Centre for Education and Research on Ageing Research

The Centre for Education and Research on Ageing (CERA) and its members undertake basic science, epidemiological and clinical research.

CERA is part of the Department of Geriatric Medicine at Concord Hospital. CERA is a multidisciplinary hub to foster collaboration between clinical and academic health professionals and facilitate the translation of research findings into clinical practice. The research objectives of CERA are:

To improve the health and productivity of older people through research into the ageing process
To improve the well-being and quality of life of older people, especially those with frailty or dementia, through research into health care
To provide leadership in the education and training of people involved in the care of older people and those involved in ageing research.

Our current research programs include:

Oral Health
Ageing liver and nanomedicines
Novel mechanisms for dementia
Surgical liaison and older people in hospital
Advanced care directives
Polypharmacy and deprescribing
Identification and management of delirium in older inpatients
Falls prevention in hospital
Geriatric Medicine Services in Australia and New Zealand
Emergency Hospital in the Home
Enhanced Education of Junior Doctors to Improve the Care and Outcomes of Hospitalised Older Adults.

Our Key Achievements

The Biogerontology group continues to explore the targeted use of medicines and other therapeutics. The group is collaborating with the Institut d'Investigacions Biomèdiques in Barcelona in the use of our nanotechnology for microRNA delivery for the prevention of liver failure.

Treating diabetes with nano insulin: positive mouse and primate studies now completed. Commercialisation with an Australian Biotech company underway in preparation for first in human clinical trials.

Preventing diabetes in an immune model of diabetes with nano insulin: mouse studies currently underway.

Amyloid- beta clearance in the liver, a novel target for preventing Alzheimer's Disease: currently underway by PhD candidate Glen Lockwood.

Targeted nanodelivery of gene therapy: currently underway by PhD candidate Lara Westwood.

Effectiveness, cost-effectiveness and implementation of Emergency Hospital in the Home (EHITH) model of care for older people: In 2022 a new model of care, EHITH, was launched within SLHD.

Collaboration with SLHD AHCC&R Disability Inclusion & Advice Service (DIAS) on development of their project, 'COVID-19 outbreaks in disability group homes within Sydney Local Health District (SLHD)'.

Professor David Le Couteur has a long-term collaboration with Professor of Geriatric Pharmacology, Sarah Hilmer, at the Kolling Institute Royal North Shore Hospital. CERA research pharmacist Sarita Lo is also a member of Professor Hilmer's research team. Their research collaborations include:

Optimising quality use of medicines in hospital to improve outcomes in older people (current)
'TO HOME' research project (Towards Optimising Hospitalised Older adults' MEdications) (recently completed and in publication phase)
Evaluation of an Intervention Bundle to Reduce Inappropriate Polypharmacy in Older Inpatients: A Pilot Study (recently completed /and in publication phase)
Designing decision support to reduce inappropriate polypharmacy in older inpatients - Understanding user perceptions and workflows (completed).

Professor David Le Couteur is a member of the University of Sydney's Charles Perkins Centre (CPC). The CPC is a multidisciplinary research centre committed to improving global health. The projects examine the impact of nutrition on longevity and later life health.

Professor David Le Couteur received the 2023 Ruthven Blackburn Medal.

Understanding and reducing falls in the inpatient hospital setting. Charlotte McLennan (PhD). Lead Supervisor Professor Cathie Sherrington (Institute of Musculoskeletal Health). Professor Vasi Naganathan is in the supervisory team.

The TOP UP Trial - A physiotherapy led telehealth and exercise intervention to improve mobility in older people receiving aged care services: an effectiveness and implementation randomised controlled trial. Rik Dawson (PhD) Lead Supervisor Professor Cathie Sherrington (Institute of Musculoskeletal Health), Vasi Naganathan (investigator).

Investigating a psychological strategy to support older adults in making informed cancer screening decisions. Jenna Smith (PhD). Primary Supervisor Professor Kirsten McCaffery, School of Public Health The University of Sydney. Professor Vasi Naganathan on supervisor team.

Intensive Care Unit (ICU) Protocols Influenza Pandemics Public's view. Dr Winston Cheung (PhD). Professor Vasi Naganathan (Lead Supervisor).

Professors Victoria Cogger, David Le Couteur and Dr Nick Hunt winner of the Health Research Award for ‘Oral Insulin’ at the NSW Health Awards 2024.

Dr Janani Thillainadesan received the 2024 ANZAHPE Clinical Education Award.

Professors Victoria Cogger, David Le Couteur and Dr Nick Hunt received the Health Research and Innovation Award from the Sydney Local Health District in November 2023.

Professor David Le Couteur, awarded Fellowship of ASCEPT 2023.

Mr George Wells, 2023 Tony Broe Prize for best NSW AT presentation (Lead Supervisor Janani Thillainadesan).

Dr Janani Thillainadesan, 2023 Sydney Health Partners Award for Using Research to Change Health Practice.

Mr George Wells Sydney Health Partners Geriatric Medicine Clinical Academic Group Early-Mid Career Researcher Award 2022.

Eleni Azarias, 2022 Tony Broe Prize for best NSW AT presentation (Lead Supervisor Vasi Naganathan, Supervisor B Janani Thillainadesan).

Amyloid- beta clearance in the liver, a novel target for preventing Alzheimer's Disease: currently underway by PhD candidate Glen Lockwood.

Our Research Team

CERA Co-Directors
Professor Vasi Naganathan	Professor of Geriatric Medicine, University of Sydney and Consultant Geriatrician, Concord Hospital
Professor Victoria Cogger	Director, ANZAC Research Institute Co-Leader Biogerontology laboratory, ANZAC Research Institute
Department of Geriatric Medicine, Concord Hospital
Professor Vasi Naganathan	Consultant Geriatrician
Professor David Le Couteur	Senior Staff Specialist in Geriatric Medicine and Professor of Geriatric Medicine, The University of Sydney
Clinical Associate Professor John Cullen	Stream Director Sydney Local Health District Aged Health Care, Rehabilitation, General Medicine, Chronic Care, Disability, Endocrinology, Andrology and Ambulatory Care Clinical Associate Professor, Concord Clinical School, The University of Sydney
Clinical Associate Professor Louise Waite	Senior Staff Specialist Geriatrician. Head of Department of Geriatric Medicine. Clinical Associate Professor, Concord Clinical School, University of Sydney
Dr Janani Thillainadesan	Staff Specialist Geriatrician, Concord Hospital and Centre for Education and Research on Ageing Conjoint Senior Lecturer, Sydney Medical School, University of Sydney NHMRC Emerging Leadership Fellow (EL1), Faculty of Medicine and Health, University of Sydney
Clinical Associate Professor Deborah Cockrell	Lead for Oral Health, CERA and Clinical Associate Professor, Concord Clinical School, University of Sydney
Dr Natasha Spalding	Staff Specialist Geriatrician and Director of RACF Outreach Service
Dr Cameron Korb-Wells	Staff Specialist Geriatrician, Aged Health & Rehabilitation, Concord Hospital Medical Director, National Centre for Veterans’ Healthcare, Concord Hospital Clinical Senior Lecturer (Concord Clinical School), University of Sydney
Steven Chu	Oral Health PhD student
Biogerontology Lab, ANZAC Research Institute
Professor Victoria Cogger	Co-leader Biogerontology laboratory
Professor David Le Couteur	Co-leader Biogerontology laboratory
Dr Nicholas Hunt	Post-doctoral researcher
Dr Amanda Brandon	Post-doctoral researcher
Dr Sophie Kang	Postdoctoral Researcher
Dr Jarrod Kennedy	Postdoctoral Researcher
Associate Professor Meng Ngu	Senior Research Fellow
Professor Peter McCourt	Visiting Scientist
Glen Lockwood	Laboratory Manager
Harrison Ross	Research Assistant
Lara Westwood	PhD Candidate
CERA Research Support Staff
Leanne Kearney	CERA Research Project Officer
Sarita Lo	CERA Research Pharmacist
Danielle Hutchinson	CERA Research Project Officer
Linda Koria	EHITH Project Officer
Donna Bonnici	Support Manager

Higher Degree Students
Steven Chu	PhD Student	Primary Supervisor: Clinical A/Professor Deborah Cockrell Auxiliary Supervisor: Professor Vasi Naganathan
Glen Lockwood	PhD Student	Primary Supervisor: Professor Victoria Cogger Auxiliary Supervisor: Professor David Le Couteur
Charlotte McLennan	PhD Student	Auxiliary Supervisor: Professor Vasi Naganathan
Bonnie Liu	PhD Student	Auxiliary Supervisor: Dr Janani Thillainadesan
Eleni Azarias	Masters (MPhil) Student	Primary Supervisor: Professor Vasi Naganathan Auxiliary Supervisor: Dr Janani Thillainadesan
Joshua Makary	Masters (MPhil) Student	Auxiliary Supervisor: Professor Vasi Naganathan
Ganeshwaran Shivapathasundram	Masters (MPhil) Student	Auxiliary Supervisor: Professor Vasi Naganathan
Bethany Stavert	Masters (MPhil) Student	Primary Supervisor: Professor Vasi Naganathan
Atul Wagh	Masters (MPhil) Student	Primary Supervisor: Professor Vasi Naganathan

Honour Students
Lina Okati	Primary Supervisor: Dr Janani Thillainadesan
Advanced Trainee Projects
Dr Carol Hunter	Primary Supervisor: Dr Janani Thillainadesan
Dr Minna Li	Primary Supervisor: Dr Janani Thillainadesan
Dr Susan Li	Primary Supervisor: Dr Janani Thillainadesan

Selected Grants

Amount awarded	Project and investigator details
$4857	Australia & New Zealand Association for Health Professional Educators (ANZAHPE) Research Grant for Research in Health Professional Education Carers’ experiences with medical doctors, insights on training, and perspectives on carer involvement in the education of health professionals to improve the care of hospitalised older patients. Primary Investigator: Thillainadesan J
$2,949,625	NHMRC/MRFF – Dementia Ageing and Aged Care Mission DigiHab: Home-Based Rehabilitation Program for Enhancing Older Australians’ Health and Independence. Associate Investigator: Naganathan V
$674,000	NHMRC Investigator Grant, 2024-2026 Nanocarriers for Oral Biologic Delivery. Chief Investigator: Hunt N
$100,000	The University of Sydney NanoPitch Health 2024 – Best Pitch Inverse Nano-Vaccination for Prevention of Autoimmune Type 1 Diabetes. Chief Investigator: Hunt N
$497,224	NHMRC Investigator Grant, 2024 Microlearning-Enhanced Education of Junior Doctors to Improve the Care and Outcomes of Hospitalised Older Adults. Investigator: Thillainadesan J
$2,953,040	NHMRC Investigator Grant, 2024-2028 Harnessing the Therapeutic Potential of Hepatotropic Silver Sulfide Quantum Dot Nanomedicines for Ageing and Age-Related Diseases. Investigator: Le Couteur D.
$468,879	HCF Research Foundation, 2022-2024 Effectiveness, cost-effectiveness and implementation of Emergency Hospital in the Home model of care for older people Investigators: Naganathan V, Cullen J, Blyth F, Cunich M.
$2,800,000	MRFF, 2022-2025 Reshaping low back pain management in the emergency department. Investigators: Maher C (CIA), Naganathan V (CIJ).
$2,500,000	Norway Research Council, 2021-2025 Pack a pill in a PACA: PACA nanomedicines for targeting age-related changes in liver endothelium to prevent age-related disease. Investigators: McCourt P, Le Couteur D, Cogger V, Citrichs, Ravan, Sorenson, Snistad, Aslund, van Gurnsven.
$2,500,000	NHMRC Centres of Research Excellence Scheme, 2020-2024 NHMRC Centre of Research Excellence in the Prevention of Fall-related Injuries Associate Investigator: Naganathan V.
$1,520,260	NHMRC Targeted Call for Research: Cultural Ethnic and Linguistic Diversity in Dementia Research, 2023-2028 A Community Based Participatory Approach to Decreasing Dementia Stigma and Increasing Help-Seeking. Investigators: Low LF, Phillipson L, Ji M, Brodaty H, Jeon Y, Naismith S, Naganathan V, Gresham M, Taibi M.

Previous Grants

Amount awarded	Grant and project details
$50,000	Vincent Fairfax Family Foundation Research Establishment Fellowship 2023 Chief Investigator: Thillainadesan J
$134,000	Heart Foundation 2023 Vanguard Grant Harnessing the Therapeutic Potential of Hepatotropic Silver Sulfide Quantum Dot Nanomedicines for Ageing and Age-Related Diseases. Associate Investigator: Thillainadesan J
$12,981,420	NHMRC Program Grant, 2019-2023 Nutrition and complexity Investigators: Simpson S, George J, Le Couteur D, Gunton J, Raubenheimer D, Durrant-Whyte H.
$1,989,324	ARC Centres of Excellence, 2017-2023 ARC Centre of Excellence in Population Ageing Research 2 (CEPAR 2), University of Sydney Node Investigators: Baird M, Blyth F, Cumming R, Piggott J, McDonald P, Anstey K, Keane M, Parker S, Sherris M, Bateman H, Clarke P, McKibbin W, Woodland A.
$979,506	NHMRC 2022 Partnership Projects Grant PRC2, 2023 Quality Coaching to Implement a Hospital Fall Prevention Strategy: Intervention Development and Evaluation in a Stepped Wedge Trial. Investigators: Sherrington C, Naganathan V, Richards B, Hallahan A, Heppleston E, Jennings M, Jackson D, Ni Chroinin D, Hill AM, Haines T.
$750,000	MRFF, 2022 Bringing oral insulin to phase I clinical studies using a novel quantum dot drug delivery platform. Investigator: Hunt N.
$586,840	NHMRC Boosting Dementia Research Grant Scheme, 2018-2020 (extended) Team Approach to Polypharmacy Evaluation and Reduction for General Practice patients with dementia: the Australian TAPERdem study Investigators: Etherton-Beer C, Parkinson L, Naganathan V, Caughey G, Redfern J, Clifford R, Page A, Mangin D
$560,241	NHMRC, 2018-2020 A targeted approach to age related disease: nanomedicines and the liver sinusoidal endothelium Investigators: Cogger V, Le Couteur D, Kuncic Z, McCourt P
$510,580	ARC, 2018-2020 A life-course approach to the nutrition-lifespan-reproduction nexus Investigators: Raubenheimer D, Solon-Biet S, Walters K, Le Couteur D
$437,000	NSW Ministry of Health, 2018-2021 Advance Care Planning in outpatient clinics – extension Investigators: Caplan G, Meller A, Naganathan V, Cullen J
$325,000	ARC Discovery Project Grant, 2017-2019 Properties of nanomaterials determine their disposal by liver cells Investigators: Cogger V, Xu Z, Roberts M
$97,800	The University of Sydney, Faculty of Medicine and Health – Moyira Elizabeth Vine Fund for Research into Schizophrenia Program, 2023 Advance Care Planning in Persons with Schizophrenia – A Qualitative Study of Experiences, Facilitators and Barriers For Persons with Schizophrenia, their Carers and Clinicians. Investigators: Wand A, Sands MB, Meller A, Smith C, Naganathan V, Peisah C
$85,000	Australian Diabetes Society, 2021 Skip Martin Postdoctoral Fellowship Investigator: Hunt N
$80,000	University of Sydney DVC Research / Thompson Fellowships, 2018 A targeted approach to age related disease: nanomedicines and the liver sinusoidal endothelium Investigator: Cogger V.
$50,000	Therapeutic Innovations Australia, 2021-2022 Synthesis and characterisation of Ag2S quantum dots and conjugation to insulin at CSIRO. Investigator: Hunt N.
$25,000	Sydney Health Partners, 2021 HIPFFIT: HIP Fracture and Frailty Improvement Translational project Clinical PI: Cullen J
$10,000	ANZ Musculoskeletal Clinical Trials Network, 2019 Safe mobility to prevent falls in acute hospitals: adaptation of the successful Safe Recovery rehabilitation unit program Naganathan V.

Our Publications

2024

Hunt NJ, Lockwood GP, Heffernan SJ, Daymond J, Ngu M, Narayanan RK, Westwood LJ, Mohanty B, Esser L, Williams CC, Kuncic Z, McCourt PAG, Le Couteur DG, Cogger VC. Oral nanotherapeutic formulation of insulin with reduced episodes of hypoglycaemia. Nat Nanotechnol 2024; doi: 10.1038/s41565-023-01565-2

Stanceski K, Zhong S, Zhang X, Khadra S, Tracy M, Koria L, Lo S, Naganathan V, Kim J, Dunn AG, Ayre J. The quality and safety of using generative AI to produce patient-centred discharge instructions. NPJ Digit Med 2024; 7(1): 329; doi: 10.1038/s41746-024-01336-w

Yap KK, Schroder J, Gerrand YW, Dobric A, Kong AM, Fox AM, Knowles B, Banting SW, Elefanty AG, Stanley EG, Yeoh GC, Lockwood GP, Cogger VC, Morrison WA, Polo JM, Mitchell GM. Liver specification of human iPSC-derived endothelial cells transplanted into mouse liver. JHEP Rep 2024; 6(5): 101023; doi: 10.1016/j.jhepr.2024.101023

Lockwood GP, Hunt NJ, Kockx M, Kang SWS, Le Couteur DG, Cogger VC. Understanding the Liver’s Role in the Clearance of Aβ40. Livers 2024; 4(2): 253-267;

Wizgier D, Meng Y, Das A, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Ribeiro RV, Shivappa N, Hebert JR, Hirani V. The association of dietary antioxidants and the inflammatory potential of the diet with poor physical function and disability in older Australian men: the Concord Health and Ageing in Men Project. Br J Nutr 2024; 131(9): 1528-1539; doi: 10.1017/S0007114524000126

Weng V, Wiles N, Jenkins D, Amanatidis S, Kidd JC, Walsh JA, Baillie AJ, Naganathan V. The effectiveness of a home-based dietetic intervention for community-dwelling older adults. Australas J Ageing 2024; 43(2): 297-305; doi: 10.1111/ajag.13264

Tran MH, van Zwieten A, Kiely KM, Blyth FM, Naganathan V, Le Couteur DG, Handelsman DJ, Seibel MJ, Waite LM, Cumming RG, Khalatbari-Soltani S. Intra-generational social mobility and mortality among older men in the Concord Health and Ageing in Men Project: A cohort study. SSM Popul Health 2024; 25: 101581; doi: 10.1016/j.ssmph.2023.101581

Smith J, Cvejic E, Houssami N, Schonberg MA, Vincent W, Naganathan V, Jansen J, Dodd RH, Wallis K, McCaffery KJ. Randomized Trial of Information for Older Women About Cessation of Breast Cancer Screening Invitations. J Gen Intern Med 2024; 39(8): 1332-1341; doi: 10.1007/s11606-024-08656-3

Pinheiro MB, Naganathan V. Appraisal of Clinical Practice Guideline: Clinical practice guideline for management of osteoporosis and fracture prevention in Canada: 2023 update. J Physiother 2024; 70(3): 241; doi: 10.1016/j.jphys.2024.05.002

Okafor CE, Keramat SA, Comans T, Page AT, Potter K, Hilmer SN, Lindley RI, Mangin D, Naganathan V, Etherton-Beer C. Cost-Consequence Analysis of Deprescribing to Optimize Health Outcomes for Frail Older People: A Within-Trial Analysis. J Am Med Dir Assoc 2024; 25(3): 539-544 e532; doi: 10.1016/j.jamda.2023.12.016

Nguyen TX, Nguyen AHP, Nguyen HTT, Nguyen TTH, Nguyen HL, Goldberg RJ, Thillainadesan J, Naganathan V, Vu HTT, Tran LV, Nguyen AT. Health-Related Quality of Life among Older Adults with Dementia Living in Vietnamese Nursing Homes. Int J Environ Res Public Health 2024; 21(2); doi: 10.3390/ijerph21020135

Narayan SW, Naganathan V, Vizza L, Underwood M, Ivers R, McLachlan AJ, Zhou L, Singh R, Tao S, Xi X, Abdel Shaheed C. Efficacy and safety of antidepressants for pain in older adults: A systematic review and meta-analysis. Br J Clin Pharmacol 2024; doi: 10.1111/bcp.16234

Marshall KH, Riddiford-Harland DL, Meller AE, Kruger V, Kirsebom M, Tran M, Caplan GA, Naganathan V, Cullen J, Gonski P, Zwar N, O'Keeffe JA, Krysinska K, Rhee JJ. Feasibility and acceptability of facilitated advance care planning in outpatient clinics: A qualitative study of health-care professionals experience. Australas J Ageing 2024; 43(2): 314-322; doi: 10.1111/ajag.13272

Marshall KH, Riddiford-Harland DL, Meller AE, Caplan GA, Naganathan V, Cullen J, Gonski P, Zwar NA, O'Keeffe JA, Krysinska K, Rhee JJ. Feasibility and Acceptability of Facilitated Advance Care Planning in Outpatient Clinics: A Qualitative Study of Patient and Caregivers Experiences. J Appl Gerontol 2024; 43(4): 339-348; doi: 10.1177/07334648231206742

Luong R, Ribeiro R, Naganathan V, Blyth F, Waite LM, Handelsman DJ, Le Couteur DG, Seibel MJ, Hirani V. Cross-sectional and longitudinal associations between empirically derived dietary patterns and frailty among older men: The Concord Health and Ageing in Men Project. J Nutr Health Aging 2024; 28(1): 100021; doi: 10.1016/j.jnha.2023.100021

Luong R, Ribeiro R, Naganathan V, Blyth F, Waite LM, Handelsman DJ, Le Couteur DG, Seibel MJ, Hirani V. Empirically derived dietary patterns are associated with major adverse cardiovascular events, all-cause mortality, and congestive cardiac failure in older men: The Concord Health and Ageing in Men Project. J Nutr Health Aging 2024; 28(2): 100020; doi: 10.1016/j.jnha.2023.100020

Chu KY, Wright FAC, Naganathan V, Stanaway F, Tran J, Cockrell D. Provision of domiciliary dental service to residential aged care facilities: A 3-year descriptive summary. Spec Care Dentist 2024; 44(3): 787-796; doi: 10.1111/scd.12912

Azarias E, Thillainadesan J, Hanger C, Scott J, Boudville A, Moran C, O'Sullivan R, Maddison J, Eagar K, Harvey G, King A, Kearney L, Naganathan V. Hospital and out-of-hospital services provided by public geriatric medicine departments in Australia and New Zealand. Australas J Ageing 2024; doi: 10.1111/ajag.13331

Aitken SJ, James S, Lawrence A, Glover A, Pleass H, Thillianadesan J, Monaro S, Hitos K, Naganathan V, collaborators SHPPC. Codesign of health technology interventions to support best-practice perioperative care and surgical waitlist management. BMJ Health Care Inform 2024; 31(1); doi: 10.1136/bmjhci-2023-100928

2023

Weir KR, Bonner C, Naganathan V, Tam CWM, Rigby D, McLachlan AJ, Jansen J. Supporting conversations about medicines and deprescribing: GPs' perspectives on a Medicines Conversation Guide. Int J Pharm Pract 2023; 31(1): 102-105; doi: 10.1093/ijpp/riac088

Wang J, James S, Hilmer SN, Aitken SJ, Soo G, Naganathan V, Kearney L, Thillainadesan J. Optimising Medications in Older Vascular Surgery Patients Through Geriatric Co-management. Drugs Aging 2023; 40(4): 335-342; doi: 10.1007/s40266-023-01015-7

Thillainadesan J, Box H, Kearney L, Naganathan V, Cunich M, Aitken SJ, Monaro SR. The experience of hospital care for older surgical patients and their carers: A mixed-methods study. Australas J Ageing 2023; doi: 10.1111/ajag.13176

Smith J, Dodd RH, Gainey KM, Naganathan V, Cvejic E, Jansen J, McCaffery KJ. Factors Influencing Primary Care Practitioners' Cancer Screening Recommendations for Older Adults: a Systematic Review. J Gen Intern Med 2023; doi: 10.1007/s11606-023-08213-4

Scott D, Blyth F, Naganathan V, Le Couteur DG, Handelsman DJ, Waite LM, Hirani V. Sarcopenia prevalence and functional outcomes in older men with obesity: Comparing the use of the EWGSOP2 sarcopenia versus ESPEN-EASO sarcopenic obesity consensus definitions. Clin Nutr 2023; 42(9): 1610-1618; doi: 10.1016/j.clnu.2023.07.014

Quek HW, Etherton-Beer C, Page A, McLachlan AJ, Lo SY, Naganathan V, Kearney L, Hilmer SN, Comans T, Mangin D, Lindley RI, Potter K. Deprescribing for older people living in residential aged care facilities: Pharmacist recommendations, doctor acceptance and implementation. Arch Gerontol Geriatr 2023; 107: 104910; doi: 10.1016/j.archger.2022.104910

Page AT, Potter K, Naganathan V, Hilmer S, McLachlan AJ, Lindley RI, Coman T, Mangin D, Etherton-Beer C. Polypharmacy and medicine regimens in older adults in residential aged care. Arch Gerontol Geriatr 2023; 105: 104849; doi: 10.1016/j.archger.2022.104849

Nguyen TX, Vu HTT, Nguyen T, Esterman A, Tran LV, Thillainadesan J, Naganathan V, Brodaty H, Nguyen AT. A Multidomain Intervention Program for Older People with Dementia: A Pilot Study. Open Access J Clin T 2023; 15: 1-10; doi: 10.2147/Oajct.S403282

Luong R, Ribeiro RV, Rangan A, Naganathan V, Blyth F, Waite LM, Handelsman DJ, Le Couteur DG, Seibel MJ, Hirani V. Haem Iron Intake Is Associated with Increased Major Adverse Cardiovascular Events, All-Cause Mortality, Congestive Cardiac Failure, and Coronary Revascularisation in Older Men: The Concord Health and Ageing in Men Project. J Nutr Health Aging 2023; 27(7): 559-570; doi: 10.1007/s12603-023-1945-6

Kwok WS, Dolja-Gore X, Khalatbari-Soltani S, Byles J, Oliveira JS, Pinheiro MB, Naganathan V, Tiedemann A, Sherrington C. Physical activity and injurious falls in older Australian women: adjusted associations and modification by physical function limitation and frailty in the Australian Longitudinal Study on Women's Health. Age Ageing 2023; 52(6); doi: 10.1093/ageing/afad108

Kiely KM, Khalatbari-Soltani S, Blyth FM, Naganathan V, Handelsman DJ, Waite LM, Le Couteur DG, Mortby ME, Cumming RG, Anstey KJ. Mixed Evidence of an Association between Self-Rated Hearing Difficulties and Falls: Prospective Analysis of Two Longitudinal Studies. Gerontology 2023; 69(1): 98-108; doi: 10.1159/000524311

Kaur S, Kidambi S, Ortega-Ribera M, Thuy LTT, Nieto N, Cogger VC, Xie WF, Tacke F, Gracia-Sancho J. In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations. Cell Mol Gastroenterol Hepatol 2023; 15(3): 559-571; doi: 10.1016/j.jcmgh.2022.11.008

Hilmer SN, Lo S, Kelly PJ, Viney R, Blyth FM, Le Couteur DG, McLachlan AJ, Arora S, Hossain L, Gnjidic D. Towards Optimizing Hospitalized Older adults' MEdications (TO HOME): Multi-centre study of medication use and outcomes in routine care. Br J Clin Pharmacol 2023; 89(8): 2508-2518; doi: 10.1111/bcp.15727

Gladka MM, Le Couteur DG, Simpson SJ. Midnight snacks might shorten your life: lifespan and healthspan advantages of eating less and at the right time. Cardiovasc Res 2023; 119(1): e108-e110; doi: 10.1093/cvr/cvad018

Etherton-Beer C, Page A, Naganathan V, Potter K, Comans T, Hilmer SN, McLachlan AJ, Lindley RI, Mangin D. Deprescribing to optimise health outcomes for frail older people: a double-blind placebo-controlled randomised controlled trial-outcomes of the Opti-med study. Age Ageing 2023; 52(5); doi: 10.1093/ageing/afad081

Wright FAC, Shu EC, Cumming RG, Naganathan V, Blyth FM, Hirani V, Le Couteur DG, Handelsman DJ, Seibel MJ, Waite LM, Stanaway FF. Oral health-related quality of life of older Australian men. Community Dent Oral Epidemiol 2023; 51(5): 767-777; doi: 10.1111/cdoe.12754

Xuan Nguyen T, Thi Thanh Vu H, Nguyen T, Esterman A, Viet Tran L, Thillainadesan J, Naganathan V, Brodaty H, Trung Nguyen A. A Multidomain Intervention Program for Older People with Dementia: A Pilot Study. Open Access J Clin T 2023; Volume 15: 1-10; doi: 10.2147/oajct.S403282

2022

Cheyne S, Lindley R, Smallwood N, Tendal B, Chapman M, Navarro DF, Good PD, McDonald S, Morgan D, Murano M, Millard T, Naganathan V, Srikanth V, Tuffin P, Vogel J, White H, Chakrabothy SP, Whiting E, William L, Yates PM, Callary M, Elliott J and Agar MR for the National COVID-19 Clinical Evidence Taskforce. Care of older people and people requiring palliative care with COVID-19: guidance from the Australian National COVID-19 Clinical Evidence Taskforce. The Medical Journal of Australia. 2022 Mar;216(4):203-208. doi.org/10.5694/mja2.51353

Chow EPF, Hsu B, Waite LM, Blyth FM, Handelsman DJ, Le Couteur DG, Naganathan V, Stanaway FF. Diagnostic accuracy of linked administrative data for dementia diagnosis in community-dwelling older men in Australia. BMC Geriatr 2022; 22(1): 858; doi: 10.1186/s12877-022-03579-2

Dai Z, Hirani V, Sahni S, Felson DT, Naganathan V, Blyth F, Le Couteur D, Handelsman D, Seibel MJ, Waite L, Kiel DP, Cumming R. Association of dietary fiber and risk of hip fracture in men from the Framingham Osteoporosis Study and the Concord Health and Ageing in Men Project. Nutr Health 2022; 28(2): 229-238; doi: 10.1177/02601060211011798

Das A, Cumming R, Naganathan V, Blyth F, Couteur DGL, Handelsman DJ, Waite LM, Ribeiro RVR, Simpson SJ, Hirani V. Associations between dietary intake of total protein and sources of protein (plant vs. animal) and risk of all-cause and cause-specific mortality in older Australian men: The Concord Health and Ageing in Men Project. J Hum Nutr Diet 2022; 35(5): 845-860; doi: 10.1111/jhn.12965

de Cabo R, Le Couteur DG. (2022) Biology of Aging. In: Harrisons Principles of Internal Medicine (21st Ed). Editors: Loscalzo J, Fauci AS, Kasper DL, Longo DL, Jameson JL, McGraw Hill. Columbus. https://accessmedicine.mhmedical.com/content.aspx?bookid=3095&sectionid…

Djekovic K, Clowes K, Spalding N, Waite L. A retrospective study of the behavioural and psychological symptoms of dementia in patients admitted to a Specialist Dementia Care Unit. Australasian Journal on Ageing. 2022 Mar. doi:10.1111/ajag.13060 (Epub ahead of print)

Eberhard J, Ruiz K, Tan J, Jayasinghe TN, Khan S, Eroglu E, Adler C, Simpson SJ, Le Couteur DG, Raubenheimer D, Macia L, Gosby AK, Ribeiro RV. A randomized clinical trial to investigate the effect of dietary protein sources on periodontal health. J Clin Periodontol 2022; 49(4): 388-400; doi: 10.1111/jcpe.13587

Gnanenthiran SR, Ng ACC, Cumming RG, Brieger DB, le Couteur DG, Waite LM, Seibel M, Handelsman DJ, Naganathan V, Kritharides L, Blyth FM. Hemoglobin, Frailty, and Long-term Cardiovascular Events in Community-Dwelling Older Men Aged >= 70 Years. Can J Cardiol 2022; 38(6): 745-753; doi: 10.1016/j.cjca.2022.01.024

Hunt NJ, Wahl D, Westwood LJ, Lockwood GP, Le Couteur DG, Cogger VC. Targeting the liver in dementia and cognitive impairment: Dietary macronutrients and diabetic therapeutics. Adv Drug Deliv Rev 2022; 190: 114537; doi: 10.1016/j.addr.2022.114537

Hunt NJ, McCourt PAG, Kuncic Z, Le Couteur DG, Cogger VC. Opportunities and Challenges for Nanotherapeutics for the Aging Population. Frontiers in Nanotechnology, 2022 Jan; 4, art. no. 832524. doi.org/10.3389/fnano.2022.832524

Ischia L, Naganathan V, Waite LM, Le Couteur DG, Thillainadesan J. COVID-19 and geriatric medicine in Australia and New Zealand. Australas J Ageing 2022; 41(2): 301-308; doi: 10.1111/ajag.13027

Khalatbari-Soltani S, Blyth FM, Naganathan V, Le Couteur DG, Handelsman DJ, Seibel MJ, Hirani V, Wright FAC, Waite LM, Cumming RG. Cohort Profile Update: The Concord Health and Ageing in Men Project (CHAMP). Int J Epidemiol 2022; 51(1): 31-+; doi: 10.1093/ije/dyab171

Le Couteur DG, Anderson RM, de Cabo R. Can we make drug discovery targeting fundamental mechanisms of aging a reality? Expert Opin Drug Discov 2022; 17(2): 97-100; doi: 10.1080/17460441.2022.1993818

Le Couteur DG, Barzilai N. New horizons in life extension, healthspan extension and exceptional longevity. Age Ageing 2022; 51(8); doi: 10.1093/ageing/afac156

Le Couteur DG, Flicker L, Hilmer SN. Geriatric medicine and health care for older people in Australia. Age Ageing 2022; 51(3); doi: 10.1093/ageing/afac001

Le Couteur DG, Raubenheimer D, Solon-Biet S, de Cabo R, Simpson SJ. Does diet influence aging? Evidence from animal studies. J Intern Med 2022; doi: 10.1111/joim.13530

Le Couteur DG, Thillainadesan J. What Is an Aging-Related Disease? An Epidemiological Perspective. J Gerontol A Biol Sci Med Sci 2022; 77(11): 2168-2174; doi: 10.1093/gerona/glac039

Lin A, Shaheen N, Ganda K, Cullen, Waite LM, Seibel M. Improving osteoporosis treatment rates in inpatients admitted with hip fracture: a healthcare improvement initiative in a tertiary referral hospital. Aging Medicine. 2022 Nov. doi.org/10.1002/agm2.12229 (Epub ahead of print)

Luong R, Ribeiro RV, Rangan A, Naganathan V, Blyth F, Waite LM, Handelsman DJ, Cumming RG, Le Couteur DG, Hirani V. Changes in Dietary Total and Nonheme Iron Intake Is Associated With Incident Frailty in Older Men: The Concord Health and Aging in Men Project. J Gerontol A Biol Sci Med Sci 2022; 77(9): 1853-1865; doi: 10.1093/gerona/glac077

Mach J, Allore H, Gnjidic D, Gemikonakli G, Kane AE, Howlett SE, de Cabo R, Le Couteur D, Hilmer SN. Preclinical frailty assessments: Phenotype and frailty index identify frailty in different mice and are variably affected by chronic medications. Exp Gerontol 2022; 161: 111700; doi: 10.1016/j.exger.2022.111700

Page AT, Potter K, Naganathan V, Hilmer S, McLachlan AJ, Lindley RI, Coman T, Mangin D, Etherton- Beer C. Polypharmacy and medicine regimens in older adults in residential aged care. Archives of Gerontology and Geriatrics. 2022 Nov 4;105:104849. doi: 10.1016/j.archger.2022.104849 (Epub ahead of print)

Raubenheimer D, Senior AM, Mirth C, Cui Z, Hou R, Le Couteur DG, Solon-Biet SM, Leopold P, Simpson SJ. An integrative approach to dietary balance across the life course. iScience 2022; 25(5): 104315; doi: 10.1016/j.isci.2022.104315

Senior AM, Legault V, Lavoie FB, Presse N, Gaudreau P, Turcot V, Raubenheimer D, Le Couteur DG, Simpson SJ, Cohen AA. Multidimensional associations between nutrient intake and healthy ageing in humans. BMC Biol 2022; 20(1): 196; doi: 10.1186/s12915-022-01395-z

Shi H, Tsai KH, Ma D, Wang X, Desai R, Parungao RJ, Hunt NJ, Cheng YY, Zhang H, Xu Y, Simanainen U, Tan Q, Cooper MS, Handelsman DJ, Maitz PK, Wang, Y. Controlled dual release of dihydrotestosterone and flutamide from polycaprolactone electrospun scaffolds accelerate burn wound healing. The FASEB Journal. 2022 May;36(5):e22310. doi: 10.1096/fj.202101803R.

Shu CC, Wright F, Naganathan V, Blyth FM, Le Couteur DG, Handelsman DJ, Stanaway FF. Does social support predict increased use of dental services in older men? Aust Dent J 2022; 67(3): 262-270; doi: 10.1111/adj.12911

Sirimanna P, Boyce S, Gunanayagam P, Gladman MA, Naganathan V. Development of a rating scale for objective assessment of performance in laparoscopic appendicectomy surgery. Anz J Surg 2022; 92(7-8): 1724-1730; doi: 10.1111/ans.17601

Sirimanna P, Ravindran P, Smigielski M, Gladman MA, Naganathan V. Validation and reliability testing of a rating scale for objective assessment of performance in laparoscopic appendicectomy surgery. Anz J Surg 2022; 92(7-8): 1731-1736; doi: 10.1111/ans.17862

Siriwardana A, Gray NA, Makris A, Li CK, Yong K, Mehta Y, Ramos J, Di Tanna GL, Gianacas C, Addo IY, Roxburgh S, Naganathan V, Foote C, Gallagher M. Treatment decision-making and care among older adults with kidney failure: protocol for a multicentre, prospective observational cohort study with nested substudies and linked qualitative research (the Elderly Advanced CKD Programme). Bmj Open 2022; 12(12): e066156; doi: 10.1136/bmjopen-2022-066156

Smith J, Dodd RH, Wallis KA, Naganathan V, Cvejic E, Jansen J, McCaffery KJ. General practitioners' views and experiences of communicating with older people about cancer screening: a qualitative study. Fam Pract 2022; doi: 10.1093/fampra/cmac126

Solon-Biet SM, Griffiths L, Fosh S, Le Couteur DG, Simpson SJ, Senior AM. Meta-analysis links dietary branched-chain amino acids to metabolic health in rodents. BMC Biol 2022; 20(1): 19; doi: 10.1186/s12915-021-01201-2

Stavert B, Monaro S, Naganathan V, Aitken S. Frailty predicts increased risk of reintervention in the 2 years after arteriovenous fistula creation. J Vasc Access 2022: 11297298221088756; doi: 10.1177/11297298221088756

Stavert BM, Monaro S, Tienstra L, Naganathan V, Aitken SJ. Protocol for a qualitative study exploring haemodialysis dependent patients' arteriovenous fistula experience, values and concerns in Sydney, Australia. Bmj Open 2022; 12(6): e058152; doi: 10.1136/bmjopen-2021-058152

Thillainadesan J, Aitken SJ, Monaro SR, Cullen JS, Kerdic R, Hilmer SN, Naganathan V. Geriatric Comanagement of Older Vascular Surgery Inpatients Reduces Hospital-Acquired Geriatric Syndromes. J Am Med Dir Assoc 2022; 23(4): 589-595 e586; doi: 10.1016/j.jamda.2021.09.037

Thillainadesan J, Hilmer SN, Fleury AM, Naganathan V. New horizons in the perioperative care of older adults. Age Ageing 2022; 51(2); doi: 10.1093/ageing/afab245

Thillainadesan J, Le Couteur DG, Haq I, Wilkinson TJ. When I say ... microlearning. Med Educ 2022; 56(8): 791-792; doi: 10.1111/medu.14848

Thillainadesan J, Monaro S, Aitken S, Kerdic R, Cullen J, Naganathan V. Geriatric Comanagement of Older Vascular Surgery Inpatients Reduces Hospital-Acquired Geriatric Syndromes. Journal of the American Medical Directors Association. 2022 Apr;23(4):589-595.e6. doi: 10.1016/j.jamda.2021.09.037. Epub 2021 Oct 29.

Thillainadesan J, Charlton G, Wang J. Targeted microlearning: Teaching geriatric medicine to Gen Y and Gen Z junior doctors. Australasian Journal on Ageing. 2022 Aug. doi: 10.1111/ajag.13130. (Epub ahead of print)

Vardy JL, Pond GR, Cysique LA, Gates TM, Lagopoulos J, Renton C, Waite LM, Tannock IF, Dhillon HM. Lack of cognitive impairment in long-term survivors of colorectal cancer. Supportive Care in Cancer. 2022 Jul; 30(7): 6123-6133. DOI: 10.1007/s00520-022-07008-3

Wright FAC, Shu EC, Cumming RG, Naganathan V, Blyth FM, Hirani V, Le Couteur DG, Handelsman DJ, Seibel MJ, Waite LM, Stanaway FF. Oral health-related quality of life of older Australian men. Community Dent Oral Epidemiol 2022; doi: 10.1111/cdoe.12754

Wu H, Mach J, Gnjidic D, Naganathan V, Blyth FM, Waite LM, Handelsman DJ, Le Couteur DG, Hilmer SN. Comparing Effects of Polypharmacy on Inflammatory Profiles in Older Adults and Mice: Implications for Translational Aging Research. J Gerontol A Biol Sci Med Sci 2022; 77(7): 1295-1303; doi: 10.1093/gerona/glac061

Xu P, Blyth FM, Naganathan V, Cumming RG, Handelsman DJ, Seibel MJ, Le Couteur DG, Waite LM, Khalatbari-Soltani S. Socioeconomic Inequalities in Elective and Nonelective Hospitalizations in Older Men. JAMA Netw Open 2022; 5(4): e226398; doi: 10.1001/jamanetworkopen.2022.6398

2021

Cervo M, Scott D, Seibel MJ, Cumming RG, Naganathan V, Blyth FM, Le Couteur DG, Handelsman DJ, Ribeiro RV, Waite LM, Hirani V. Adherence to Mediterranean Diet and its Associations with Circulating Cytokines, Musculoskeletal Health and Incident Falls in Community-Dwelling Older Men: The Concord Health and Ageing in Men Project. Clinical Nutrition 2021 Oct 23;40(12):5753-5763. 10.1016/j.clnu.2021.10.010

Chu KY, Cockrell D,Naganathan V, Stanaway F, Wright FAC. Oral health status of newly admitted residents living in residential aged care. Australian Dental Journal. 2021 December;66(4):391-396 10.1111/adj.12864

Dai Z, Hirani V, Sahni S, Felson DT, Naganathan V, Blyth F, Le Couteur D, Handelsman D, Seibel MJ, Waite L, Kiel DP, Cumming R. Association of dietary fiber and risk of hip fracture in men from the Framingham Osteoporosis Study and the Concord Health and Ageing in Men Project. Nutrition and Health. 2021 May 4;2601060211011798. 10.1177/02601060211011798. (Epub ahead of print)

Das A, Cumming RG, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Ribeiro RV, Simpson JS, Hirani V. Associations between dietary intake of total protein and sources of protein (plant vs. animal) and risk of all-cause and cause-specific mortality in older Australian men: The Concord Health and Ageing in Men Project. Journal of Human Nutrition and Dietetics. 2021 (Early Online 21 Nov 10.1111/jhn.12965

Das A, Cumming RG, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Ribeiro RV, Simpson SJ, Hirani V. Associations between nutrient intakes and dietary patterns with different sarcopenia definitions in older Australian men: the concord health and ageing in men project. Public Health Nutrition. 2021 Oct;24(14):4490-4505. doi: 10.1017/S1368980020003547. Epub 2020 Oct 7. Erratum in: Public Health Nutr. 2021 Feb;24(2):378-383. PMID: 33023717.

Das A, Cumming RG, Naganathan V, Ribeiro RV, Le Couteur DG, Handelsman DJ, Waite LM, Hirani V. The association between antioxidant intake, dietary pattern and depressive symptoms in older Australian men: the Concord Health and Ageing in Men Project. European journal of nutrition. 2021 Feb;60(1):443-454. 10.1007/s00394-020-02255-8

Duong, M. H., McLachlan, A. J., Bennett, A. A., Jokanovic, N., Le Couteur, D. G., Baysari, M. T., Gnjidic, D., Blyth, F., Hilmer, S. N. Iterative development of clinician guides to support deprescribing decisions and communication for older patients in hospital: a novel methodology. Drugs & Aging 2021,38, 75-87. 10.1007/s40266-020-00820-8

Fotheringham AK, Solon-Biet SM. Bielefeldt-Ohmann H, McCarthy DA, McMahon AC, Ruohonen K, Li I, Sullivan MA, Whiddett RO, Borg DJ, Cogger VC, Ballard WO, Turner N, Melvin RG, Raubenheime D, Le Couteur DG, Simpson SJ, Forbes JM. Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure. iScience, 2021 Oct 16;24(11):103308 10.1016/j.isci.2021.103308

Gibney JM, Naganathan V, Lim MAWT. Oral health is Essential to the Well-Being of Older People. The American Journal of Geriatric Psychiatry. 2021 Oct;29(10):1053-1057. doi: 10.1016/j.jagp.2021.06.002. Epub 2021 Jun 11. PMID: 34246517.

Hew JJ , Parungao RJ, Mooney CP, Smyth JK, Kim S, Tsai KHY, Shi H, Chong C, Chan RCF, Attia B, Nicholls D, Li Z, Solon-Biet SM, Le Couteur DG, Simpson SJ, Jeschke MG, Maitz PK, Wang Y. Low-protein diet accelerates wound healing in mice post-acute injury. Burns & Trauma 2021 Aug 9;9:tkab010. 10.1093/burnst/tkab010

Hilmer SN, Mirko P, Le Couteur DG, Schwartz J, Thuermann P. Development, evaluation and use of COVID-19 vaccines in older adults: preliminary principles for the pandemic and beyond. British Journal of Clinical Pharmacology 2021; 87(9) 3459-3461. 10.1111/bcp.14967

Hsu B, Korda R, Naganathan V, Lewis P, Ooi S, Brieger D, Jorm L. Burden of cardiovascular diseases in older adults using aged care services. Age and Ageing. 2021;50(5): 1845–1849. 10.1093/ageing/afab083

Hunt N, Lockwood G, Kang S, Westwood L, Limantoro C, Chrzanowski W, McCourt P, Kuncic Z, Le Couteur D, Cogger V. Quantum Dot Nanomedicine Formulations Dramatically Improve Pharmacological Properties and Alter Uptake Pathways of Metformin and Nicotinamide Mononucleotide in Aging Mice. ACS Nano 2021 23;15(3):4710-4727. 10.1021/acsnano.0c09278

Khalatbari-Soltani S, Blyth FM, Naganathan V, Le Couteur DG, Handelsman DJ, Seibel MJ, Hirani V, Wright FAC, Waite LM, Cumming RG. Cohort Profile update: The Concord Health and Ageing in Men Project (CHAMP). International Journal of Epidemiology. 2021 October; 51(1):31-32h. 10.1093/ije/dyab171

Khalatbari-Soltani S, Cumming R.G, Chomik R, Blyth F.M, Naganathan V, Handelsman D.J, Le Couteur D.G, Waite L.M, and Stanaway F. The association between home ownership and the health of older men: cross-sectional analysis of the Australian Concord Health and Ageing in Men Project. Australasian Journal on Ageing. 2021 Sep;40(3):e199-e206. 10.1111/ajag.12896

Khalatbari-Soltani S, Stanaway F, Sherrington C, Blyth FM, Naganathan V, Handelsman DJ, Seibel MJ, Waite LM, Le Couteur DG, Cumming RG. The prospective association between socioeconomic status and falls among community-dwelling older men. Journal of Gerontology Medical Science. 2021;76(10):1821-1828. 10.1093/gerona/glab038

Krishnan A, Waite LM, Stanaway FF. Representation of racial and ethnic minority groups in cohort studies evaluating risk factors for dementia: protocol for a scoping review. BMJ Open. 2021 May 13;11(5):e044404. 10.1136/bmjopen-2020-044404.

Le Couteur DG, Handelsman DJ, Stanaway F, Waite LM, Blyth FM, Naganathan V, Cumming RG, Hirani V. Sarcopenic obesity and amino acids: Concord Health and Ageing in Men Project. Journal of Gerontology Biological Science 2021 May 22;76(6):1000-1004. 10.1093/gerona/glab076

Le Couteur DG, Solon-Biet SM, Parker BL, Pulpitel T, Brandon AE, Hunt NJ, Wali JA, Gokarn R, Senior AM, Cooney GJ, Raubenheimer D, Cogger VC, James DE, Simpson SJ. Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol and rapamycin. Cell Metabolism. 2021 Nov 6;S1550-4131(21)00528-3. doi: 10.1016/j.cmet.2021.10.016.

Mach J, Gemikonakli G, Logan C, Vander Wyk B, Allore H, Ekambareshwar S, Kane AE, Howlett SE, de Cabo R, Le Couteur DG, Hilmer SN. Chronic polypharmacy with increasing Drug Burden Index (DBI) exacerbates frailty and impairs physical function, with effects attenuated by deprescribing, in aged mice. The journals of gerontology Series A, Biological sciences and medical sciences. 2021 May 22;76(6):1010-1018. 10.1093/gerona/glaa060

Mesinovic J, Scott D, Seibel MJ, Cumming RG, Naganathan V, Blyth FM, Le Couteur DG, Waite LM, Handelsman DJ, Hirani V. Risk Factors for Incident Falls and Fractures in Older Men with and without Type 2 Diabetes Mellitus: The Concord Health and Ageing in Men Project, Journals Gerontology Medical Science. 2021 May 22;76(6):1090-1100. 10.1093/gerona/glab062

Milledge K, Cumming R, Wright F, Naganathan V, Blyth F, Le Couteur D, Waite L, Handelsman D, Hirani, V. Associations between the composition of Functional Tooth Units and nutrient intake in older men: The Concord Health and Ageing in Men Project. Public Health Nutrition 2021; 24(18), 6335-6345. 10.1017/S1368980021003566.

Ng B, Duong M, Lo S, Le Couteur D, Hilmer S. Deprescribing perceptions and practice: reported by multidisciplinary hospital clinicians after, and by medical students before and after, viewing an e-learning module. Research in Social and Administrative Pharmacy 2021 17(11):1997-2005. 10.1016/j.sapharm.2021.03.002

Parkinson L, Magin P, Etherton-Beer C, Naganathan V and Mangin D. Engaging General Practice and patients with AusTAPER, a pharmacist facilitated web-based deprescribing tool. Journal of Pharmacy Practice and Research 2021: 51(2): 154-159. 10.1002/jppr.1713

Scott D, Blyth F, Naganathan V, Le Couteur DG, Handelsman DJ, Seibel MJ, Waite LM, Hirani V. Prospective associations of chronic and intrusive pain with sarcopenia and physical disability among older Australian men: The Concord Health and Ageing in Men Project. Experimental Gerontology 2021 Oct 1;153:111501. 10.1016/j.exger.2021.111501.

Smith J, Dodd RH, Gainey KM, Naganathan V, Cvejic E, Jansen J and McCaffery KJ. Patient-reported factors associated with older adults’ cancer screening decision-making: A systematic review. JAMA Network Open 2021 Nov 1;4(11):e2133406. 10.1001/jamanetworkopen.2021.33406

Smith J, Dodd RH, Hersch J, McCaffery KJ, Naganathan V, Cvejic E and Jansen J. Psychosocial and clinical predictors of continued cancer screening in older adults. Patient Education and Counseling. 2021 Dec;104(12):3093-3096. 10.1016/j.pec.2021.04.027

Stanaway FF, Ribeiro RV, Khalatbari-Soltani S, Cvejic E, Blyth FM, Naganathan V, Handelsman DJ, Le Couteur DG, Simpson SJ, Waite LM, Cumming RG, Hirani V. Diet quality in an ethnically diverse population of older men in Australia. European Journal of Clinical Nutrition. 2021 Dec;75(12):1792-1800. 10.1038/s41430-021-00893-7

Takehara S, Wright FAC, Naganathan V, Hirani V, Blyth FM, Le Couteur DG, Waite LM, Seibel MJ, Handelsman DJ, Cumming RG. A cross-sectional study of perceived dental treatment needs and oral health status in community-dwelling older Australian men: The Concord Health and Ageing in Men Project. International Dental Journal. 2021 Jun;71(3):224-232. 10.1111/idj.12623

Thillainadesan J, Hilmer SN, Mudge AM, Aitken SJ, Kearney L, Monaro SR, Li SJ, Schasser S, Kerdic R, Tang R, Naganathan V. Understanding the role and value of process quality indicators in older vascular surgery inpatients. The Journal of Surgical Research. 2021 Jun 23;267:91-101. 10.1016/j.jss.2021.05.003

Thillainadesan J, Jansen J, Close J, Hilmer S, Naganathan V. Geriatrician perspectives on perioperative care: a qualitative study. BMC Geriatrics. 2021; 68. 10.1186/s12877-021-02019-x

Thillainadesan Janani, Mudge Alison, Aitken Sarah, Cullen John, Yumol Minna, Close Jacqueline, Norris C, Kerdic Richard, Naganathan Vasikaran. The prognostic performance of frailty for delirium and functional decline in vascular surgery patients. Journal of the American Geriatrics Society. 2021;69(3): 688-695. 10.1111/jgs.16907

Thillainadesan Janani, Yumol Minna F., Suen Michael, Hilmer Sarah, Naganathan Vasi. Enhanced Recovery After Surgery in Older Adults Undergoing Colorectal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Diseases of the Colon and Rectum. 2021;64(8):1020-1028. doi:10.1097/DCR.0000000000002128

Wahl, D., Gokarn, R., Solon-Biet, S., Cogger, V., LaRocca, T., Raubenheimer, D., Simpson, S., Le Couteur, D. (2021). Modeling nutrition and brain aging in rodents. In Martin CR, Preedy VR, Rajendram R (Eds.), Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging, (pp. 517-526). London: Academic Press. 10.1016/C2018-0-02036-8

Wali JA, Milner A, Luk A, Pulpitel T, Dodgson T, Facey H, Wahl D, Kebede M, Senior AM, Sullivan M, Brandon A, Yau B, Lockwood G, Koay YC, Ribeiro R, Solon-Biet SM1, Bell-Anderson K, O’ Sullivan J, Macia L, Forbes J, Cooney GJ, Cogger VC, Holmes A, Raubenheimer D, Le Couteur DG, Simpson SJ. Impact of dietary carbohydrate type and protein-carbohydrate interaction on metabolic health. Nature Metabolism 2021; 3:810-828. 10.1038/s42255-021-00393-9

Wali JA, Raubenheimer D, Senior AM, Le Couteur DG, Simpson SJ. Cardio-metabolic consequences of dietary carbohydrates: reconciling contradictions using nutritional geometry. Cardiovascular research. 2021 Jan 21;117(2):386-401. 10.1093/cvr/cvaa136

Weir KR, Naganathan V, Carter SM, Tam CWM, McCaffery K, Bonner C, Rigby D, McLachlan AJ, Jansen J. The role of older patients’ goals in GP decision-making about medicines: A qualitative study. BMC Family Practice 2021; 22:13 10.1186/s12875-020-01347-y

Wu H, Le Couteur DG, Hilmer SN. Mortality trends of stroke and dementia: changing landscapes and new challenges. Journal of American Geriatrics Society 2021; 69(10) 2888-2898. 10.1111/jgs.17322

Wu H, Mach J, Le Couteur DG, Hilmer SN. Nationwide mortality trends of delirium in Australia and the United States from 2006 to 2016. Australasian Journal on Ageing. Published online Mar 2021. 10.1111/ajag.12926

Wu, H, Mach J, Gemikonakli G, Tran T, Allore H, Gnjidic D, Howlett SE, de Cabo R, Le Couteur DG, Hilmer SN. Polypharmacy Results in Functional Impairment in Mice: Novel Insights into Age and Sex Interactions. J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):1748-1756. 10.1093/gerona/glab088

Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. (November 2021) 3rd Revised Edition. Editors: Lord SR, Sherrington S and Naganathan V. Cambridge University Press. https://doi.org/10.1017/9781108594455

Chapters

a. Noguchi N and Naganathan V. Medical Risk Factors for Falls. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 172–91.

b. Ma L and Naganathan V. Medications as Risk Factors for Falls. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 192–201.

c. Lord SR, Sherrington C and Naganathan V. The Relative Importance of Fall Risk Factors: Analysis and Summary. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 237–48.

d. Latt MD and Naganathan V. The Medical Management of Older People at Risk of Falls. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 322–40.

e. Lord SR, Sherrington C and Naganathan V. Bringing It All Together. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 469–80.

2020

Aitken SJ, Randall DA, Noguchi N, Blyth FM, Naganathan V. Multiple Peri-Operative Complications are Associated with Reduced Long Term Amputation Free Survival Following Revascularisation for Lower Limb Peripheral Artery Disease: A Population Based Linked Data Study. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. 2020;59(3):437-45. 10.1016/j.ejvs.2019.11.014

Aitken S. J.,Lujic S.,Randall D. A.,Noguchi N.,Naganathan V.,Blyth F. M. Predicting outcomes in older patients undergoing vascular surgery using the Hospital Frailty Risk Score. British Journal of Surgery. 2020 Oct online: 10.1002/bjs.12043

Aitken SJ, Thillainadesan T, Monaro S, Naganathan Vasi. Collaborative models of care for older vascular surgery patients admitted to hospital. ANZ Journal of Surgery. 2020;90(7-8): 1232-1233. 10.1111/ans.16086

Bernier M, Harney D, Koay YC, Diaz A, Singh A, Wahl D, Pulpitel T, Ali A, Guiterrez V, Mitchell SJ, Kim EY, Mach J, Price NL, Aon MA, LeCouteur DG, Cogger VC, Fernandez-Hernando C, O'Sullivan J, Larance M, Cuervo AM, de Cabo R. Elucidating the mechanisms by which disulfiram protects against obesity and metabolic syndrome. NPJ aging and mechanisms of disease. 2020;6:8. 10.1038/s41514-020-0046-6

Bernier M, Mitchell SJ, Wahl D, Diaz A, Singh A, Seo W, Wang M, Ali A, Kaiser T, Price NL, Aon MA, Kim EY, Petr MA, Cai H, Warren A, Di Germanio C, Di Francesco A, Fishbein K, Guiterrez V, Harney D, Koay YC, Mach J, Enamorado IN, Pulpitel T, Wang Y, Zhang J, Zhang L, Spencer RG, Becker KG, Egan JM, Lakatta EG, O'Sullivan J, Larance M, LeCouteur DG, Cogger VC, Gao B, Fernandez-Hernando C, Cuervo AM, de Cabo R. Disulfiram Treatment Normalizes Body Weight in Obese Mice. Cell metabolism. 2020. 32(2), 203-214.e4. 10.1016/j.cmet.2020.04.019

Bertoldo MJ, Listijono DR, Ho WJ, Riepsamen AH, Goss DM, Richani D, Jin XL, Mahbub S, Campbell JM, Habibalahi A, Loh WN, Youngson NA, Maniam J, Wong ASA, Selesniemi K, Bustamante S, Li C, Zhao Y, Marinova MB, Kim LJ, Lau L, Wu RM, Mikolaizak AS, Araki T, Le Couteur DG, Turner N, Morris MJ, Walters KA, Goldys E, O'Neill C, Gilchrist RB, Sinclair DA, Homer HA, Wu LE. NAD+ Repletion Rescues Female Fertility during Reproductive Aging. Cell reports. 2020;30(6):1670-81.e7. 10.1016/j.celrep.2020.01.058

Cervo MMC, Scott D, Seibel MJ, Cumming RG, Naganathan V, Blyth FM, Le Couteur DG, Handelsman DJ, Ribeiro RV, Waite LM, Shivappa N, Hebert JR, Hirani V. Proinflammatory Diet Increases Circulating Inflammatory Biomarkers and Falls Risk in Community-Dwelling Older Men. The Journal of nutrition. 2020;150(2):373-81. 10.1093/jn/nxz256

Chen R, Irving M, Clive Wright FA, Cunich M. An evaluation of health workforce models addressing oral health in residential aged care facilities: A systematic review of the literature. Gerodontology. 2020; 37(3): 222-232. 10.1111/ger.12475

Cumming R, Khalatbari-Soltani S, Blyth F, Naganathan V, Le Couteur D. Not all older men have the chronic diseases associated with severe COVID-19. Australasian Journal on Ageing. 2020;39(4): 381-382. 10.1111/ajag.12839

Das A, Cumming RG, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Ribeiro RV, Simpson JS, Hirani V. Dietary and supplemental antioxidant intake and risk of major adverse cardiovascular events in older men: The Concord Health and Ageing in Men Project. Nutrition, Metabolism and Cardiovascular Diseases 31: 1102-1112, 2021. 10.1016/j.numecd.2020.11.032

Das A, Cumming RG, Naganathan V, Blyth F, Ribeiro RV, Le Couteur DG, Handelsman DJ, Waite LM, Simpson SJ, Hirani V. Prospective Associations Between Dietary Antioxidant Intake and Frailty in Older Australian Men: The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(2):348-56. 10.1093/gerona/glz054

Ford GA, Lord JM, Ferguson MAJ, Bountra C, Le Couteur DG. Organizational Innovation for Developing New Medicines That Target Aging and Age-Related Conditions. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(1):87-8. 10.1093/gerona/glz062

Freire T, Senior AM, Perks R, Pulpitel T, Clark X, Brandon AE, Wahl D, Hatchwell L, Le Couteur DG, Cooney GJ, Larance M, Simpson SJ, Solon-Biet SM. Sex-specific metabolic responses to 6 hours of fasting during the active phase in young mice. The Journal of physiology. 2020;598(11):2081-92. 10.1113/JP278806

Gnanenthiran SR, Ng ACC, Cumming R, Brieger DB, Le Couteur D, Waite L, Handelsman D, Naganathan V, Kritharides L, Blyth F. Low total cholesterol is associated with increased major adverse cardiovascular events in men aged ≥70 years not taking statins. Heart (British Cardiac Society). 2020;106(9):698-705. 10.1136/heartjnl-2019-315449

Handelsman DJ, Desai R, Seibel MJ, Le Couteur DG, Cumming RG. Circulating Sex Steroid Measurements of Men by Mass Spectrometry Are Highly Reproducible after Prolonged Frozen Storage. The Journal of steroid biochemistry and molecular biology. 2020;197:105528. 10.1016/j.jsbmb.2019.105528

Hew JJ, Parungao RJ, Tsai KH, Shi H, Ma D, Nicholls C, Li Z, Solon-Biet SM, D'Souza M, Le Couteur DG, Simpson SJ, Jeschke MG, Maitz PK, Wang Y. Geometric framework reveals that a moderate protein, high carbohydrate intake is optimal for severe burn injury in mice. The British journal of nutrition. 2020;123(9):1056-67. 10.1017/S0007114520000276

Hide D, Warren A, Fernández-Iglesias A, Maeso-Díaz R, Peralta C, Le Couteur DG, Bosch J, Cogger VC, Gracia-Sancho J. Ischemia/Reperfusion Injury in the Aged Liver: The Importance of the Sinusoidal Endothelium in Developing Therapeutic Strategies for the Elderly. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(2):268-77. 10.1093/gerona/glz012

Hsu B, Naganathan V, Blyth FM, Hirani V, Le Couteur DG, Waite LM, Seibel MJ, Handelsman DJ, Cumming RG. Frailty and Cause-Specific Hospitalizations in Community-Dwelling Older Men. The journal of nutrition, health & aging. 2020;24(6):563-9. 10.1007/s12603-020-1352-1

Hubbard RE, Maier AB, Hilmer SN, Naganathan V, Etherton-Beer C, Rockwood K. Frailty in the face of COVID-19. Age and ageing. 2020;49(4):499-500. 10.1093/ageing/afaa095

Hunt NJ, Lockwood GP, Kang SWS, Pulpitel T, Clark X, Mao H, McCourt PAG, Cooney GJ, Wali JA, Le Couteur FH, Le Couteur DG, Cogger VC. The Effects of Metformin on Age-Related Changes in the Liver Sinusoidal Endothelial Cell. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(2):278-85. 10.1093/gerona/glz153

Hunt NJ, Lockwood GP, Le Couteur FH, McCourt PAG, Singla N, Kang SWS, Burgess A, Kuncic Z, Le Couteur DG, Cogger VC. Rapid Intestinal Uptake and Targeted Delivery to the Liver Endothelium Using Orally Administered Silver Sulfide Quantum Dots. ACS nano. 2020;14(2):1492-507. 10.1021/acsnano.9b06071

Johnson George, Blinkhorn Anthony, Byun Roy, Foster Kirsty, Wright Fredrick A Clive. The workforce outcomes of dental graduates from a metropolitan school ‘Rural Clinical Placement Program’ versus a ‘Rural Clinical School’. International Dental Journal. 2020;70(3):214-226. 10.1111/idj.12541

Khalatbari-Soltani S, Blyth FM, Naganathan V, Handelsman DJ, Le Couteur DG, Seibel MJ, Waite LM, Cvejic E, Cumming RG. Socioeconomic status, health-related behaviours, and death among older people: the Concord health and aging in men project prospective cohort study. BMC geriatrics. 2020;20(1):261. 10.1186/s12877-020-01648-y

Khalatbari-Soltani S, Stanaway F, Cvejic E, Blyth F, Naganathan V, Handelsman D, Le Couteur D, Seibel M, Waite L, and Cumming R. Contribution of psychosocial factors to socioeconomic inequalities in mortality among older Australian men: a population-based cohort study. International Journal for Equity in Health. 2020. 19, 177. 10.1186/s12939-020-01277-2

Le Couteur DG, Anderson RM, Newman AB. COVID-19 Through the Lens of Gerontology. The journals of gerontology Series A, Biological sciences and medical sciences. 2020 Sep 16;75(9):e119-e120. 10.1093/gerona/glaa077

Le Couteur DG, Anderson RM, Newman AB. Erratum to: COVID-19 Through the Lens of Gerontology. The journals of gerontology Series A, Biological sciences and medical sciences. 2020. doi.org/10.1093/gerona/glaa080

Le Couteur DG, Ribeiro R, Senior A, Hsu B, Hirani V, Blyth FM, Waite LM, Simpson SJ, Naganathan V, Cumming RG, Handelsman DJ. Branched chain amino acids, cardiometabolic risk factors and outcomes in older men: the Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2020 Sep 25;75(10):1805-1810. 10.1093/gerona/glz192

Le Couteur DG, Stanaway F, Waite LM, Cullen J, Lindley RI, Blyth FM, Naganathan V, Cumming RG, Handelsman DJ. Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2020 Sep 25;75(10):1858-1862. 10.1093/gerona/glaa105

Le Couteur, D., Solon-Biet, S., Cogger, V., Ribeiro, R., De Cabo, R., Raubenheimer, D., Cooney, G., Simpson, S. Branched chain amino acids, aging and age-related health.Ageing Research Reviews, 2020;64, 1-11. 10.1016/j.arr.2020.101198

Li J, Zhao Y, Choi J, Ting KK, Coleman P, Chen J, Cogger VC, Wan L, Shi Z, Moller T, Zheng X, Vadas MA, Gamble JR. Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice. PLoS biology. 2020;18(6):e3000734. 10.1371/journal.pbio.3000734

Moth EB, Blinman P, Stefanic N, Naganathan V, Grimison P, Stockler MR, Beale P, Martin A, Kiely BE. Estimating survival time in older adults receiving chemotherapy for advanced cancer. Journal of geriatric oncology. 2020;11(4):617-25. 10.1016/j.jgo.2019.08.013

Moth EB, Kiely BE, Martin A, Naganathan V, Della-Fiorentina S, Honeyball F, Zielinski R, Steer C, Mandaliya H, Ragunathan A, Blinman P. Older adults' preferred and perceived roles in decision-making about palliative chemotherapy, decision priorities and information preferences. Journal of geriatric oncology. 2020;11(4):626-32. 10.1016/j.jgo.2019.07.026

Ortega-Ribera M, Hunt NJ, Gracia-Sancho J, Cogger VC. The Hepatic Sinusoid in Aging and Disease: Update and Advances From the 20th Liver Sinusoid Meeting. Hepatology communications. 2020;4(7):1087-98. 10.1002/hep4.1517

Scott D, Seibel MJ, Cumming R, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Hsu B, Waite LM, Hirani V. Associations of Body Composition Trajectories with Bone Mineral Density, Muscle Function, Falls, and Fractures in Older Men: The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(5):939-45. 10.1093/gerona/glz184

Scott D, Seibel MJ, Cumming R, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Hsu B, Waite LM, Hirani V. Comparison of clinical risk factors for incident fracture in obese and non-obese community-dwelling older men. Bone. 2020;137:115433. 10.1016/j.bone.2020.115433

Simpkins DM, Hohenberg MI, Naganathan V, White K. Help, I'm a specialist! Perspectives of recently qualified geriatricians on the experiences and challenges of working as a consultant geriatrician. Australasian journal on ageing. 2020;39(1):73-80. 10.1111/ajag.12670

Solon-Biet SM, McMahon AC, Ballard JWO, Ruohonen K, Wu LE, Cogger VC, Warren A, Huang X, Pichaud N, Melvin RG, Gokarn R, Khalil M, Turner N, Cooney GJ, Sinclair DA, Raubenheimer D, Le Couteur DG, Simpson SJ. Published Erratum: The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. Cell metabolism. 2020;31(3):654. 10.1016/j.cmet.2020.01.010

Stanaway FF, Blyth FM, Naganathan V, Le Couteur DG, Ribeiro R, Hirani V, Waite LM, Handelsman DJ, Seibel MJ, Cumming RG. Mortality Paradox of Older Italian-Born Men in Australia: The Concord Health and Ageing in Men Project. Journal of immigrant and minority health. 2020;22(1):102-9. 10.1007/s10903-019-00874-w

Takehara S, Wright FAC, Waite LM, Naganathan V, Hirani V, Blyth FM, Le Couteur DG, Seibel MJ, Handelsman DJ, Cumming RG. Oral health and cognitive status in the Concord Health and Ageing in Men Project: A cross-sectional study in community-dwelling older Australian men. Gerodontology. 2020;37(4):353-360. DOI: 10.1111/ger.12469

Teng Claris, Loy Clement T, Sellars Marcus, Pond Dimity, Latt Mark D, Waite Louise M, Sinka Victoria, Logeman Charlotte, Tong Allison. Making Decisions About Long-Term Institutional Care Placement Among People With Dementia and Their Caregivers: Systematic Review of Qualitative Studies. The Gerontologist. 2020;60(4): e329–e346. 10.1093/geront/gnz046

Thillainadesan J, Scott IA, Le Couteur DG. Frailty, a multisystem ageing syndrome. Age and ageing. 2020 Aug 24;49(5):758-763. 10.1093/ageing/afaa112

Thillainadesan J, Yumol MF, Hilmer S, Aitken SJ, Naganathan V. Interventions to Improve Clinical Outcomes in Older Adults Admitted to a Surgical Service: A Systematic Review and Meta-analysis. Journal of the American Medical Directors Association. 2020 Dec;21(12):1833-1843.e20. 10.1016/j.jamda.2020.03.023

Valdez E, Wright FAC, Naganathan V, Milledge K, Blyth FM, Hirani V, Le Couteur DG, Handelsman DJ, Waite LM, Cumming RG. Frailty and oral health: Findings from the Concord Health and Ageing in Men Project. Gerodontology. 2020;37(1):28-37. doi: 10.1111/ger.12438

Wahl, D., Anderson, R. M., Le Couteur, D. G. Antiaging therapies, cognitive impairment, and dementia. Journals of Gerontology Series A-Biological Sciences & Medical Sciences. 2020; 75(9), 1643-1652. 10.1093/gerona/glz135

Wang H, Burke LJ, Patel J, Tse BW, Bridle KR, Cogger VC, Li X, Liu X, Yang H, Crawford DHG, Roberts MS, Gao W, Liang X. Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury. Theranostics. 2020;10(15):6715-27. 10.7150/thno.44900

Weir KR, Naganathan V, Bonner C, McCaffery K, Rigby D, McLachlan AJ, Jansen J. Pharmacists' and older adults' perspectives on the benefits and barriers of Home Medicines Reviews - a qualitative study. Journal of health services research & policy. 2020;25(2):77-85. 10.1177/1355819619858632

Wright FAC, Takehara S, Stanaway FF, Naganathan V, Blyth FM, Hirani V, Le Couteur DG, Handelsman DJ, Waite LM, Seibel MJ, Cumming RG. Associations between oral health and depressive symptoms: Findings from the Concord Health and Ageing in Men Project. Australasian journal on ageing. 2020;39(3): e306-e314. doi.org/10.1111/ajag.12763

Wu, H., Mach, J., Le Couteur, D. G., Hilmer, S. N. Fall-related mortality trends in Australia and the United Kingdom: implications for research and practice. Maturitas. 2020;142, 68-72. 10.1016/j.maturitas.2020.07.008

2019

Baysari MT, Duong M, Zheng WY, Nguyen A, Lo S, Ng B, Ritchie A, Le Couteur D, McLachlan A, Bennett A, Hilmer S. Delivering the right information to the right person at the right time to facilitate deprescribing in hospital: a mixed methods multisite study to inform decision support design in Australia. BMJ open. 2019;9(9):e030950. 10.1136/bmjopen-2019-030950

Gaddam RR, Chambers S, Fraser R, Cogger VC, Le Couteur DG, Ishii I, Bhatia M. Cystathionine-Gamma-Lyase-Derived Hydrogen Sulfide-Regulated Substance P Modulates Liver Sieve Fenestrations in Caecal Ligation and Puncture-Induced Sepsis. International journal of molecular sciences. 2019;20(13). 10.3390/ijms20133191

Gibney JM, Wright FA, D'Souza M, Naganathan V. Improving the oral health of older people in hospital. Australasian journal on ageing. 2019 Mar;38(1):33-38. doi: 10.1111/ajag.12588

Hsu B, Hirani V, Cumming RG, Naganathan V, Blyth FM, Wright FC, Waite LM., Seibel MJ., Handelsman DJ., Le Couteur DG.. Cross-Sectional and Longitudinal Relationships Between Inflammatory Biomarkers and Frailty in Community-dwelling Older Men: The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2019;74(6):835-41. 10.1093/gerona/glx142

Hunt NJ, Kang SWS, Lockwood GP, Le Couteur DG, Cogger VC. Hallmarks of Aging in the Liver. Computational and structural biotechnology journal. 2019;17:1151-61. 10.1016/j.csbj.2019.07.021

Hunt NJ, Lockwood GP, Warren A, Mao H, McCourt PAG, Le Couteur DG, Cogger V. Manipulating fenestrations in young and old liver sinusoidal endothelial cells. American journal of physiology Gastrointestinal and liver physiology. 2019;316(1):G144-g54. 10.1152/ajpgi.00179.2018

Johnson G, Byun R, Foster K, Wright F, Blinkhorn A. A longitudinal workforce analysis of a Rural Clinical Placement Program for final year dental students. Australian Dental Journal. 2019 Jun;64(2):181-192. doi: 10.1111/adj.12691. PMID: 30929266.

Jokanovic N, Aslani P, Carter S, Duong M, Gnjidic D, Jansen J, Le Couteur D, Hilmer S. Development of consumer information leaflets for deprescribing in older hospital inpatients: a mixed-methods study. BMJ open. 2019;9(12):e033303. 10.1136/bmjopen-2019-033303

Kang SWS, Cogger VC, Le Couteur DG, Fu D. Multiple cellular pathways regulate lipid droplet homeostasis for the establishment of polarity in collagen sandwich-cultured hepatocytes. American journal of physiology Cell physiology. 2019;317(5):C942-c52. 10.1152/ajpcell.00051.2019

Kashyap M, Thuermann P, Le Couteur DG, Abernethy DR, Hilmer SN. IUPHAR International geriatric clinical pharmacology curriculum for medical students. Pharmacological research. 2019;141:611-5. 10.1016/j.phrs.2019.01.032

Koay YC, Wali JA, Luk AWS, Macia L, Cogger VC, Pulpitel TJ, Wahl D, Solon-Biet SM, Holmes A, Simpson SJ, O'Sullivan JF. Ingestion of resistant starch by mice markedly increases microbiome-derived metabolites. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019;33(7):8033-42. 10.1096/fj.201900177R

Mach J., Huizer-Pajkos A., Cogger V., McKenzie C., Le Couteur D., de Cabo R., Jones B., Hilmer S.. Corrigendum to: The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats. The journals of gerontology Series A, Biological sciences and medical sciences. 2019;74(3):332. 10.1093/gerona/gly160

Maeso-Díaz R, Ortega-Ribera M, Lafoz E, Lozano JJ, Baiges A, Francés R, Albillos A, Peralta C, García-Pagán JC, Bosch J, Cogger VC, Gracia-Sancho J. Aging Influences Hepatic Microvascular Biology and Liver Fibrosis in Advanced Chronic Liver Disease. Aging and disease. 2019;10(4):684-98. 10.14336/AD.2019.0127

Mao H, Diekmann R, Liang HPH, Cogger VC, Le Couteur DG, Lockwood GP, Hunt NJ, Schüttpelz M, Huser TR, Chen VM and McCourt PAG. Cost-efficient nanoscopy reveals nanoscale architecture of liver cells and platelets. Nanophotonics;8(7): 1299-1313. doi.org/10.1515/nanoph-2019-0066

Morimoto J., Senior A., Ruiz K., Wali J., Pulpite, T., Solon-Biet S., Cogger V., Raubenheimer D., Le Couteur D., Simpson S., Eberhard J.. Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis. PloS one. 2019;14(3):e0212796. 10.1371/journal.pone.0212796

Moth EB, Kiely BE, Stefanic N, Naganathan V, Martin A, Grimison P, StocklerMR, Beale P, Blinman P. Predicting chemotherapy toxicity in older adults: Comparing the predictive value of the CARG Toxicity Score with oncologists' estimates of toxicity based on clinical judgement. Journal of geriatric oncology. 2019;10(2):202-9. 10.1016/j.jgo.2018.08.010

Moth, E., Kiely, B., Stefanic, N., Naganathan, V., Martin, A., Grimison, P., Stockler, M., Beale, P., Blinman, P.. Oncologists' perceptions on the usefulness of geriatric assessment measures and the CARG toxicity score when prescribing chemotherapy for older patients with cancer. Journal of geriatric oncology. 2019;10(2):210-5. 10.1016/j.jgo.2018.11.004

Naganathan V. Prescribing to the Oldest Old. In: Nagaratnam N., Nagaratnam K., Cheuk G., editors. Advanced Age Geriatric Care: A Comprehensive Guide. Springer, Cham; 2019. p 297-304. doi.org/10.1007/978-3-319-96998-5

Naganathan V., Nagaratnam K. Managing Osteoporosis in Oldest of Old. In: Nagaratnam N., Nagaratnam K., Cheuk G., editors. Advanced Age Geriatric Care: A Comprehensive Guide. Springer, Cham; 2019. p 217-221. doi.org/10.1007/978-3-319-96998-5

Narayan SW, Pearson SA, Litchfield M, Le Couteur DG, Buckley N, McLachlan AJ, Zoega H. Anticholinergic medicines use among older adults before and after initiating dementia medicines. British journal of clinical pharmacology. 2019;85(9):1957-63. 10.1111/bcp.13976

Rhee J, Meller A, Krysinska K, Gonski P, Naganathan V, Zwar N, Hayen A, Cullen J, O’Keefe JA, McDonald J, Harris-Roxas B, Caplan GA. Advance care planning for patients with advanced illnesses attending hospital outpatient clinics study: a study protocol for a randomised controlled trial. BMJ open. 2019;9(1):e023107. 10.1136/bmjopen-2018-023107

Ribeiro R.V., Solon-Biet S.M., Pulpitel T., Senior A.M., Cogger V.C., Clark X., O’Sullivan J., Koay Y.C., Hirani V., Blyth F.M., Seibel M.J., Waite L.M., Naganathan V., Cumming R.G., Handelsman D.J., Simpson S.J., Couteur D.G.L. Of Older Mice and Men: Branched-Chain Amino Acids and Body Composition. Nutrients. 2019;11(8). 10.3390/nu11081882

Ribeiro RV, Simpson SJ, Le Couteur DG, Raubenheimer D, Eberhard J, Ruiz K, Macia L, Todorova Y, Gosby AK. The nutrition for healthy living study: A randomised clinical trial assessing the effect of protein sources on healthy ageing Nutrition and Healthy Aging 2019;5(1): 43-51. 10.3233/NHA-180055

Scott IA, Hilmer SN, Le Couteur DG. Going Beyond the Guidelines in Individualising the Use of Antihypertensive Drugs in Older Patients. Drugs & aging. 2019;36(8):675-85. 10.1007/s40266-019-00683-8

Scott, D., Seibel M., Cumming R., Naganathan V., Blyth F., Le Couteur D., Handelsman D., Waite L., Hirani V. Does Combined Osteopenia/Osteoporosis and Sarcopenia Confer Greater Risk of Falls and Fracture Than Either Condition Alone in Older Men? The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2019;74(6):827-34. 10.1093/gerona/gly162

Senior AM, Solon-Biet SM, Cogger VC, Le Couteur DG, Nakagawa S, Raubenheimer D, Simpson SJ. Dietary macronutrient content, age-specific mortality and lifespan. Proceedings Biological sciences. 2019;286(1902):20190393. 10.1098/rspb.2019.0393

Shu CC, Hsu B, Cumming RG, Blyth FM, Waite LM, Le Couteur DG, Handelsman DJ, Naganathan V. Caregiving and all-cause mortality in older men 2005-15: the Concord Health and Ageing in Men Project. Age and ageing. 2019;48(4):571-6. doi.org/10.1093/ageing/afz039

Simpson SJ, Le Couteur DG. The diet and the damage done. Nature metabolism. 2019;1(11):1030-1. 10.1038/s42255-019-0128-6

Solon-Biet SM, Cogger VC, Pulpitel T, Wahl D, Clark X, Bagley E, Gregoriou GC, Senior AM, Wang QP, Brandon AE, Perks R, O'Sullivan J, Koay YC, Bell-Anderson K, Kebede M, Yau B, Atkinson C, Svineng G, Dodgson T, Wali JA, Piper MDW, Juricic P, Partridge L, Rose AJ, Raubenheimer D, Cooney GJ, Le Couteur DG, Simpson SJ. Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nature metabolism. 2019;1(5):532-45. 10.1038/s42255-019-0059-2

Solon-Biet SM, Wahl D, Raubenheimer D, Cogger V., Le Couteur DG, Simpson SJ. The geometric framework: An approach for studying the impact of nutrition on healthy aging. Drug Discovery Today: Disease Models 2019; 27; 61-68. doi.org/10.1016/j.ddmod.2019.03.002

Thillainadesan J, Hilmer SN, Close J, Kearney L, Naganathan V Geriatric medicine services for older surgical patients in acute hospitals: Results from a binational survey Australasian Journal on Ageing 2019; 38(4):278-283. 10.1111/ajag.12675

Thomas R, Sims R, Beller E, Scott A., Doust J, Le Couteur DG, Pond D, Loy C, Forlini C., Glasziou P. An Australian community jury to consider case-finding for dementia: Differences between informed community preferences and general practice guidelines. Health Expectations, 2019 22(3), 475-484. 10.1111/hex.12871

Toyama T, van den Broek-Best O, Ohkuma T, Handelsman D, Waite LM, Seibel MJ, Cumming R, Naganathan V, Sherrington C, Hirani V, Wang AY. Associations of Impaired Renal Function With Declines in Muscle Strength and Muscle Function in Older Men: Findings From the CHAMP Study. The journals of gerontology Series A, Biological sciences and medical sciences. 2019;74(11):1812-20. 10.1093/gerona/glz100

Tran J, Wright FAC, Takehara S, Chu C-C, Naganathan V., Hirani V., Blyth FM, Le Couteur DG, Waite L, Handelsman DJ, Seibel M, Milledge K, Cumming RG. Oral health behaviours of older Australian men: the Concord Health and Ageing in Men Project. Australian dental journal. 2019;64(3):246-55. 10.1111/adj.12694

Wahl D, Gokarn R, Mitchell SJ, Solon-Biet SM, Cogger VC, Simpson SJ, Le Couteur DG., de Cabo R. Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice. Nutrition and healthy aging. 2019;5(2):111-7. 10.3233/NHA-180059

Wahl D, Solon-Biet SM, Cogger VC, Fontana L, Simpson SJ, Le Couteur DG, Ribeiro RV. Aging, lifestyle and dementia. Neurobiology of disease. 2019;130:104481. 10.1016/j.nbd.2019.104481

Weir KR, Bonner C, McCaffery K, Naganathan V, Carter SM, Rigby D, Trevena L, Mclachlan A, Jansen J. Pharmacists and patients sharing decisions about medicines: Development and feasibility of a conversation guide. Research in social & administrative pharmacy : RSAP. 2019;15(6):682-90. 10.1016/j.sapharm.2018.08.009

Weir KR, Naganathan V, Rigby D, McCaffery K, Bonner C, Trevena L, McLachlan A, Jansen J. Home medicines reviews: a qualitative study of GPs’ experiences. Australian journal of primary health. 2019;26(1) 24-30 https://doi.org/10.1071/PY19072.

Wright FAC, Law GG, Milledge KL, Chu SK, Hsu B, Valdez E, Naganathan V, Hirani V, Blyth FM, LeCouteur DG, Waite LM, Handelsman DJ, Seibel MJ, Cumming RG. Chewing function, general health and the dentition of older Australian men: The Concord Health and Ageing in Men Project. Community dentistry and oral epidemiology. 2019;47(2):134-41. 10.1111/cdoe.12435

Our Presentations

2024

Koria L. Emergency Hospital In The Home (EHITH) for People Living with Dementia Australian Dementia Research Forum 2024 Sydney, Australia November 2024.

Thillainadesan J. Enhancing Geriatrics Care and Medical Education through Microlearning Australian & New Zealand Association for Health Professional Educators Adelaide, Australia July 2024.

Koria L. Emergency Hospital In The Home (EHITH) for People Living with Dementia Australian Dementia Research Forum 2024 Gold Coast, Australia June 2024.

Naganathan V. Research Career Pathways for Geriatricians and Advanced Trainees The Australian and New Zealand Society of Geriatric Medicine Annual Scientific Meeting 2024 Christchurch, New Zealand May 2024.

Cogger V. International Women’s Day Centenary Institute Sydney, Australia May 2024.

Cogger V. Targeted Drug Delivery EU Horizon Meeting Sommeroya, Norway April 2024.

Naganathan V. Examples of Research that have the potential to influence every day clinical practice Concord Connects Sydney, Australia February 2024.

Cogger V. Needle-free insulin Concord Connects Sydney, Australia February 2024.

2023

Naganathan V. Strategy and Development of Geriatric Workforce Capacity Building and Training in Australia. The 4th Vietnam National Geriatric Conference Program Hanoi, Vietnam November 2023.

Thillainadesan J. Perioperative Management of Frailty and Sarcopenia. 9th Asian Conference for Frailty and Sarcopenia Singapore October 2023.

Naganathan V. The Challenges Ahead - An Australasian Perspective. Australian and New Zealand Society of Geriatric Medicine (ANZSGM) NZ Retreat Hawke's Nest, New Zealand October 2023.

Cogger V. Big Ideas, the Little Idea that Grew. Sydney Innovation Week Sydney, Australia September 2023.

Thillainadesan J. Innovative Pedagogy Enhances Care of Older Surgical Patients. The Association for Medical Education in Europe (AMEE) 2023 Glasgow, UK August 2023.

Thillainadesan J. Let’s Talk About Microlearning in Medical Education. The Association for Medical Education in Europe (AMEE) 2023 Glasgow, UK August 2023.

Hunt N. Human Duodenum Uptake and Animal Model Toxicity of Oral Insulin Nanotechnology (EA-1). Australasian Diabetes Congress 2023 Adelaide, Australia August 2023.

Cogger V. Insulin: Evolving New Therapies. Cardiovascular Drug Discovery Initiative Annual Workshop Sydney, Australia June 2023.

Hunt N. Oral Insulin from Discovery to Company Formation. Drug Discovery and Innovation & Industry SIG Student & ECR Virtual Symposium Virtual June 2023.

Hunt N. Characterisation of Nano Insulin Formulations. Sydney Analytical 5th Anniversary Symposium Sydney, Australia June 2023.

Naganathan V. Hospital and Out-of-Hospital Services Provided by Public Geriatric Medicine departments in Australia and New Zealand. IAGG Asia/Oceania Regional Congress Yokohama, Japan June 2023.

Le Couteur D. Macronutrients and Aging. The Okinawa Ratio. Journal of Internal Medicine Key Symposia Okinawa, Japan May 2023.

Naganathan V. Successes and Failures: Healthcare Innovations and Ageing Research Falls in Hospital. Australian and New Zealand Society for Geriatric Medicine Annual Scientific Meeting 2023 Brisbane, Australia May 2023.

Naganathan V. Aged Care Perspective. 2023 Healthcare Reform Town Hall Session Plan Virtual May 2023.

Azarias E. Hospital and Out-of-Hospital Services Provided by Public Geriatric Medicine departments in Australia and New Zealand. The Australian and New Zealand Society of Geriatric Medicine Annual Scientific Meeting 2023 Brisbane, Australia May 2023.

Hunt N. Current and Emerging Nanomedicine Therapeutics. Lecture for NANO4001 course (USyd) Sydney, Australia April 2023.

Thillainadesan J. Microteaching in Vascular-Geriatrics. Sydney Health Partners Perioperative and Surgical Education Conference Sydney, Australia March 2023.

2022

Blyth F. Populations and patients - are they two sides of the same coin? Sydney Health Partners Geriatric Clinical Academic Group (CAG) Launch. Sydney. 2022.

Cogger V. The Biology of the Ageing Liver. The 2022 Liver Sinusoid Meeting, China.

Hunt N. Oral nanoformulations of Insulin. British Pharmacological Society. 2022.

Hunt N. Oral Nanotherapeutic Formulations of Liraglutide. APSA-ASCEPT 2022 Perth, Australia December 2022.

Kawamura J. (Supervisor Dr Thillainadesan - Year 2 medical student project) Prevalence and association of antipsychotic drugs with falls in hospitalised older adults. APSA-ASCEPT 2022 Joint Conference (Australasian Pharmaceutical Science Association / Australasian Society of Clinical and Experimental Pharmacologists) Australia November 2022.

Lin J. (Supervisor Dr Thillainadesan - Year 2 medical student project) Pharmacist consultations in hospitalised older surgical patients. APSA-ASCEPT 2022 Joint Conference (Australasian Pharmaceutical Science Association / Australasian Society of Clinical and Experimental Pharmacologists) Australia November 2022.

Naganathan V. Gerontology training programs and research projects in Australia. The 3rd Vietnam National Geriatric Conference Program, Hanoi, Vietnam. 2022.

Naganathan V. How does research influence everyday clinical practice? Sydney Health Partners Geriatric Clinical Academic Group (CAG) Launch. Sydney. 2022.

Naganathan V. Perspectives on the Teaching of Geriatric Medicine. Australian and New Zealand Society for Geriatric Medicine South Australian Division Annual Meeting Adelaide, Australia October 2022.

Naganathan V. Research Does (and does not) Influence Everyday Geriatric Medicine Practice and Service Development. Australian and New Zealand Society for Geriatric Medicine South Australian Division Annual Meeting Adelaide, Australia October 2022.

Naganathan V. Research does (and does not) influence everyday Geriatric Medicine Practice and Service Development. Professor Vasi Naganathan, ANZSGM State Meetings in QLD and South Australia. 2022.

Thillainadesan J. A collaborative model of proactive geriatrician care and education of junior doctors improves hospital care of older surgical patients (oral presentation). Australian and New Zealand Society for Geriatric Medicine (ANZSGM) Virtual Annual Scientific Meeting. 2022.

Thillainadesan J. A shared Model of Care on Vascular Surgery Wards. 61st Annual 2022 Princess Alexandria Hospital Health Symposium Brisbane, Australia August 2022.

Thillainadesan J. CGA delivery and education to improve clinician practice and patient outcomes. John A. Burns School of Medicine Geriatric Fellows, Hawaii, USA. 2022.

Thillainadesan J. Collaborative model of care. Sydney Health Partners Geriatric Clinical Academic Group (CAG) Launch. Sydney. 2022.

Thillainadesan J. Frailty and the surgical patient. COALFACE GERIATRICS: Managing Comorbidity in an Older Person (Hunter Postgraduate Medical Institute). 2022.

Thillainadesan J. Geriatric Surgical Services around Australia and New Zealand. Virtual roadshow by Australian and New Zealand Society for Geriatric Medicine. 2022.

Thillainadesan J. Geriatrician Comanagement and Education of Junior Doctors Improve the Care of Hospitalized Older Surgical Patients. Gerontological Society of America (GSA) Annual Scientific Meeting Indiana, USA November 2022.

Thillainadesan J. Health Professions Education Research Micro-Conference (virtual). 2022.

Thillainadesan J. How to Manage Quality of life and Life Expectancy – Frailty and co-Morbidities in Urology Management. 19th Urological Association of Asia Congress Sydney, Australia October 2022.

Thillainadesan J. Perioperative Care in vascular Wards. ANZCA 2022 Perioperative Medicine Special Interest Group meeting Noosa, Australia November 2022.

Thillainadesan J. The Role of Frailty and Resilience in Surgery. Evidence-Based Perioperative Medicine - Asia Congress 2022 Singapore December 2022.

Thillainadesan J. What matters to older surgical patients and their carers during hospitalisation? Australian and New Zealand Society for Geriatric Medicine (ANZSGM) Virtual Annual Scientific Meeting. 2022.

Thillainadesan J. What Matters to Older Surgical Patients and their Carers during their Hospitalization?. Gerontological Society of America (GSA) Annual Scientific Meeting Indiana, USA November 2022.

Centre for Education and Research on Ageing Research

Our current research programs include:

Our Key Achievements

Our Research Team

Selected Grants

Our Publications

2024

Our Presentations

2024

Centre for Education and Research on Ageing Research

Centre for Education and Research on Ageing Research

Our Organisation

Make a Donation

Our Hospitals

Care in our Community

Right to Information

Your feedback

Plans

Publications

Quick Links