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Institute of Haematology Research

The Royal Prince Alfred Institute of Haematology research unit performs high quality research in both clinical medicine and laboratory studies. We operate an expanding clinical trials unit with a growing trial portfolio which provides new treatment options that would otherwise be not accessible to members of our community. We have a large laboratory research program with major interests in immunotherapy, multiple myeloma, molecular diagnostics and coagulation disorders. The commitment to both clinical and laboratory research promotes excellence in our staff, and drives better outcomes and experiences for our patients and their families.

Our Key Research Themes

Selected Grants

Amount awarded Grant and project details
$2,917,087 MRFF, 2022-2024
A national, multi-centre study evaluating Thrombotic Thrombocytopenia Syndrome (TTS) associated with ChAdOx1 (AZD1222) and other SARS-CoV-2 vaccines (viral vector & m-RNA)
Investigator: Passam F
$1,678,493 MRFF, 2022-2024
More efficient delivery of high-cost standard-of-care therapies in relapsed multiple myeloma using real-time feedback of patient-reported outcome measures: the MY-PROMPT-2 trial
Investigators: Ho PJ, King T
$1,000,000 Sydney Cardiovascular Fellowship, 2018-2023
Investigator: Passam F
$550,000 NSW Cardiovascular EMCR Grant, 2020-2023
Targets for the prevention of cardiovascular thrombosis in metabolic syndrome
Investigator: Passam F
$216,976 Heart Research Institute/New Zealand Partnership Award, 2022-2024
Role of ER stress in platelet function
Investigator: Passam F
$150,000 University of Sydney Nano Institute Grand Challenge, 2022-2024
Organ-on-chip for blood clot assessment
Investigator: Passam F
$150,000 Ramaciotti Foundations Health Investment Grant, 2021-2023
Targeting protein disulfide isomerase for the prevention ofthrombotic disease
Investigator: Passam F

Our Publications

2022

Clarke AJ, Carroll AS, Bryant C, Halmagyi GM. Truncal sensory polyneuropathy in light-chain amyloidosis. Practical Neurology. 2022 Oct 26.
Dunkerton S, Penninkilampi R, Beadnall H, Fulham M, Colebatch A, Jankelowitz S, Ahmed R, Thayer Z, Halmagyi M, Abadir E. Erdheim-Chester disease presenting as precipitous cognitive decline. Practical Neurology. 2022 Oct 25.
Dupuy A, Ju LA, Chiu J, Passam FH. Mechano-Redox Control of Integrins in Thromboinflammation. Antioxid Redox Signal. 2022 Nov;37(13-15):1072-1093. PMID: 35044225.
Enjeti AK, Agarwal R, Blombery P, Chee L, Chua CC, Grigg A, Hamad N, Iland H, Lane S, Perkins A, Singhal D. Panel-based gene testing in myelodysplastic/myeloproliferative neoplasm-overlap syndromes: Australasian Leukaemia and Lymphoma Group (ALLG) consensus statement. Pathology. 2022 Apr 20.
Epstein-Peterson ZD, Derkach A, Geyer S, Mrózek K, Kohlschmidt J, Park JH, Rajeeve S, Stein EM, Zhang Y, Iland H, Campbell LJ. Effect of additional cytogenetic abnormalities on survival in arsenic trioxide-treated acute promyelocytic leukemia. Blood Advances. 2022 Jun 14;6(11):3433-9.
Favaloro EJ, Clifford J, Leitinger E, Parker M, Sung P, Chunilal S, Tran H, Kershaw G, Fu S, Passam F, Ahuja M, Ho SJ, Duncan E, Yacoub O, Tan CW, Kaminskis L, Modica N, Pepperell D, Ballard L, Clarke L, Lee CSM, Gardiner EE, Young-Ill Choi P, Tohidi-Esfahani I, Bird R, Brighton T, Chen VM. Assessment of immunological anti-platelet factor 4 antibodies for vaccine-induced thrombotic thrombocytopenia (VITT) in a large Australian cohort: A multicenter study comprising 1284 patients. J Thromb Haemost. 2022 Dec;20(12):2896-2908. PMID: 36107495.
Fowler NH, Dickinson M, Dreyling M, Martinez-Lopez J, Kolstad A, Butler J, Ghosh M, Popplewell L, Chavez JC, Bachy E, Kato K. Tisagenlecleucel in adult relapsed or refractory follicular lymphoma: the phase 2 ELARA trial. Nature medicine. 2022 Feb;28(2):325-32.
Huang Y, Uyulmaz S, Khoo L, Ch'ng S. Complex head and neck microsurgery/neurosurgery in Gray platelet syndrome. ANZ Journal of Surgery. 2022 Dec 15.
Iland HJ, Russell NH, Dillon R, Schuh AC, Tedjaseputra A, Wei AH, Khwaja A, Knapper S, Lane SW, Reynolds J, McMullin MF. Characteristics and outcomes of patients with acute promyelocytic leukemia and extreme hyperleukocytosis at presentation. Blood Advances. 2022 Sep 8.
Jaeger U, Tam CS, Borchmann P, McGuirk JP, Johansen M, Waller EK, Jaglowski S, Andreadis C, Foley SR, Westin JR, Fleury I. Long-term safety for patients with tisagenlecleucel-treated relapsed/refractory diffuse large B-cell lymphoma. Blood Advances. 2022 Aug 23;6(16):4816-20.
Kavurma MM, Bursill C, Stanley CP, Passam F, Cartland SP, Patel S, Loa J, Figtree GA, Golledge J, Aitken S, Robinson DA. Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery disease. Front Cardiovasc Med. 2022 Nov 16;9:1054576. PMID: 36465438.
Kershaw G, Dix C, Chen VM, Cai N, Khoo TL. Emicizumab assay evaluations and results from an Australian field study of emicizumab measurement. Pathology. 2022 Oct 1;54(6):755-62.
Krigstein M, Iland HJ, Wei AH. Applying molecular measurable residual disease testing in acute myeloid leukaemia. Pathology. 2022 Nov 23.
Lay AJ, Dupuy A, Hagimola L, Tieng J, Larance M, Zhang Y, Yang J, Kong YX, Chiu J, Gray EC, Qin Z, Schmidt D, Maclean JAA, Hofma BR, Ellis ML, Kalev- Zylinska ML, Argon Y, Jackson SP, Hogg P, Passam FH. Endoplasmic reticulum protein 5 attenuates platelet endoplasmic reticulum stress and secretion in a mouse model. Blood Adv. 2022 Dec 12. PMID: 36508284.
Lee CSM, Liang HPH, Connor DE, Dey A, Tohidi-Esfahani I, Campbell H, Whittaker S, Capraro D, Favaloro EJ, Donikian D, Kondo M, Hicks SM, Choi PY, Gardiner EE, Clarke LJ, Tran H, Passam FH, Brighton TA, Chen VM. A novel flow cytometry procoagulant assay for diagnosis of vaccine-induced immune thrombotic thrombocytopenia. Blood Adv. 2022 Jun 14;6(11):3494-3506. PMID: 35359002.
Passam FH, Chen G, Chen VM, Qi M, Krilis SA, Giannakopoulos B. Βeta-2-glycoprotein I exerts antithrombotic function through its domain V in mice. J Autoimmun. 2022 Jan;126. PMID: 34794103.
Rabbolini D, Liang HP, Morel-Kopp MC, Connor D, Whittaker S, Dunkley S, Donikian D, Kondo M, Chen W, Stevenson WS, Campbell H. Building platelet phenotypes: diaphanous-related formin 1 (DIAPH1)-related disorder. Platelets. 2022 Apr 3;33(3):432-42.
Seth I, Bhagavata Srinivasan SP, Bulloch G, Yi DS, Frankel A, Hsu K, Passam F, Garsia R, Corte TJ. Diffuse alveolar haemorrhage as a rare complication of antiphospholipid syndrome. Respirol Case Rep. 2022 Apr 5;10(5):e0948. PMID: 35414937.
Taher A, Abadir E, McCluskey P, Hamad N, Lo TH, Heydon P. Presumptive Recurrence of Intra-ocular Lymphoma Despite Chimeric Antigen Receptor T-cell Therapy. Retinal Cases and Brief Reports. 2022 Mar 2.
Yu V, Ebrahimi N, Cachalia T, Jacques A, Wyburn K, McCaughan GW, Dunkley S, Crawford MD, Pulitano C, Laurence JM. Combined Liver-Kidney Transplant for Juvenile Polycystic Kidney Disease and Concomitant Hereditary Factor V Deficiency. Experimental and Clinical Transplantation: Official Journal of the Middle East Society for Organ Transplantation. 2022 Nov 1;20(11):1043-5.