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Thoracic Medicine Research

The Department of Thoracic Medicine pursues a diverse range of research from basic clinical and applied physiology to innovation in clinical care as well as answering practical questions that are important to the community. The Department is one of Australia's most active clinical laboratories with a focus on translational research while maintaining a strong focus on undergraduate and postgraduate education. Senior members of the Department have maintained a strong commitment with local and international professional societies and are regarded as experts in their field.

Investigator-Initiated studies

Our Department's research activities focus on five main streams; Airways physiology, cilia function, cardio-respiratory function, sleep medicine, and interventional pulmonology. The laboratory is conducting a number of studies evaluating novel measures of airway function with a focus on translational research into small airway structure and function. Some of these studies are conducted in collaboration with the Woolcock Institute of Medical research and The University of Sydney. Other research collaborations have included the Concord Hospital Departments of Cardiology, Endocrinology, Andrology and Nuclear Medicine, Royal North Shore Hospital, Macquarie University, University of Technology, The George Institute for Global Health, The Alfred Hospital and The Austin Hospital.

Clinical Trials

The Department continues to be active in a range of Clinical Trials, some funded by Industry and others via NHMRC, that study the effects of new and novel therapeutic interventions for the treatment of asthma, interstitial lung disease, bronchiectasis and chronic obstructive pulmonary disease (COPD). There has been an expansion of clinical trial in interstitial lung disease associated with the development of new treatments. 

Clinical Care Initiatives

In keeping with a focus on improving patient care and clinically relevant research, the Department has developed sub-specialty clinics for Airways Diseases (including asthma and COPD), Severe Asthma service bronchiectasis, primary ciliary dyskinesia, sleep medicine and a metabolic-respiratory failure clinic. Regular multidisciplinary meetings are also conducted for interstitial lung disease and lung cancer. We have recently created the first multicenter database for Airways Diseases in NSW and the launch of the National Bronchiectasis registry.

Our Research Team

Professor Matthew Peters Investigator, Head of Department
Professor Alvin Ing Investigator/Sub-investigator
Dr Elizabeth Veitch Investigator/Sub-investigator
Professor Lucy Morgan Investigator/Sub-investigator
Associate Professor Claude Farah Investigator/Sub-investigator
Associate Professor Tajalli Saghaie Investigator/Sub-investigator
Dr Leon Laks Investigator/Sub-investigator
Dr Ruby Brillante Investigator/Sub-investigator
Dr Lydia Makarie-Rofail Investigator/Sub-investigator
Dr Soo Wei Foo Investigator/Sub-investigator
Dr Alice Cottee Investigator/Sub-investigator
Dr Clarence Yeong Investigator/Sub-investigator
Associate Professor Leigh Seccombe Scientist
Dr Kate Dusanovski Scientist
Winnie Ho Scientist
Caoimhe Tierney Scientist
Neil Alberto Scientist
Michael Zawal Scientist
Eva McKenna Scientist
Nicola Reed Research Scientist
Mayrose Chan Research Scientist
Sofia Yao Research Scientist
Tharindi Ip Research Scientist
Dr Regina Leung Physiotherapist
Yasmin De Silva Physiotherapist

Our Publications

2023

Bates JHT, Milne S, Handley BM, Rutting S, Chapman DG, King GG, Farah CS, Robinson PD, Thamrin C. Model analysis of multiple breath nitrogen washout data: robustness to variations in breathing pattern. J Clin Monit Comput. 2023 Apr;37(2):409-420. doi: 10.1007/s10877-022-00915-0. Epub 2022 Sep 23. 
Chen W, Tran TN, Sadatsafavi M, Murray R, Wong NCB, Ali N, Ariti C, Bulathsinhala L, Gil EG, FitzGerald JM, Alacqua M, Al-Ahmad M, Altraja A, Al-Lehebi R, Bhutani M, Bjermer L, Bjerrum AS, Bourdin A, von Bülow A, Busby J, Canonica GW, Carter V, Christoff GC, Cosio BG, Costello RW, Fonseca JA, Gibson PG, Yoo KH, Heaney LG, Heffler E, Hew M, Hilberg O, Hoyte F, Iwanaga T, Jackson DJ, Jones RC, Koh MS, Kuna P, Larenas-Linnemann D, Lehmann S, Lehtimäki L, Lyu J, Mahboub B, Maspero J, Menzies-Gow AN, Newell A, Sirena C, Papadopoulos NG, Papaioannou AI, Perez-de-Llano L, Perng Steve DW, Peters M, Pfeffer PE, Porsbjerg CM, Popov TA, Rhee CK, Salvi S, Taillé C, Taube C, Torres-Duque CA, Ulrik C, Ra SW, Wang E, Wechsler ME, Price DB. Impact of Initiating Biologics in Patients With Severe Asthma on Long-Term Oral Corticosteroids or Frequent Rescue Steroids (GLITTER): Data From the International Severe Asthma Registry. J Allergy Clin Immunol Pract. 2023 Sep;11(9):2732-2747. doi: 10.1016/j.jaip.2023.05.044. Epub 2023 Jun 8. 
Cushen B, Koh MS, Tran TN, Martin N, Murray R, Uthaman T, Goh CYY, Vella R, Eleangovan N, Bulathsinhala L, Maspero JF, Peters MJ, Schleich F, Pitrez P, Christoff G, Sadatsafavi M, Torres-Duque CA, Porsbjerg C, Altraja A, Lehtimäki L, Bourdin A, Taube C, Papadopoulos NG, Zsuzsanna C, Björnsdóttir U, Salvi S, Heffler E, Iwanaga T, Al-Ahmad M, Larenas-Linnemann D, van Boven JFM, Aarli BB, Kuna P, Loureiro CC, Al-Lehebi R, Lee JH, Marina N, Bjermer L, Sheu CC, Mahboub B, Busby J, Menzies-Gow A, Wang E, Price DB; ISAR Inventory Study Group. Adult Severe Asthma Registries: A Global and Growing Inventory. Pragmat Obs Res. 2023 Oct 20;14:127-147. doi: 10.2147/POR.S399879.
Harvey ES, Peters MJ. Asthma registries: Tedious paperwork or a versatile tool for the generation of knowledge-Insights from the Australasian Severe Asthma Registry (ASAR). Respirology. 2023 Nov;28(11):986-988. doi: 10.1111/resp.14585. Epub 2023 Aug 23. 
Kritikos V, Harvey ES, Stevens S, Katelaris CH, Langton D, Rimmer J, Farah CS, Gillman A, Hew M, Radhakrishna N, Thomas D, Gibson PG; Australian Mepolizumab Registry Investigators. Comorbidities Modify the Phenotype but Not the Treatment Effectiveness to Mepolizumab in Severe Eosinophilic Asthma. J Allergy Clin Immunol Pract. 2023 Mar;11(3):885-895.e13. doi: 10.1016/j.jaip.2022.12.004. Epub 2022 Dec 23. 
Pfeffer PE, Ali N, Murray R, Ulrik C, Tran TN, Maspero J, Peters M, Christoff GC, Sadatsafavi M, Torres-Duque CA, Altraja A, Lehtimäki L, Papadopoulos NG, Salvi S, Costello RW, Cushen B, Heffler E, Iwanaga T, Al-Ahmad M, Larenas-Linnemann D, Kuna P, Fonseca JA, Al-Lehebi R, Rhee CK, Perez-de-Llano L, Perng Steve DW, Mahboub B, Wang E, Goh C, Lyu J, Newell A, Alacqua M, Belevskiy AS, Bhutani M, Bjermer L, Bjornsdottir U, Bourdin A, Bulow AV, Busby J, Canonica GW, Cosio BG, Dorscheid DR, Muñoz-Esquerre M, FitzGerald JM, Gil EG, Gibson PG, Heaney LG, Hew M, Hilberg O, Hoyte F, Jackson DJ, Koh MS, Ko HB, Lee JH, Lehmann S, Chaves Loureiro C, Lúðvíksdóttir D, Menzies-Gow AN, Mitchell P, Papaioannou AI, Popov TA, Porsbjerg CM, Salameh L, Sirena C, Taillé C, Taube C, Tohda Y, Wechsler ME, Price DB. Comparative effectiveness of anti-IL5 and anti-IgE biologic classes in patients with severe asthma eligible for both. Allergy. 2023 Jul;78(7):1934-1948. doi: 10.1111/all.15711. Epub 2023 Mar 27. 
Seccombe LM, Heath D, Farah CS, Di Michiel JR, Veitch EM, Peters MJ. Mechanisms of gas transfer impairment utilizing nitric oxide following severe COVID-19 pneumonitis. Physiol Rep. 2023 Apr;11(7):e15660. doi: 10.14814/phy2.15660. 
Soremekun S, Heaney LG, Skinner D, Bulathsinhala L, Carter V, Chaudhry I, Hosseini N, Eleangovan N, Murray R, Tran TN, Emmanuel B, Garcia Gil E, Menzies-Gow A, Peters M, Lugogo N, Jones R, Price DB. Asthma exacerbations are associated with a decline in lung function: a longitudinal population-based study. Thorax. 2023 Jul;78(7):643-652. doi: 10.1136/thorax-2021-217032. Epub 2022 Aug 3. 
Tomaszewski EL, Atkinson MJ, Janson C, Karlsson N, Make B, Price D, Reddel HK, Vogelmeier CF, Müllerová H, Jones PW; NOVELTY Scientific Community; NOVELTY study investigators. Chronic Airways Assessment Test: psychometric properties in patients with asthma and/or COPD. Respir Res. 2023 Apr 8;24(1):106. doi: 10.1186/s12931-023-02394-6. 
Vertigan AE, Harvey ES, Beyene T, Van Buskirk J, Holliday EG, Bone SL, McDonald VM, Horvat JC, Murphy VE, Jensen ME, Morgan GG, Zosky GR, Peters M, Farah CS, Jenkins CR, Katelaris CH, Harrington J, Langton D, Bardin P, Katsoulotos GP, Upham JW, Chien J, Bowden JJ, Rimmer J, Bell R, Gibson PG. Impact of Landscape Fire Smoke Exposure on Patients With Asthma With or Without Laryngeal Hypersensitivity. J Allergy Clin Immunol Pract. 2023 Oct;11(10):3107-3115.e2. doi: 10.1016/j.jaip.2023.06.015. Epub 2023 Jun 15.