A NSW Government website

On

Endocrinology Research

The Department of Endocrinology is involved in local, national and international research. This includes studies in basic science, systems research and clinical research with patients in both the hospital and community. Areas of specific interest and expertise include bone disease, thyroid cancer, men's health and ageing.

Our Research Team

Dr Nic Kormas Head of Department and Senior Clinical Researcher
Professor Markus Seibel AM Research Lead, Senior Clinical Researcher
Professor Hong Zhou Research Lead, Senior Researcher
Professor Mark Cooper Senior Clinical Researcher
Associate Professor Kirtan Ganda Senior Clinical Researcher
Dr Ayanthi Wijerwardene Clinical Researcher
Dr Eugenie Macfarlane Research Staff
Lauryn Cavanagh Research Staff
Klaus Sommer Research Staff
Joseph Tannous Research Staff
Dr Mawson Wang PhD candidate. "Secondary fracture prevention in primary care".
Supervisor: Professor Markus Seibel
Co-Supervisor: Associate Professor Kirtan Ganda
Asim Shah PhD candidate. "Non-invasive measurement of blood glucose control".
Supervisor: Professor Mark Cooper
Dr Serena Lim PhD candidate. 
Supervisor: Associate Professor Kirtan Ganda

Selected Grants

Amount awarded Grant and project details
$850,000 NHMRC Ideas Grant, 2024-2027
Glucocorticoid rhythmicity and its critical role in bone loss and osteoarthritis during chronic disruption of circadian rhythm.
Investigators: Zhou H, Macfarlane E.
$101,728.83 NHMRC Postgraduate Scholarship 2024-2026
Making the first osteoporotic fracture the last: Evaluating a new integrated Model of osteoporosis management in primary care.
Investigator: Wang M.
$10,000 Endocrine Society of Australia, 2024-2025
Clinical utility of ctDNA in metastatic medullary thyroid cancer.
Investigator: Wijewardene A.
$120,000 National Natural Science Foundation of China (NSFC), 2022-2025
11β-HSD1 regulating skin glucocorticoid metabolism in post-burn wound healing and scarring.
Investigators: Wang Y, Cooper M, Zheng D, Wang, S, Yin S, Pan X, Ding X, Tang Q.
$1,500,000 NHMRC Investigator Grant, 2021-2025
Investigator Grant Leadership Lvl 3, Making the first fracture the last
Investigator: Seibel MJ.
$639,166 NHMRC Ideas Grant, 2020-2025
Skeletal glucocorticoid signalling is required for high-fat diet-induced bone loss and obesity
Investigators: Zhou H (CIA), Swarbrick M (CIB), Kim S (CIC).

Our Publications

2024

Bolton P, Seibel MJ, Moses D, Moore M, Goodger B.   A quality improvement project to increase treatment rates of osteoporosis in general practice. Aust Health Rev. 2024 Oct;49:AH24214. doi: 10.1071/AH24214.
Ganda K, Bennett M, Center JR, Daly RM, Seibel MJ, Talevski J, Winzenberg T. Defining the key clinician skills and attributes for competency managing patients with osteoporosis and fragility fractures. J Bone Miner Res. 2024 Nov 29;39(12):1835-1836. doi: 10.1093/jbmr/zjae146.
Jones AR, Currie D, Peng C, Ebeling PR, Center JR, Duque G, Lybrand S, Lyubomirsky G, Mitchell RJ, Pearson S, Seibel MJ, Occhipinti JA. Expanding access to fracture liaison services in Australia for people with minimal trauma fractures: a system dynamics modelling study. Med J Aust. 2024 Mar 18;220(5):243-248. doi: 10.5694/mja2.52241. Epub 2024 Feb 26.
Kanagaretnam H, Parameshwaran K, Ganda K, Seibel MJ. Thyrotoxic periodic paralysis complicated by carbimazole-associated myositis. BMJ Case Rep. 2024 Sep 24;17(9):e260722. doi: 10.1136/bcr-2024-260722.
Lawless AK, Kumar S, Bindra J, Sywak M, Chou A, Turchini J, Papachristos A, Wijewardene A, Sidhu S, Ahadi M, Tacon L, Glover A, Clark K, Tsang V, Pang L, Clifton-Bligh RJ, Robinson B, Gill AJ, Guminski A, Eade T, Gild ML. Anaplastic thyroid cancer: A review of recent evidence and summary of an Australian institutional protocol. Asia Pac J Clin Oncol. 2024 Dec;20(6):681-689. doi: 10.1111/ajco.14106. Epub 2024 Aug 15.
Luong R, Ribeiro R, Naganathan V, Blyth F, Waite LM, Handelsman DJ, Le Couteur DG, Seibel MJ, Hirani V. Cross-sectional and longitudinal associations between empirically derived dietary patterns and frailty among older men: The Concord Health and Ageing in Men Project. J Nutr Health Aging. 2024 Jan;28(1):100021. doi: 10.1016/j.jnha.2023.100021. Epub 2024 Jan 1.
Luong R, Ribeiro R, Naganathan V, Blyth F, Waite LM, Handelsman DJ, Le Couteur DG, Seibel MJ, Hirani V. Empirically derived dietary patterns are associated with major adverse cardiovascular events, all-cause mortality, and congestive cardiac failure in older men: The Concord Health and Ageing in Men Project. J Nutr Health Aging. 2024 Feb;28(2):100020. doi: 10.1016/j.jnha.2023.100020. Epub 2024 Jan 1.
Macfarlane E, Zhou H, Seibel MJ. The glucocorticoid receptor in skeletal health and disease: insights from targeted knockout mice. J Endocrinol. 2024 Mar 28;261(2):e230399. doi: 10.1530/JOE-23-0399. 
Phillips J, Subedi D, Lewis SC, Keerie C, Cronin O, Porteous M, Moore D, Cetnarskyj R, Ranganath L, Selby PL, Turgut T, Hampson G, Chandra R, Ho S, Tobias J, Young-Min S, McKenna MJ, Crowley RK, Fraser WD, Tang JCY, Gennari L, Nuti R, Brandi ML, Del Pino-Montes J, Devogelaer JP, Durnez A, Isaia GC, Di Stefano M, Guanabens N, Blanch Rubio J, Seibel MJ, Walsh JP, Rea SL, Kotowicz MA, Nicholson GC, Duncan EL, Major G, Horne A, Gilchrist N, Ralston SH    Randomised trial of genetic testing and targeted intervention to prevent the development and progression of Paget's disease of bone. Ann Rheum Dis. 2024 Mar 12;83(4):529-536. doi: 10.1136/ard-2023-224990.
Wang M, Knight A, Demeshko A, Girgis CM, Bolton P, Das A, Auwyang A, Williams B, Moses D, D'Este C, Seibel MJ. Integrated model of secondary fracture prevention in primary care (INTERCEPT): protocol for a cluster randomised controlled multicentre trial. BMC Prim Care. 2024 Sep 28;25(1):349. doi: 10.1186/s12875-024-02601-3.
Wang M, Kumar S, Wong P, Girgis CM. Choosing the right drug for the right patient: an evidence-based guide towards individualized management of osteoporosis. Endocrinology Today. 2024;13(2):34–40.
Wang M, Seibel MJ. Secondary fracture prevention in primary care: a narrative review. Osteoporos Int. 2024 Aug;35(8):1359-1376. doi: 10.1007/s00198-024-07036-1. Epub 2024 Apr 23.
Wijewardene A, Gild M, Tacon L, Tsang V, Gill AJ, Glover AR, Sywak M, Sidhu S, Robinson B, Roach P, Schembri G, Hoang J, Clifton-Bligh R. Reducing noise in radioactive iodine activity selection: the utility of an online clinical calculator. Endocr Connect. 2024 Oct 9;13(11):e240299. doi: 10.1530/EC-24-0299.