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Intensive Care Service Research

The RPA Intensive Care Service (ICS) conducts and participates in research activities at a local, national, and international level. Our participation in clinical research exerts a positive influence on the quality of care for all the critically ill adults that we care for. The ICS has an active local research program and makes a prolific contribution to investigator-initiated randomised clinical trials in intensive care medicine via its membership of the Australian and New Zealand Intensive Care Society Clinical Trials Group (ANZICS CTG). 

RPA is one of the few hospitals in Australia which provides an Extracorporeal Membrane Oxygenation (ECMO) service. The Intensive Care Service, in collaboration with the Cardiology, Anaesthetics and Cardiothoracic Surgery Departments, has established an ECMO research program to further refine this advanced form of life support. 

Our Research Team

Associate Professor David Gattas Director of Research
Principal Investigator
Co-investigator
Heidi Buhr Research Clinical Nurse Consultant
Principal Investigator
Co-investigator
Jennifer Coles Research Clinical Nurse Consultant and Research Coordinator
Principal Investigator
Co-investigator

Selected Grants

Amount awarded Grant and project details
$1,800,000 NHMRC, 2019-2023
A phase III multicentre blinded randomised controlled clinical non-inferiority trial of cryopreserved platelets vs. conventional liquid-stored platelets for the management of post-surgical bleeding.
Investigators: Reade M, Marks D, French C, McQuilten Z, Weinberg L, Irving D, Wood E, Bannon P, Johnson L, Gattas D​​​​​​​

Our Publications

2022

Angriman F, Ferreyro BL, Angeloni N, da Costa BR, Wald R, Bagshaw SM, Adhikari NKJ; STARRT-AKI Investigators. The Effect of an Accelerated Renal Replacement Therapy Initiation Is Not Modified by Baseline Risk. Ann Am Thorac Soc. 2022 Sep;19(9):1613-1618. doi: 10.1513/AnnalsATS.202201-046RL. PMID: 35587363.
Bagshaw SM, Neto AS, Smith O, Weir M, Qiu H, Du B, Wang AY, Gallagher M, Bellomo R, Wald R; STARRT-AKI Investigators. Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial. Intensive Care Med. 2022 Dec;48(12):1736-1750. doi: 10.1007/s00134-022-06912-w. Epub 2022 Nov 4. Erratum in: Intensive Care Med. 2023 Feb 9;: PMID: 36331570.
Barakat-Johnson M, Lai M, Stephenson J, Buhr H, Campbell J, Dolton A, Jones S, Leong T, Reddy N, Coyer F. Efficacy of a heel offloading boot in reducing heel pressure injuries in patients in Australian intensive care units: A single-blinded randomised controlled trial. Intensive & Critical Care Nursing, 2022, Vol 70. Available at: doi:https://doi-org.ezproxy.library.sydney.edu.au/10.1016/j.iccn.2022.103205
Clayton NA, Ward EC, Nicholls C, Giannone R, Skylas K, Maitz PK. The addition of respiratory muscle strength training to facilitate swallow and pulmonary rehabilitation following massive tissue loss and severe deconditioning: A case series. Aust Crit Care. 2022 Mar;35(2):210-216. doi: 10.1016/j.aucc.2021.03.003. Epub 2021 Apr 23. PMID: 33902987
Dennis M; RESET Study Group and Sydney ECMO Research Interest Group (includes Duffin S, Forrest P, Oliver M, Totaro R, Southwood T, Gattas D et al). Out-of-hospital cardiac arrest outcomes, end-tidal carbon dioxide and extracorporeal cardiopulmonary resuscitation eligibility: New South Wales pilot data. Emerg Med Australas. 2022 Jun;34(3):452-455. doi: 10.1111/1742-6723.13972. Epub 2022 Apr 7. PMID: 35388615.
Ferrie S, Weiss NB, Chau HY, Torkel S, Stepniewski ME. Association of Subjective Global Assessment with outcomes in the intensive care unit: a retrospective cohort study. Nutrition & Dietetics 2022; 2022;79:572-581.
Ferrie S. Evidence as foundation of practice. Editorial, Nutrition & Dietetics 2022; 79:184-186.
Finfer S, Micallef S, Hammond N, Navarra L, Bellomo R, Billot L, Delaney A, Gallagher M, Gattas D, Li Q, Mackle D, Mysore J, Saxena M, Taylor C, Young P, Myburgh J; PLUS Study Investigators & ANZICS Clinical Trials Group. Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults. N Engl J Med. 2022 Mar 3;386(9):815-826. doi: 10.1056/NEJMoa2114464. Epub 2022 Jan 18. PMID: 35041780.
Hodgson C, Bailey M, Bellomo R, Brickell K, Broadley T, Buhr H, Gabbe B, Gould D, Harrold M, Higgins A, Hurford S, Iwashyna T, Serpa Neto A, Nichol A, Presneill J, Schaller S, Sivasuthan, J, Tipping C, Webb S, Young P; TEAM Study Investigators & ANZICS Clinical Trials Group (2022). Early active mobilization during mechanical ventilation in the ICU. New England Journal of Medicine, 387(19), 1747-1758. doi:10.1056/nejmoa2209083
Hodgson C, Higgins A, Bailey M, Anderson S, Bernard S, Fulcher B, Koe D, Linke N, Board J, Brodie D, Buhr H, Burrell A, Cooper D, Fan E, Fraser J, Gattas D, Hopper I, Huckson S, Litton E, McGuinness S, Nair P, Orford N, Parke R, Pellegrino V, Pilcher D, Sheldrake J, Reddi B, Stub D, Trapani T, Udy A, Serpa Neto, A; EXCEL Study Investigators on behalf of the International ECMO Network & ANZICS Clinical Trials Group (2022). Incidence of death or disability at 6 months after Extracorporeal Membrane Oxygenation in Australia: A prospective, multicentre, registry-embedded cohort study. The Lancet Respiratory Medicine, 10(11), 1038-1048. doi:10.1016/s2213-2600(22)00248-x
Hodgson CL, Higgins AM, Bailey MJ, Mather AM, Beach L, Bellomo R, Bissett B, Boden IJ, Bradley S, Burrell A, Cooper DJ, Fulcher BJ, Haines KJ, Hodgson IT, Hopkins J, Jones AYM, Lane S, Lawrence D, van der Lee L, Liacos J, Linke NJ, Gomes LM, Nickels M, Ntoumenopoulos G, Myles PS, Patman S, Paton M, Pound G, Rai S, Rix A, Rollinson TC, Tipping CJ, Thomas P, Trapani T, Udy AA, Whitehead C, Anderson S, Neto AS; COVID-Recovery Study Investigators and the ANZICS Clinical Trials Group. Comparison of 6-Month Outcomes of Survivors of COVID-19 versus Non-COVID-19 Critical Illness. Am J Respir Crit Care Med. 2022 May 15;205(10):1159-1168. doi: 10.1164/rccm.202110-2335OC. Erratum in: Am J Respir Crit Care Med. 2022 Sep 1;206(5):653. PMID: 35258437.
Karcher C, Jurisevic C, Southwood T, McCormack D, Rogers A, Levine A, Dunning J. The Australasian ANZSCTS/ANZICS Guidelines on Cardiothoracic Advanced Life Support (CALS-ANZ). Critical Care and Resuscitation 24, no. 3 (2022): 218-223. https://doi.org/10.51893/2022.3.AS3
O'Leary MJ, Skowronski G, Critchley C, O'Reilly L, Forlini C, Sheahan L, Stewart C, Kerridge I. Death determination, organ donation and the importance of the Dead Donor Rule following withdrawal of life-sustaining treatment: a survey of community opinions. Intern Med J. 2022 Feb;52(2):238-248. doi: 10.1111/imj.15221. PMID: 33528090
Patanwala A, Moran B, Johnstone C, Koelzow H, Penm J (2022). Effectiveness of Transdermal Buprenorphine for Pain Control in the ICU After Major Surgical Procedures. Critical care explorations, 4(4).
Pound GM, Jones D, Eastwood GM, Paul E, Hodgson CL; Australia and New Zealand Cardiac Arrest Outcome and Determinants of ECMO (ANZ-CODE) Investigators. Long-Term Functional Outcome and Quality of Life Following In-Hospital Cardiac Arrest-A Longitudinal Cohort Study. Crit Care Med. 2022 Jan 1;50(1):61-71. doi: 10.1097/CCM.0000000000005118. PMID: 34166283
Premraj L, Brown A, Burrell A, Fraser J, Pilcher D. Hyperoxia during venoarterial ECMO: Culprit or co-variate? A comment from the BLENDER investigators. Crit Care 26, 345 (2022). https://doi.org/10.1186/s13054-022-04213-8
Reade MC, Marks DC, Howe B, McGuinness S, Parke R, Navarra L, Charlewood R, Johnson L, McQuilten Z; CLIP-II and CLIPNZ-II Investigators.; CLIP-II and CLIPNZ-II Investigators (includes Gattas D). Cryopreserved platelets compared with liquid-stored platelets for the treatment of surgical bleeding: protocol for two multicentre randomised controlled blinded non-inferiority trials (the CLIP-II and CLIPNZ-II trials). BMJ Open. 2022 Dec 20;12(12):e068933. doi: 10.1136/bmjopen-2022-068933. PMID: 36600425; PMCID: PMC9772641.
REMAP-CAP Writing Committee for the REMAP-CAP Investigators. Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2022;327(13):1247-1259. doi:10.1001/jama.2022.2910
Thiara S, Serpa Neto A, Burrell AJC, Fulcher BJ, Hodgson CL. Association of Respiratory Parameters at Venovenous Extracorporeal Membrane Oxygenation Liberation With Duration of Mechanical Ventilation and ICU Length of Stay: A Prospective Cohort Study. Crit Care Explor. 2022 May 2;4(5):e0689. doi: 10.1097/CCE.0000000000000689. PMID: 35517643; PMCID: PMC9067359.
Thomson IK, Hedley J, Rosales BM, Wyburn K, O'Leary MJ, Webster AC. Potential organ donors with primary brain tumours: missed opportunities for donation and transplantation identified in Australian cohort study 2010-2015. ANZ J Surg. 2022 Nov;92(11):2996-3003. doi: 10.1111/ans.18037. Epub 2022 Sep 21. PMID: 36129448
Tran D, Gibson H, Maiorana A, Verrall C, Baker D, Clode M, Lubans D, Zannino D, Bullock A, Ferrie S, Briody J, Simm P, Wijesekera, D'Almeida M, Gosbell S, Davis G, Weintraub R, Keech A, Puranik R, Ugander M, Justo R, Zentner D, Majumdar A, Grigg L, Coombes J, d'Udekem Y, Morris N, Ayer J, Celermajer D, Cordina R. Exercise intolerance, benefits, and prescription for people living with a Fontan circulation: the Fontan Fitness Intervention Trial (F-FIT)-rationale and design. Frontiers in Pediatrics 2022; vol 9: article 799125
Waller KMJ, De La Mata NL, Rosales BM, Hedley JA, Kelly PJ, Thomson IK, O'Leary MJ, Cavazzoni E, Ramachandran V, Rawlinson WD, Wyburn KR, Webster AC. Characteristics and Donation Outcomes of Potential Organ Donors Perceived to Be at Increased Risk for Blood-borne Virus Transmission: An Australian Cohort Study 2010-2018. Transplantation. 2022 Feb 1;106(2):348-357. doi: 10.1097/TP.0000000000003715. PMID: 33988336
Writing Committee for the REMAP-CAP Investigators. Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial. JAMA. 2023;329(1):39-51. doi:10.1001/jama.2022.23257
Zampieri FG, da Costa BR, Vaara ST, Lamontagne F, Rochwerg B, Nichol AD, McGuinness S, McAuley DF, Ostermann M, Wald R, Bagshaw SM; STARRT-AKI Investigators. A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial. Crit Care. 2022 Aug 25;26(1):255. doi: 10.1186/s13054-022-04120-y. PMID: 36008827; PMCID: PMC9404618.