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Ear Nose and Throat Surgery Research

The Department of Otolaryngology Head and Neck Surgery at Royal Prince Alfred Hospital is founded on the idea of academic and surgical excellence in otorhinolaryngologic surgery and management of these conditions. Our surgeons have a diverse range of interests and specialise in multiple areas including head and neck surgical oncology, rhinology, anterior and lateral skull base surgery and otology including cochlear implantation. Our department is committed to an evidence-based approach to patient education and appropriate care, the department strives to further the field through high quality research.

Selected Grants

Amount awarded Grant and project details
$450,000 Passe and Williams Academic Surgeon Scientist Fellowship, 2022-2023
Surgeon Scientist Fellowship
Investigator: Creber N.
$88,600 Grace Kathleen Fanton Bequest Research Grant, 2022-2026
Bridging the Gap: A Comparative Study Between a Mouse Model of Endolymphatic Hydrops and Human Meniere’s Disease
Investigators: Camp A, Mukherjee P, Creber N.

Our Publications

2022

Briggs R, CS Birman, N Baulderstone, AT Lewis, IHY Ng, A Östblom, A Rousset, S Tari, MCF Tong, Robert Cowan, Clinical Performance, Safety, and Patient-Reported Outcomes of an Active Osseointegrated Steady-State Implant System  Otol Neurotol 43 (7), 827-834.
Cheung LL, Kong J, Chu PY, Sanli H, Walton J, Birman CS. Misplaced Cochlear Implant Electrodes Outside the Cochlea: A Literature Review and Presentation of Radiological and Electrophysiological Findings. Otol Neurotol. 2022 Jun 1;43(5):567-579. doi: 10.1097/MAO.0000000000003523. Epub 2022 Mar 8.
Cheung MMY, Tsang TW, Watkins R, Birman C, Popova S, Elliott EJ. Ear Abnormalities Among Children with Fetal Alcohol Spectrum Disorder: A Systematic Review and Meta-Analysis.J Pediatr. 2022 Mar;242:113-120.e16. doi: 10.1016/j.jpeds.2021.11.016. Epub 2021 Nov 13.
Cosway B, Fussey J, Kim D, Wykes J, Elliott M, Smith J. Sporadic Medullary Thyroid Cancer: A Systematic Review and Meta-Analysis of Clinico-Pathological and Mutational Characteristics Predicting Recurrence. Thyroid Res. 2022 Jul 22;15(1):12.
Creber NJ, Eastwood HT, Hampson AJ, Lo J, Zhang D, Chambers S, Bester CW, Thorne PR, O'Leary SJ.. Spironolactone Ameliorates Cochlear Implant Induced Endolymphatic Hydrops. Otology & Neurotology 43(6):p 685-693, July 2022.
Deutsch F, Bullen IR, Nguyen K, Tran N-G, Elliott MS, Tran N. Current state of play for HPV-positive oropharyngeal cancers. Cancer Treat Rev. 2022 Nov;110:102439.
Hannigan, I.P., Rosengren S.M., Young A.S., Bradshaw, A.P., Calic Z., Kwok B, Alraddy B, Gibson W.P.R, Kong J.H., Flanagan S, Halmagyi G.M., Watson S.R.D., Welgampola M.S. A Portrait of Menière's Disease Using Contemporary Hearing and Balance Tests. Otol Neurotol 2022 43(4):e489-e496.
Ho J, Rimmer J, Sewell W, Earls P, Alvarado R, Walker S, Campbell RG, Sacks R, Kalish LH, Harvey RJ. Comparison of sinonasal histopathological changes in biological treatment of eosinophilic chronic rhinosinusitis. American Journal of Rhinology & Allergy 2022;36(1):72-80. doi: 10.1177/19458924211021031
Hulme KR, Mahar A, Campbell RG, Clifton-Bligh R, Palme CE, Gupta R. Phosphaturic Mesenchymal Tumours in the Head and Neck: Report of three cases and review of literature. Head and Neck Pathology. Vol.:(0123456789)1 https://doi.org/10.1007/s12105-022-01419-8
Hurrell M, Heller G, Elliott MS, Gao K, Ebrahimi A, Clark JR, Shannon K, Palme CE, Wykes J, Gupta R, Ch'ng S, Nguyen K, Low T-H. Recursive Partitioning to Determine Order of Significance of Regional Metastasis Characteristics in Head and Neck Cutaneous Squamous Cell Carcinoma. Ann Surg Oncol. 2022 Oct;29(11):7000-7001.
Irawati N, Moghadam A, Abdul-Razak M, Strach M, Elliott MS, Ch'ng S, Shannon K, Palme CE, Clark JR, Wykes J, Low T-H. Outcomes after definitive treatment for head and neck angiosarcoma. ANZ J Surg. 2022 Jun;92(6):1407-1414.                                 
Kwok BYC, Rosengren SM, Kong JHK, Birman CS, Hoskisson E, Young AS, Argaet EC, Fratturo L, Rivas C, Greenberg SL, Saxby AJ, Welgampola MS Impact of Cochlear Implantation on Canal and Otolith Function.Otol Neurotol. 2022 Mar 1;43(3):304-312. doi: 10.1097/MAO.0000000000003459.
Lee V, Patel P, O'Brien D, Scangas G, Campbell R, Chandra R, Davis G, Han J, Le C, Lee J, Luong A, Poetker D, Ramadan H, Setzen M, Smith K, Wise S, Villwock J, Ference E. Indications for Absorbable Steroid-Eluting Sinus Implants: Viewpoint via the Delphi Method. Int Forum Allergy Rhinol 2022. doi: 10.1002/alr.23044
Lee, M. F. H., & Ananda, A. (2022). Self-assembling RADA16 peptide hydrogel supports hemostasis, synechiae reduction, and wound healing in a sheep model of endoscopic nasal surgery [Article]. Auris Nasus Larynx. https://doi.org/10.1016/j.anl.2022.09.012
Mehta N, Chu P, Birman CS To Use the Back-up Cochlear Implant or Not? Using Intra-operative Impedance to Guide Your Decisions. Otol Neurotol. 2022 Mar 2. doi: 10.1097/MAO.0000000000003483. Online ahead of print.PMID: 35239618
Nandakumar, B. S., Mukherjee, P., Yung, A. E., Nirmalananda, A., & Ch'ng, S. (2022). Grafts in septorhinoplasty: a systematic review and future directions [Review]. Australian Journal of Otolaryngology, 5, Article 28. https://doi.org/10.21037/ajo-22-12
O'Leary S, Mylanus E, Venail F, Lenarz T, Birman C, Di Lella F, Roland JT Jr, Gantz B, Beynon A, Sicard M, Buechner A, Lai WK, Boccio C, Choudhury B, Tejani VD, Plant K, English R, Arts R, Bester C. "Monitoring Cochlear Health With Intracochlear Electrocochleography During Cochlear Implantation: Findings From an International Clinical Investigation" Ear Hear. 2022 Nov 8.
Osie G, Wegreckim K, Alvarado R, Campbell RG, Kalish L, Rimmer J, Sacks R, Harvey RH. Features of inhalant allergy on nasal endoscopy: a systematic review and meta-analysis. Rhinology 2022.
Perkovic A, Ho J, Kanjawasee D, Alvarado R, Rimmer J, Kalish LH, Campbell RG, Sacks R, Harvey RJ. Age of presentation as a distinguishing feature between persistent rhinitis and chronic rhinosinusitis. Int Forum Allergy Rhinol 2022;12:217-219.
Phung D, Fradet L, Riffat F, Novakovic D, Elliott MS, Nguyen K, Makeham J, Palme CE. Translaryngeal Ultrasound in Thyroid Surgery - State of the Art Review. ANZ J Surg. 2022 Mar;92(3):385-389.
Phung D, Navid Amadi, Ruta Gupta, Jonathan Clark, James Wykes, Sydney Ch'ng, Carsten Palme, Kerwin Shannon, Raymond Wu, Jenny Lee, Tsu-Hui Hubert Low. Survival outcomes of perineural spread in head and neck cutaneous squamous cell carcinoma. ANZ J Surg. 2022 Sep;92(9):2299-2304.
Pogson, J. M., Taylor R.L., Bradshaw A.P., McGarvie L., D'Souza M., Flanagan S., Kong J.H., Biggs N., Shivalingam B., Greenberg S., Croxson G., Halmagyi G.M., Welgampola M.S. et al. The human vestibulo-ocular reflex and compensatory saccades in schwannoma patients before and after vestibular nerve section. Clin Neurophysiol (2022) doi:10.1016/j.clinph.2022.02.014.
Sacks PL, Kalish LH. Campbell RG, Sacks R, Harvey RH. Prognostic factors and outcomes in minimal access resections of skull base and sinonasal epithelial malignancy. ANZ J Surgery 2022;92(12):3253-3258.
Seresirikachorn K, Kalish L, Kondo M, Png L, Campbell RG, Alvarado R, Harvey RH. Prelacrimal approach to maxillary sinus pathology. Am J Rhinol Allergy 2022;37(3):369-373.
Sit A, Alvarado R, Earls P, Rimmer J, Kalish L, Campbell R, Sewell W, Harvey R. Defining eosinophilic subpopulations in chronic rhinosinusitis. Am J Rhinol Allergy 2022.
Walter S, Ho J, Alvarado R, Grayson J, Earls P, Rimmer J, Kalish LH, Sacks R, Gomes JP, Campbell RG, Harvey RH. Mepolizumab decreases tissue eosinophils while increasing type-2 cytokines in eosinophilic chronic rhinosinusitis. Clinical and Experimental Allergy 2022;52(12):1403-1413.
Wong WK, Lee MF, Saxby AJ Giant Cholesteatoma: A Case Report and Review of the Literature. Otol Neurotol. 2022 Jul 1;43(6):e658-e622.
Yung A, Crouch G, Varey A, Lo S, Elliott MS, Lee J, Rawson R, Gupta R, Hong A, Clark JR, Ch'ng S. Benchmarking Survival Outcomes Following Surgical Management of pT3 and pT4 Cutaneous Squamous Cell Carcinoma of the Head and Neck. Ann Surg Oncol. 2022 Aug;29(8):5124-5138.