A NSW Government website


Endocrinology Research

The RPA Department of Endocrinology comprises: 

  • The Diabetes Centre 
  • Metabolism and Obesity Service 
  • Endocrinology and Metabolism Centre 
  • The Charles Perkins Centre (CPC) RPA Clinic (Endocrinology Node) 
  • The Greg Brown Diabetes & Endocrinology Research Laboratory.

The research undertaken by our department is broad in scope, reflecting the breadth of Endocrine related disease. Major diseases studied are diabetes mellitus and its complications, thyroid disease including cancer and Graves' disease, pituitary disease, and morbid obesity and its management (with particular interest in people with obesity and mental illness and intellectual delay and genetic disorders such as Prader-Willi syndrome). Research includes clinical intervention studies, clinical audit and health care delivery research, and translational research including biomarker studies and testing of findings and potential mediators of disease in preclinical models.

Our Research Team

Diabetes Centre

Dr Ted Wu Director of Diabetes
Associate Professor Margaret McGill AM Assistant Director
Clinical Professor Jencia Wong Endocrinology Senior Staff Specialist, Director of Research
Dr Timothy Middleton Endocrinology Staff Specialist and Associate Director of Research. Clinical Lecturer, The University of Sydney
Dr Maria Constantino CDE Data Manager Diabetes Centre and Diabetes Data Driven Research Group
Associate Professor Glynis Ross Visiting Medical Officer Endocrinology, Clinician Researcher
Connie Luo Nurse Practitioner Diabetes
Amanda Gauld Clinical Nurse Specialist, Research and Clinical Trials Coordinator
Stephanie Noonan Diabetes Educator, Clinical Trials Coordinator, Registered Nurse
Yi Shi Diabetes Educator, Clinical Trials Coordinator, Registered Nurse
Georgia Lonergan Diabetes Educator, Clinical Trials Coordinator, Registered Nurse
Holly Murdoch Registered Nurse
Dr Arianne Sweeting Staff Specialist, Skip Martin Fellow
Dr Angela Lee Endocrinology Staff Specialist, Clinical Lecturer The University of Sydney
Dr Pamela Jean Ho Visiting Medical Officer Endocrinology, Clinician Researcher
Dr Eddy Tabet Endocrinology Staff Specialist, Clinician Researcher

Endocrine and Metabolism Centre

Dr Albert Hsieh Director
Dr Ash Gargya Staff Specialist
Dr Nimalie Perera Staff Specialist
Dr Jessica Bindra Endocrine Advanced Trainee
Dr Xi May Zhen Endocrine Advanced Trainee
Dr Arunan Sriravindrarajah Endocrine Advanced Trainee
Dr Senthil Thillainadesan Honorary Medical Officer
Professor Arthur Conigrave Clinical Academic
Julie Hetherington Nurse Practitioner, Clinical Nurse Consultant
Roghaya Fatouros Registered Nurse
Rupinder Kaur Dehar Registered Nurse

The Greg Brown Diabetes and Endocrinology Research Laboratory

Professor Stephen Twigg Head of Department Endocrinology, Medical Head of the Greg Brown Diabetes and Endocrinology Research Laboratory
Dr Danqing Min Principal Hospital Scientist, Laboratory Manager
Associate Professor Paul Williams Honorary Associate Professor
Associate Professor Susan McLennan Honorary Associate Professor
Associate Professor Elizabeth Chua Staff Specialist Endocrinologist
Associate Professor Qihan Dong Honorary Associate Professor
Dr Xiaoyu Wang Research Fellow 
Dr Callum Baker Exercise Physiologist, Postdoctoral Fellow
Dr Su Su Thae Hnit Postdoctoral Fellow
Dr Amber Xie Postdoctoral Fellow
James Gerofi Exercise Physiologist, Project Manager
Coco Xiaoge Huang Research Affiliate
Adelea Kee Research Affiliate

Charles Perkins Centre, RPA Clinic

María Lastra Cagigas PhD Postdoctoral Fellow
Tiana Maria Pelaia Research Assistant 

Selected Grants

Amount awarded Grant and project details
$3,174,380 NHMRC Clinical Trial Scheme, 2020-2025
Can Flash Glucose Monitoring improve blood glucose levels in Indigenous Australians with type 2 diabetes?
Investigators: Ekinci E (CIA), Twigg (CIF) 
$2,500,000 NHMRC  Investigator Grant, 2020-2024
Food and exercise as medicine: a new medical approach for the prevention of age-related diseases.
Investigator: Fontana L (CIA)
$2,500,000 Australian Youth and Health Foundation, 2019-2024
Effects of comprehensive lifestyle modification on atherosclerosis progression in patients with coronary artery disease measured by non-invasive CT coronary angiography.
Investigator: Fontana L (CIA)
$2,500,000 MRFF, 2020-2024
Diabetes Across the Life Course: Northern Australia Partnership.
Investigators: Maple-Brown L, Ross G (Associate Investigator)
$1,925,000 Australian Youth and Health Foundation, 2022-2029
Food and exercise as medicine: education is key.
Investigator: Fontana L (CIA)
$1,920,566 NHMRC, 2020-2024
Can a pre-conception weight loss program improve maternal and infant outcomes for women with overweight or obesity? A pragmatic randomised controlled trial.
Investigators: Gordon A (CIA), Markovic (CIII)
$1,500,000 NovoNordisk, 2019-2022
Novel Biomarkers in diabetes.
Investigator: Hocking S (secondary CI)
$1,050,013 Philip Bushell Foundation, 2021-2024
Improving the outcomes of chemotherapy treatment for cancer by reducing damage to normal cells.
Investigator: Fontana L (CIA)
$750,000 The University of Sydney, 2018- current
DVC Research/Strategic Research Recruitment and Retention Program (SRRRP) Picasso (DVCR-419).
Investigator: Fontana L.
$547,202 NHMRC, 2021-2023
Characterisation of erusiolin - a new peptide hormone.
Investigators: Larance M (CIA), Hocking S (CIB)
$500,000 Diabetes Australia, 2021-2024
The Dr. Alan Stocks Kellion Victory Medal Research Program (KVMRP).
Investigator: Twigg S.
$172,442 The Reginald Ward and Adrian Cotter Foundation, 2022-2024
PACE-G (plus): Investigating further impacts of exercise on health.
Investigator: Twigg S.
$120,000 MRFF Sydney Health Partners, 2022-2023
Improving Engagement in Patients with Young Adult Onset Type 2 Diabetes.
Investigators: Middleton T, Chow C, Wong J.
$60,000 Diabetes Australia/Diabetes Research Grant Program, 2020-2022
Can exercise training treat established NASH fibrosis in diabetes.
Investigators: Twigg S, Min D, Keating S, Wang X, Johnson N, Gorrell M.
$50,000 Exercise Sports Science Australia, 2022-2023
The effects of Exercise in Adults with Diabetic Foot Ulcers: The DFUEx Study.
Investigators: Johnson N, Twigg S, Baker C, Min D, Chuter V.
$38,240 The University of Sydney, 2021-2022
DVC Research COVID-19 Support Funds.
Investigator: Twigg S.
$1000 UNSW, 2022
UNSW CVMM EMCR Conference Award.
Investigator: Baker C.
$700 Australian Diabetes, 2022
ADS Travel Grant.
Investigator: Baker C.
$700 Australian Diabetes, 2022
ADC travel grant.
Investigator:  Siwan E.

Our Publications


Badorrek S, Franklin J, Devadas M, Williams K. Support needs of people undertaking bariatric surgery: A narrative review. Clin Obes. 2023 Aug;13(4):e12605. doi: 10.1111/cob.12605. Epub 2023 Jun 7.
Bessell E, Markovic TP, Caterson ID, Fuller NR. Changes in Prediabetes Status Among Adults During a 6-Month Randomized Placebo-controlled Supplement Trial With Nutrition and Lifestyle Counselling and 6-Month Follow-up. Can J Diabetes. 2023 Oct;47(7):571-578. doi: 10.1016/j.jcjd.2023.05.004. Epub 2023 May 13.
Constantino M, Chobanian A, Twigg SM, McGill M, Wu T, Middleton T, Tabet E, Mallawaarachchi A, Molloy L, Gauld A, Wong J. IDF2022-0694 Pre-genetic screening and the use of GLP-1 RA and SGLT-2i in monogenic diabetes: A real-world audit-based study. Diabetes Res Clin Pract. 2023;197:110453. DOI: 10.1016/j.diabres.2023.110453
Demaria M, Bertozzi B, Veronese N, Spelta F, Cava E, Tosti V, Piccio L, Early DS, Fontana L. Long-term intensive endurance exercise training is associated to reduced markers of cellular senescence in the colon mucosa of older adults. NPJ Aging. 2023 Feb 27;9(1):3. doi: 10.1038/s41514-023-00100-w.
Eer ASY, Ho RCY, Hearn T, Hachem M, Freund M, Burchill LJ, Atkinson-Briggs S, Singh S, Eades S, O'Brien RC, Furler JS, O'Neal DN, Story DA, Zajac JD, Braat S, Brown A, Clarke P, Sinha AK, McLean AG, Twigg SM, Ekinci EI. Feasibility and acceptability of the use of flash glucose monitoring encountered by Indigenous Australians with type 2 diabetes mellitus: initial experiences from a pilot study. BMC Health Serv Res. 2023 Dec 8;23(1):1377. doi: 10.1186/s12913-023-10121-6.
Franklin J, Sim KA, Swinbourne JM, Maston G, Manson E, Nelthorpe H, Markovic T, Hocking S. Obesity, lifestyle behaviours and psychological effects of the COVID-19 lockdown: A survey of patients attending a tertiary weight loss clinic. Clin Obes. 2023 Apr;13(2):e12567. doi: 10.1111/cob.12567. Epub 2022 Nov 12.
Franklin RC, Franklin JL, Swinbourne JM, Manson E, Loughnan G, Markovic T, Hocking S. Understanding the confluence of injury and obesity in a Grade 2 obesity and above population. Aust N Z J Public Health. 2023 Feb;47(1):100008. doi: 10.1016/j.anzjph.2022.100008. Epub 2023 Jan 12.
Gibson AA, Gale J, Stamatakis E, Lindley RI, Fontana L, Cistulli PA, Nassar N. Impact of lifestyle risk factors on admission to nursing home care: a cohort study of 127 108 people aged 60 years and over. J Epidemiol Community Health. 2023 Nov;77(11):744-751. doi: 10.1136/jech-2023-220518. Epub 2023 Aug 24.
Hamilton EJ, Twigg SM. Diabetes-related foot disease: new insights with an antipodean focus. J Endocrinol. 2023 May 2;257(3):e220238. doi: 10.1530/JOE-22-0238.
Huang CX, Siwan E, Fox SL, Longfield M, Twigg SM, Min D. Comparison of digital and traditional skin wound closure assessment methods in mice. Lab Anim Res. 2023 Oct 27;39(1):25. doi: 10.1186/s42826-023-00176-1.
Jamieson EL, Dimeski G, Flatman R, Hickman PE, Ross Dallas Jones G, V Marley J, David McIntyre H, McNeil AR, Nolan CJ, Potter JM, Sweeting A, Ward P, Williams P, Rita Horvath A. Oral glucose tolerance test to diagnose gestational diabetes mellitus: Impact of variations in specimen handling. Clin Biochem. 2023 May;115:33-48. doi: 10.1016/j.clinbiochem.2022.10.002. Epub 2022 Oct 13.
Kim M, Holton M, Sweeting A, Koreshe E, McGeechan K, Miskovic-Wheatley J. Using health administrative data to model associations and predict hospital admissions and length of stay for people with eating disorders. BMC Psychiatry. 2023 May 10;23(1):326. doi: 10.1186/s12888-023-04688-x.
Kong APS, Lim S, Yoo SH, Ji L, Chen L, Bao Y, Yeoh E, Chan SP, Wang CY, Mohan V, Cohen N, McGill MJ, Twigg SM. Asia-Pacific consensus recommendations for application of continuous glucose monitoring in diabetes management. Diabetes Res Clin Pract. 2023 Jul;201:110718. doi: 10.1016/j.diabres.2023.110718. Epub 2023 May 23.
Lambert T, Middleton T, Chen R, Sureshkumar P. Prevalence of, and factors associated with, diabetes mellitus in people with severe mental illness attending a multidisciplinary, outpatient cardiometabolic health assessment service. BMJ Open Diabetes Res Care. 2023 Jan;11(1):e003055. doi: 10.1136/bmjdrc-2022-003055.
Law KK, Coyle DH, Neal B, Huang L, Barrett EM, Arnott C, Chow CK, Di Tanna GL, Lung T, Mozaffarian D, Berkowitz SA, Wong J, Wu T, Twigg S, Gauld A, Simmons D, Piya MK, MacMillan F, Khoo CL, Tian M, Trieu K, Wu JHY. Protocol for a randomized controlled trial of medically tailored meals compared to usual care among individuals with type 2 diabetes in Australia. Contemp Clin Trials. 2023 Sep;132:107307. doi: 10.1016/j.cct.2023.107307. Epub 2023 Jul 28.
Lazarus JV, Mark HE, Allen AM, Arab JP, Carrieri P, Noureddin M, Alazawi W, Alkhouri N, Alqahtani SA, Arrese M, Bataller R, Berg T, Brennan PN, Burra P, Castro-Narro GE, Cortez-Pinto H, Cusi K, Dedes N, Duseja A, Francque SM, Hagström H, Huang TT, Wajcman DI, Kautz A, Kopka CJ, Krag A, Miller V, Newsome PN, Rinella ME, Romero D, Sarin SK, Silva M, Spearman CW, Tsochatzis EA, Valenti L, Villota-Rivas M, Zelber-Sagi S, Schattenberg JM, Wong VW, Younossi ZM; Healthy Livers, Healthy Lives Collaborators. A global research priority agenda to advance public health responses to fatty liver disease. J Hepatol. 2023 Sep;79(3):618-634. doi: 10.1016/j.jhep.2023.04.035. Epub 2023 Jun 20.
Lazarus JV, Mark HE, Anstee QM, Arab JP, Batterham RL, Castera L, Cortez-Pinto H, Crespo J, Cusi K, Dirac MA, Francque S, George J, Hagström H, Huang TT, Ismail MH, Kautz A, Sarin SK, Loomba R, Miller V, Newsome PN, Ninburg M, Ocama P, Ratziu V, Rinella M, Romero D, Romero-Gómez M, Schattenberg JM, Tsochatzis EA, Valenti L, Wong VW, Yilmaz Y, Younossi ZM, Zelber-Sagi S; NAFLD Consensus Consortium. Advancing the global public health agenda for NAFLD: a consensus statement. Nat Rev Gastroenterol Hepatol. 2022 Jan;19(1):60-78. doi: 10.1038/s41575-021-00523-4. Epub 2021 Oct 27.
Lazzarini PA, Raspovic A, Prentice J, Commons RJ, Fitridge RA, Charles J, Cheney J, Purcell N, Twigg SM. Australian evidence-based guidelines for the prevention and management of diabetes-related foot disease: a guideline summary. Med J Aust. 2023 Nov 20;219(10):485-495. doi: 10.5694/mja2.52136. Epub 2023 Oct 23.
Lin B, Twigg SM. Dose-dependent response to long-term clomiphene citrate in male functional hypogonadotropic hypogonadism. Endocrinol Diabetes Metab Case Rep. 2023 Feb 16;2023(1):22-0242. doi: 10.1530/EDM-22-0242.
Longfield MS, Lourdesamy J, Min D, Twigg SM. Do diabetes-related foot ulcer wound fluid measures have clinical utility as biomarkers for healing? A systematic review. J Wound Care. 2023 Apr 1;32(Sup4a):xlvii-lxii. doi: 10.12968/jowc.2023.32.Sup4a.xlvii.
Manewell SM, Aitken SJ, Nube VL, Crawford AM, Constantino MI, Twigg SM, Menz HB, Sherrington C, Paul SS. Timing of minor and major amputation in patients with diabetes-related foot ulceration admitted to two public tertiary referral hospitals in Australia. ANZ J Surg. 2023 Jun;93(6):1510-1516. doi: 10.1111/ans.18224. Epub 2022 Dec 28.
Manewell SM, Rao P, Haneman K, Zheng M, Charaf H, Menz HB, Sherrington C, Paul SS. Prevention and management of foot and lower limb health complications in adults undergoing dialysis: a scoping review. J Foot Ankle Res. 2023 Nov 20;16(1):81. doi: 10.1186/s13047-023-00679-z.
Martínez-Huenchullán SF, Fox SL, Tam CS, Maharjan BR, Olaya-Agudo LF, Ehrenfeld P, Williams PF, Mclennan SV, Twigg SM. Constant-moderate versus high-intensity interval training on heart adiponectin levels in high-fat fed mice: a preventive and treatment approach. Arch Physiol Biochem. 2023 Feb;129(1):41-45. doi: 10.1080/13813455.2020.1797098. Epub 2020 Jul 25.
Mitra S, Kroeger CM, Xu J, Avery L, Masedunskas A, Cassidy S, Wang T, Hunyor I, Wilcox I, Huang R, Chakraborty B, Fontana L. Testing the Effects of App-Based Motivational Messages on Physical Activity and Resting Heart Rate Through Smartphone App Compliance in Patients With Vulnerable Coronary Artery Plaques: Protocol for a Microrandomized Trial. JMIR Res Protoc. 2023 Oct 2;12:e46082. doi: 10.2196/46082.
Nube VL, Alison JA, Twigg SM. Diabetic foot ulcers: weekly versus second-weekly conservative sharp wound debridement. J Wound Care. 2023 Jun 2;32(6):383-390. doi: 10.12968/jowc.2023.32.6.383.
Nube VL, Zwarteveen J, Frank G, Manewell S, Rao P, Cocks M, Twigg SM, Allison J. Challenges faced by people with diabetes‑related foot ulcers in attending hospital‑based high risk foot services: results of a consumer survey. Wound Practice and Research. 2023; 31-3.
Reyes PA, Immanuel J, Hague WM, Teede H, Hibbert E, Nolan CJ, Peek MJ, Wong V, Flack JR, McLean M, Dalal R, Harreiter J, Kautzky-Willer A, Rajagopal R, Sweeting A, Ross GP, Cheung NW, Simmons D. The relationship between body mass index and sleep in women with risk factors for gestational diabetes mellitus. Obes Sci Pract. 2023 Jun 17;9(6):573-580. doi: 10.1002/osp4.689.
Saavedra D, Añé-Kourí AL, Barzilai N, Caruso C, Cho KH, Fontana L, Franceschi C, Frasca D, Ledón N, Niedernhofer LJ, Pereira K, Robbins PD, Silva A, Suarez GM, Berghe WV, von Zglinicki T, Pawelec G, Lage A. Aging and chronic inflammation: highlights from a multidisciplinary workshop. Immun Ageing. 2023 Jun 8;20(1):25. doi: 10.1186/s12979-023-00352-w.
Sherfan J, Samad N, Hsieh A, Sullivan D, Fuller PJ. Usefulness of Functional Thyroid-Stimulating and Thyroid-Blocking Immunoglobulin Bioassays in an Atypical Presentation of Graves' Disease. AACE Clin Case Rep. 2023 Feb 25;9(3):67-70. doi: 10.1016/j.aace.2023.02.004.
Simmons D, Immanuel J, Cheung NW, Hague W, Teede H, Nolan CJ, Backman HE, Hibbert E, Peek MJ, McLean M, Sweeting A, Mohan V, Harreiter J, Tobogm Core Investigator Group. Neonatal Outcomes in Early and Incident Gestational Diabetes Mellitus—Are They Normalized with Treatment from 24–28 Weeks’ Gestation? Diabetes. 2023 Jun 20;72(Supplement_1):281–OR. DOI: 10.2337/db23-281-OR.
Simmons D, Sweeting A. Defining gestational diabetes: not just about cutoffs. Lancet Diabetes Endocrinol. 2023 May;11(5):303-304. doi: 10.1016/S2213-8587(23)00092-X. Epub 2023 Mar 31.
Siwan E, Parry SN, Williams KH, McGill MJ, Wu T, Wong J, Twigg SM, Min D. Circulating soluble CD163 as a potential biomarker of diabetes complications. J Diabetes Complications. 2023 Aug;37(8):108525. doi: 10.1016/j.jdiacomp.2023.108525. Epub 2023 Jun 5.
Tedesco C, Notarnicola M, Bonfiglio C, Rendina M, Castellaneta A, Dileo A, Giannelli G, Fontana L. Impact of Increased Extra-Virgin Olive Oil Intake on Nonalcoholic Fatty Liver Disease Prevalence: Differential Effect in Obese versus Normal Weight Individuals. Nutrients. 2023;15(21):4673. DOI: 10.3390/nu15214673.
Thomas MC, Neuen BL, Twigg SM, Cooper ME, Badve SV. SGLT2 inhibitors for patients with type 2 diabetes and CKD: a narrative review. Endocr Connect. 2023 Jul 31;12(8):e230005. doi: 10.1530/EC-23-0005.
Tosti V, Barve R, Bertozzi B, Veronese N, Early DS, Head RD, Fontana L. When a Calorie Is Not a Calorie: Metabolic and Molecular Effects of Intermittent Fasting in Humans. Aging Biology. 2023;10.59368/agingbio.20230013.
Twigg S, Lim S, Yoo SH, Chen L, Bao Y, Kong A, Yeoh E, Chan SP, Robles J, Mohan V, Cohen N, McGill M, Ji L. Asia-Pacific Perspectives on the Role of Continuous Glucose Monitoring in Optimizing Diabetes Management. J Diabetes Sci Technol. 2023 May 26:19322968231176533. doi: 10.1177/19322968231176533. Epub ahead of print.
Twigg SM, Fontana L. Balancing hormonal shifts: exploring the impact of ageing and dietary restriction. Lancet Diabetes Endocrinol. 2023 Dec;11(12):884-886. doi: 10.1016/S2213-8587(23)00300-5. Epub 2023 Nov 2.
van Abswoude DH, Pellikaan K, Nguyen N, Rosenberg AGW, Davidse K, Hoekstra FME, Rood IM, Poitou C, Grugni G, Høybye C, Markovic TP, Caixàs A, Crinò A, van den Berg SAA, van der Lely AJ, de Graaff LCG. Kidney disease in adults with Prader-Willi syndrome: international cohort study and systematic literature review. Front Endocrinol (Lausanne). 2023 Jul 21;14:1168648. doi: 10.3389/fendo.2023.1168648. Erratum in: Front Endocrinol (Lausanne). 2024 Jan 22;15:1357219. doi: 10.3389/fendo.2024.1357219.
Wang T, Kroeger CM, Cassidy S, Mitra S, Ribeiro RV, Jose S, Masedunskas A, Senior AM, Fontana L. Vegetarian Dietary Patterns and Cardiometabolic Risk in People With or at High Risk of Cardiovascular Disease: A Systematic Review and Meta-analysis. JAMA Netw Open. 2023 Jul 3;6(7):e2325658. doi: 10.1001/jamanetworkopen.2023.25658.
Wang T, Masedunskas A, Willett WC, Fontana L. Vegetarian and vegan diets: benefits and drawbacks. Eur Heart J. 2023 Sep 21;44(36):3423-3439. doi: 10.1093/eurheartj/ehad436.
Yu J, Sweeting AN, Gianacas C, Houston L, Lee V, Fletcher RA, Perkovic V, Li Q, Neuen BL, Berwanger O, Heerspink HJL, de Zeeuw D, Arnott C. The effects of canagliflozin in type 2 diabetes in subgroups defined by population-specific body mass index: Insights from the CANVAS Program and CREDENCE trial. Diabetes Obes Metab. 2023 Dec;25(12):3724-3735. doi: 10.1111/dom.15267. Epub 2023 Sep 6.