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Renal Medicine Research

Renal Medicine is a research-active department operating from the Kidney Centre and Transplant Unit at RPA and the Kidney Node, Charles Perkins Centre, University of Sydney. Research spans from basic immunology through clinical trials, cohort studies to epidemiology. Highlights include microbiota in kidney disease, trials in transplantation, antibodies in transplantation, immunosuppression and kidney disease in people with HIV.

Our Research Team

Professor Steve Chadban Programme Lead
Professor Kate Wyburn Senior Researcher
Dr Tracey Ying Senior Researcher
Clinical Associate Professor Huiling Wu Principal Scientist
Professor David Gracey Senior Researcher
Dr John Saunders Clinical Trials Principal Investigator
Dr Paul Snelling Clinical Trials Principal Investigator
Dr Leyla Aouad Clinical Researcher
Dr Pat Lan Senior Research Fellow
Dr Susan Wan Post Doc Fellow
Ellen Yeo Clinical Trial Coordinator

Selected Grants

Amount awarded Grant and project details
$369,182 NHMRC Partnership Grant, 2019-2024
Maximising Organ Donor offer Utility System-wide (the MODUS study)
Investigators: Webster A (CIA), Wyburn K (CIB), Morton R (CIC), McCaffery K (CID), Kelly P (CIE), Clayton P (CIF), Muscat D (CIG), De La Mata N (CIH)
$2,237,625
(CAN)
CIHR, 2020-2024
CARSK Study: A RCT of screening for CAD while waitlisted for kidney transplantation
Associate Investigator: Chadban S
$778,232 NHMRC Ideas Grant, 2021-2025
Improving Kidney Transplant Outcomes Using Normothermic Machine Perfusion
Investigators: Rogers N (CIA), Patrick E (CIB), Pleass H (CIC), Laurence J (CID), Wyburn K (CIE)

Our Publications

2022

Anderson MA, Chimbetete C, Shamu T, Dahwa R, Gracey DM. Brief Report: Validation of the D:A:D Chronic Kidney Disease Risk Score Incorporating Proteinuria in People Living With HIV in Harare, Zimbabwe. J Acquir Immune Defic Syndr. 2022 Aug 15;90(5):562-566.
Athavale A, Wyburn K, Snelling P, Chadban SJ. Dialysis Disequilibrium: Is Acidosis More Important than Urea? Case Rep Nephrol. 2022; 2022: 4964033.  
Carroll RP, Boyer M, Gebski V, Hockley B, Johnston JK, Kireta S, Tan H, Taylor A, Wyburn K, Zalcberg JR. Immune checkpoint inhibitors in kidney transplant recipients: a multicentre, single-arm, phase 1 study. Lancet Oncol. 2022 Aug;23(8):1078-1086.
Collins MG, Fahim MA, Pascoe EM, Hawley CM, Johnson DW, Varghese J, Hickey LE, Clayton PA, Gill JS, Dansie KB, McConnochie RC, Vergara LA, Kiriwandeniya C, Reidlinger D, Mount PF, Weinberg L, McArthur CJ, Coates PT, Endre ZH, Goodman D, Howard K, Howell M, Jamboti JS, Kanellis J, Laurence JM, Lim WH, McTaggart SJ, O'Connell PJ, Pilmore HL, Wong G, Chadban SJ. Baseline Characteristics and Representativeness of Participants in the BEST-Fluids Trial: A Randomized Trial of Balanced Crystalloid Solution Versus Saline in Deceased Donor Kidney Transplantation. Transplant Direct. 2022 Nov 4;8(12):e1399. doi: 10.1097/TXD.0000000000001399. PMID: 36479278; PMCID: PMC9722559.
Cutting RB, Webster AC, Cross NB, Dunckley H, Beaglehole B, Dittmer I, Irvine J, Walker C, Jones M, Wyld M, Kelly PJ, Wyburn K, De La Mata NL. AcceSS and Equity in Transplantation (ASSET) New Zealand: Protocol for population-wide data linkage platform to investigate equity in access to kidney failure health services in New Zealand. PLoS One. 2022 Aug 25;17(8):e0273371.
Drak D, Heron JE, Shamu T, Chimbetete C, Dahwa R, Gracey DM. Predictors of renal impairment and proteinuria after commencement of antiretroviral therapy in a Zimbabwean HIV cohort. HIV Med. 2022 Oct;23(9):1002-1006.
Drak D, Shamu T, Heron JE, Chimbetete C, Dahwa R, Gracey DM. Renal function and associated mortality risk in adults commencing HIV antiretroviral therapy in Zimbabwe. AIDS. 2022 Apr 1;36(5):631-636.
Jian Tan, Duan Ni, Jemma Taitz, Gabriela Veronica Pinget, Mark Read, Alistair Senior, Jibran Abdul Wali, Reem Elnour, Erin Shanahan, Huiling Wu, Steven J. Chadban, Ralph Nanan, Nicholas Jonathan Cole King, Georges Emile Grau, Stephen J. Simpson, Laurence Macia. Dietary protein increases T-cell-independent sIgA production through changes in gut microbiota-derived extracellular vesicles. Nat Commun. 2022; 13: 4336.  Published online 2022 Jul 27. doi: 10.1038/s41467-022-31761-y
Julian Singer, Leyla J. Aouad, Kate Wyburn, David M. Gracey, Tracey Ying, Steven J. Chadban. The Utility of Pre- and Post-Transplant Oral Glucose Tolerance Tests: Identifying Kidney Transplant Recipients With or at Risk of New Onset Diabetes After Transplant. Transpl Int. 2022; 35: 10078.  Published online 2022 Mar 17. PMCID: PMC8967957
Kidney Trials Network. Correction to: Statistical analysis plan for better evidence for selecting transplant fluids (BEST-fluids): a randomised controlled trial of the effect of intravenous fluid therapy with balanced crystalloid versus saline on the incidence of delayed graft function in deceased donor kidney transplantation. Trials. 2022 Feb7;23(1):123. doi: 10.1186/s13063-022-06050-0. Erratum for: Trials. 2022 Jan18;23(1):52. PMID: 35130942; PMCID: PMC8819917.
Lai C, Chadban SJ, Loh YW, Kwan TK, Wang C, Singer J, Niewold P, Ling Z, Spiteri A, Getts D, King NJC, Wu H. Targeting inflammatory monocytes by immune-modifying nanoparticles prevents acute kidney allograft rejection. Kidney Int.2022 Nov;102(5):1090-1102. doi: 10.1016/j.kint.2022.06.024. Epub 2022 Jul 16. PMID: 35850291.
Lim WH, Ooi E, Pilmore HL, Johnson DW, McDonald SP, Clayton P, Hawley C, Mulley WR, Francis R, Collins MG, Jaques B, Larkins NG, Davies CE, Wyburn K, Chadban SJ, Wong G. Interactions Between Donor Age and 12-Month Estimated Glomerular Filtration Rate on Allograft and Patient Outcomes After Kidney Transplantation. Transpl Int. 2022 Feb 7;36:10199. doi: 10.3389/ti.2022.10199.
Nickerson PW, Böhmig GA, Chadban S, Kumar D, Mannon RB, van Gelder T, Lee JC, Adler S, Chong E, Djamali A. Clazakizumab for the treatment of chronic active antibody-mediated rejection (AMR) in kidney transplant recipients: Phase 3 IMAGINE study rationale and design. Trials. 2022 Dec 22;23(1):1042. doi:10.1186/s13063-022-06897-3.
Pascoe EM, Chadban SJ, Fahim MA, Hawley CM, Johnson DW, Collins MG; BEST-fluids Investigators; Australasian Elaine M. Pascoe, Steven J. Chadban, Magid A. Fahim, Carmel M. Hawley, David W. Johnson, Michael G. Collins, for the BEST-fluids Investigators and the Australasian Kidney Trials Network. Statistical analysis plan for Better Evidence for Selecting Transplant Fluids (BEST-Fluids): a randomised controlled trial of the effect of intravenous fluid therapy with balanced crystalloid versus saline on the incidence of delayed graft function in deceased donor kidney transplantation. Trials. 2022; 23: 52.  
Perkins GB, Tunbridge M, Salehi T, Sheng Chai C, Kireta S, Johnston J, Penko D, Nitschke J, Yeow AEL, Al-Delfi Z,  Drogemuller CJ, Garcia-Valtanen PG, Masavuli MG, Hope CM, Singer J, Aggarwal A, Stella AO, Turville SG, Hurtado PR, Barry SC, Hissaria P, Grubor-Bauk B, Chadban SJ*, Coates PT*. Concurrent vaccination of kidney transplant recipients and close household cohabitants against COVID-19. Kidney Int. 2022 May; 101(5): 1077-1080.  Published online 2022 Mar 16. PMCID: PMC8923876
Prunster J, Wong G, Larkins N, Wyburn K, Francis R, Mulley WR, Ooi E, Pilmore H, Davies CE, Lim WH. Kidney Donor Profile Index and allograft outcomes: interactive effects of estimated post-transplant survival score and ischaemic time. Clin Kidney J. 2022 Oct 31;16(3):473-483.
Reakes E, Drak D, Gracey D. A suspected case of hyponatraemia induced rhabdomyolysis: a case report. BMC Nephrol. 2022 May 11;23(1):180.
Singer J, Tunbridge M, Perkins GB, Salehi T, Ying T, Wu H, Coates PT, Chadban SJ. Rapamycin and inulin for third-dose vaccine response stimulation (RIVASTIM): Inulin - study protocol for a pilot, multicentre, randomised, double-blinded, controlled trial of dietary inulin to improve SARS-CoV-2 vaccine response in kidney transplant recipients. BMJ Open. 2022 Dec 1;12(12):e062747. doi: 10.1136/bmjopen-2022-062747. PMID: 36456021; PMCID: PMC9716412.
Sobels E, Best M, Chadban S, Pais R. End Stage Kidney Disease Patient Experiences of Renal Supportive Care in an Australian Teaching Hospital - A Qualitative Study. J Pain Symptom Manage. 2022; 63:737-746.
Talbot B, Farnbach S, Tong A, Chadban S, Sen S, Garvey V, Gallagher M, Knight J. Patient and Clinician Perspectives on the use of Remote Patient Monitoring in Peritoneal Dialysis. Can J Kidney Health Dis. 2022; 9: 20543581221084499.  
Tangri N, Chadban S, Cabrera C, Retat L, Sánchez JJG. Projecting the Epidemiological and Economic Impact of Chronic Kidney Disease Using Patient-Level Microsimulation Modelling: Rationale and Methods of Inside CKD. Adv Ther.2022 Oct 28:1-17. doi: 10.1007/s12325-022-02353-5. Epub ahead of print. PMID:36307575; PMCID: PMC9616410.
Tunbridge M, Perkins GB, Singer J, Salehi T, Ying T, Grubor-Bauk B, Barry S, Sim B, Hissaria P, Chadban SJ, Coates PT. Rapamycin and inulin for booster vaccine response stimulation (RIVASTIM)-rapamycin: study protocol for a randomised, controlled trial of immunosuppression modification with rapamycin to improve SARS-CoV-2 vaccine response in kidney transplant recipients. Trials. 2022 Sep 15;23(1):780. doi: 10.1186/s13063-022-06634-w. PMID: 36109788; PMCID:PMC9477178.
Turner D, Drak D, Gracey D, Anderson L. Patterns of biopsy-proven renal disease in people living with HIV: 10 years experience in Sydney, Australia. BMC Nephrol. 2022 Apr 18;23(1):148.
Vinson AJ, Singh S, Chadban S, Cherney D, Gaber O, Gill JS, Helgeson E, Herzog CA, Jardine M, Jha V, Kasiske BL, Mannon RB, Michos ED, Mottl AK, Newby K, Roy-Chaudhury P, Sawinski D, Sharif A, Sridhar VS, Tuttle KR, Vock DM, Matas A. Premature Death in Kidney Transplant Recipients: The Time for Trials is Now. J Am Soc Nephrol. 2022 Apr;33(4):665-673. PMID: 35292438; PMCID: PMC8970447
Wang YM, Shaw K, Zhang GY, Chung EYM, Hu M, Cao Q, Wang Y, Zheng G, Wu H, Chadban SJ, McCarthy HJ, Harris DCH, Mackay F, Grey ST, Alexander SI. Interleukin-33 Exacerbates IgA Glomerulonephritis in Transgenic Mice Overexpressing B Cell Activating Factor. J Am Soc Nephrol. 2022 May;33(5):966-984. doi: 10.1681/ASN.2021081145. Epub 2022 Apr 6. PMID: 35387873; PMCID: PMC9063894.
Wyld MLR, Mata NL, Viecelli A, Swaminathan R, O'Sullivan KM, O'Lone E, Rowlandson M, Francis A, Wyburn K, Webster AC. Sex-Based Differences in Risk Factors and Complications of Chronic Kidney Disease. Semin Nephrol. 2022 Mar;42(2):153-169.
Yu V, Ebrahimi N, Cachalia T, Jacques A, Wyburn K, McCaughan GW, Dunkley S, Crawford MD, Pulitano C, Laurence JM. Combined Liver-Kidney Transplant for Juvenile Polycystic Kidney Disease and Concomitant Hereditary Factor V Deficiency. Exp Clin Transplant. 2022 Nov;20(11):1043-1045.