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Orthopaedic Surgery Research

The Department of Orthopaedic Surgery at Royal Prince Alfred Hospital is founded on the idea of academic and surgical excellence in musculoskeletal injuries and conditions. Our surgeons have a diverse range of interests and specialise in multiple areas including joint reconstruction/replacement (arthroplasty), trauma and oncology. Committed to an evidence-based approach to patient education and appropriate care, the department strives to further the field through high quality research.

Our Research Team

Dr Jeffrey Petchell Head of Department, 
Orthopaedic Surgeon,
Research Lead (Upper limb surgery)
Professor Ian Harris Orthopaedic Surgeon, 
Research Lead and Expert Advisor 
Associate Professor Mark Horsley Orthopaedic Surgeon,
Research Lead (Foot and ankle surgery)
Dr Richard Boyle Orthopaedic Surgeon, 
Research Lead (Bone and soft tissue tumours)
Dr Brett Fritsch Orthopaedic Surgeon,
Research Lead (Robotic surgery)
Dr Sanjeev Gupta Orthopaedic Surgeon,
Education Lead, 
Research Lead (Lower limb arthroplasty)
Dr Christopher Smithers Orthopaedic Surgeon, 
Research Lead (Upper limb surgery)
Dr Maurice Guzman Orthopaedic Surgeon,
Research Lead (Robotic surgery, Bone and soft tissue tumours and lower limb arthroplasty)
Dr Daniel Franks Orthopaedic Surgeon,
Research Lead (Bone and soft tissue tumours and lower limb arthroplasty)
Dr Verinder Sidhu Orthopaedic Surgeon,
Research Lead (Trauma, foot & ankle surgery)
Kate Alexander Research Manager 
Philip Hay Orthopaedic Research Officer
Dr John Farey PhD student. The Role of Dual Mobility Total Hip Replacement in the Management of Femoral Neck Fractures in Older Patients: Reducing the Risk of Prosthetic Dislocation.  Supervisors: Professor Christine Lin, Professor Ian Harris.
Sascha Karunaratne PhD student. Decision Making in TKA. Supervisors: Professor Michael Solomon, Professor Ian Harris, Professor Lyndal Trevena, Associate Professor Mark Horsley.
Dr Verinder Sidhu PhD student. CRISTAL: A cluster randomised, crossover non-inferiority trail of aspirin compared to low molecular weight heparin for venous thromboembolism prophylaxis and safety in hip or knee arthroplasty, a registry nested study. Supervisor: Professor Ian Harris.
Dr William Collins Master of Philosophy, Classification of Pelvic Reconstruction. Supervisor: Professor Ian Harris.

Selected Grants

Amount awarded Grant and project details
$4,744,165 NHMRC, 2023-2027
ROADMAP: RandOmisedArthroplasty infection worlDwide Multidomain Adaptive Platform trial.
RPA Investigator: Harris I.
$1,166,592 NHMRC, 2023-2027
Strengthening Healthcare Systems with Patient Reported Outcome Measures (PROMs).
RPA Investigator: Harris I.
$2,645,721 Medical Research Future Fund (MRFF), 2023-2026
Next-gen clinical registries: common data models, AI & cloud computing.
RPA Investigator: Harris I.
$1,491,743 Medical Research Future Fund (MRFF), 2023-2026
Restructuring musculoskeletal health services to ensure equitable access to effective, affordable allied health care.
RPA Investigator: Harris I.

Our Publications

2024

Murphy GT, Rudraraju R, Mathews T, Sidhu V, Miller A, Brown K, Nicholls A. The tibial tubercle-trochlear groove distance: a comparison study between EOS and MRI in the paediatric population. Skeletal Radiol. 2024 Jan;53(1):85-91. doi: 10.1007/s00256-023-04385-6. Epub 2023 Jun 10.
Karunaratne S, Harris IA, Horsley M, Trevena L, Solomon M. Establishing a hierarchy of total knee arthroplasty patients' goals and its congruity to health professionals' perceptions: a cohort study. ANZ J Surg. 2024 Feb;94(1-2):234-240. doi: 10.1111/ans.18817. Epub 2023 Dec 10.
Teng MJ, Zadro JR, Pickles K, Copp T, Shaw MJ, Khoudair I, Horsley M, Warnock B, Hutchings OR, Petchell JF, Ackerman IN, Drayton A, Liu R, Maher CG, Traeger AC. RECITAL: a non-inferiority randomised control trial evaluating a virtual fracture clinic compared with in-person care for people with simple fractures (study protocol). BMJ Open. 2024 Feb 5;14(2):e080800. doi: 10.1136/bmjopen-2023-080800.
Murphy GT, Le M, Frangos Young A, Le M, Guzman MS, Franks D, Boyle R, Stalley P. Unique case of a broken axle in a GMRS tumour prosthesis: insights and challenges. ANZ J Surg. 2024 May;94(5):970-972. doi: 10.1111/ans.18940. Epub 2024 Mar 12.
Broekhuis D, Meurs WMH, Kaptein BL, Karunaratne S, Carey Smith RL, Sommerville S, Boyle R, Nelissen RGHH. High accuracy of positioning custom triflange acetabular components in tumour and total hip arthroplasty revision surgery. Bone Jt Open. 2024 Apr 1;5(4):260-268. doi: 10.1302/2633-1462.54.BJO-2023-0185.R1.
CRISTAL Study Group. Aspirin or enoxaparin for VTE prophylaxis after primary partial, total or revision hip or knee arthroplasty: A secondary analysis from the CRISTAL cluster randomized trial. PLoS One. 2024 Apr 16;19(4):e0298152. doi: 10.1371/journal.pone.0298152.
Jeys LM, Thorkildsen J, Kurisunkal V, Puri A, Ruggieri P, Houdek MT, Boyle RA, Ebeid W, Botello E, Morris GV; BOOM Consensus Scientific Committee; Laitinen MK; BOOM Consensus Scientific Committee; Abudu A, Ae K, Agarwal M, Ajit Singh V, Akiyama T, Albergo JI, Alexander J, Alpan B, Aoude A, Asavamongkolkul A, Aston W, Baad-Hansen T, Balach T, Benevenia J, Bergh P, Bernthal N, Binitie O, Boffano M, Bramer J, Branford White H, Brennan B, Cabrolier J, Calvo Haro JA, Campanacci DA, Cardoso R, Carey Smith R, Casales Fresnga N, Casanova JM, Ceballos O, Chan CM, Chung YG, Clara-Altamirano MA, Cribb G, Dadia S, Dammerer D, de Vaal M, Delgado Obando J, Deo S, Di Bella C, Donati DM, Endo M, Eralp L, Erol B, Evans S, Eward W, Fiorenza F, Freitas J, Funovics PT, Galli Serra M, Ghert M, Ghosh K, Gomez Mier LC, Gomez Vallejo J, Griffin A, Gulia A, Guzman M, Hardes J, Healey J, Hernandez A, Hesla A, Hongsaprabhas C, Hornicek F, Hosking K, Iwata S, Jagiello J, Johnson L, Johnston A, Joo M, Jutte P, Kapanci B, Khan Z, Kobayashi H, Kollender Y, Koob S, Kotrych D, Le Nail LR, Legosz P, Lehner B, Leithner A, Lewis V, Lin P, Linares F, Lozano Calderon S, Mahendra A, Mahyudin F, Mascard E, Mattei JC, McCullough L, Medellin Rincon MR, Morgan-Jones R, Moriel Garcesco DJ, Mottard S, Nakayama R, Narhari P, O'Toole G, Vania O, Olivier A, Omar M, Ortiz-Cruz E, Ozger H, Ozkan K, Palmerini E, Papagelopoulos P, Parry M, Patton S, Petersen MM, Powell G, Puhaindran M, Raja A, Rajasekaran RB, Repsa L, Ropars M, Sambri A, Schubert T, Shehadeh A, Siegel G, Sommerville S, Spiguel A, Stevenson J, Sys G, Temple T, Traub F, Tsuchiya H, Valencia J, Van de Sande M, Vaz G, Velez Villa R, Vyrva O, Wafa H, Wan Faisham Numan WI, Wang E, Warnock D, Werier J, Wong KC, Norio Y, Zhaoming Y, Zainul Abidin S, Zamora T, Zumarraga JP, Abou-Nouar G, Gebert C, Randall RL. Controversies in orthopaedic oncology. Bone Joint J. 2024 May 1;106-B(5):425-429. doi: 10.1302/0301-620X.106B5.BJJ-2023-1381. 
Alexander K, Karunaratne S, Sidhu V, Fritsch B, Gupta S, Horsley M, Guzman M, Boyle R, McBride K, Steffens D. Evaluating the cost of robotic-assisted total and unicompartmental knee arthroplasty. J Robot Surg. 2024 May 8;18(1):206. doi: 10.1007/s11701-024-01932-8. 
Murphy GT, Shatz J, Bonar SF, Mahar A, Boyle R. Rate of evolution on imaging of a benign primary bone tumour - giant cell tumour. ANZ J Surg. 2024 Jul-Aug;94(7-8):1409-1411. doi: 10.1111/ans.19029. Epub 2024 May 10.
Crebert MJ, Kasunic D, Karunaratne SR, Alexander KG, Scholtz AC, Boyle RA, Steffens D. Patient-Reported Outcomes and Range of Motion Following Knee Arthroplasty Using a Megaprosthesis in Non-Oncological Patients: A Systematic Review. J Arthroplasty. 2024 Oct;39(10):2633-2644.e4. doi: 10.1016/j.arth.2024.05.028. Epub 2024 May 15.
Lun KK, Tang M, Lewin A, Harris IA. Aspirin as Venous Thromboembolism Prophylaxis in Arthroplasty Patients: An Analysis of Clinical Practice Guidelines Recommendations. J Arthroplasty. 2024 Oct;39(10):2405-2412.e1. doi: 10.1016/j.arth.2024.05.050. Epub 2024 May 24.
Karunaratne S, Harris IA, Horsley M, Trevena L, Solomon M. Second opinion in lower limb total joint arthroplasty: do surgeons agree on surgical management? ANZ J Surg. 2024 Jul-Aug;94(7-8):1427-1428. doi: 10.1111/ans.19113. Epub 2024 May 31.
CRISTAL Economic Analysis Study Group. Cost-effectiveness of enoxaparin versus aspirin in the prevention of venous thromboembolism after total hip or knee arthroplasty: an analysis from the CRISTAL cluster-randomized trial. Bone Joint J. 2024 Jun 1;106-B(6):589-595. doi: 10.1302/0301-620X.106B6.BJJ-2023-0783.R2.
Karunaratne S, Harris IA, Horsley M, Trevena L, Solomon M. The achievement of pre-operative expectations in patients undergoing knee arthroplasty: a cohort study evaluating unique patient goals. J Patient Rep Outcomes. 2024 Jun 6;8(1):56. doi: 10.1186/s41687-024-00734-8.
Harris IA, Sidhu VS, MacDessi SJ, Solomon M, Haddad FS. Aspirin for thromboembolic prophylaxis. Bone Joint J. 2024 Jul 1;106-B(7):642-645. doi: 10.1302/0301-620X.106B7.BJJ-2024-0621.
Chan NY, Le M, Reinecker S, Prince M, Murphy GT. Lumbar disk herniation in pregnancy: its incidence, presentation and management: a systematic review. J Spine Surg. 2024 Jun 21;10(2):274-285. doi: 10.21037/jss-24-3. Epub 2024 Jun 13.
Dowsett G, Murphy G, Le M, Chopra S, Sivaji S, Franks D, Boyle R, Guzman M. Combined intra and extraosseous schwannoma of the calcaneus. ANZ J Surg. 2024 Sep;94(9):1657-1659. doi: 10.1111/ans.19139. Epub 2024 Aug 14.
Le M, Murphy GT, Young AF, Chan N, Constantin H, Symes M, Adie S, Guzman M. Effect of insurance type on Management of Vancouver B Periprosthetic Fractures: length of stay, discharge destination and cost implications. ANZ J Surg. 2024 Dec;94(12):2219-2224. doi: 10.1111/ans.19290. Epub 2024 Oct 29.

Our Presentations

2024

Fritsch B. The effect of internal brace on graft healing in single bundle ACLR using hamstring autograft. 2024 ACL Study Group Meeting. Japan. 28 January - 01 February 2024.
Hay P, Sidhu VS, Petchell J, Alexander K, Holder C, McAuliffe MJ, Harris IA. Is there a relationship between patient socioeconomic position and the use of technology assistance in total knee arthroplasty? Analysis of data from the Australian Orthopaedic Association National Joint Replacement Registry.   Surgical Robotics and Innovation Summit 2024. 16 Jun 2024.
Hay P, Alexander K, Horsley M, Boyle R, Fritsch B, Gupta S, Guzman M, Franks D, Sidhu VS, Steffens D. Prospective Short-term Evaluation of Health-Related Quality of Life Outcomes following Robotic Arthroplasty. Surgical Robotics and Innovation Summit 2024. 16 Jun 2024.
Fritsch B (moderator). Fireside Chat. Arthrex Orthopaedic Technology and Innovation Forum. Sydney. 06-07 September 2024.
Fritsch B. My journey to ACL repair. Arthrex Orthopaedic Technology and Innovation Forum. Sydney. 06-07 September 2024.
Fritsch B (panelist). ACL repair: case discussion. Arthrex Orthopaedic Technology and Innovation Forum. Sydney. 06-07 September 2024.
Fritsch B (moderator). Optimal strategies for ACL surgery. Arthrex Orthopaedic Technology and Innovation Forum. Sydney. 06-07 September 2024.
Boyle R, Franks D (co-chairs). 3-D Printing in Pelvic Reconstruction. International Society of Limb Salvage (ISOLS) 2024. 8-11 October 2024.
Boyle R (chair). Chondroid Tumours - BOOM Consensus Findings. International Society of Limb Salvage (ISOLS) 2024. 8-11 October 2024.
Boyle R (moderator). Abstract Session. International Society of Limb Salvage (ISOLS) 2024. 8-11 October 2024.
Boyle R. Surgery & reconstruction techniques for ewings. Australia New Zealand Sarcoma Association Sarcoma Community Connection 2024. 10 October 2024.
Franks D. Does engineering matter / design / fixation / how to keep it in!. International Society of Limb Salvage (ISOLS) 2024. 8-11 October 2024.
Guzman M (chair). Instructional Course Lecture. International Society of Limb Salvage (ISOLS) 2024. 8-11 October 2024.
Guzman M (chair). Artificial Intelligence and Sarcoma Care. International Society of Limb Salvage (ISOLS) 2024. 8-11 October 2024.
Collins W, Boyle R , Guzman M, Franks D, Hay P, Alexander K, Sidhu V, Zadro J, Harris I. Video Abstract: A Novel Classification System for Pelvic Reconstruction, International Society of Limb Salvage. International Society of Limb Salvage (ISOLS) 2024. 8-11 October 2024.
Alexander K, Guzman M, Franks D, Byrne A, Blyth H, Myers H, Coker D, Grimison P, Hong A, Bhadri V, Strach M, Karim R, Luk P, Potter A, Colebatch A, Schatz J, Davidson E, Brown W, Watts A, Kramer K, Hogan S, Steffens D, Boyle R. RPA Outcomes in Bone and Soft Tissue Tumours (ROBUST) Database: An Update on the Royal Prince Alfred Hospital and Chris O'Brien Lifehouse Experience. Australia New Zealand Sarcoma Association ASM 2024. 10-11 October 2024.
Collins W, Boyle R , Guzman M, Franks D, Hay P, Alexander K, Sidhu V, Zadro J, Harris I. Video Abstract: A Novel Classification System for Pelvic Reconstruction, International Society of Limb Salvage.AOA ASM. 13-17 October 2024.
Fritsch B. The hypoplastic femoral condyle does not exist. Australian Orthopaedic Association Annual Scientific Meeting. Brisbane. 16 October 2024.
Fritsch B. The hypoplastic femoral condyle does not exist. Australian Knee Society Meeting. Gold Coast. 17-20 October 2024.
Fritsch B. The hypoplastic LFC does not exist in valgus knees. Magellan Society Biennial Meeting. Noosa. 20-23 October 2024.
Fritsch B. What is a healed ACL? Magellan Society Biennial Meeting. Noosa. 20-23 October 2024.
Fritsch B. UKA vs HTO. Corin user group. 04 December 2024.
Fritsch B. UKA vs HTO - decision algorithm. QLD Journal Club. 05 December 2024.