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Renal Medicine Research

Our Renal Research Unit continues to have an active and expanding program of clinical research. With fourteen active trials, the main theme of our program is involvement in studies designed to improve the outcomes for people with kidney disease. Our program includes studies initiated by investigators, collaborative groups and pharmaceutical clinical trials investigating the progression and complications of chronic kidney disease. 

Selected Grants

Amount awarded Grant and project details
$5,736,696 NHMRC Clinical Trials and Cohort Studies, 2023-2027
Oral fenofibrate therapy to retard Chronic Kidney Disease in Type 2 diabetes.
Investigator: Jardine M (CIC).
$4,057,466 NHMRC Clinical Trials and Cohort Studies, 2023-2027
Dexmedetomidine in Cardiac surgical Intraoperative Drug Evaluation (DECIDE).
Investigator: Jardine M (CIB).
$3,257,170 NHMRC Investigator Grants, 2023-2027
Leadership 2: Addressing unmet needs in chronic disease through innovations in trial design and delivery.
Investigator: Jardine M.
$1,954,074 NHMRC Investigator Grants, 2022-2025
Transforming Outcomes for Pulmonary Fibrosis.
Investigator: Jardine M (CIA).
$5,000,000 NHMRC Synergy Grant, 2021-2025
Defining the role and therapeutic manipulation of the gut-lung axis in respiratory disease.
Investigator: Jardine M (CID).
$4,353,258 NHMRC CTCS Project Grant, 2020-2024
Evaluation of the efficacy and safety of health service dialysate sodium practice on clinical outcomes.
Investigator: Jardine M (CIA).
$5,522,418 NHMRC Project Grant, 2019-2024
Treatment of cardiovascular disease with very low dose Rivaroxaban in Advanced Chronic Kidney disease (The TRACK Trial).
Investigator: Jardine M (CIC).

Our Publications

2024

Cheung CK, Barratt J, Carroll K, Lafayette RA, Liew A, Suzuki Y, Tesař V, Trimarchi H, Wong MG, Zhang H, Perkovic V, Rizk DV. Targeting APRIL in the Treatment of IgA Nephropathy. Clin J Am Soc Nephrol. 2024 Mar 1;19(3):394-398. doi: 10.2215/CJN.0000000000000338. Epub 2023 Oct 6. 
Mathur M, Barratt J, Chacko B, Chan TM, Kooienga L, Oh KH, Sahay M, Suzuki Y, Wong MG, Yarbrough J, Xia J, Pereira BJG; ENVISION Trial Investigators Group. A Phase 2 Trial of Sibeprenlimab in Patients with IgA Nephropathy. N Engl J Med. 2024 Jan 4;390(1):20-31. doi: 10.1056/NEJMoa2305635. Epub 2023 Nov 2.
Sun J, Wong MG. Haematuria in immunoglobulin a nephropathy: To be or not to be? Nephrology (Carlton). 2024 Feb;29(2):63-64. doi: 10.1111/nep.14272. Epub 2024 Jan 17. 
Vaara ST, Serpa Neto A, Bellomo R, Adhikari NKJ, Dreyfuss D, Gallagher M, Gaudry S, Hoste E, Joannidis M, Pettilä V, Wang AY, Kashani K, Wald R, Bagshaw SM, Ostermann M; STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Investigators. Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis. Crit Care Explor. 2024 Feb 19;6(2):e1053. doi: 10.1097/CCE.0000000000001053. 
Francis A, Wainstein M, Irish G, Abdul Hafidz MI, Chen T, Cho Y, Htay H, Kanjanabuch T, Lalji R, Neuen BL, See E, Shah A, Smyth B, Tungsanga S, Viecelli A, Yeung EK, Arruebo S, Bello AK, Caskey FJ, Damster S, Donner JA, Jha V, Johnson DW, Levin A, Malik C, Nangaku M, Okpechi IG, Tonelli M, Ye F, Wong MG, Bavanandan S; Regional Board and ISN-GKHA Team Authors. Capacity for the management of kidney failure in the International Society of Nephrology Oceania and South East Asia (OSEA) region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA). Kidney Int Suppl (2011). 2024 Apr;13(1):110-122. doi: 10.1016/j.kisu.2024.01.004. Epub 2024 Apr 8.
Trachtman H, Radhakrishnan J, Rheault MN, Alpers CE, Barratt J, Heerspink HJL, Noronha IL, Perkovic V, Rovin B, Trimarchi H, Wong MG, Mercer A, Inrig J, Rote W, Murphy E, Bedard PW, Roth S, Bieler S, Komers R. Focal Segmental Glomerulosclerosis Patient Baseline Characteristics in the Sparsentan Phase 3 DUPLEX Study. Kidney Int Rep. 2024 Jan 28;9(4):1020-1030. doi: 10.1016/j.ekir.2024.01.032.
Trần TB, Ambrens M, Nguyễn J, Coleman E, Gilanyi Y, Letton M, Pandit A, Lock L, Thom JM, Sen S, Lambert K, Arnold R. Preferences of people with chronic kidney disease regarding digital health interventions that promote healthy lifestyle: qualitative systematic review with meta-ethnography. BMJ Open. 2024 May 27;14(5):e082345. doi: 10.1136/bmjopen-2023-082345.
Letton ME, Trần TB, Flower S, Wewege MA, Wang AY, Sandler CX, Sen S, Arnold R. Digital Physical Activity and Exercise Interventions for People Living with Chronic Kidney Disease: A Systematic Review of Health Outcomes and Feasibility. J Med Syst. 2024 Jul 1;48(1):63. doi: 10.1007/s10916-024-02081-z. 
Wang AY, Serpa Neto A, Gallagher M, Wald R, Bagshaw SM, Bellomo R; STARRT-AKI Investigators. Association of Age, Frailty, and Strategy for Initiation of Renal-Replacement Therapy: A Post Hoc analysis of the STARRT-Acute Kidney Injury Trial. Blood Purif. 2024;53(10):781-792. doi: 10.1159/000540323. Epub 2024 Jul 24. 
Kim D, Lv J, Hladunewich M, Jha V, Hooi LS, Monaghan H, Shan S, Reich HN, Barbour S, Billot L, Zhang H, Perkovic V, Wong MG; TESTING trial steering committee. The Efficacy and Safety of Reduced-Dose Oral Methylprednisolone in High-Risk Immunoglobulin A Nephropathy. Kidney Int Rep. 2024 Apr 3;9(7):2168-2179. doi: 10.1016/j.ekir.2024.03.032. 
Cooper M, Cherney DZI, Greene TH, Heerspink HJL, Jardine M, Lewis JB, Wong MG, Baquero E, Heise M, Jochems J, Lanchoney D, Liss C, Reiser D, Scotney P, Velkoska E, Dwyer JP. Vascular Endothelial Growth Factor-B Blockade with CSL346 in Diabetic Kidney Disease: A Phase 2A Randomized Controlled Trial. J Am Soc Nephrol. 2024 Nov 1;35(11):1546-1557. doi: 10.1681/ASN.0000000000000438. Epub 2024 Aug 16. 
Cheung CK, Barratt J, Lafayette R, Liew A, Suzuki Y, Tesař V, Trimarchi H, Wong MG, Zhang H, Rizk DV. Targeting APRIL in the treatment of glomerular diseases. Kidney Int. 2024 Nov;106(5):806-818. doi: 10.1016/j.kint.2024.08.012. Epub 2024 Sep 7.
Hunter-Dickson M, Wong MG. The role of endothelin receptor antagonists in IgA nephropathy. Nephrology (Carlton). 2024 Sep;29 Suppl 2:30-33. doi: 10.1111/nep.14364.
Li J, Lv J, Wong MG, Shi S, Zan J, Monaghan H, Perkovic V, Zhang H; TESTING Study Biomarker Group. Correlation of Urinary Soluble CD163 Levels With Disease Activity and Treatment Response in IgA Nephropathy. Kidney Int Rep. 2024 Aug 3;9(10):3016-3026. doi: 10.1016/j.ekir.2024.07.031.
Li PK, Ng JK, Cai GY, Chen W, Chow KM, Fan S, He JC, Hooi LS, Pei Y, Teo BW, Wong MG, Wu IW, Zhou J, Tian N, Ye Z, Yu X. Navigating the Global Economic Landscape of Dialysis: A Summary of Expert Opinions from The 4th International Congress of Chinese Nephrologists. Kidney Dis (Basel). 2024 Jul 24;10(5):384-397. doi: 10.1159/000540152.
Hunter-Dickson M, Sen S. Audit of haemodialysis adequacy to provide more personalised and green nephrology care. Nephrology. 2024;29:65.
Khanna R, Chandra A, Sen S, Konyukhov Y, Fuentes E, Burmistrov I, Kravchenko M. Microplastics and nanoplastics as environmental contaminants of emerging concern: Potential hazards for human health. Sustainability. 2024;16(19):8704.
Theivendran T, Sen S. Development of criteria led discharge for uncomplicated kidney and urinary tract infections: A quality assurance study of admissions at Concord Hospital over a 12-month period. Nephrology. 2024;29:85–86.
Tran TB, Tahir NUE, Bates A, Nguyễn J, Cheikh Hassan HI, Sen S, Lambert K, Arnold R. Physical activity recommendations for people with chronic kidney disease: Are research participants representative of real-world patients? J Clin Exerc Physiol. 2024;13(s2):424.
Van KL, Chong J, Tienstra L, Konda M, Van der Linde R, Chen V, Sen S, Lambert K, Arnold R. Impact of prophylactic-dose enoxaparin anticoagulation on anti-Xa levels, bleeding and extracorporeal circuit thrombosis in patients on chronic intermittent haemodialysis. Nephrology. 2024;29:102–103.
Wang AY, Ngo J, Perera PS, Higgins K, Eyles N, Endre Z, Sen S, Wong MG, Wynter LA, Killen JP, Bompoint S. ePidEmiology, Risk FactORs, and outcoMes of AKI (PERFORM-AKI): FR-PO034. J Am Soc Nephrol. 2024;35(10 Suppl):10–1681.