AW Morrow Gastroenterology and Liver Centre Research

The AW Morrow Gastroenterology and Liver Centre has a strong and robust research base. Key research strengths include Hepatology, Liver Transplant, Hepatocellular Carcinoma, Inflammatory Bowel Disease, Colorectal and Endoscopy.

Our Research Themes at the Laboratory Level

The role of liver stem cells in liver disease

This work is lead by Professor McCaughan and has defined a novel characteristic of liver stem cells within the inflammatory/fibrotic niche that develops during chronic liver disease and cirrhosis. This work has found that a cellular structure, called the primary cilium, transduces signals from the local environment to the liver stem cell compartment leading to proliferation and migration of cells. One of the key mediators is the hedgehog molecule and we have defined this hedgehog pathway and the response of these cells in mouse liver models. We have confirmed these findings in human liver disease and are now working in collaboration with the Cellular and Molecular Regenerative Institute at Edinburgh University to grow organoids and are using a unique mouse model to explore the exact function of these signals. These cells can repopulate an injured liver and replace hepatocytes, significantly improving liver function.

The role of molecular pathways in primary liver cancer

This work has been exploring pathogenic pathways in hepatocellular cancer and more recently biliary cancer. This research includes reduced liver cancer development in knockout mice for SP1 and SP2 and microRNA 181a. Currently, in close collaboration with Dr Maintain Palendira in the Charles Perkins Centre at the University of Sydney, we are using tissue Immune mass cytometry to explore cell-cell interactions within human liver cancer tissues . This is the only attempt to do this in Australia as we have access to one of only two machines capable of providing this technology. We are able to label cells with over thirty unique antibodies to detect complex cell subsets that are undetectable using usual approaches.

Recently we have developed a unique mouse model of primary biliary cancer which has similarities to human disease. We have also used new strategies that target the tumour endothelium and the tumour associated immune infiltrate in experimental models. We believe that such multiple approaches to liver cancer is crucial to understand the complex nature of the problem and to produce new effective therapeutics.

The role of the Oligopeptidase Gene family in liver diseases and cancer

This work is lead by Professor Mark Gorrell and has made major breakthroughs in the study of Type II Diabetes associated with liver disease, liver cancer and also liver fibrosis. The work has been able to show that the serum Fibroblast Activation Protein (FAP) is able to show how liver transplants are spontaneously accepted and the potential to select humans for immunosuppressive withdrawal. The work has identified that liver cytotoxic T cells which would normally reject and damage the liver are eliminated by the liver in the early phases of transplantation by a normal mechanism whereby liver cells actually eat the activated immune cells. The process has been named by us as suicidal empiriopolesis. The work also increases our understanding of how viruses and autoimmune liver diseases are associated with progression to chronicity and non-resolution of disease.

In collaboration with Professor Heath at the Walter and Eliza Hall Institute in Melbourne, Dr Bertolino has furthermore identified blood memory cells that reside in the liver. These cells are very efficient in protecting against malaria infection and this potentially provides new strategies to protect individuals against pathogens that attack the liver such as malaria and other viruses. More recently, a novel type of macrophage cell has been discovered by Dr Bertolino's group, where a novel liver macrophage which is located in the liver capsule is currently under examination for playing a role in protecting the liver against pathogenic effects from the peritoneal cavity. Professor McCaughan has been part of an international consortium that has developed molecular signatures for human liver allograft rejection and injury that is already helping in treatment decision making following liver transplantation in our patients.

Our Research Themes at the Clinical Level

New therapies for Hepatitis B and C	New HCV therapies are one of the most exciting advances in the whole of medicine for many years leading the potential to eventually eradicate HCV infection worldwide. We have significant community care nurse lead programs to deliver these therapies to the wider HCV infected populations. Chief Investigator studies in Australia have lead to the use of the new Hepatitis C treatments in patients with liver failure and undergoing liver transplantation. For the first time we have seen reversibility of HCV related liver failure resulting in a decrease in the need for transplantation in these patients. Professor McCaughan and Associate Professor Strasser have also been active participants and leaders in the International Liver Transplant Society consensus statements for the treatment and management of hepatitis C. Treatment outcomes in First nations peoples have also been investigated and outcomes published. New therapies are emerging to cure HBV infection and we have been involved in those studies .Furthermore we have participated in the development of national and Asian pacific consensus guidelines for the management of hepatitis B infection.
New therapies for Hepatocellular Cancer (HCC)	HCC accounts for the vast majority of primary liver cancers, representing the 4th leading cause of cancer-related death worldwide. The WHO has estimated that >1 million people will die from liver cancer in 2030. Despite recent advances, 5-year survival remains dismal at <20%. In Australia HCC is the fastest growing solid cancer apart from thyroid cancer. We have been involved in key studies that have examined the outcomes of HCC therapies in national studies. Outcomes of HCC in our liver transplant patients have also been studied together with quality care parameters through a national consensus process. In a collaborative study with St George Hospital and UNSW we have been studying the role of the microbiome in HCC patients associated with fatty liver diseases and have described outcomes of patients with non - viral associated HCC.
Improving Outcomes for patients with advanced liver disease	This population has a high mortality and an increasing need for improved therapies. Dr Avik Majumdar and Dr Ken Liu, together with our dieticians Helen Vidot and Joanne Heyman, have lead studies involving nutritional intervention including developing sarcopenia and frailty guidelines for intervention in gastrointestinal bleeding, treatment of infections together with management of hepatic encephalopathy and ascites. Furthermore, we have been investigating the use of non-invasive markers for the diagnosis of cirrhosis.
Outcomes in Primary Sclerosing Cholangitis (PSC) and drug induced liver injury	Our patients with PSC and inflammatory bowel disease were analysed in the largest Australian study of PSC and has lead to a national outcomes study including studies of the microbiome. We have published a large study of drug induced severe liver injury indicating that herbal medicines play a major role in these cases.
Endoscopy research	Colonoscopy guidelines New therapy for leaks and perforations of the bowel New therapy for achalasia, the new POEM procedure Double balloon ERCP to treat biliary strictures in patients without a native bile duct New techniques to biopsy the biliary tree Endoscopic ultrasound (EUS) procedures to diagnose and treat intra-abdominal collections, tumours and pancreatic cysts Use of EUS to drain the biliary system Development of a screening protocol for development of pancreatic cancer
Inflammatory bowel disease research	Clinical trials for new therapies in Ulcerative Colitis and Inflammatory Bowel Disease Detection of pre cancer lesions in IBD Guidelines for the use of biological agents
Outcomes in liver transplantation includes the following studies	Outcomes following the use of split liver techniques in liver transplantation Prolonged function of human livers in machine perfusion devises Development of new scoring systems for the allocation of livers for patients on the liver transplant waiting list

Selected Grants

Amount awarded	Grant and project details
$4,000,000	Cancer Institute NSW, 2021-2026 The APRICA program - Accelerated translational research in Liver Cancer RPA Investigator: McCaughan G (CIB)
$3,989,422	MRFF, 2021-2025 Improving Diagnosis in Cancers with Low Survival Rates : Microbial based biomarkers powered by artificial intelligence for early detection of liver cancer in Australia. The Australian Liver Cancer Microbiome Consortium. RPA Chief Investigator: McCaughan G
$1,800,000	Australian Cancer Research Foundation, 2022-2026 ACRF Molecular Theranostics Laboratory Investigators: Hogg PJ, Simes J, Stockler M, Gorrell M, McCaughan G, Codd R.
$450,000	Cancer Council NSW Project Grant, 2020-2022 New therapies for Liver Cancer Investigators: McCaughan G, Chen J

Our Publications

2023

Abdelmalak J, Strasser SI, Ngu N, Dennis C, Sinclair M, Majumdar A, Collins K, Bateman K, Dev A, Abasszade JH, Valaydon Z, Saitta D, Gazelakis K, Byers S, Holmes J, Thompson AJ, Pandiaraja D, Bollipo S, Sharma S, Joseph M, Nicoll A, Batt N, Sawhney R, Tang MJ, Lubel J, Riordan S, Hannah N, Haridy J, Sood S, Lam E, Greenhill E, Majeed A, Kemp W, Zalcberg J, Roberts SK. Improved Survival Outcomes with Surgical Resection Compared to Ablative Therapy in Early-Stage HCC: A Large, Real-World, Propensity-Matched, Multi-Centre, Australian Cohort Study. Cancers (Basel). 2023 Dec 7;15(24):5741. doi: 10.3390/cancers15245741.

Allen NC, Martin AJ, Snaidr VA, Eggins R, Chong AH, Fernandéz-Peñas P, Gin D, Sidhu S, Paddon VL, Banney LA, Lim A, Upjohn E, Schaider H, Ganhewa AD, Nguyen J, McKenzie CA, Prakash S, McLean C, Lochhead A, Ibbetson J, Dettrick A, Landgren A, Allnutt KJ, Allison C, Davenport RB, Mumford BP, Wong B, Stagg B, Tedman A, Gribbin H, Edwards HA, De Rosa N, Stewart T, Doolan BJ, Kok Y, Simpson K, Low ZM, Kovitwanichkanont T, Scolyer RA, Dhillon HM, Vardy JL, Chadban SJ, Bowen DG, Chen AC, Damian DL. Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients. N Engl J Med. 2023 Mar 2;388(9):804-812. doi: 10.1056/NEJMoa2203086.

Anderson E, Waller K, Tamilarasan AG, Lin H, Paramsothy S, Leong RW. Adalimumab originator versus adalimumab biosimilars in inflammatory bowel disease in Australia. Expert Opin Biol Ther. 2023 Jul-Dec;23(8):819-825. doi: 10.1080/14712598.2023.2203812. Epub 2023 Apr 19.

Chetwood JD, Sabih AH, Chan K, Salimi S, Sheiban A, Lin E, Chin S, Gu B, Sastry V, Coulshed A, Tsoutsman T, Bowen DG, Majumdar A, Strasser SI, McCaughan GW, Liu K. Epidemiology, characteristics, and outcomes of patients with acute-on-chronic liver failure in Australia. J Gastroenterol Hepatol. 2023 Aug;38(8):1325-1332. doi: 10.1111/jgh.16197. Epub 2023 Apr 25.

Choi KKH, Bonnichsen M, Liu K, Massey S, Staudenmann D, Saxena P, Kaffes AJ. Outcomes of patients with hepaticojejunostomy anastomotic strictures undergoing endoscopic and percutaneous treatment. Endosc Int Open. 2023 Jan 4;11(1):E24-E31. doi: 10.1055/a-1952-2135.

Clark PJ, Valery PC, Strasser SI, Weltman M, Thompson AJ, Levy M, Leggett B, Zekry A, Rong J, Angus P, George J, Bollipo S, McGarity B, Sievert W, Macquillan G, Tse E, Nicoll A, Wade A, Chu G, Harding D, Cheng W, Farrell G, Roberts SK. Liver Disease and Poor Adherence Limit Hepatitis C Cure: A Real-World Australian Treatment Cohort. Dig Dis Sci. 2023 Jan;68(1):291-303. doi: 10.1007/s10620-022-07483-y. Epub 2022 May 13.

De Martin E, McCaughan GW. Antibody-mediated rejection in liver transplant recipients: Some questions, some answers. Liver Transpl. 2023 Dec 1;29(12):1260-1261. doi: 10.1097/LVT.0000000000000239. Epub 2023 Aug 7.

Ganley M, Holz LE, Minnell JJ, de Menezes MN, Burn OK, Poa KCY, Draper SL, English K, Chan STS, Anderson RJ, Compton BJ, Marshall AJ, Cozijnsen A, Chua YC, Ge Z, Farrand KJ, Mamum JC, Xu C, Cockburn IA, Yui K, Bertolino P, Gras S, Le Nours J, Rossjohn J, Fernandez-Ruiz D, McFadden GI, Ackerley DF, Painter GF, Hermans IF, Heath WR. mRNA vaccine against malaria tailored for liver-resident memory T cells. Nat Immunol. 2023 Sep;24(9):1487-1498. doi: 10.1038/s41590-023-01562-6. Epub 2023 Jul 20.

Gill M, Mudaliar S, Prince D, Than NN, Cordina R, Majumdar A. Poor correlation of 2D shear wave elastography and transient elastography in Fontan-associated liver disease: A head-to-head comparison. JGH Open. 2023 Sep 14;7(10):690-697. doi: 10.1002/jgh3.12967.

Grootveld AK, Kyaw W, Panova V, Lau AWY, Ashwin E, Seuzaret G, Dhenni R, Bhattacharyya ND, Khoo WH, Biro M, Mitra T, Meyer-Hermann M, Bertolino P, Tanaka M, Hume DA, Croucher PI, Brink R, Nguyen A, Bannard O, Phan TG. Apoptotic cell fragments locally activate tingible body macrophages in the germinal center. Cell. 2023 Mar 16;186(6):1144-1161.e18. doi: 10.1016/j.cell.2023.02.004. Epub 2023 Mar 2.

Howell J, Van H, Pham MD, Sawhney R, Li F, Bhat P, Lubel J, Kemp W, Bloom S, Majumdar A, McCaughan GW, Hall S, Spelman T, Doyle JS, Hellard M, Visvanathan K, Thompson A, Drummer HE, Anderson D. Validation of a novel point-of-care test for alanine aminotransferase measurement: A pilot cohort study. Liver Int. 2023 May;43(5):989-999. doi: 10.1111/liv.15531. Epub 2023 Feb 16.

Jacob R, Danta M, Feller R, Williams D, Sanagapalli S. Empiric Esophageal Dilatation for Solid-Food Dysphagia: Presence of Mucosal Tear on Relook Endoscopy Predicts Symptomatic Response. Am J Gastroenterol. 2023 Oct 1;118(10):1888-1890. doi: 10.14309/ajg.0000000000002319. Epub 2023 May 12.

Jacob R, Prince DS, Kench C, Liu K. Alcohol and its associated liver carcinogenesis. J Gastroenterol Hepatol. 2023 Aug;38(8):1211-1217. doi: 10.1111/jgh.16248. Epub 2023 Jun 1.

Jacob R, Prince DS, Pipicella JL, Nguyen A, Bagatella M, Alvaro F, Maley M, Foo H, Middleton P, Kayes T, DiGirolamo J, Davison SA, Levy MT. Routine screening of emergency admissions at risk of chronic hepatitis (SEARCH) identifies and links hepatitis B cases to care. Liver Int. 2023 Jan;43(1):60-68. doi: 10.1111/liv.15414. Epub 2022 Sep 14.

Janko N, Majeed A, Clements W, Fink MA, Lubel J, Goodwin M, Nicoll A, Strasser SI, Sood S, Bollipo S, Bate J, Bowers KA, George J, Kemp W, Roberts SK. Wide variation in pre-procedural blood product transfusion practices in cirrhosis: a national multidisciplinary survey. Hepatol Commun. 2023 Apr 26;7(5):e0147. doi: 10.1097/HC9.0000000000000147.

Kaur R, Hakim J, Jeremy R, Coorey G, Kalman E, Jenkin R, Bowen DG, Hart J. Students' perceived research skills development and satisfaction after completion of a mandatory research project: results from five cohorts of the Sydney medical program. BMC Med Educ. 2023 Jul 12;23(1):502. doi: 10.1186/s12909-023-04475-y.

Knapp L-K. An update to the management of hepatocellular carcinoma. Medicine Today. 2023;24:23-8.

Koh B, Tan DJH, Ng CH, Fu CE, Lim WH, Zeng RW, Yong JN, Koh JH, Syn N, Meng W, Wijarnpreecha K, Liu K, Chong CS, Muthiah M, Luu HN, Vogel A, Singh S, Yeoh KG, Loomba R, Huang DQ. Patterns in Cancer Incidence Among People Younger Than 50 Years in the US, 2010 to 2019. JAMA Netw Open. 2023 Aug 1;6(8):e2328171. doi: 10.1001/jamanetworkopen.2023.28171.

Lau NS, Ly M, Dennis C, Ewenson K, Ly H, Huang JL, Cabanes-Creus M, Chanda S, Wang C, Lisowski L, Liu K, Kench J, McCaughan G, Crawford M, Pulitano C. Liver splitting during normothermic machine perfusion: a novel method to combine the advantages of both in-situ and ex-vivo techniques. HPB (Oxford). 2023 May;25(5):543-555. doi: 10.1016/j.hpb.2023.02.003. Epub 2023 Feb 8.

Lau NS, Ly M, Dennis C, Jacques A, Cabanes-Creus M, Toomath S, Huang J, Mestrovic N, Yousif P, Chanda S, Wang C, Lisowski L, Liu K, Kench JG, McCaughan G, Crawford M, Pulitano C. Long-term ex situ normothermic perfusion of human split livers for more than 1 week. Nat Commun. 2023 Aug 8;14(1):4755. doi: 10.1038/s41467-023-40154-8.

Laube R, Liu K. Gut microbiome and immune responses in gastrointestinal cancer. In: Microbiome in Gastrointestinal Cancer. Springer Nature; 2023.

Lin A, Wong K, Visser SK, Jo H, Al-Hindawi Y, Kosbab-Jackson K, Cocks M, Volovets A, Haber P, Hammond K, Taylor N, Yozghatlian V, Lau EM, Marshall NS, Aquino-Salomon T, Sivam S. Diagnosis of cystic fibrosis in adults: Australian Cystic Fibrosis Data Registry data, 2000-2019. Med J Aust. 2023 Feb 20;218(3):138-139. doi: 10.5694/mja2.51797. Epub 2022 Dec 1.

Lin H, Yiu DC, Chin S, Liu K, Yip TC. Metformin in patients with hepatocellular carcinoma receiving immunotherapy. J Hepatol. 2023 May;78(5):e180-e182. doi: 10.1016/j.jhep.2022.12.011. Epub 2022 Dec 23.

Liu K, Chen J, Zhao Y, Boland J, Ting KK, Lockwood G, McKenzie C, Kench J, Vadas MA, Gamble JR, McCaughan GW. Novel miRNA-based drug CD5-2 reduces liver tumor growth in diethylnitrosamine-treated mice by normalizing tumor vasculature and altering immune infiltrate. Front Immunol. 2023 Sep 18;14:1245708. doi: 10.3389/fimmu.2023.1245708.

Liu K, Dennis C, Prince DS, Marsh-Wakefield F, Santhakumar C, Gamble JR, Strasser SI, McCaughan GW. Vessels that encapsulate tumour clusters vascular pattern in hepatocellular carcinoma. JHEP Rep. 2023 May 11;5(8):100792. doi: 10.1016/j.jhepr.2023.100792.

Ly M, Lau NS, McKenzie C, Kench JG, McCaughan G, Crawford M, Pulitano C. Does an Additional Bile Duct Flush With Low-viscosity Preservation Solution Reduce Bile Duct Injury? A Single-blinded Randomized Clinical Trial. Transplant Direct. 2023 Feb 8;9(3):e1443. doi: 10.1097/TXD.0000000000001443.

Ly M, Lau NS, McKenzie C, Kench JG, Seyfi D, Majumdar A, Liu K, McCaughan G, Crawford M, Pulitano C. Histological Assessment of the Bile Duct before Liver Transplantation: Does the Bile Duct Injury Score Predict Biliary Strictures? J Clin Med. 2023 Oct 27;12(21):6793. doi: 10.3390/jcm12216793.

McMullen L, Khoo L, Anderson L, Strasser S, Gracey DM. BK viraemia as a cause of anaemia in after ABO-incompatible liver transplant: a case report. BMC Infect Dis. 2023 Sep 18;23(1):609. doi: 10.1186/s12879-023-08601-5.

Nash E, Kench J, Watson G, Liu K. A case of drug reaction with eosinophilia and systemic symptoms (DRESS) due to rivaroxaban. Pathology. 2023 Dec;55(7):1022-1024. doi: 10.1016/j.pathol.2023.05.012. Epub 2023 Jul 20.

Pollok JM, Tinguely P, Berenguer M, Niemann CU, Raptis DA, Spiro M; ERAS4OLT.org collaborative. Enhanced recovery for liver transplantation: recommendations from the 2022 International Liver Transplantation Society consensus conference. Lancet Gastroenterol Hepatol. 2023 Jan;8(1):81-94. doi: 10.1016/S2468-1253(22)00268-0. Erratum in: Lancet Gastroenterol Hepatol. 2023 Feb;8(2):117. doi: 10.1016/S2468-1253(22)00429-0.

Prince DS, Nash E, Liu K. Alcohol-Associated Liver Disease: Evolving Concepts and Treatments. Drugs. 2023 Nov;83(16):1459-1474. doi: 10.1007/s40265-023-01939-9. Epub 2023 Sep 25.

Rodríguez-Perálvarez ML, Gómez-Orellana AM, Majumdar A, Bailey M, McCaughan GW, Gow P, Guerrero M, Taylor R, Guijo-Rubio D, Hervás-Martínez C, Tsochatzis EA. Development and validation of the Gender-Equity Model for Liver Allocation (GEMA) to prioritise candidates for liver transplantation: a cohort study. Lancet Gastroenterol Hepatol. 2023 Mar;8(3):242-252. doi: 10.1016/S2468-1253(22)00354-5. Epub 2022 Dec 14.

Sim YK, Chong MC, Gandhi M, Pokharkar YM, Zhu Y, Shi L, Lequn L, Chen CH, Kudo M, Lee JH, Strasser SI, Chanwat R, Chow PKH; Asia-Pacific Hepatocellular Carcinoma Trials Group. Real-World Data on the Diagnosis, Treatment, and Management of Hepatocellular Carcinoma in the Asia-Pacific: The INSIGHT Study. Liver Cancer. 2023 Oct 9;13(3):298-313. doi: 10.1159/000534513.

Song SJ, Yip TC, Wong GL, Wong VW, Liu K. Editorial: Can liver fat quantification stratify cardiovascular risk in type 2 diabetes? Aliment Pharmacol Ther. 2023 Nov;58(10):1107-1108. doi: 10.1111/apt.17677.

Teoh AYB, Napoleon B, Kunda R, Arcidiacono PG, Kongkam P, Larghi A, Van der Merwe S, Jacques J, Legros R, Thawee RE, Saxena P, Aerts M, Archibugi L, Chan SM, Fumex F, Kaffes AJ, Ma MTW, Messaoudi N, Rizzatti G, Ng KKC, Ng EKW, Chiu PWY. EUS-Guided Choledocho-duodenostomy Using Lumen Apposing Stent Versus ERCP With Covered Metallic Stents in Patients With Unresectable Malignant Distal Biliary Obstruction: A Multicenter Randomized Controlled Trial (DRA-MBO Trial). Gastroenterology. 2023 Aug;165(2):473-482.e2. doi: 10.1053/j.gastro.2023.04.016. Epub 2023 Apr 28.

Thompson AJ, Jackson K, Bonanzinga S, Hall SAL, Hume S, Burns GS, Sundararajan V, Ratnam D, Levy MT, Lubel J, Nicoll AJ, Strasser SI, Sievert W, Desmond PV, Ngu MC, Sinclair M, Meredith C, Matthews G, Revill PA, Littlejohn M, Bowden DS, Canchola JA, Torres J, Siew P, Lau J, La Brot B, Kuchta A, Visvanathan K. Baseline serum HBV RNA is associated with the risk of hepatitis flare after stopping nucleoside analog therapy in HBeAg-negative participants. Hepatol Commun. 2023 Jul 17;7(8):e0188. doi: 10.1097/HC9.0000000000000188.

Verdina M, Seibold F, Grandmaison G, Michetti P, Barras-Moret AC, Liu K, Vaucher J, Staudenmann D. Survey of dietary beliefs and habits of inflammatory bowel disease patients. Clin Nutr ESPEN. 2023 Oct;57:624-629. doi: 10.1016/j.clnesp.2023.07.090. Epub 2023 Aug 13.

Waller KMJ, Bowen DG, Strasser SI. Transforming Genes to Protect Against Liver Disease: Will siRNA-based Therapeutics Reduce the Need for Liver Transplantation? Transplantation. 2023 Mar 1;107(3):556-557. doi: 10.1097/TP.0000000000004474. Epub 2023 Feb 21.

Wu CW, Lui RN, Wong VW, Yam TF, Yip TC, Liu K, Lai JC, Tse YK, Mok TS, Chan HL, Ng KK, Wong GL, Chan SL. Baveno VII Criteria Is an Accurate Risk Stratification Tool to Predict High-Risk Varices Requiring Intervention and Hepatic Events in Patients with Advanced Hepatocellular Carcinoma. Cancers (Basel). 2023 Apr 26;15(9):2480. doi: 10.3390/cancers15092480.

2022

Barreto SG, Strasser SI, McCaughan GW, Fink MA, Jones R, McCall J, Munn S, Macdonald GA, Hodgkinson P, Jeffrey GP, Jaques B, Crawford M, Brooke-Smith ME, Chen JW. Expansion of Liver Transplantation Criteria for Hepatocellular Carcinoma from Milan to UCSF in Australia and New Zealand and Justification for Metroticket 2.0. Cancers (Basel). 2022 Jun 3;14(11):2777. doi: 10.3390/cancers14112777.

Bart NK, Liu K, Kotlyar E, Keogh AM. Portopulmonary Hypertension: The Interplay Between the Liver and Pulmonary Arteries. Heart Lung Circ. 2022 Sep;31(9):1185-1187. doi: 10.1016/j.hlc.2022.07.010.

Beumer BR, van Vugt JLA, Sapisochin G, Yoon P, Bongini M, Lu D, Xu X, De Simone P, Pintore L, Golse N, Nowosad M, Bennet W, Tsochatzis E, Koutli E, Abbassi F, Claasen MPAW, Merli M, O'Rourke J, Gambato M, Benito A, Majumdar A, Tan EK, Ebadi M, Montano-Loza AJ, Berenguer M, Metselaar HJ, Polak WG, Mazzaferro V, IJzermans JNM; Collaborators. Impact of muscle mass on survival of patients with hepatocellular carcinoma after liver transplantation beyond the Milan criteria. J Cachexia Sarcopenia Muscle. 2022 Oct;13(5):2373-2382. doi: 10.1002/jcsm.13053. Epub 2022 Aug 10.

Bonnichsen M, Stoklosa T, Bowen D, Majumdar A. Safety first, a harmful interaction between rivaroxaban and berberine. Intern Med J. 2022 May;52(5):887-888. doi: 10.1111/imj.15774.

Brown RS Jr, Collins MA, Strasser SI, Emmett A, Topp AS, Burroughs M, Ferreira R, Feld JJ. Efficacy and Safety of 8- or 12 Weeks of Glecaprevir/Pibrentasvir in Patients with Evidence of Portal Hypertension. Infect Dis Ther. 2022 Apr;11(2):913-924. doi: 10.1007/s40121-022-00599-8. Epub 2022 Feb 17.

Cassandra R. Harapas, Kim S. Robinson, Kenneth Lay, Jasmine Wong, Ricardo Moreno Traspas, Nasrin Nabavizadeh, Annick Rass-Rothschild, Bertrand Boisson, Scott B. Drutman, Pawat Laohamonthonkul, Devon Bonner, Jingwei Rachel Xiong, Mark D. Gorrell, Sophia Davidson, Chien-Hsiung Yu, Mark D. Fleming, Jonas Gudera, Jerry Stein, Miriam Ben-Harosh, Emily Groopman, Akiko Shimamura, Hannah Tamary, Hülya Kayserili, Nevin Hatipoğlu, Jean-Laurent Casanova, Jonathan A. Bernstein, Franklin L. Zhong, Seth L. Masters, Bruno Reversade 2022 DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling. Science Immunology 7(75):eabi4611. doi:10.1126/sciimmunol.abi4611 (IF 17.73)

Chen J, Cheng NC, Boland J, Liu K, Kench J, Watkins DN, Ferrira-Gonzalez S, Forbes SJ, McCaughan GW. Deletion of kif3a in CK19 positive cells leads to primary cilia loss, biliary cell proliferation and cystic liver lesions in TAA-treated mice. Biochim Biophys Acta Mol Basis Dis. 2022;1868:166335.

Chen J, Zhao Y, Zhang F, Li J, Boland JA, Cheng NC, Liu K, Tiffen JC, Bertolino P, Bowen DG, Krueger A, Lisowski L, Alexander IE, Vadas MA, El-Omar E, Gamble JR, McCaughan GW. Liver-specific deletion of miR-181ab1 reduces liver tumour progression via upregulation of CBX7. Cell Mol Life Sci. 2022 Jul 22;79(8):443. doi: 10.1007/s00018-022-04452-6.

Chetwood JD, Koorey D, Bryant C. Hyperammonaemic encephalopathy. Intern Med J. 2022 Apr;52(4):693-694. doi: 10.1111/imj.15738.

Chetwood JD, Popuri R, Majumdar A, Saxena P. All in all, not just a clip on the wall. Dig Liver Dis. 2022 Oct;54(10):1437-1438. doi: 10.1016/j.dld.2022.03.010. Epub 2022 Apr 6.

Chetwood JD, Shin JS, Koorey D Gastrointestinal: Esophageal nodularity in a 32-year-old female patient. [Review] Journal of Gastroenterology & Hepatology. 37(10):1840, 2022 10.

Chetwood JD, Volovets A, Sivam S, Koh C. Surgical considerations in cystic fibrosis: what every general surgeon needs to know. ANZ J Surg. 2022 Oct;92(10):2425-2432. doi: 10.1111/ans.17948. Epub 2022 Aug 3.PMID: 35920692 Free PMC article. Review.

Chetwood JD, Wells MG, Tsoutsman T, Pulitano C, Crawford MD, Liu K, Strasser SI, McCaughan GW, Majumdar A. MELD-GRAIL and MELD-GRAIL-Na Are Not Superior to MELD or MELD-Na in Predicting Liver Transplant Waiting List Mortality at a Single-center Level. Transplant Direct. 2022 Jun 10;8(7):e1346. doi: 10.1097/TXD.0000000000001346. eCollection 2022 Jul

Clark PJ, Valery PC, Strasser SI, Weltman M, Thompson AJ, Levy M, Leggett B, Zekry A, Rong J, Angus P, George J, Bollipo S, McGarity B, Sievert W, Macquillan G, Tse E, Nicoll A, Wade A, Chu G, Harding D, Cheng W, Farrell G, Roberts SK. Liver Disease and Poor Adherence Limit Hepatitis C Cure: A Real-World Australian Treatment Cohort. Dig Dis Sci. 2022 May 13. doi: 10.1007/s10620-022-07483-y. Online ahead of print.

Clark PJ, Valery PC, Ward J, Strasser SI, Weltman M, Thompson A, Levy MT, Leggett B, Zekry A, Rong J, Angus P, George J, Bollipo S, McGarity B, Sievert W, Macquillan G, Tse E, Nicoll A, Wade A, Chu G, Harding D, Cheng W, Farrell G, Roberts SK. Hepatitis C treatment outcomes for Australian First Nations Peoples: equivalent SVR rate but higher rates of loss to follow-up. BMC Gastroenterol. 2022 Jul 11;22(1):339. doi: 10.1186/s12876-022-02416-5.

Coupland H, Day C, Haber P, Pritchard-Jones J, McKee K, George J, McCaughan G. Client resistance to hepatitis C treatment initiation in opioid agonist treatment clinics in Sydney, Australia: A qualitative study. Drug Alcohol Rev. 2022 Mar;41(3):706-714. doi: 10.1111/dar.13414. Epub 2021 Nov 28.

De Martin E, Londoño MC, Emamaullee J, Lerut J, Potts J, Aluvihare V, Spiro M, Raptis DA, McCaughan G;. The optimal immunosuppression management to prevent early rejection after liver transplantation: A systematic review of the literature and expert panel recommendations. Clin Transplant. 2022 Oct;36(10):e14614. doi: 10.1111/ctr.14614. Epub 2022 Feb 24.

Dennis C, Prince DS, Moayed-Alaei L, Remash D, Carr-Boyd E, Bowen DG, Strasser SI, Crawford M, Pulitano C, Kench J, McCaughan GW, McKenzie C, Liu K. Association between vessels that encapsulate tumour clusters vascular pattern and hepatocellular carcinoma recurrence following liver transplantation. Front Oncol. 2022 Oct 26;12:997093. doi: 10.3389/fonc.2022.997093. eCollection 2022.

English K, Tan SY, Kwan R, Holz LE, Sierro F, McGuffog C, Kaisho T, Heath WR, MacDonald KP, McCaughan GW, Bowen DG, Bertolino P. The liver contains distinct interconnected networks of CX3CR1+ macrophages, XCR1+ type 1 and CD301a+ type 2 conventional dendritic cells embedded within portal tracts. Immunol Cell Biol. 2022 Jul;100(6):394-408. doi: 10.1111/imcb.12559. Epub 2022 Jun 19.

Gill M, Majumdar A. Editorial: optimising hepatitis B vaccine response in inflammatory bowel disease-time to get some skin in the game. Aliment Pharmacol Ther. 2022 Jul;56(2):353-354. doi: 10.1111/apt.17044.

Grootveld A, Kyaw W, Panova V, Lau A; Ashwin E, Seuzaret G, Dhenni R, Bhattacharyya, Hua Khoo W, Biro M, Mitra T, Meyer-Hermann M, Bertolino P, TanakaM, Hume D, Croucher P, Brink R, Nguyen A, Bannard O, Phan TG.Locally activated tingible body macrophages use cellular processes to chase and capture motile apoptotic cell fragments in the germinal centre. Cell in Press (IF 66.85).

Gu B, Venkatesh K, Williams AJ, Ng W, Corte C, Gholamrezaei A, Ghaly S, Xuan W, Paramsothy S, Connor S. Higher infliximab and adalimumab trough levels are associated with fistula healing in patients with fistulising perianal Crohn's disease. World J Gastroenterol. 2022 Jun 21;28(23):2597-2608. doi: 10.3748/wjg.v28.i23.2597.PMID: 35949350 Free PMC article.

Hall SAL, Burns GS, Anagnostou D, Vogrin S, Sundararajan V, Ratnam D, Levy MT, Lubel JS, Nicoll AJ, Strasser SI, Sievert W, Desmond PV, Ngu MC, Angus P, Sinclair M, Meredith C, Matthews G, Revill PA, Jackson K, Littlejohn M, Bowden DS, Locarnini SA, Visvanathan K, Thompson AJ. Stopping nucleot(s)ide analogues in non-cirrhotic HBeAg-negative chronic hepatitis B patients: HBsAg loss at 96 weeks is associated with low baseline HBsAg levels. Aliment Pharmacol Ther. 2022 Jul;56(2):310-320. doi: 10.1111/apt.16968. Epub 2022 May 6.

Hall SAL, Burns GS, Mooney BJ, Millen R, Morris R, Vogrin S, Sundararajan V, Ratnam D, Levy MT, Lubel JS, Nicoll AJ, Strasser SI, Sievert W, Desmond PV, Ngu MC, Angus P, Sinclair M, Meredith C, Matthews G, Revill PA, Jackson K, Littlejohn M, Bowden S, Locarnini SA, Thompson AJ, Visvanathan K. Hepatitis B Virus Flares After Nucleot(s)ide Analogue Cessation Are Associated With Activation of Toll-Like Receptor Signaling Pathways. J Infect Dis. 2022 Dec 28;227(1):123-132. doi: 10.1093/infdis/jiac375.

Howell J, Majumdar A, Fink MA, Byrne M, McCaughan G, Strasser SI, Crawford M, Hodgkinson P, Stuart KA, Tallis C, Chen J, Wigg A, Jones R, Jaques B, Jeffrey G, Adams L, Wallace MC, Munn S, Gane E, Thompson AJ, Gow P. Turning the Tide on Hepatitis C Virus-Related Liver Transplantation: The Return on Investment in Hepatitis C Virus Treatment in Australia and New Zealand. Liver Transpl. 2022 Feb;28(2):236-246. doi: 10.1002/lt.26329. Epub 2021 Nov 10.

Howell J, Van H, Pham M, Sawhney R, Li F, Bhat P, Lubel J, Kemp W, Bloom S, Majumdar A, McCaughan G, Hall S, Spelman T, Doyle JS, Hellard M, Visvanathan K, Thompson AJ, Drummer HE, Anderson D. Validation of novel point-of-care test for alanine aminotransferase measurement: A pilot cohort study. Clin Liver Dis (Hoboken). 2022 Oct 10;20(4):136-139. doi: 10.1002/cld.1261. eCollection 2022 Oct.

Jacob R, Liu K, Marinelli T. Successful liver transplantation for hepatitis B-related acute liver failure in a patient with active COVID-19. Transpl Infect Dis. 2022 Aug;24(4):e13889. doi: 10.1111/tid.13889. Epub 2022 Jul 9.

Jing Ren, Xiaoyu Wang, Christine Yee, Mark D. Gorrell, Susan V. McLennan, Stephen M. Twigg 2022 Sitagliptin is more effective than Gliclazide in Preventing Pro-Fibrotic and Pro-Inflammatory Changes in a Rodent model of Diet-Induced Non-Alcoholic Fatty Liver Disease (NAFLD). Molecules 27(3):727. Doi 10.3390/molecules27030727 PMID 35163991

Jing Ren, Xiaoyu Wang, Sarah Parry, Christine Yee, Mark D. Gorrell, Susan V. McLennan, Stephen M. Twigg 2022 Targeting CCN2 Protects Against Progressive Non-Alcoholic Steatohepatitis in a Preclinical Model Induced by High-Fat Feeding and Type 2 Diabetes. Journal of Cell Communication and Signaling - E-Pub 22.1.22 doi 10.1007/s12079-022-00667-1. PMID 35038159.

Khan S, Gilhotra R, Di Jiang C, Rowbotham D, Chong A, Majumdar A, White C, Huelsen A, Brooker J, O'Beirne J, Schauer C, Efthymiou M, Vaughan R, Chandran S. The role of a novel self-expanding metal stent in variceal bleeding: a multicenter Australian and New Zealand experience. Endosc Int Open. 2022 Mar 14;10(3):E238-E245. doi: 10.1055/a-1729-0104. eCollection 2022 Mar.

Kynaston A, Liu K, Davis A, Kao S, McKenzie C. A case of steroid-responsive nivolumab-induced cholangitis. Pathology. 2022; 54:820-823

Lau G, Yu ML, Wong G, Thompson A, Ghazinian H, Hou JL, Piratvisuth T, Jia JD, Mizokami M, Cheng G, Chen GF, Liu ZW, Baatarkhuu O, Cheng AL, Ng WL, Lau P, Mok T, Chang JM, Hamid S, Dokmeci AK, Gani RA, Payawal DA, Chow P, Park JW, Strasser SI, Mohamed R, Win KM, Tanwandee T, Sarin SK, Omata M. Correction to: APASL clinical practice guideline on hepatitis B reactivation related to the use of immunosuppressive therapy. Hepatol Int. 2022 Apr;16(2):486-487. doi: 10.1007/s12072-022-10301-2. Epub 2022 Jan 25.

Lau NS, Ly M, Dennis C, Liu K, Kench J, Crawford M, Pulitano C.Artif Organs. Long-term normothermic perfusion of human livers for longer than 12 days. 2022 Dec;46(12):2504-2510. doi: 10.1111/aor.14372. Epub 2022 Aug 5.

Lau NS, Ly M, Liu K, Majumdar A, Strasser SI, Biswas RK, McCaughan GW, Crawford M, Pulitano C. Is it safe to expand the indications for split liver transplantation in adults? A single-center analysis of 155 in-situ splits. Clin Transplant. 2022 Jul;36(7):e14673. doi: 10.1111/ctr.14673. Epub 2022 Apr 26.

Lin A, Wong K, Visser SK, Jo H, Al-Hindawi Y, Kosbab-Jackson K, Cocks M, Volovets A, Haber P, Hammond K, Taylor N, Yozghatlian V, Lau EM, Marshall NS, Aquino-Salomon T, Sivam S. Diagnosis of cystic fibrosis in adults: Australian Cystic Fibrosis Data Registry data, 2000-2019. Med J Aust. 2022 Dec 1. doi: 10.5694/mja2.51797. Online ahead of print.

Lin H, Cheuk-Yan Yiu D, Chin S, Liu K, Cheuk-Fung Yip T. Metformin in patients with hepatocellular carcinoma receiving immunotherapy.J Hepatol. 2022 Dec 23:S0168-8278(22)03463-8. doi: 10.1016/j.jhep.2022.12.011. Online ahead of print.PMID: 36572351

Liu K, Yip TCF, Masson S, Fateen W, Schwantes-An TH, McCaughan GW, Morgan TR, Aithal GP, Seth D. Validation of the aMAP score to predict hepatocellular carcinoma development in a cohort of alcohol-related cirrhosis patients. Liver Cancer Int. 2022;3:99-104

Liu XT, Chung LH, Liu D, Chen J, Huang Y, Teo JD, Han XD, Zhao Y, Guan FHX, Tran C, Lee JY, Couttas TA, Liu K, McCaughan GW, Gorrell MD, Don AS, Zhang S, Qi Y. Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein. Oncogenesis. 2022 Nov 4;11(1):67. doi: 10.1038/s41389-022-00444-0.

Lubel JS, Strasser SI, Thompson AJ, Cowie BC, MacLachlan J, Allard NL, Holmes J, Kemp WW, Majumdar A, Iser D, Howell J, Matthews GV. Australian consensus recommendations for the management of hepatitis B. Med J Aust. 2022 May 16;216(9):478-486. doi: 10.5694/mja2.51430. Epub 2022 Mar 6.

Ly M, Lau NS, McKenzie C, Kench JG, McCaughan G, Crawford M, Pulitano C. The Delay of Arterialization After Initial Portal Reperfusion More Than Warm Ischemia Time May Determine Ischemic-type Biliary Injury. Transplantation. 2022 Feb 1;106(2):e167-e168. doi: 10.1097/TP.0000000000003936.

Madill-Thomsen KS, Abouljoud M, Bhati C, Ciszek M, Durlik M, Feng S, Foroncewicz B, Francis I, Grąt M, Jurczyk K, Klintmalm G, Krasnodębski M, McCaughan G, Miquel R, Montano-Loza A, Moonka D, Mucha K, Myślak M, Pączek L, Perkowska-Ptasińska A, Piecha G, Reichman T, Sanchez-Fueyo A, Tronina O, Wawrzynowicz-Syczewska M, Więcek A, Zieniewicz K, Halloran PF. The molecular phenotypes of injury, steatohepatitis, and fibrosis in liver transplant biopsies in the INTERLIVER study. Am J Transplant. 2022 Mar;22(3):909-926. doi: 10.1111/ajt.16890. Epub 2021 Dec 3.

Maharaj AD, Lubel J, Lam E, Clark PJ, Duncan O, George J, Jeffrey GP, Lipton L, Liu H, McCaughan G, Neo EL, Philip J, Strasser SI, Stuart K, Thompson A, Tibballs J, Tu T, Wallace MC, Wigg A, Wood M, Zekry A, Greenhill E, Ioannou LJ, Ahlenstiel G, Bowers K, Clarke SJ, Dev A, Fink M, Goodwin M, Karapetis CS, Levy MT, Muller K, O'Beirne J, Pryor D, Seow J, Shackel N, Tallis C, Butler N, Olynyk JK, Reed-Cox K, Zalcberg JR, Roberts SK. Monitoring quality of care in hepatocellular carcinoma: A modified Delphi consensus. Hepatol Commun. 2022 Nov;6(11):3260-3271. doi: 10.1002/hep4.2089. Epub 2022 Sep 25

Majumdar A, Tsochatzis EA. Binge drinking and fibrogenesis: More than just a hangover. Liver Int. 2022 Jan;42(1):6-8. doi: 10.1111/liv.15119.

Majumdar A, Tsochatzis EA. Non-invasive tests and advanced chronic liver disease in NAFLD: two steps forward and one step back? Gut. 2022 Jun;71(6):1236-1237. doi: 10.1136/gutjnl-2021-325994. Epub 2021 Sep 14.

Manuneedhi Cholan P, Morris S, Luo K, Chen J, Boland JA, McCaughan GW, Britton WJ, Oehlers SH. Transplantation of high fat fed mouse microbiota into zebrafish larvae identifies MyD88-dependent acceleration of hyperlipidaemia by Gram-positive cell wall components. Biofactors. 2022 Mar;48(2):329-341. doi: 10.1002/biof.1796. Epub 2021 Oct 19.

Marsh-Wakefield F, Ferguson AL, Liu K, Santhakumar C, McCaughan G, Palendira U. Approaches to spatially resolving the tumour immune microenvironment of hepatocellular carcinoma. Ther Adv Med Oncol. 2022 Jul 22;14:17588359221113270. doi: 10.1177/17588359221113270. eCollection 2022.

Méndez-Sánchez N, Bugianesi E, Gish RG, Lammert F, Tilg H, Nguyen MH, Sarin SK, Fabrellas N, Zelber-Sagi S, Fan JG, Shiha G, Targher G, Zheng MH, Chan WK, Vinker S, Kawaguchi T, Castera L, Yilmaz Y, Korenjak M, Spearman CW, Ungan M, Palmer M, El-Shabrawi M, Gruss HJ, Dufour JF, Dhawan A, Wedemeyer H, George J, Valenti L, Fouad Y, Romero-Gomez M, Eslam M; Global multi-stakeholder consensus on the redefinition of fatty liver disease. Global multi-stakeholder endorsement of the MAFLD definition. Lancet Gastroenterol Hepatol. 2022 May;7(5):388-390. doi: 10.1016/S2468-1253(22)00062-0. Epub 2022 Mar 3.

Nahar KJ, Marsh-Wakefield F, Rawson RV, Gide TN, Ferguson AL, Allen R, Quek C, da Silva IP, Tattersal S, Kiely CJ, Sandanayake N, Carlino MS, McCaughan G, Wilmott JS, Scolyer RA, Long GV, Menzies AM, Palendira U. Distinct pretreatment innate immune landscape and posttreatment T cell responses underlie immunotherapy-induced colitis. JCI Insight. 2022 Nov 8;7(21):e157839. doi: 10.1172/jci.insight.157839.

Nash E, Chetwood J, Strasser SI, Liu K. Drug-induced liver injury from herbal and dietary supplements: a problem in the East and West alike. Hepatol Int. 2022 Apr;16(2):477-478. doi: 10.1007/s12072-021-10289-1. Epub 2022 Jan 23.

Oguz Bolgi, Maria Silva-Garcia, Breyan Ross, Esther Pilla, Vijayalakshmi Kari, Markus Killisch, Melanie Spitzner, Nadine Stark, Christof Lenz, Konstantin Weiss, Laura Donzelli, Mark D. Gorrell, Marian Grade, Jan Riemer, Henning Urlaub, Matthias Dobbelstein, Robert Huber, Ruth Geiss-Friedlander 2022 Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA-damage repair. EMBO Reports. Doi 10.15252/embr.202154136

Patwala K, Prince DS, Celermajer Y, Alam W, Paul E, Strasser SI, McCaughan GW, Gow P, Sood S, Murphy E, Roberts S, Freeman E, Stratton E, Davison SA, Levy MT, Clark-Dickson M, Nguyen V, Bell S, Nicoll A, Bloom A, Lee AU, Ryan M, Howell J, Valaydon Z, Mack A, Liu K, Dev A. Lenvatinib for the treatment of hepatocellular carcinoma-a real-world multicenter Australian cohort study. Hepatol Int. 2022 Oct;16(5):1170-1178. doi: 10.1007/s12072-022-10398-5. Epub 2022 Aug 25.

Prince DS, Schlaphoff G, Davison SA, Huo YR, Xiang H, Chan MV, Lee AU, Thailakanathan C, Jebeili H, Rogan C, Al-Omary A, Gupta S, Lockart I, Tiwari N, Clark-Dickson M, Hillhouse JW, Laube R, Chang J, Nguyen V, Danta M, Cheng R, Strasser SI, Zekry A, Levy MT, Chan C, Liu K. Selective internal radiation therapy for hepatocellular carcinoma: A 15-year multicenter Australian cohort study. J Gastroenterol Hepatol. 2022 Nov;37(11):2173-2181. doi: 10.1111/jgh.15986. Epub 2022 Sep 2.PMID: 36031345

Rajadurai A, Zorron Cheng Tao Pu L, Cameron R, Tagkalidis P, Holt B, Bassan M, Gupta S, Croagh D, Swan M, Saxena P, Efthymiou M, Vaughan R, Chandran S; ANZEC. Endoscopic ultrasound-guided gallbladder and bile duct drainage with lumen apposing metal stent: A large multicenter cohort (with videos). J Gastroenterol Hepatol. 2022 Jan;37(1):179-189. doi: 10.1111/jgh.15688. Epub 2021 Oct 7.

Rodríguez-Perálvarez ML, Gómez-Orellana AM, Majumdar A, Bailey M, McCaughan GW, Gow P, Guerrero M, Taylor R, Guijo-Rubio D, Hervás-Martínez C, Tsochatzis EA. Development and validation of the Gender-Equity Model for Liver Allocation (GEMA) to prioritise candidates for liver transplantation: a cohort study. Lancet Gastroenterol Hepatol. 2022 Dec 14:S2468-1253(22)00354-5. doi: 10.1016/S2468-1253(22)00354-5. Online ahead of print.

Sagnella SM, White AL, Yeo D, Saxena P, van Zandwijk N, Rasko JEJ. Locoregional delivery of CAR-T cells in the clinic. Pharmacol Res. 2022 Aug;182:106329. doi: 10.1016/j.phrs.2022.106329. Epub 2022 Jun 27.

Salimi S, Pandya K, Davis RJ, Crawford M, Pulitano C, Strasser SI, McCaughan GW, Majumdar A, Liu K. Impact of Intensive Care Unit Discharge Delay on Liver Transplantation Outcomes. J Clin Med. 2022 May 2;11(9):2561. doi: 10.3390/jcm11092561.

Santhakumar C, Ormiston W, McCall JL, Bartlett A, Duncan D, Holden A. Portal vein embolization with absolute ethanol to induce hypertrophy of the future liver remnant. CVIR Endovasc. 2022 Jul 23;5(1):36. doi: 10.1186/s42155-022-00312-3.PMID: 35869399 Free PMC article.

Simone E Jaenisch, Abbott, CA, Gorrell, Mark D, Bampton, P, Butler, RN, Roger Yazbeck 2022 Circulating dipeptidyl peptidase activity is a potential biomarker for inflammatory bowel disease. Clinical and Translational Gastroenterology doi 10.14309/ctg.0000000000000452 PMID 35060938

Staudenmann D, Choi KKH, Kaffes AJ, Saxena P. Current endoscopic closure techniques for the management of gastrointestinal perforations. Ther Adv Gastrointest Endosc. 2022 Feb 27;15:26317745221076705. doi: 10.1177/26317745221076705. eCollection 2022 Jan-Dec.

Staudenmann D, Mudaliar S, Kaffes AJ, Saxena P. Lumen-apposing metal stents salvage that accidentally dislodged during a necrosectomy of a WON (with video). Endosc Ultrasound. 2022 Mar-Apr;11(2):147-148. doi: 10.4103/EUS-D-21-00054.

Tan N, Ngu N, Worland T, Lee T, Abrahams T, Pandya K, Freeman E, Hannah N, Gazelakis K, Madden RG, Lynch KD, Valaydon Z, Sood S, Dev A, Bell S, Thompson A, Ding J, Nicoll AJ, Liu K, Gow P, Lubel J, Kemp W, Roberts, SK, Majeed A. Epidemiology and outcomes of primary sclerosing cholangitis: an Australian multicentre retrospective cohort study. Hepatol Int. 2022;16:1094-1104.

Tavabie OD, McCaughan G, Aluvihare VR. Those Donor Leucocytes Again? This Time It's VITT! Liver Transpl. 2022 Feb;28(2):164-166. doi: 10.1002/lt.26372. Epub 2021 Dec 8.

Tran DL, Gibson H, Maiorana AJ, Verrall CE, Baker DW, Clode M, Lubans DR, Zannino D, Bullock A, Ferrie S, Briody J, Simm P, Wijesekera V, D'Almeida M, Gosbell SE, Davis GM, Weintraub R, Keech AC, Puranik R, Ugander M, Justo R, Zentner D, Majumdar A, Grigg L, Coombes JS, d'Udekem Y, Morris NR, Ayer J, Celermajer DS, Cordina R. Exercise Intolerance, Benefits, and Prescription for People Living With a Fontan Circulation: The Fontan Fitness Intervention Trial (F-FIT)-Rationale and Design. Front Pediatr. 2022 Jan 6;9:799125. doi: 10.3389/fped.2021.799125. eCollection 2021.

Yeo D, Bastian A, Strauss H, Saxena P, Grimison P, Rasko JEJ. Exploring the Clinical Utility of Pancreatic Cancer Circulating Tumor Cells. Int J Mol Sci. 2022 Jan 31;23(3):1671. doi: 10.3390/ijms23031671.

Yeo D, Giardina C, Saxena P, Rasko JEJ. The next wave of cellular immunotherapies in pancreatic cancer. Mol Ther Oncolytics. 2022 Feb 1;24:561-576. doi: 10.1016/j.omto.2022.01.010. eCollection 2022 Mar 17.

Yip TCF, Gill M, Wong GLH, Liu K. Management of hepatitis B virus reactivation due to treatment of COVID-19. Hepatol Int. 2022;16:257-268

Yu V, Ebrahimi N, Cachalia T, Jacques A, Wyburn K, McCaughan GW, Dunkley S, Crawford MD, Pulitano C, Laurence JM. Combined Liver-Kidney Transplant for Juvenile Polycystic Kidney Disease and Concomitant Hereditary Factor V Deficiency. Exp Clin Transplant. 2022 Nov;20(11):1043-1045. doi: 10.6002/ect.2022.0229.

Yuen MF, Locarnini S, Lim TH, Strasser SI, Sievert W, Cheng W, Thompson AJ, Given BD, Schluep T, Hamilton J, Biermer M, Kalmeijer R, Beumont M, Lenz O, De Ridder F, Cloherty G, Ka-Ho Wong D, Schwabe C, Jackson K, Lai CL, Gish RG, Gane E. Combination treatments including the small-interfering RNA JNJ-3989 induce rapid and sometimes prolonged viral responses in patients with CHB. J Hepatol. 2022 Nov;77(5):1287-1298. doi: 10.1016/j.jhep.2022.07.010. Epub 2022 Jul 20.

Zhu S, Rao X, Qian Y, Chen J, Song R, Yan H, Yang X, Hu J, Wang X, Han Z, Zhu Y, Liu R, Jong-Leong Wong J, McCaughan GW, Zheng X. Liver Endothelial Heg Regulates Vascular/Biliary Network Patterning and Metabolic Zonation Via Wnt Signaling. Cell Mol Gastroenterol Hepatol. 2022;13(6):1757-1783. doi: 10.1016/j.jcmgh.2022.02.010. Epub 2022 Feb 22.

2021

Behary, J., Amorim, N., Jiang, X., Raposo, A., Gong, L., McGovern, E., Ibrahim, R., Chu, F., Stephens, C., Jebeili, H., Koay, Y., O'Sullivan, J., et al (2021). Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma. Nature Communications, 12(1), 187.

Behary, J., Raposo, A., Amorim, N., Zheng, H., Gong, L., McGovern, E., Chen, J., Liu, X., Beretov, J., Theocharous, C., McCaughan, G., et al (2021). Defining the temporal evolution of gut dysbiosis and inflammatory responses leading to hepatocellular carcinoma in Mdr2 ?/? mouse model. BMC Microbiology, 21(1), 113.

Boyle S, Tobin JWD, Perram J, Hamad N, Gullapalli V, Barraclough A, Singaraveloo L, Han MH, Blennerhassett R, Nelson N, Johnston AM, Talaulikar D, Karpe K, Bhattacharyya A, Cheah CY, Subramoniapillai E, Bokhari W, Lee C, Hawkes EA, Jabbour A, Strasser SI, Chadban SJ, Brown C, Mollee P, Hapgood G. Management and Outcomes of Diffuse Large B-cell Lymphoma Post-transplant Lymphoproliferative Disorder in the Era of PET and Rituximab: A Multicenter Study From the Australasian Lymphoma Alliance. Hemasphere. 2021 Oct 11;5(11):e648.

Chetwood, J., Mudaliar, S., Staudenmann, D., Shin, J., Liu, K., Majumdar, A., Kaffes, A., Strasser, S., McCaughan, G., Saxena, P. (2021). Emerging role of endoscopic ultrasound-guided liver biopsy. Gut, 70(8), 1600-1601.

Drak, D., Tangirala, N., Fink, M., Adams, L., Fawcett, J., Jeffrey, G., Byrne, M., McCaughan, G., Chadban, S., Wyburn, K., Gracey, D., et al (2021). Trends and Outcomes in Simultaneous Liver and Kidney Transplantation in Australia and New Zealand. Transplantation Proceedings, 53(1), 136-140. .

Gandhi M, Ling WH, Chen CH, Lee JH, Kudo M, Chanwat R, Strasser SI, Xu Z, Lai SH, Chow PK. Impact of COVID-19 on Hepatocellular Carcinoma Management: A Multicountry and Region Study. J Hepatocell Carcinoma. 2021 Sep 23;8:1159-1167. doi: 10.2147/JHC.S329018.

Henderson, J., Xiang, M., Huang, C., Wetzel, S., Jiang, L., Lai, J., Wu, W., Kench, J., Bachovchin, W., Roediger, B., McCaughan, G., Zhang, H., Gorrell, M. (2021). Dipeptidyl peptidase inhibition enhances cd8 t cell recruitment and activates intrahepatic inflammasome in a murine model of hepatocellular carcinoma. Cancers, 13(21), 5495.

Huang, C., Emran, A., Endaya, J., McCaughan, G., Gorrell, M., Zhang, H. (2021). Dpp9: Comprehensive in silico analyses of loss of function gene variants and associated gene expression signatures in human hepatocellular carcinoma. Cancers, 13(7), 1686-1698.

Kortt NC, Santhakumar C, Davis RJ, Strasser SI, McCaughan GW, Liu K, Majumdar A. Prevalence and outcomes of Clostridioides difficile infection in liver transplant recipients. Transpl Infect Dis. 2022 Feb;24(1):e13758. doi: 10.1111/tid.13758. Epub 2021 Dec 7

Lau G, Yu ML, Wong G, Thompson A, Ghazinian H, Hou JL, Piratvisuth T, Jia JD, Mizokami M, Cheng G, Chen GF, Liu ZW, Baatarkhuu O, Cheng AL, Ng WL, Lau P, Mok T, Chang JM, Hamid S, Dokmeci AK, Gani RA, Payawal DA, Chow P, Park JW, Strasser SI, Mohamed R, Win KM, Tawesak T, Sarin SK, Omata M. APASL clinical practice guideline on hepatitis B reactivation related to the use of immunosuppressive therapy. Hepatol Int. 2021 Oct;15(5):1031-1048. doi: 10.1007/s12072-021-10239-x. Epub 2021 Aug 24. Erratum in: Hepatol Int. 2022 Apr;16(2):486-487.

Lau, N., Jacques, A., McCaughan, G., Crawford, M., Liu, K., Pulitano, C. (2021). Addressing the challenges of split liver transplantation through technical advances. A systematic review. Transplantation Reviews, 35(3), 100627.

Lau, N., Liu, K., McCaughan, G., Crawford, M., Pulitano, C. (2021). Are split liver grafts a suitable option in high-risk liver transplant recipients? Current Opinion in Organ Transplantation, 26(6), 675-680.

Lau, N., Liu, X., Almoflihi, A., Xu, J., McCaughan, G., Crawford, M., Pulitano, C. (2021). Liberal Use of Interposition Grafts for Arterial Reconstruction Is Safe and Effective in Adult Split Liver Transplantation. Transplantation Direct, 7(8), e735.

Lau, N., Ly, M., Jacques, A., Ewenson, K., Mestrovic, N., Almoflihi, A., Koutalistras, N., Liu, K., Kench, J., McCaughan, G., et al (2021). Prolonged Ex Vivo Normothermic Perfusion of a Split Liver: An Innovative Approach to Increase the Number of Available Grafts. Transplantation Direct, 7(10), e763.

Laube R, Sabih AH, Strasser SI, Lim L, Cigolini M, Liu K. Palliative care in hepatocellular carcinoma. J Gastroenterol Hepatol. 2021 Mar;36(3):618-628. doi: 10.1111/jgh.15169. Epub 2020 Jul 15.

Liu K, Yeo D, Crawford M, Strasser SI, McCaughan GW. Beware of Portal Vein Thrombosis After Laparoscopic Sleeve Gastrectomy in Liver Transplant Recipients. Liver Transpl. 2021 Jul;27(7):1066-1067. doi: 10.1002/lt.26049. Epub 2021 Apr 21.

Liu, X., Pandya, K., West, C., Virtue, S., McCaughan, G. (2021). Prevalence and Impact of Fatty Liver Disease in Adult Deceased Liver Transplant Donors: Metabolic-Associated Fatty Liver Disease or Nonalcoholic Fatty Liver Disease? Liver Transplantation, 27(10), 1498-1501.

Liu, X., Yeo, D., Crawford, M., Strasser, S., McCaughan, G. (2021). Beware of Portal Vein Thrombosis After Laparoscopic Sleeve Gastrectomy in Liver Transplant Recipients. Liver Transplantation, 27(7), 1066-1067.

Loomba R, Noureddin M, Kowdley KV, Kohli A, Sheikh A, Neff G, Bhandari BR, Gunn N, Caldwell SH, Goodman Z, Wapinski I, Resnick M, Beck AH, Ding D, Jia C, Chuang JC, Huss RS, Chung C, Subramanian GM, Myers RP, Patel K, Borg BB, Ghalib R, Kabler H, Poulos J, Younes Z, Elkhashab M, Hassanein T, Iyer R, Ruane P, Shiffman ML, Strasser S, Wong VW, Alkhouri N; ATLAS Investigators. Combination Therapies Including Cilofexor and Firsocostat for Bridging Fibrosis and Cirrhosis Attributable to NASH. Hepatology. 2021 Feb;73(2):625-643. doi: 10.1002/hep.31622.

Lubel JS, Roberts SK, Strasser SI, Shackel N. Australian recommendations for the management of hepatocellular carcinoma. Med J Aust. 2021 Oct 4;215(7):334-334.e1. doi: 10.5694/mja2.51252. Epub 2021 Sep 12.

Lubel JS, Roberts SK, Strasser SI, Thompson AJ, Philip J, Goodwin M, Clarke S, Crawford DH, Levy MT, Shackel N. Australian recommendations for the management of hepatocellular carcinoma: a consensus statement. Med J Aust. 2021 Jun;214(10):475-483. doi: 10.5694/mja2.50885. Epub 2020 Dec 13. Erratum in: Med J Aust. 2021 Aug 2;215(3):105.

Ma H, Lim TH, Leerapun A, Weltman M, Jia J, Lim YS, Tangkijvanich P, Sukeepaisarnjaroen W, Ji Y, Le Bert N, Li D, Zhang Y, Hamatake R, Tan N, Li C, Strasser SI, Ding H, Yoon JH, Stace NH, Ahmed T, Anderson DE, Yan L, Bertoletti A, Zhu Q, Yuen MF. Therapeutic vaccine BRII-179 restores HBV-specific immune responses in patients with chronic HBV in a phase Ib/IIa study. JHEP Rep. 2021

Nash E, Sabih AH, Chetwood J, Wood G, Pandya K, Yip T, Majumdar A, McCaughan GW, Strasser SI, Liu K. Drug-induced liver injury in Australia, 2009-2020: the increasing proportion of non-paracetamol cases linked with herbal and dietary supplements. Med J Aust. 2021 Sep 20;215(6):261-268. doi: 10.5694/mja2.51173. Epub 2021 Jul 17.

Ni H, Schmidli R, Savkovic S, Strasser SI, Hetherington J, Desai R, Handelsman DJ. Depot Pure GnRH Antagonist for Long-term Treatment of Ovarian Hyperthecosis Monitored by Multisteroid LCMS Profiling. J Endocr Soc. 2021 Nov 8;5(12):bvab167. doi: 10.1210/jendso/bvab167.

Papaluca T, Roberts SK, Strasser SI, Stuart KA, Farrell G, MacQuillan G, Dore GJ, Wade AJ, George J, Hazeldine S, O'Beirne J, Wigg A, Fisher L, McGarity B, Sawhney R, Sinclair M, Thomas J, Valiozis I, Weltman M, Wilson M, Woodward A, Ahlenstiel G, Haque M, Levy M, Prewett E, Sievert W, Sood S, Tse E, Valaydon Z, Bowden S, Douglas M, New K, O'Keefe J, Hellard M, Doyle J, Stoove M, Thompson AJ. Efficacy and Safety of Sofosbuvir/Velpatasvir/Voxilaprevir for Hepatitis C Virus (HCV) NS5A-Inhibitor Experienced Patients With Difficult to Cure Characteristics. Clin Infect Dis. 2021 Nov 2;73(9):e3288-e3295. doi: 10.1093/cid/ciaa1318.

Prince, D., McCaughan, G. (2021). Adrenal insufficiency in cirrhosis - don't forget the hypothalamus. Clinical Gastroenterology and Hepatology, 19(5), 1074.

Prince, D., Pipicella, J., Fraser, M., Alvaro, F., Maley, M., Foo, H., Middleton, P., Davison, S., Dore, G., McCaughan, G., et al (2021). Screening Emergency Admissions at Risk of Chronic Hepatitis C (SEARCH) to diagnose or re-diagnose infections is effective in Australia. Journal of Viral Hepatitis, 28(1), 121-128.

Remash D, Prince DS, McKenzie C, Strasser SI, Kao S, Liu K. Immune checkpoint inhibitor-related hepatotoxicity: A review. World J Gastroenterol. 2021 Aug 28;27(32):5376-5391. doi: 10.3748/wjg.v27.i32.5376.

Sabih AH, Laube R, Strasser SI, Lim L, Cigolini M, Liu K. Palliative medicine referrals for hepatocellular carcinoma: a national survey of gastroenterologists. BMJ Support Palliat Care. 2021 Mar 18:bmjspcare-2020-002807. doi: 10.1136/bmjspcare-2020-002807. Epub ahead of print.

Than, N., Chin, S., Kench, J., McCaughan, G., Majumdar, A. (2021). Steroid-refractory T-cell mediated rejection after human metapneumovirus infection in a liver transplant recipient. Pathology, 53(6), 793-794.

Tu T, Rodrigo C, Strasser SI, Bowden DS, MacLachlan JH, Drummer HE. The Inaugural Australian Centre for Hepatitis Virology Public Panel Discussion on Viral Hepatitis Research-Lessons in Scientific Community Outreach. Viruses. 2021 Sep 15;13(9):1838.

Vajdic, C., van Leeuwen, M., McCaughan, G. (2021). Extrahepatic cancer risk after liver transplantation for hepatocellular carcinoma: Incidence, risk and prevention. Hepatoma Research, 7, 34.

Xi, C., Di Fazio, A., Nadvi, N., Xiang, M., Zhang, H., Deshpande, C., Chen, Y., Sharifi Tabar, M., Wang, X., Bailey, C., McCaughan, G., Church, W., Gorrell, M. (2021). An improved production and purification protocol for recombinant soluble human fibroblast activation protein alpha. Protein Expression and Purification, 181, 1-8.

Younossi ZM, Stepanova M, Noureddin M, Kowdley KV, Strasser SI, Kohli A, Ruane P, Shiffman ML, Sheikh A, Gunn N, Caldwell SH, Huss RS, Myers RP, Wai-Sun Wong V, Alkhouri N, Goodman Z, Loomba R. Improvements of Fibrosis and Disease Activity Are Associated With Improvement of Patient-Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis. Hepatol Commun. 2021 May 12;5(7):1201-1211. doi: 10.1002/hep4.1710.

2020

Adams LA, Roberts SK, Strasser SI, Mahady SE, Powell E, Estes C, Razavi H, George J. Nonalcoholic fatty liver disease burden: Australia, 2019-2030. J Gastroenterol Hepatol. 2020 Sep;35(9):1628-1635.

Almadi MA, Itoi T, Moon JH, Goenka MK, Seo DW, Rerknimitr R, Lau JY, Maydeo AP, Lee JK, Nguyen NQ, Niaz SK, Sud R, Ang TL, Aljebreen A, Devereaux BM, Kochhar R, Reichenberger J, Yasuda I, Kaffes AJ, Kitano M, Peetermans J, Goswamy PG, Rousseau MJ, Reddy DN, Lakhtakia S, Lee YN, Rai VK, Kamada K, Tanaka R, Tonozuka R, Tsuchida A, Song TJ, Ramchandani MK; SpyGlass AMEA Registry Group. Using single-operator cholangioscopy for endoscopic evaluation of indeterminate biliary strictures: results from a large multinational registry. Endoscopy. 2020 Jul;52(7):574-582.

Ansar, S., Tran, K., Pinner, J., Majumdar, A., McKenzie, C. (2020). A rare cause of ductopenia: adult onset Alagille syndrome. Pathology, 52(5), 610-612.

Baiges, A., Turon, F., Simon-Talero, M., Tasayco, S., Bueno, J., Zekrini, K., Plessier, A., Franchi-Abella, S., Guerin, F., Majumdar, A., et al (2020). Congenital Extrahepatic Portosystemic Shunts (Abernethy Malformation): An International Observational Study. Hepatology, 71(2), 658-669.

Bassendine, M., Bridge, S., McCaughan, G., Gorrell, M. (2020). Covid-19 and co-morbidities: a role for Dipeptidyl Peptidase 4 (DPP4) in disease severity? Journal of Diabetes, 12(9), 649-658.

Cabanes-Creus, M., Hallwirth, C., Westhaus, A., Ng, B., Liao, S., Zhu, E., Navarro, R., Baltazar, G., Drouyer, M., Scott, S., Logan, G., Ginn, S., Alexander, I., Lisowski, L., et al (2020). Restoring the natural tropism of AAV2 vectors for human liver. Science Translational Medicine, 12(560), eaba3312.

Chetwood JD, Mudaliar S, Staudenmann D, Shin JS, Liu K, Majumdar A, Kaffes A, Strasser S, McCaughan GW, Saxena P. Emerging role of endoscopic ultrasound- guided liver biopsy. Gut. 2020 Sep 18:gutjnl-2020-322704.

Cochrane, C., Vaghjiani, V., Szczepny, A., Jayasekara, W., Gonzalez-Rajal, A., Kikuchi, K., McCaughan, G., Burgess, A., Gough, D., Watkins, D., et al (2020). Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling. Journal of Clinical Investigation, 130(8), 4006-4018.

Gill, M., Majumdar, A. (2020). Metabolic associated fatty liver disease: Addressing a new era in liver transplantation. World Journal of Hepatology, 12(12), 1168-1181.

Goodall, K., Nguyen, A., Matsumoto, A., McMullen, J., Eckle, S., Bertolino, P., Sullivan, L., Andrews, D. (2019). Multiple receptors converge on H2-Q10 to regulate NK and gamma delta T-cell development. Immunology and Cell Biology, 97(3), 326-339.

Holz, L., Chua, Y., de Menezes, M., Anderson, R., Draper, S., Compton, B., Chan, S., Mathew, J., Li, J., Kedzierski, L., Bertolino, P., Bowen, D., et al (2020). Glycolipid-peptide vaccination induces liver-resident memory CD8+ T cells that protect against rodent malaria. Science Immunology, 5(48), eaaz8035.

Jeffrey, A., Jeffrey, G., Stormon, M., Thomas, G., O'Loughlin, E., Shun, A., Hardikar, W., Jones, R., McCall, J., Evans, H., McCaughan, G., Crawford, M., et al (2020). Outcomes for children after second liver transplantations are similar to those after first transplantations: a binational registry analysis. Medical Journal of Australia, 213(10), 464-470.

Johansen, M., Irving, A., Montagutelli, X., Tate, M., Rudloff, I., Nold, M., Hansbro, N., Kim, R., Donovan, C., Liu, G., McCaughan, G., Gorrell, M., Cole, A., Moreno, C., Le Couteur, D., Hesselson, D., Triccas, J., Neely, G., Gamble, J., Simpson, S., et al (2020). Animal and translational models of SARS-CoV-2 infection and COVID-19. Mucosal Immunology, 13(6), 877-891.

Koshy, A., Gow, P., Han, H., Teh, A., Jones, R., Testro, A., Lim, H., McCaughan, G., Jeffrey, G., Crawford, M., et al (2020). Cardiovascular mortality following liver transplantation: Predictors and temporal trends over 30 years. European Heart Journal - Quality of Care and Clinical Outcomes, 6(4), 243-253.

Lai, S., Bleasel, J., McGrath, J., Majumdar, A., Kirwan, P., Anderson, L., Strasser, S., Gracey, D. (2020). BK nephropathy as a cause of renal dysfunction in an ABO-incompatible liver transplant patient. Transplantation, 104(3), e83-e84.

Lai, S., Newman, A., Mawson, J., Abou-Daher, F., Watson, N., Majumdar, A., Wyburn, K., Chadban, S., Gracey, D. (2020). Rapid reduction of high-level pre-formed donor-specific antibodies after simultaneous liver-kidney transplantation: a re of two cases. BMC Nephrology, 21(1), 47.

Laube R, Sabih AH, Strasser SI, Lim L, Cigolini M, Liu K. Palliative care in hepatocellular carcinoma. J Gastroenterol Hepatol. 2021 Mar;36(3):618-628. doi: 10.1111/jgh.15169. Epub 2020 Jul 15.

Liu, G., Baird, A., Parsons, M., Fan, K., Skerrett-Byrne, D., Nair, P., Makanyengo, S., Chen, J., Neal, R., Goggins, B., McCaughan, G., et al (2020). Platelet activating factor receptor acts to limit colitis-induced liver inflammation. The FASEB Journal, 34(6), 7718-7732.

Lum L, Lee A, Vu M, Strasser S, Davis R. Epidemiology and risk factors for invasive fungal disease in liver transplant recipients in a tertiary transplant center. Transpl Infect Dis. 2020 Dec;22(6):e13361.

Madill-Thomsen, K., Abouljoud, M., Bhati, C., Ciszek, M., Durlik, M., Feng, S., Foroncewicz, B., Francis, I., Gr?t, M., Jurczyk, K., et al (2020). The molecular diagnosis of rejection in liver transplant biopsies: First results of the INTERLIVER study. American Journal Of Transplantation, 20(8), 2156-2172.

Majeed, A., Majumdar, A., Bailey, M., Kemp, W., Bellomo, R., Pilcher, D., Roberts, S. (2020). The authors reply. Critical Care Medicine, 48(3), e258-e259.

Majumdar, A., Campos, S., Gurusamy, K., Pinzani, M., Tsochatzis, E. (2020). Defining the Minimum Acceptable Diagnostic Accuracy of Noninvasive Fibrosis Testing in Cirrhosis: A Decision Analytic Modeling Study. Hepatology, 71(2), 627-642.

Majumdar, A., Tsochatzis, E. (2020). Changing trends of liver transplantation and mortality from non-alcoholic fatty liver disease. Metabolism: Clinical and Experimental, 111, 154291.

McCarthy RE, Bowen DG, Strasser SI, McKenzie C. The dangers of herbal weight loss supplements: a case report of drug-induced liver injury secondary to Garcinia cambogia ingestion. Pathology. 2021 Jun;53(4):545-547.

McCaughan, G., Bowen, D., Bertolino, P. (2020). Induction Phase of Spontaneous Liver Transplant Tolerance. Frontiers in Immunology, 11, 1908.

Moffitt, L., Bilandzic, M., Wilson, A., Chen, Y., Gorrell, M., Oehler, M., Plebanski, M., Stephens, A. (2020). Hypoxia regulates dpp4 expression, proteolytic inactivation, and shedding from ovarian cancer cells. International Journal of Molecular Sciences, 21(21), 1-14.

Pandya K, Liu K, Strasser SI. Hepatobiliary and Pancreatic: Diaphragmatic paralysis after transarterial chemoembolization of hepatocellular carcinoma. J Gastroenterol Hepatol. 2020 Feb;35(2):181.

Pandya, K., Sastry, V., Panlilio, M., Yip, T., Salimi, S., West, C., Virtue, S., Wells, M., Crawford, M., Pulitano, C., Strasser, S., McCaughan, G., Majumdar, A., Liu, K. (2020). Differential Impact of Extended Criteria Donors After Brain Death or Circulatory Death in Adult Liver Transplantation. Liver Transplantation, 26(12), 1603-1617.

Papaluca T, Roberts SK, Strasser SI, Stuart KA, Farrell G, MacQuillan G, Dore GJ, Wade AJ, George J, Hazeldine S, O'Beirne J, Wigg A, Fisher L, McGarity B, Sawhney R, Sinclair M, Thomas J, Valiozis I, Weltman M, Wilson M, Woodward A, Ahlenstiel G, Haque M, Levy M, Prewett E, Sievert W, Sood S, Tse E, Valaydon Z, Bowden S, Douglas M, New K, O'Keefe J, Hellard M, Doyle J, Stoove M, Thompson AJ. Efficacy and safety of sofosbuvir/velpatasvir/voxilaprevir for HCV NS5A-inhibitor experienced patients with difficult to cure characteristics. Clin Infect Dis. 2020 Sep 5:ciaa1318.

Praktiknjo, M., Simon-Talero, M., Romer, J., Roccarina, D., Martinez, J., Lampichler, K., Baiges, A., Low, G., LLop, E., Majumdar, A., et al (2020). Total area of spontaneous portosystemic shunts independently predicts hepatic encephalopathy and mortality in liver cirrhosis. Journal of Hepatology, 72, 1140-1150.

Prince DS, Liu K, Pavendranathan G, Strasser SI, Bollipo S, Kanazaki R. The impact of the COVID-19 pandemic on gastroenterology trainees in Australia. J Gastroenterol Hepatol. 2020 Oct;35(10):1841-1842.

Roberts, S., Strasser, S., Nicoll, A., Kemp, W., Majeed, A., Mitchell, J., Stuart, K., Gow, P., Sood, S., MacQuillan, G., George, J., et al (2020). Efficacy and safety profile of calcineurin inhibitor salvage therapy in autoimmune hepatitis. Scandinavian Journal of Gastroenterology, 55(11), 1309-1317.

Salimi, S., Pandya, K., Sastry, V., West, C., Virtue, S., Wells, M., Crawford, M., Pulitano, C., McCaughan, G., Majumdar, A., Strasser, S., Liu, K. (2020). Impact of Having a Planned Additional Operation at Time of Liver Transplant on Graft and Patient Outcomes. Journal of Clinical Medicine, 9(2), 1-9.

Santhakumar, C., Gane, E., Liu, K., McCaughan, G. (2020). Current perspectives on the tumor microenvironment in hepatocellular carcinoma. Hepatology International, 14(6), 947-957.

Schnitzbauer AA, Filmann N, Adam R, Bachellier P, Bechstein WO, Becker T, Bhoori S, Bilbao I, Brockmann J, Burra P, Chazoullières O, Cillo U, Colledan M, Duvoux C, Ganten TM, Gugenheim J, Heise M, van Hoek B, Jamieson N, de Jong KP, Klein CG, Klempnauer J, Kneteman N, Lerut J, Mäkisalo H, Mazzaferro V, Mirza DF, Nadalin S, Neuhaus P, Pageaux GP, Pinna AD, Pirenne J, Pratschke J, Powel J, Rentsch M, Rizell M, Rossi G, Rostaing L, Roy A, Scholz T, Settmacher U, Soliman T, Strasser S, Söderdahl G, Troisi RI, Turrión VS, Schlitt HJ, Geissler EK. mTOR Inhibition Is Most Beneficial After Liver Transplantation for Hepatocellular Carcinoma in Patients With Active Tumors. Ann Surg. 2020 Nov;272(5):855-862.

Staudenmann DA, Kaffes AJ, Saxena P. Endoscopic Ultrasound-Guided Vascular Procedures: A Review. Clin Endosc. 2020 Sep;53(5):519-524.

Valencia-Hernandez, A., Ng, W., Ghazanfari, N., Ghilas, S., de Menezes, M., Holz, L., Huang, C., English, K., Naung, M., Tan, P., Bowen, D., Bertolino, P., et al (2020). A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice. Cell Host and Microbe, 27(6), 950-962.e7.

Vidot, H., Kline, K., Cheng, R., Finegan, L., Lin, A., Kempler, E., Strasser, S., Bowen, D., McCaughan, G., Carey, S., Allman-Farinelli, M., et al (2020). Reply to comments on the editor re: The relationship of obesity, nutritional status and muscle wasting in patients assessed for liver transplantation, nutrients 2019,11,2097. Nutrients, 11(2097.).

Werner JM, Hornung M, Krah R, Götz M, Schnitzbauer AA, Schlitt HJ, Geissler EK; International SiLVER study group. HCC recurrence in HCV-infected patients after liver transplantation: SiLVER Study reveals benefits of sirolimus in combination with CNIs - a post-hoc analysis. Transpl Int. 2020 Aug;33(8):917-924.

Wong MY, Saxena P, Kaffes AJ. Benign Biliary Strictures: A Systematic Review on Endoscopic Treatment Options. Diagnostics (Basel). 2020 Apr 15;10(4):221.

Xi, C., Di Fazio, A., Nadvi, N., Patel, K., Xiang, M., Zhang, H., Deshpande, C., Low, J., Chen, Y., McMillan, C., Osborne, B., Vieira de Ribeiro, A., McCaughan, G., Mackay, J., Church, W., Gorrell, M., et al (2020). A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2. Molecules, 25(22).

Zajac J, Anderson H, Adams L, Wangmo D, Suhail S, Almen A, Berns L, Coerber B, Dawson L, Hunger A, Jehn J, Johnson J, Plack N, Strasser S, Williams M, Bhattacharyya S, Hati S. Effects of Distal Mutations on Prolyl-Adenylate Formation of Escherichia coli Prolyl-tRNA Synthetase. Protein J. 2020 Oct;39(5):542-553.

2019

Ardalan ZS, Chandran S, Vasudevan A, Angus PW, Grigg A, He S, Macdonald G, Strasser SI, Tate CJ, Kennedy GA,10, Testro AG, Gow PJ. Management of Patients With Erythropoietic Protoporphyria-Related Progressive Liver Disease. Liver Transpl. 2019 Nov;25(11):1620-1633.

Baars JE, Keegan M, Bonnichsen MH, Aepli P, Theyventhiran R, Farrell E, Kench JG, Saxena P, Kaffes AJ. The ideal technique for processing SpyBite tissue specimens: a prospective, single-blinded, pilot-study of histology and cytology techniques. Endosc Int Open. 2019 Oct;7(10):E1241-E1247.

Baiges A, Turon F, Simón-Talero M, Tasayco S, Bueno J, Zekrini K, Plessier A, Franchi-Abella S, Guerin F, Mukund A, Eapen CE, Goel A, Shyamkumar NK, Coenen S, De Gottardi A, Majumdar A, Onali S, Shukla A, Carrilho FJ, Nacif L, Primignani M, Tosetti G, La Mura V,15, Nevens F, Witters P, Tripathi D, Tellez L, Martínez J, Álvarez-Navascués C, Fraile López ML, Procopet B, Piscaglia F, de Koning B, Llop E, Romero-Cristobal M, Tjwa E, Monescillo-Francia A, Senzolo M, Perez-LaFuente M, Segarra A, Sarin SK, Hernández-Gea V, Patch D, Laleman W, Hartog H, Valla D, Genescà J, García-Pagán JC; REHEVASC, VALDIG an EASL consortium, Abernethy group. Congenital Extrahepatic Portosystemic Shunts (Abernethy Malformation): An International Observational Study. Hepatology. 2019 Jun 18. [Epub ahead of print]

Ben Roediger, Quintin Lee, Shweta Tikoo, Joanna C.A. Cobbin, James M. Henderson, Marisa Henry, Maria Wynne, Sara F. Santagostino, Szun S. Tay, David Harris, John F. Bertram, John P. Dowling, Patrick Bertolino, Jack H. Lai, Wengen Wu, William W. Bachovchin, Mark D. Gorrell, Babak Shaban, Edward C. Holmes, Christopher J. Jolly, Sébastien Monette and Wolfgang Weninger. An atypical parvovirus driving chronic tubulointerstitial nephropathy and kidney fibrosis. Cell 2018;175:530-543.

Bukhari MA, Brewer O, Chen YI, Ngamruengphong S, Sanaei O, Saxena P, Khashab MA. Endosonography-guided alteration of upper surgical anatomy to facilitate endoscopic management of biliary cast syndrome post-liver transplantation. Endoscopy. 2019 Dec;51(12):E374-E375.

Calzadilla-Bertot L, Jeffrey GP, Jacques B, McCaughan G, Crawford M, Angus P, Jones R, Gane E, Munn S, Macdonald G, Fawcett J, Wigg A, Chen J, Fink M, Adams LA. Increasing Incidence of Nonalcoholic Steatohepatitis as an Indication for Liver Transplantation in Australia and New Zealand. Liver Transpl. 2019 Jan;25(1):25-34.

Cook SJ, Lee Q, Wong ACH, Spann BC, Vincent JN, Wong JJ, Schlitzer A, Gorrell MD, Weninger W, Roediger B. Differential chemokine receptor expression and usage by pre-cDC1 and pre-cDC2. Immunology & Cell Biology 2018; 96:1131-1139.

Crossan C, Majumdar A, Srivastava A, Thorburn D, Rosenberg W, Pinzani M, Longworth L, Tsochatzis EA . Referral pathways for patients with NAFLD based on non-invasive fibrosis tests: Diagnostic accuracy and cost analysis. Liver Int. 2019;39(11):2052-2060.

d'Avigdor WMH, Budzinska MA, Lee M, Lam R, Kench J, Stapelberg M, McLennan SV, Farrell G, George J, McCaughan GW, Tu T, Shackel NA. Virus Genotype-Dependent Transcriptional Alterations in Lipid Metabolism and Inflammation Pathways in the Hepatitis C Virus-infected Liver. Sci Rep. 2019 Jul 22;9(1):10596.

Doyle JS, Raggatt M, Slavin M, McLachlan S-A, Strasser SI, Sasadeusz J, Howell J, Hajkowicz K, Nandurkar H, Johnston A, Bak N, Thompson AJ, on behalf of the Hepatitis B Management During Cancer Therapy Consensus Statement Group. Hepatitis B management during immunosuppression for haematological and solid-organ malignancies: an Australian consensus statement 2018. Med J Aust. 2019 Jun;210(10):462-468.

Durmush D, Kaffes AJ. Small bowel strictures. Curr Opin Gastroenterol. 2019 May;35(3):235-242.

Flórido M, Muflihah H, Lin LCW, Xia Y, Sierro F, Palendira M, Feng CG, Bertolino P, Stambas J, Triccas JA & Britton WJ. Pulmonary immunization with a recombinant influenza A virus vaccine induces lung-resident CD4+ memory T cells that are associated with protection against tuberculosis. (2018). Mucosal Immunol., 6,1743-1752.

Gall MG, Zhang HE, Lee Q, Jolly CJ, McCaughan GW, Cook A, Roediger B, Gorrell MD. Immune regeneration in irradiated mice is not impaired by the absence of DPP9 enzymatic activity. Sci Rep. 2019 May 13;9(1):7292.

Gardiner A, Liu K, Bonnichsen M, Joshi V, Davis RJ, Strasser SI. Immunity to vaccine-preventable viral infections in Australians being evaluated for liver transplantation. Transplantation. 2019 Jun 28. [Epub ahead of print]

Ge N, Brugge WR, Saxena P, Sahai A, Adler DG, Giovannini M, Pausawasdi N, Santo E, Mishra G, Tam W, Kida M, de la Mora-Levy JG, Sharma M, Umar M, Katanuma A, Lee L, Garg PK, Eloubeidi MA, Yu HK, Raijman I, Arturo Arias BL, Bhutani M, Carrara S, Rai P, Mukai S, Palazzo L, Dietrich CF, Nguyen NQ, El-Nady M, Poley JW, Guaraldi S, Kalaitzakis E, Sabbagh LC, Lariño-Noia J, Gress FG, Lee YT, Rana SS, Fusaroli P, Hocke M, Dhir V, Lakhtakia S, Ratanachu-Ek T, Chalapathi Rao AS, Vilmann P, Okasha HH, Irisawa A, Ponnudurai R, Leong AT, Artifon E, Iglesias-Garcia J, Saftoiu A, Larghi A, Robles-Medranda C, Sun S. An international, multi-institution survey of the use of EUS in the diagnosis of pancreatic cystic lesions. Endosc Ultrasound. 2019 Nov-Dec;8(6):418-427.

Goodall KJ, Nguyen A, Matsumoto A, McMullen JR, Eckle SB, Bertolino P, Sullivan LC and Andrews DM. Multiple receptors converge on H2-Q10 to regulate NK and γδT-cell development. Immunol Cell Biol. 2019 Mar;97(3):326-339.

Gorrell M: F1000Prime https://f1000.com/prime/734650074. Recommendation of [Sanyal A et al., Lancet 2019 392(10165):2705-2717]. In F1000Prime, 13 Aug 2019; 10.3410/f.734650074.793563632.

Gorrell M: F1000Prime https://f1000.com/prime/735574100. Recommendation of [AR Griswold, et al., Cell Chem Biol 2019 26(6):901-907.e6. DOI: 10.1016/j.chembiol.2019.03.007 "A Chemical Strategy for Protease Substrate Profiling."] In F1000Prime, 17 Jul 2019; 10.3410/f.735574100.793562430.

Gorrell, M. D. & Zhang, H. E. DPP8. in Encyclopedia of Signaling Molecules (ed Sangdun Choi) Ch. 101654, 1414-1417 (Springer International Publishing, 2018).

Hu X, Aivazian K, McKenzie C, Wong M, Kaffes A, Saxena P. A Rare Case of Duodenal Adenocarcinoma Presenting as a Subepithelial Lesion in a Patient Undergoing Investigation for Iron Deficiency Anaemia. Case Rep Gastrointest Med. 2019 Oct 7;2019:3434620 eCollection 2019.

Kaffes A. Benign biliary strictures: how we are evolving to the perfect endoscopic strategy. Endoscopy. 2019 Dec;51(12):1115-1116

Kanda T, Lau GKK, Wei L, Moriyama M, Yu ML, Chuang WL, Ibrahim A, Lesmana CRA, Sollano J, Kumar M, Jindal A, Sharma BC, Hamid SS, Dokmeci AK, Mamun-Al-Mahtab, McCaughan GW, Wasim J, Crawford DHG, Kao JH, Yokosuka O, Sarin SK, Omata M. APASL clinical practice recommendation: how to treat HCV-infected patients with renal impairment? Hepatol Int. 2019 Mar;13(2):103-109

Laaksonen MA, Webster AC, McCaughan GW, Keogh AM, Grulich AE, Vajdic CM. Longitudinal immunosuppression data can minimize misclassification bias in solid organ transplantation cohorts. Clin Transplant. 2019 Feb;33(2):e13470

Lay AJ, Zhang HE, McCaughan GW, Gorrell MD. Fibroblast activation protein in liver fibrosis. Front Biosci (Landmark Ed). 2019 Jan 1;24:1-17.

Majeed A, Majumdar A, Bailey M, Kemp W, Bellomo R, Pilcher D, Roberts SK. Declining Mortality of Cirrhotic Variceal Bleeding Requiring Admission to Intensive Care: A Binational Cohort Study. Crit Care Med. 2019;47(10):1317-1323.

Majumdar A, Campos S, Gurusamy K, Pinzani M, Tsochatzis EA. Defining the Minimum Acceptable Diagnostic Accuracy of Noninvasive Fibrosis Testing in Cirrhosis: A Decision Analytic Modeling Study. Hepatology. 2019 Jul 11. [Epub ahead of print]

Majumdar A, Roberts SK, Pilcher D. Are liver transplant centres critical for the critically ill patient with cirrhosis? J Hepatol. 2019 Sep;71(3):637-638

Majumdar A, Tsochatzis EA. Curve Your Enthusiasm: The Decision to Use Expanded or Original Baveno VI Criteria to Exclude High-Risk Varices. Clinical Gastroenterology and Hepatology. 2019 Sep 28. [Epub ahead of print]

Mekonnen ZA, Grubor-Bauk B, English K, Leung P, Masavuli MG, Shrestha AC, Bertolino P, Bowen DG, Lloyd AR, Gowans EJ, Wijesundara DK. Single-Dose Vaccination with a Hepatotropic Adeno-associated Virus Efficiently Localizes T Cell Immunity in the Liver with the Potential To Confer Rapid Protection against Hepatitis C Virus. J Virol. 2019 Sep 12;93(19). pii: e00202-19.

Mudaliar S, Liu K, Pavendranathan G, Kench JG, Strasser SI. Hepatobiliary and Pancreatic: Kasabach-Merritt syndrome in adult. J Gastroenterol Hepatol. 2019 May 28. doi: 10.1111/jgh.14676. [Epub ahead of print]

Mudaliar S, Liu K, Strasser SI. Surface antigen negative hepatitis B infection: the importance of screening before B cell-depleting therapy. Med J Aust. 2019 May 8. doi: 10.5694/mja2.50165. [Epub ahead of print]

Nicoll AJ, Roberts SK, Lim R, Mitchell J, Weltman M, George J, Wigg A, Stuart K, Gow P, MacQuillan G, Tse E, Levy M, Sood S, Zekry A, Cheng W, Mitchell J, Skoien R, Sievert W, Strasser SI, McCaughan GW; ALA Clinical Research Network, Gastroenterological Society of Australia. Beneficial response to mycophenolate mofetil by patents with autoimmune hepatitis, who have failed standard therapy, is predicted by older age and lower immunoglobulin G and INR levels. Aliment Pharmacol Ther. 2019 May;49(10):1314-1322.

Nicoll AJ, Roberts SK, Mitchell J, Strasser SI, McCaughan GW; Australian Liver Association Clinical Research Network. Letter: elderly AIH patients-an important subgroup. Authors' reply. Aliment Pharmacol Ther. 2019 Sep;50(5):615

Nicoll AJ, Roberts SK, Strasser SI; Tapestry Investigators of the Australian Liver Association Clinical Research Network. Editorial: tailoring mycophenolate mofetil rescue therapy for success in autoimmune hepatitis-authors' reply. Aliment Pharmacol Ther. 2019 Jun;49(11):1450-1451.

Prince DS, Liu K, McCaughan GW, Kench J, Strasser SI. Heterozygosity for the Alpha-1-Antitrypsin Z Allele in Cirrhosis Is Associated With More Advanced Disease. Liver Transpl. 2019 Aug;25(8):1285-1286.

Purcell T, Wade A, Accadia L, Strasser S, Read P, Allard N, Baker D, Pedrana A, Doyle J. Eliminating hepatitis C: Part 3. Curing hepatitis C in general practice. Medicine Today 2019; 20(8): 20-26.

Ruane P, Strasser SI, Gane EJ, Hyland RH, Shao J, Dvory-Sobol H, Tran T, Stamm LM, Brainard DM, Nyberg L, Shafran S. Sofosbuvir/Velpatasvir/Voxilaprevir for Patients with HCV Who Previously Received a Sofosbuvir/Velpatasvir-Containing Regimen: Results from a Retreatment Study. J Viral Hepat. 2019 Jun;26(6):770-773.

Sheu A, Chan Y, Ferguson A, Bakhtyari MB, Hawke W, White C, Chan YF, Bertolino P, Woon HG, Palendira U, Sierro F, Lau SM. A pro-inflammatory CD4+ T cell phenotype in gestational in diabetes mellitus diabetes mellitus. (2018). Diabetologia, 61 (7), 1633-1643.

Strasser SI, Thompson AJ, Roberts SK, George J and Clinical Cases in Hepatitis 2018 Steering Committee. Clinical Cases in Hepatitis: Towards improving liver disease management in Australia. J Gastroenterol Hepatol. 2019; 34:5-15.

Vidot H, Cvejic E, Finegan LJ, Shores EA, Bowen DG, Strasser SI, McCaughan GW, Carey S, Allman-Farinelli M, Shackel NA. Supplementation with Synbiotics and/or Branched Chain Amino Acids in Hepatic Encephalopathy: A Pilot Randomised Placebo-Controlled Clinical Study. Nutrients. 2019 Aug 6;11(8). pii: E1810.

Vidot H, Kline K, Cheng R, Finegan L, Lin A, Kempler E, Strasser SI, Bowen DG, McCaughan GW, Carey S, Allman-Farinelli M, Shackel NA. The Relationship of Obesity, Nutritional Status and Muscle Wasting in Patients Assessed for Liver Transplantation. Nutrients. 2019 Sep 4;11(9). pii: E2097.

Xu W, Liu K, Chen M, Sun JY, McCaughan GW, Lu XJ, Ji J. Immunotherapy for hepatocellular carcinoma: recent advances and future perspectives. Ther Adv Med Oncol. 2019 Jul 23;11:1758835919862692

Yee C, Main NM, Terry A, Stevanovski I, Maczurek A, Morgan AJ, Calabro S, Potter AJ, Iemma TL, Bowen DG, Ahlenstiel G, Warner FJ, McCaughan GW, McLennan SV, Shackel NA. CD147 mediates intrahepatic leukocyte aggregation and determines the extent of liver injury. PLoS One. 2019 Jul 10;14(7):e0215557.

Zhang HE, Hamson EJ, Koczorowska MM, Tholen S, Chowdhury S, Bailey CG, Lay AJ, Twigg SM, Lee Q, Roediger B, Biniossek ML, O'Rourke MB, McCaughan GW, Keane FM, Schilling O, Gorrell MD. Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics. Mol Cell Proteomics. 2019 Jan;18(1):65-85

AW Morrow Gastroenterology and Liver Centre Research

Our Research Themes at the Laboratory Level

Our Research Themes at the Clinical Level

Selected Grants

Our Publications

2023

AW Morrow Gastroenterology and Liver Centre Research

AW Morrow Gastroenterology and Liver Centre Research

Our Organisation

Make a Donation

Our Hospitals

Right to Information

Plans

Publications

Quick Links