrinology. 2021 May 1;162(5):bqab020. doi: 10.1210/endocr/bqab020. PMID: 33522579. |
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Takehara S, Hirani V, Wright FAC, Naganathan V, Blyth FM, Le Couteur DG, Waite LM, Seibel MJ, Handelsman DJ, Cumming RG. Appetite, oral health and weight loss in community-dwelling older men: an observational study from the Concord Health and Ageing in Men Project (CHAMP). BMC Geriatr. 2021 Apr 16;21(1):255. doi: 10.1186/s12877-021-02169-y. PMID: 33863274; PMCID: PMC8052725. |
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Takehara S, Wright FAC, Naganathan V, Hirani V, Blyth FM, Couteur DGL, Waite LM, Seibel MJ, Handelsman DJ, Cumming RG. A Cross-Sectional Study of Perceived Dental Treatment Needs and Oral Health Status in Community-Dwelling Older Australian Men: The Concord Health and Ageing in Men Project. Int Dent J. 2021 Jun;71(3):224-232. doi: 10.1111/idj.12623. Epub 2021 Jan 27. PMID: 34024332. |
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Wittert G, Bracken K, Robledo KP, Grossmann M, Yeap BB, Handelsman DJ, Stuckey B, Conway A, Inder W, McLachlan R, Allan C, Jesudason D, Fui MNT, Hague W, Jenkins A, Daniel M, Gebski V, Keech A. Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial. Lancet Diabetes Endocrinol. 2021 Jan;9(1):32-45. doi: 10.1016/S2213-8587(20)30367-3. PMID: 33338415. |
Our Presentations
2022
| Hutchison JC, Trim PJ, Whiley PAF, Handelsman DJ, Snell M, Loveland KL. Chronic excess of activin A perturbs lipid profile and steroid production in the mouse gonads and adrenal gland. Proceeding of the Society for Reproductive Biology Annual Scientific meeting, Christchurch, New Zealand, November 2022 |
| Kweon S, Gibson E, Golebiowski B, Desai R, Handelsman DJ, Stapleton F. Serum sex hormones and ocular surface symptoms and signs in postmenopausal women. Proceeding of the American Academy of Optometry (AAO) scientific program meeting, San Diego, California, USA, October 2022 |
| Nie T, Venkatesh V, Golub S, Stok K, Desai R, Handelsman DJ, Zajac JD, Grossmann M. Davey RA. Estradiol increases endocortical deposition, trabecular bone volume and bone strength in an adolescent male-to-female mouse model of gender affirming hormone therapy. Proceedings of American Society of Bone and Mineral Research meeting, Austin, Texas, USA, September 2022 (awarded Young Investigator Award) |