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Renal Medicine Research

Renal Medicine is a research-active department operating from the Kidney Centre and Transplant Unit at RPA and the Kidney Node, Charles Perkins Centre, University of Sydney. Research spans from basic immunology through clinical trials, cohort studies to epidemiology. Highlights include microbiota in kidney disease, trials in transplantation, antibodies in transplantation, immunosuppression and kidney disease in people with HIV.

Our Research Team

Professor Steve Chadban Programme Lead
Professor Kate Wyburn Senior Researcher
Dr Tracey Ying Senior Researcher
Clinical Associate Professor Huiling Wu Principal Scientist
Professor David Gracey Senior Researcher
Dr John Saunders Clinical Trials Principal Investigator
Dr Paul Snelling Clinical Trials Principal Investigator
Dr Leyla Aouad Clinical Researcher
Dr Pat Lan Senior Research Fellow
Dr Susan Wan Post Doc Fellow
Ellen Yeo Clinical Trial Coordinator

Selected Grants

Amount awarded Grant and project details
$369,182 NHMRC Partnership Grant, 2019-2024
Maximising Organ Donor offer Utility System-wide (the MODUS study)
Investigators: Webster A (CIA), Wyburn K (CIB), Morton R (CIC), McCaffery K (CID), Kelly P (CIE), Clayton P (CIF), Muscat D (CIG), De La Mata N (CIH)
$2,237,625
(CAN)
CIHR, 2020-2024
CARSK Study: A RCT of screening for CAD while waitlisted for kidney transplantation
Associate Investigator: Chadban S
$778,232 NHMRC Ideas Grant, 2021-2025
Improving Kidney Transplant Outcomes Using Normothermic Machine Perfusion
Investigators: Rogers N (CIA), Patrick E (CIB), Pleass H (CIC), Laurence J (CID), Wyburn K (CIE)

Our Publications

2023

Allen NC, Martin AJ, Snaidr VA, Eggins R, Chong AH, Fernandéz-Peñas P, Gin D, Sidhu S, Paddon VL, Banney LA, Lim A, Upjohn E, Schaider H, Ganhewa AD, Nguyen J, McKenzie CA, Prakash S, McLean C, Lochhead A, Ibbetson J, Dettrick A, Landgren A, Allnutt KJ, Allison C, Davenport RB, Mumford BP, Wong B, Stagg B, Tedman A, Gribbin H, Edwards HA, De Rosa N, Stewart T, Doolan BJ, Kok Y, Simpson K, Low ZM, Kovitwanichkanont T, Scolyer RA, Dhillon HM, Vardy JL, Chadban SJ, Bowen DG, Chen AC, Damian DL. Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients. N Engl J Med. 2023 Mar 2;388(9):804-812. doi: 10.1056/NEJMoa2203086.
Athavale A, Miles N, Pais R, Snelling P, Chadban SJ. Transdermal Magnesium for the Treatment of Peripheral Neuropathy in Chronic Kidney Disease: A Single-Arm, Open-Label Pilot Study. J Palliat Med. 2023 Dec;26(12):1654-1661. doi: 10.1089/jpm.2023.0229. Epub 2023 Jul 25.
Baroux N, Gilles DS, Lamy T, Biche V, Wyburn K, Quirin N. Risk factors for loss to follow-up and outcomes after kidney donation in New Caledonian living donors. Nephrology (Carlton). 2023 Mar;28(3):187-195. doi: 10.1111/nep.14143. Epub 2023 Jan 27.
Bleasel JM, Wan SS, Chadban SJ, Ying T, Gracey DM, Aouad LJ, Chen QA, Utsiwegota M, Mawson J, Wyburn KR. ABO Incompatible Kidney Transplantation Without B-cell Depletion is Associated With Increased Early Acute Rejection: A Single-Center Australian Experience. Transpl Int. 2023 Sep 20;36:11567. doi: 10.3389/ti.2023.11567.
Byers BW, Drak D, Shamu T, Chimbetete C, Dahwa R, Gracey DM. Assessing renal impairment in treatment-naïve adolescents living with HIV commencing antiretroviral therapy in Zimbabwe. AIDS. 2023 Apr 1;37(5):789-794. doi: 10.1097/QAD.0000000000003482. Epub 2023 Jan 13.
Chadban SJ, Singer J, Coates PT. That sinking gut feeling: is transplant-induced dysbiosis contributing to allograft outcomes? Kidney Int. 2023 Mar;103(3):454-457. doi: 10.1016/j.kint.2022.11.022.
Collins MG, Fahim MA, Pascoe EM, Hawley CM, Johnson DW, Varghese J, Hickey LE, Clayton PA, Dansie KB, McConnochie RC, Vergara LA, Kiriwandeniya C, Reidlinger D, Mount PF, Weinberg L, McArthur CJ, Coates PT, Endre ZH, Goodman D, Howard K, Howell M, Jamboti JS, Kanellis J, Laurence JM, Lim WH, McTaggart SJ, O'Connell PJ, Pilmore HL, Wong G, Chadban SJ; BEST-Fluids Investigators; Australasian Kidney Trials Network. Balanced crystalloid solution versus saline in deceased donor kidney transplantation (BEST-Fluids): a pragmatic, double- blind, randomised, controlled trial. Lancet. 2023 Jul 8;402(10396):105-117. doi: 10.1016/S0140-6736(23)00642-6. Epub 2023 Jun 18. Erratum in: Lancet. 2023 Jul 1;402(10395):26. doi: 10.1016/S0140-6736(23)01315-6.
Georgevsky D, Ying L, Krishnan S, Laurence J, Robinson D, Campbell N, Wyburn K, Marinelli T, Davis R, Narayan R, Lutz T, Chan A, Heaney SA, Kitzing YX, Anderson L, Liyanagama K, Robson J, Carter J, Testa G, Johannesson L, Marren A. First uterine transplant case at the Royal Prince Alfred Hospital. Aust N Z J Obstet Gynaecol. 2023 Aug;63(4):599-602. doi: 10.1111/ajo.13700. Epub 2023 May 18.
Hedley JA, Kelly PJ, Wyld M, Shah K, Morton RL, Byrnes J, Rosales BM, De La Mata NL, Wyburn K, Webster AC. Cost-effectiveness of Interventions to Increase Utilization of Kidneys From Deceased Donors With Primary Brain Malignancy in an Australian Setting. Transplant Direct. 2023 Apr 19;9(5):e1474. doi: 10.1097/TXD.0000000000001474.
Heron JE, McManus H, Vickers T, Ryan K, Wright E, Carter A, Stoove M, Asselin J, Grulich A, Donovan B, Guy R, Varma R, Chen M, Ryder N, Lewis DA, Templeton DJ, O'Connor CC, Gracey DM; ACCESS Collaboration. Renal impairment associated with tenofovir disoproxil fumarate for antiretroviral therapy and HIV pre- exposure prophylaxis: An observational cohort study. PLoS One. 2023 Feb 24;18(2):e0280339. doi: 10.1371/journal.pone.0280339.
Hunter-Dickson M, Drak D, Anderson M, Shamu T, Chimbetete C, Dahwa R, Gracey DM. Comparison of CG, CKD-EPI[AS] and CKD-EPI[ASR] equations to estimate glomerular filtration rate and predict mortality in treatment naïve people living with HIV in Zimbabwe. BMC Nephrol. 2023 May 8;24(1):129. doi: 10.1186/s12882-023-03159-5.
Irish GL, Campbell S, Kanellis J, Wyburn K, Clayton PA. Temporal validation of the Australian estimated post-transplant survival score. Nephrology (Carlton). 2023 May;28(5):292-298. doi: 10.1111/nep.14158.
Jackson S, Combes A, Latif E, Tran M, Lam S, Gore N, Utsiwegota M, Mawson J, Smith L, Palma C, Laurence J, Crawford M, Pulitano C, Wyburn K, Chadban S, Leslie S, Vasilaras A. Laparoscopic donor nephrectomy-Technique and peri- operative outcomes in an Australian transplant center. Clin Transplant. 2023 May;37(5):e14945. doi: 10.1111/ctr.14945. Epub 2023 Feb 27.
Josephson MA, Becker Y, Budde K, Kasiske BL, Kiberd BA, Loupy A, Małyszko J, Mannon RB, Tönshoff B, Cheung M, Jadoul M, Winkelmayer WC, Zeier M; for Conference Participants. Challenges in the management of the kidney allograft: from decline to failure: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2023 Dec;104(6):1076-1091. doi: 10.1016/j.kint.2023.05.010. Epub 2023 May 24.
Li YJ, Ma J, Loh YW, Chadban SJ, Wu H. Short-chain fatty acids directly exert anti-inflammatory responses in podocytes and tubular epithelial cells exposed to high glucose. Front Cell Dev Biol. 2023 May 4;11:1182570. doi: 10.3389/fcell.2023.1182570.
Lim WH, Chen JHC, Minas K, Johnson DW, Ladhani M, Ooi E, Boudville N, HawleyC, Viecelli AK, Roberts M, Wyburn K, Walker R, Borlace M, Pilmore H, Davies CE, Lok CE, Teixeira-Pinto A, Wong G. Sex Disparity in Cause-Specific and All-Cause Mortality Among Incident Dialysis Patients. Am J Kidney Dis. 2023 Feb;81(2):156-167.e1. doi: 10.1053/j.ajkd.2022.07.007. Epub 2022 Aug 25.
McMullen L, Khoo L, Anderson L, Strasser S, Gracey DM. BK viraemia as a cause of anaemia in after ABO-incompatible liver transplant: a case report. BMC Infect Dis. 2023 Sep 18;23(1):609. doi: 10.1186/s12879-023-08601-5.
Shi B, Ying T, Chadban SJ. Survival after kidney transplantation compared with ongoing dialysis for people over 70 years of age: A matched-pair analysis. Am J Transplant. 2023 Oct;23(10):1551-1560. doi: 10.1016/j.ajt.2023.07.006. Epub 2023 Jul 17.
Shi B, Ying T, Xu J, Wyburn K, Laurence J, Chadban SJ. Obesity is Associated With Delayed Graft Function in Kidney Transplant Recipients: A Paired Kidney Analysis. Transpl Int. 2023 May 30;36:11107. doi: 10.3389/ti.2023.11107.
Sommerer C, Legendre C, Citterio F, Watarai Y, Oberbauer R, Basic-Jukic N, Han J, Gawai A, Bernhardt P, Chadban S. Cardiovascular Outcomes in De Novo Kidney Transplant Recipients Receiving Everolimus and Reduced Calcineurin Inhibitor or Standard Triple Therapy: 24-month Post Hoc Analysis From TRANSFORM Study. Transplantation. 2023 Jul 1;107(7):1593-1604. doi: 10.1097/TP.0000000000004555. Epub 2023 Jun 20.
Stoler S, van Hal SJ, Chadban S, Le T, Torzillo P, Scarlato RM, Wyburn K, Perkins GB, Marinelli T. Protracted COVID-19 pneumonitis early post-ABO incompatible kidney transplantation: Management considerations and the role of whole genome sequencing. Nephrology (Carlton). 2023 Nov;28(11):639-643. doi: 10.1111/nep.14235. Epub 2023 Aug 27.
Sypek M, Francis A, Chadban S. Predicting graft survival in pediatric kidney transplantation: Does the Box fit? Am J Transplant. 2023 Oct;23(10):1481-1482. doi: 10.1016/j.ajt.2023.08.021. Epub 2023 Aug 29.
Writing Group for the CKD Prognosis Consortium; Grams ME, Coresh J, Matsushita K, Ballew SH, Sang Y, Surapaneni A, Alencar de Pinho N, Anderson A, Appel LJ, Ärnlöv J, Azizi F, Bansal N, Bell S, Bilo HJG, Brunskill NJ, Carrero JJ, Chadban S, Chalmers J, Chen J, Ciemins E, Cirillo M, Ebert N, Evans M, Ferreiro A, Fu EL, Fukagawa M, Green JA, Gutierrez OM, Herrington WG, Hwang SJ, Inker LA, Iseki K, Jafar T, Jassal SK, Jha V, Kadota A, Katz R, Köttgen A, Konta T, Kronenberg F, Lee BJ, Lees J, Levin A, Looker HC, Major R, Melzer Cohen C, Mieno M, Miyazaki M, Moranne O, Muraki I, Naimark D, Nitsch D, Oh W, Pena M, Purnell TS, Sabanayagam C, Satoh M, Sawhney S, Schaeffner E, Schöttker B, Shen JI, Shlipak MG, Sinha S, Stengel B, Sumida K, Tonelli M, Valdivielso JM, van Zuilen AD, Visseren FLJ, Wang AY, Wen CP, Wheeler DC, Yatsuya H, Yamagata K, Yang JW, Young A, Zhang H, Zhang L, Levey AS, Gansevoort RT. Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes: An Individual- Participant Data Meta-Analysis. JAMA. 2023 Oct 3;330(13):1266-1277. doi: 10.1001/jama.2023.17002.