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Centre for Education and Research on Ageing Research
The Centre for Education and Research on Ageing (CERA) and its members undertake basic science, epidemiological and clinical research.
CERA is part of the Department of Geriatric Medicine at Concord Hospital. CERA is a multidisciplinary hub to foster collaboration between clinical and academic health professionals and facilitate the translation of research findings into clinical practice. The research objectives of CERA are:
- To improve the health and productivity of older people through research into the ageing process
- To improve the well-being and quality of life of older people, especially those with frailty or dementia, through research into health care
- To provide leadership in the education and training of people involved in the care of older people and those involved in ageing research.
Our current research programs include:
- Oral Health
- Ageing liver and nanomedicines
- Novel mechanisms for dementia
- Surgical liaison and older people in hospital
- Advanced care directives
- Polypharmacy and deprescribing
- Identification and management of delirium in older inpatients
- Falls prevention in hospital
- Geriatric Medicine Services in Australia and New Zealand
- Emergency Hospital in the Home.
Our Key Achievements
| The Biogerontology group continues to explore the targeted use of medicines and other therapeutics. The group is collaborating with the Institut d'Investigacions Biomèdiques in Barcelona in the use of our nanotechnology for microRNA delivery for the prevention of liver failure. |
| Dr Nicholas Hunt has been awarded a SOAR fellowship through the University of Sydney and has published key findings in ACS Nano using our nanotechnology platform. |
| CERA led a study on the teaching of Geriatric medicine at medical schools in Australia. This data was provided to the Royal Commission into Aged care Quality and Safety who were interested in knowing more about this study. CERA members also contributed submissions. |
| A new perioperative model of care has been adopted by the Sydney Local Health District based on research conducted by CERA PhD students Dr Sarah Aitken and Dr Janani Thillainadesan. |
| COVID-19: Numerous CERA members had key advisory roles during the height of the COVID-19 epidemic, through participation in various National / State / Local taskforces and advisory bodies. |
| Dr Janani Thillainadesan awarded ANZSGM Career Investigator Prize and UK Age Anaesthesia Association Annual Scientific Meeting (ASM) Best Oral Presentation Prize in 2021. |
| Deborah Cockrell has been appointed a Member (AM) in the General Division of the Order of Australia for her significant service to dentistry, profession organisation and to education. |
| CERA/Geriatric Medicine Outreach-OHT, Integrating Oral Health in Residential Care Program won both the SLHD 2018 Quality Award in the "Delivering Integrated Care" Category and the 2018 Chairman's Award. |
| Nicholas Hunt was awarded the "Distinction in Scholarship" by the American Journal of Physiology for his publication in the journal. |
| PhD students submitted and/or graduated: Janani Thillainadesan, Sarah Aitken. Jennifer Gibney, Naomi Noguchi, Devin Wahl, Rahul Gokarn, Sun Woo Sophie Kan. |
| Current Masters (MPhil) students: Dr Eleni Azarias, Dr Atul Wagh, Dr Bethany Stavert, Dr Joshua Makary. |
| Sachiko Takehara received the Endeavour Fellowship from Japan to collaborate with Oral Health Programme and CHAMP. |
Our Research Team
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CERA Co-Directors |
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|---|---|
| Professor Vasi Naganathan | Professor of Geriatric Medicine, University of Sydney and Consultant Geriatrician, Concord Hospital |
| Professor Victoria Cogger | Associate Dean (Research Education), The University of Sydney / Co-leader Biogerontology laboratory |
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Department of Geriatric Medicine, Concord Hospital |
|
| Professor Vasi Naganathan | Consultant Geriatrician |
| Professor David Le Couteur | Senior Staff Specialist in Geriatric Medicine and Professor of Geriatric Medicine, The University of Sydney |
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Clinical Associate Professor John Cullen
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Stream Director Sydney Local Health District Aged Health Care, Rehabilitation, General Medicine, Chronic Care, Disability, Endocrinology, Andrology and Ambulatory Care Clinical Associate Professor, Concord Clinical School, The University of Sydney |
| Clinical Associate Professor Louise Waite |
Senior Staff Specialist Geriatrician. Head of Department of Geriatric Medicine. Clinical Associate Professor, Concord Clinical School, University of Sydney |
| Dr Janani Thillainadesan | Staff Specialist Geriatrician and Conjoint Lecturer, Concord Clinical School, University of Sydney |
| Clinical Associate Professor Deborah Cockrell | Lead for Oral Health, CERA and Clinical Associate Professor, Concord Clinical School, University of Sydney |
| Dr Natasha Spalding | Staff Specialist Geriatrician and Director of RACF Outreach Service |
| Dr Cameron Korb-Wells | Geriatrician |
| Dr Virginia Painter | Geriatrician |
| Dr Alice Minchin | Advanced Trainee |
| Dr George Wells | Advanced Trainee |
| Dr Nadine Elias | Advanced Trainee |
| Dr Kate Djekovic | Advanced Trainee |
| Steven Chu | Oral Health PhD student |
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Biogerontology Lab, ANZAC Research Institute |
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| Professor Victoria Cogger | Co-leader Biogerontology laboratory |
| Professor David Le Couteur | Co-leader Biogerontology laboratory |
| Dr Nicholas Hunt | Post-doctoral researcher |
| Glen Lockwood | Laboratory Manager |
| Lara Westwood | PhD Candidate |
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CERA Research Support Staff |
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| Leanne Kearney | CERA Research Project Officer |
| Sarita Lo | CERA Research Pharmacist |
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Higher Degree Students |
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| Winston Cheung | PhD Candidate |
| Steven Chu | PhD Candidate |
| Glen Lockwood | PhD Candidate |
| Charlotte McLennan | PhD Candidate |
| Jenna Smith | PhD Candidate |
| Eleni Azarias | Masters (MPhil) student |
| Joshua Makary | Masters (MPhil) student |
| Bethany Stavert | Masters (MPhil) student |
| Atul Wagh | Masters (MPhil) student |
Selected Grants
| Amount awarded | Project and investigator details |
|---|---|
| $12,981,420 | NHMRC Program Grant, 2019-2023 Nutrition and complexity Investigators: Simpson S, George J, Le Couteur D, Gunton J, Raubenheimer D, Durrant-Whyte H |
| $2,500,000 | NHMRC Centres of Research Excellence Scheme, 2020-2024 NHMRC Centre of Research Excellence in the Prevention of Fall-related Injuries Associate Investigator: Naganathan V |
| $1,989,324 | ARC Centres of Excellence, 2017-2023 ARC Centre of Excellence in Population Ageing Research 2 (CEPAR 2), University of Sydney Node Investigators: Baird M, Blyth F, Cumming R, Piggott J, McDonald P, Anstey K, Keane M, Parker S, Sherris M, Bateman H, Clarke P, McKibbin W, Woodland A |
| $468,879 | HCF Research Foundation, 2022-2024 Effectiveness, cost-effectiveness and implementation of Emergency Hospital in the Home model of care for older people Investigators: Naganathan V, Cullen J, Blyth F, Cunich M |
| Amount awarded | Grant and project details |
|---|---|
| $586,840 | NHMRC Boosting Dementia Research Grant Scheme, 2018-2020 (extended) Team Approach to Polypharmacy Evaluation and Reduction for General Practice patients with dementia: the Australian TAPERdem study Investigators: Etherton-Beer C, Parkinson L, Naganathan V, Caughey G, Redfern J, Clifford R, Page A, Mangin D |
| $560,241 | NHMRC, 2018-2020 A targeted approach to age related disease: nanomedicines and the liver sinusoidal endothelium Investigators: Cogger V, Le Couteur D, Kuncic Z, McCourt P |
| $510,580 | ARC, 2018-2020 A life-course approach to the nutrition-lifespan-reproduction nexus Investigators: Raubenheimer D, Solon-Biet S, Walters K, Le Couteur D |
| $437,000 | NSW Ministry of Health, 2018-2021 Advance Care Planning in outpatient clinics – extension Investigators: Caplan G, Meller A, Naganathan V, Cullen J |
| $325,000 | ARC Discovery Project Grant, 2017-2019 Properties of nanomaterials determine their disposal by liver cells Investigators: Cogger V, Xu Z, Roberts M |
| $85,000 | Australian Diabetes Society, 2021 Skip Martin Postdoctoral Fellowship Investigator: Hunt N |
| $80,000 | University of Sydney DVC Research / Thompson Fellowships, 2018 A targeted approach to age related disease: nanomedicines and the liver sinusoidal endothelium Investigator: Cogger V. |
| $25,000 | Sydney Health Partners, 2021 HIPFFIT: HIP Fracture and Frailty Improvement Translational project Clinical PI: Cullen J |
| $10,000 | ANZ Musculoskeletal Clinical Trials Network, 2019 Safe mobility to prevent falls in acute hospitals: adaptation of the successful Safe Recovery rehabilitation unit program Naganathan V. |
Our Publications
2022
| Cheyne S, Lindley R, Smallwood N, Tendal B, Chapman M, Navarro DF, Good PD, McDonald S, Morgan D, Murano M, Millard T, Naganathan V, Srikanth V, Tuffin P, Vogel J, White H, Chakrabothy SP, Whiting E, William L, Yates PM, Callary M, Elliott J and Agar MR for the National COVID-19 Clinical Evidence Taskforce. Care of older people and people requiring palliative care with COVID-19: guidance from the Australian National COVID-19 Clinical Evidence Taskforce. The Medical Journal of Australia. 2022 Mar;216(4):203-208. doi.org/10.5694/mja2.51353 |
| de Cabo R, Le Couteur DG. (2022) Biology of Aging. In: Harrisons Principles of Internal Medicine (21st Ed). Editors: Loscalzo J, Fauci AS, Kasper DL, Longo DL, Jameson JL, McGraw Hill. Columbus. https://accessmedicine.mhmedical.com/content.aspx?bookid=3095§ionid=265470089 |
| Djekovic K, Clowes K, Spalding N, Waite L. A retrospective study of the behavioural and psychological symptoms of dementia in patients admitted to a Specialist Dementia Care Unit. Australasian Journal on Ageing. 2022;00:1–9. doi:10.1111/ajag.13060 (Epub ahead of print) |
| Ischia L., Naganathan V., Waite L.M., Le Couteur D.G., Thillainadesan J. COVID-19 and Geriatric Medicine in Australia and New Zealand. Australasian Journal on Ageing. 2022 Jun;41(2):301-308 doi.org/10.1111/ajag.13027. |
| Le Couteur DG, Anderson RM, de Cabo R. Can we make drug discovery targeting fundamental mechanisms of aging a reality? (invited editorial) Expert Opinion on Drug Discovery, 2022; 17:2, 97-100 10.1080/17460441.2022.1993818 |
| Le Couteur DG, Flicker L, Hilmer SN. Geriatric medicine and health care for older people in Australia. Age and Ageing 2022 March; 51(3):afac001. doi.org/10.1093/ageing/afac001 |
| Luong, R., Ribeiro., R.V., Rangan, A., Naganathan, V., Blyth, F., Waite, L.M., Handelsman, D.J., Cumming, R.G., Le Couteur, D.G., Hirani, V. Changes in Dietary Total and Nonheme Iron Intake Is Associated With Incident Frailty in Older Men: The Concord Health and Aging in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2022 Mar ;glac077. doi: 10.1093/gerona/glac077 (Epub ahead of print) |
| Shu CC, Wright FAC, Naganathan V, Blyth M, Le Couteur DG, Handelsman D.J, Stanaway FF. Does social support predict increased use of dental services in older men? Australian Dental Journal. 2022 Apr 03 https://doi.org/10.1111/adj.12911 (Epub ahead of print) |
| Sirimanna, P., Boyce, S., Gunanayagam, P., Gladman, M.A. and Naganathan, V. Development of a rating scale for objective assessment of performance in laparoscopic appendicectomy surgery. ANZ Journal of Surgery. 2022 https://doi.org/10.1111/ans.17601 (Epub ahead of print) |
| Thillainadesan J, Hilmer SN, Fleury AM, Naganathan V. New horizons in the perioperative care of older adults. Age and Ageing. 2022 Feb 2;51(2):afab245. doi: 10.1093/ageing/afab245 |
| Thillainadesan J., Monaro S., Aitken S., Kerdic R., Cullen J., Naganathan V. Geriatric Comanagement of Older Vascular Surgery Inpatients Reduces Hospital-Acquired Geriatric Syndromes. Journal of the American Medical Directors Association. 2022 Apr;23(4):589-595.e6. doi: 10.1016/j.jamda.2021.09.037. Epub 2021 Oct 29. PMID: 34756839 |
| Wu, H., Mach, J., Gnjidic, D., Naganathan, V., Blyth, F., Waite, L., Handelsman, D., Le Couteur, D., Hilmer, S. Comparing Effects of Polypharmacy on Inflammatory Profiles in Older Adults and Mice: Implications for Translational Ageing Research. Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2022 Mar 17. glac061, https://doi.org/10.1093/gerona/glac061 (Epub ahead of print) |
| Xu P, Blyth F.M, Naganathan V, Cumming R.G, Handelsman D.J, Seibel M.J, Le Couteur D.G, Waite L.M, and Khalatbari-Soltani S: Socioeconomic inequalities in elective and non-elective hospitalizations in older men. JAMA Network Open. 2022 Apr 1;5(4):e226398. doi:10.1001/jamanetworkopen.2022.6398 |
| Cervo M, Scott D, Seibel MJ, Cumming RG, Naganathan V, Blyth FM, Le Couteur DG, Handelsman DJ, Ribeiro RV, Waite LM, Hirani V. Adherence to Mediterranean Diet and its Associations with Circulating Cytokines, Musculoskeletal Health and Incident Falls in Community-Dwelling Older Men: The Concord Health and Ageing in Men Project. Clinical Nutrition 2021 Oct 23;40(12):5753-5763. 10.1016/j.clnu.2021.10.010 |
| Chu KY, Cockrell D,Naganathan V, Stanaway F, Wright FAC. Oral health status of newly admitted residents living in residential aged care. Australian Dental Journal. 2021 December;66(4):391-396 10.1111/adj.12864 |
| Dai Z, Hirani V, Sahni S, Felson DT, Naganathan V, Blyth F, Le Couteur D, Handelsman D, Seibel MJ, Waite L, Kiel DP, Cumming R. Association of dietary fiber and risk of hip fracture in men from the Framingham Osteoporosis Study and the Concord Health and Ageing in Men Project. Nutrition and Health. 2021 May 4;2601060211011798. 10.1177/02601060211011798. (Epub ahead of print) |
| Das A, Cumming RG, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Ribeiro RV, Simpson JS, Hirani V. Associations between dietary intake of total protein and sources of protein (plant vs. animal) and risk of all-cause and cause-specific mortality in older Australian men: The Concord Health and Ageing in Men Project. Journal of Human Nutrition and Dietetics. 2021 (Early Online 21 Nov 10.1111/jhn.12965 |
| Das A, Cumming RG, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Ribeiro RV, Simpson SJ, Hirani V. Associations between nutrient intakes and dietary patterns with different sarcopenia definitions in older Australian men: the concord health and ageing in men project. Public Health Nutrition. 2021 Oct;24(14):4490-4505. doi: 10.1017/S1368980020003547. Epub 2020 Oct 7. Erratum in: Public Health Nutr. 2021 Feb;24(2):378-383. PMID: 33023717. |
| Das A, Cumming RG, Naganathan V, Ribeiro RV, Le Couteur DG, Handelsman DJ, Waite LM, Hirani V. The association between antioxidant intake, dietary pattern and depressive symptoms in older Australian men: the Concord Health and Ageing in Men Project. European journal of nutrition. 2021 Feb;60(1):443-454. 10.1007/s00394-020-02255-8 |
| Duong, M. H., McLachlan, A. J., Bennett, A. A., Jokanovic, N., Le Couteur, D. G., Baysari, M. T., Gnjidic, D., Blyth, F., Hilmer, S. N. Iterative development of clinician guides to support deprescribing decisions and communication for older patients in hospital: a novel methodology. Drugs & Aging 2021,38, 75-87. 10.1007/s40266-020-00820-8 |
| Fotheringham AK, Solon-Biet SM. Bielefeldt-Ohmann H, McCarthy DA, McMahon AC, Ruohonen K, Li I, Sullivan MA, Whiddett RO, Borg DJ, Cogger VC, Ballard WO, Turner N, Melvin RG, Raubenheime D, Le Couteur DG, Simpson SJ, Forbes JM. Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure. iScience, 2021 Oct 16;24(11):103308 10.1016/j.isci.2021.103308 |
| Gibney JM, Naganathan V, Lim MAWT. Oral health is Essential to the Well-Being of Older People. The American Journal of Geriatric Psychiatry. 2021 Oct;29(10):1053-1057. doi: 10.1016/j.jagp.2021.06.002. Epub 2021 Jun 11. PMID: 34246517. |
| Hew JJ , Parungao RJ, Mooney CP, Smyth JK, Kim S, Tsai KHY, Shi H, Chong C, Chan RCF, Attia B, Nicholls D, Li Z, Solon-Biet SM, Le Couteur DG, Simpson SJ, Jeschke MG, Maitz PK, Wang Y. Low-protein diet accelerates wound healing in mice post-acute injury. Burns & Trauma 2021 Aug 9;9:tkab010. 10.1093/burnst/tkab010 |
| Hilmer SN, Mirko P, Le Couteur DG, Schwartz J, Thuermann P. Development, evaluation and use of COVID-19 vaccines in older adults: preliminary principles for the pandemic and beyond. British Journal of Clinical Pharmacology 2021; 87(9) 3459-3461. 10.1111/bcp.14967 |
| Hsu B, Korda R, Naganathan V, Lewis P, Ooi S, Brieger D, Jorm L. Burden of cardiovascular diseases in older adults using aged care services. Age and Ageing. 2021;50(5): 1845–1849. 10.1093/ageing/afab083 |
| Hunt N, Lockwood G, Kang S, Westwood L, Limantoro C, Chrzanowski W, McCourt P, Kuncic Z, Le Couteur D, Cogger V. Quantum Dot Nanomedicine Formulations Dramatically Improve Pharmacological Properties and Alter Uptake Pathways of Metformin and Nicotinamide Mononucleotide in Aging Mice. ACS Nano 2021 23;15(3):4710-4727. 10.1021/acsnano.0c09278 |
| Khalatbari-Soltani S, Blyth FM, Naganathan V, Le Couteur DG, Handelsman DJ, Seibel MJ, Hirani V, Wright FAC, Waite LM, Cumming RG. Cohort Profile update: The Concord Health and Ageing in Men Project (CHAMP). International Journal of Epidemiology. 2021 October; 51(1):31-32h. 10.1093/ije/dyab171 |
| Khalatbari-Soltani S, Cumming R.G, Chomik R, Blyth F.M, Naganathan V, Handelsman D.J, Le Couteur D.G, Waite L.M, and Stanaway F. The association between home ownership and the health of older men: cross-sectional analysis of the Australian Concord Health and Ageing in Men Project. Australasian Journal on Ageing. 2021 Sep;40(3):e199-e206. 10.1111/ajag.12896 |
| Khalatbari-Soltani S, Stanaway F, Sherrington C, Blyth FM, Naganathan V, Handelsman DJ, Seibel MJ, Waite LM, Le Couteur DG, Cumming RG. The prospective association between socioeconomic status and falls among community-dwelling older men. Journal of Gerontology Medical Science. 2021;76(10):1821-1828. 10.1093/gerona/glab038 |
| Krishnan A, Waite LM, Stanaway FF. Representation of racial and ethnic minority groups in cohort studies evaluating risk factors for dementia: protocol for a scoping review. BMJ Open. 2021 May 13;11(5):e044404. 10.1136/bmjopen-2020-044404. |
| Le Couteur DG, Handelsman DJ, Stanaway F, Waite LM, Blyth FM, Naganathan V, Cumming RG, Hirani V. Sarcopenic obesity and amino acids: Concord Health and Ageing in Men Project. Journal of Gerontology Biological Science 2021 May 22;76(6):1000-1004. 10.1093/gerona/glab076 |
| Le Couteur DG, Solon-Biet SM, Parker BL, Pulpitel T, Brandon AE, Hunt NJ, Wali JA, Gokarn R, Senior AM, Cooney GJ, Raubenheimer D, Cogger VC, James DE, Simpson SJ. Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol and rapamycin. Cell Metabolism. 2021 Nov 6;S1550-4131(21)00528-3. doi: 10.1016/j.cmet.2021.10.016. |
| Mach J, Gemikonakli G, Logan C, Vander Wyk B, Allore H, Ekambareshwar S, Kane AE, Howlett SE, de Cabo R, Le Couteur DG, Hilmer SN. Chronic polypharmacy with increasing Drug Burden Index (DBI) exacerbates frailty and impairs physical function, with effects attenuated by deprescribing, in aged mice. The journals of gerontology Series A, Biological sciences and medical sciences. 2021 May 22;76(6):1010-1018. 10.1093/gerona/glaa060 |
| Mesinovic J, Scott D, Seibel MJ, Cumming RG, Naganathan V, Blyth FM, Le Couteur DG, Waite LM, Handelsman DJ, Hirani V. Risk Factors for Incident Falls and Fractures in Older Men with and without Type 2 Diabetes Mellitus: The Concord Health and Ageing in Men Project, Journals Gerontology Medical Science. 2021 May 22;76(6):1090-1100. 10.1093/gerona/glab062 |
| Milledge K, Cumming R, Wright F, Naganathan V, Blyth F, Le Couteur D, Waite L, Handelsman D, Hirani, V. Associations between the composition of Functional Tooth Units and nutrient intake in older men: The Concord Health and Ageing in Men Project. Public Health Nutrition 2021; 24(18), 6335-6345. 10.1017/S1368980021003566. |
| Ng B, Duong M, Lo S, Le Couteur D, Hilmer S. Deprescribing perceptions and practice: reported by multidisciplinary hospital clinicians after, and by medical students before and after, viewing an e-learning module. Research in Social and Administrative Pharmacy 2021 17(11):1997-2005. 10.1016/j.sapharm.2021.03.002 |
| Parkinson L, Magin P, Etherton-Beer C, Naganathan V and Mangin D. Engaging General Practice and patients with AusTAPER, a pharmacist facilitated web-based deprescribing tool. Journal of Pharmacy Practice and Research 2021: 51(2): 154-159. 10.1002/jppr.1713 |
| Scott D, Blyth F, Naganathan V, Le Couteur DG, Handelsman DJ, Seibel MJ, Waite LM, Hirani V. Prospective associations of chronic and intrusive pain with sarcopenia and physical disability among older Australian men: The Concord Health and Ageing in Men Project. Experimental Gerontology 2021 Oct 1;153:111501. 10.1016/j.exger.2021.111501. |
| Smith J, Dodd RH, Gainey KM, Naganathan V, Cvejic E, Jansen J and McCaffery KJ. Patient-reported factors associated with older adults’ cancer screening decision-making: A systematic review. JAMA Network Open 2021 Nov 1;4(11):e2133406. 10.1001/jamanetworkopen.2021.33406 |
| Smith J, Dodd RH, Hersch J, McCaffery KJ, Naganathan V, Cvejic E and Jansen J. Psychosocial and clinical predictors of continued cancer screening in older adults. Patient Education and Counseling. 2021 Dec;104(12):3093-3096. 10.1016/j.pec.2021.04.027 |
| Stanaway FF, Ribeiro RV, Khalatbari-Soltani S, Cvejic E, Blyth FM, Naganathan V, Handelsman DJ, Le Couteur DG, Simpson SJ, Waite LM, Cumming RG, Hirani V. Diet quality in an ethnically diverse population of older men in Australia. European Journal of Clinical Nutrition. 2021 Dec;75(12):1792-1800. 10.1038/s41430-021-00893-7 |
| Takehara S, Wright FAC, Naganathan V, Hirani V, Blyth FM, Le Couteur DG, Waite LM, Seibel MJ, Handelsman DJ, Cumming RG. A cross-sectional study of perceived dental treatment needs and oral health status in community-dwelling older Australian men: The Concord Health and Ageing in Men Project. International Dental Journal. 2021 Jun;71(3):224-232. 10.1111/idj.12623 |
| Thillainadesan J, Hilmer SN, Mudge AM, Aitken SJ, Kearney L, Monaro SR, Li SJ, Schasser S, Kerdic R, Tang R, Naganathan V. Understanding the role and value of process quality indicators in older vascular surgery inpatients. The Journal of Surgical Research. 2021 Jun 23;267:91-101. 10.1016/j.jss.2021.05.003 |
| Thillainadesan J, Jansen J, Close J, Hilmer S, Naganathan V. Geriatrician perspectives on perioperative care: a qualitative study. BMC Geriatrics. 2021; 68. 10.1186/s12877-021-02019-x |
| Thillainadesan Janani, Mudge Alison, Aitken Sarah, Cullen John, Yumol Minna, Close Jacqueline, Norris C, Kerdic Richard, Naganathan Vasikaran. The prognostic performance of frailty for delirium and functional decline in vascular surgery patients. Journal of the American Geriatrics Society. 2021;69(3): 688-695. 10.1111/jgs.16907 |
| Thillainadesan Janani, Yumol Minna F., Suen Michael, Hilmer Sarah, Naganathan Vasi. Enhanced Recovery After Surgery in Older Adults Undergoing Colorectal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Diseases of the Colon and Rectum. 2021;64(8):1020-1028. doi:10.1097/DCR.0000000000002128 |
| Wahl, D., Gokarn, R., Solon-Biet, S., Cogger, V., LaRocca, T., Raubenheimer, D., Simpson, S., Le Couteur, D. (2021). Modeling nutrition and brain aging in rodents. In Martin CR, Preedy VR, Rajendram R (Eds.), Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging, (pp. 517-526). London: Academic Press. 10.1016/C2018-0-02036-8 |
| Wali JA, Milner A, Luk A, Pulpitel T, Dodgson T, Facey H, Wahl D, Kebede M, Senior AM, Sullivan M, Brandon A, Yau B, Lockwood G, Koay YC, Ribeiro R, Solon-Biet SM1, Bell-Anderson K, O’ Sullivan J, Macia L, Forbes J, Cooney GJ, Cogger VC, Holmes A, Raubenheimer D, Le Couteur DG, Simpson SJ. Impact of dietary carbohydrate type and protein-carbohydrate interaction on metabolic health. Nature Metabolism 2021; 3:810-828. 10.1038/s42255-021-00393-9 |
| Wali JA, Raubenheimer D, Senior AM, Le Couteur DG, Simpson SJ. Cardio-metabolic consequences of dietary carbohydrates: reconciling contradictions using nutritional geometry. Cardiovascular research. 2021 Jan 21;117(2):386-401. 10.1093/cvr/cvaa136 |
| Weir KR, Naganathan V, Carter SM, Tam CWM, McCaffery K, Bonner C, Rigby D, McLachlan AJ, Jansen J. The role of older patients’ goals in GP decision-making about medicines: A qualitative study. BMC Family Practice 2021; 22:13 10.1186/s12875-020-01347-y |
| Wu H, Le Couteur DG, Hilmer SN. Mortality trends of stroke and dementia: changing landscapes and new challenges. Journal of American Geriatrics Society 2021; 69(10) 2888-2898. 10.1111/jgs.17322 |
| Wu H, Mach J, Le Couteur DG, Hilmer SN. Nationwide mortality trends of delirium in Australia and the United States from 2006 to 2016. Australasian Journal on Ageing. Published online Mar 2021. 10.1111/ajag.12926 |
| Wu, H, Mach J, Gemikonakli G, Tran T, Allore H, Gnjidic D, Howlett SE, de Cabo R, Le Couteur DG, Hilmer SN. Polypharmacy Results in Functional Impairment in Mice: Novel Insights into Age and Sex Interactions. J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):1748-1756. 10.1093/gerona/glab088 |
| Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. (November 2021) 3rd Revised Edition. Editors: Lord SR, Sherrington S and Naganathan V. Cambridge University Press. https://doi.org/10.1017/9781108594455 |
| Chapters |
| a. Noguchi N and Naganathan V. Medical Risk Factors for Falls. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 172–91. |
| b. Ma L and Naganathan V. Medications as Risk Factors for Falls. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 192–201. |
| c. Lord SR, Sherrington C and Naganathan V. The Relative Importance of Fall Risk Factors: Analysis and Summary. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 237–48. |
| d. Latt MD and Naganathan V. The Medical Management of Older People at Risk of Falls. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 322–40. |
| e. Lord SR, Sherrington C and Naganathan V. Bringing It All Together. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 469–80. |
| Aitken SJ, Randall DA, Noguchi N, Blyth FM, Naganathan V. Multiple Peri-Operative Complications are Associated with Reduced Long Term Amputation Free Survival Following Revascularisation for Lower Limb Peripheral Artery Disease: A Population Based Linked Data Study. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. 2020;59(3):437-45. 10.1016/j.ejvs.2019.11.014 |
| Aitken S. J.,Lujic S.,Randall D. A.,Noguchi N.,Naganathan V.,Blyth F. M. Predicting outcomes in older patients undergoing vascular surgery using the Hospital Frailty Risk Score. British Journal of Surgery. 2020 Oct online: 10.1002/bjs.12043 |
| Aitken SJ, Thillainadesan T, Monaro S, Naganathan Vasi. Collaborative models of care for older vascular surgery patients admitted to hospital. ANZ Journal of Surgery. 2020;90(7-8): 1232-1233. 10.1111/ans.16086 |
| Bernier M, Harney D, Koay YC, Diaz A, Singh A, Wahl D, Pulpitel T, Ali A, Guiterrez V, Mitchell SJ, Kim EY, Mach J, Price NL, Aon MA, LeCouteur DG, Cogger VC, Fernandez-Hernando C, O'Sullivan J, Larance M, Cuervo AM, de Cabo R. Elucidating the mechanisms by which disulfiram protects against obesity and metabolic syndrome. NPJ aging and mechanisms of disease. 2020;6:8. 10.1038/s41514-020-0046-6 |
| Bernier M, Mitchell SJ, Wahl D, Diaz A, Singh A, Seo W, Wang M, Ali A, Kaiser T, Price NL, Aon MA, Kim EY, Petr MA, Cai H, Warren A, Di Germanio C, Di Francesco A, Fishbein K, Guiterrez V, Harney D, Koay YC, Mach J, Enamorado IN, Pulpitel T, Wang Y, Zhang J, Zhang L, Spencer RG, Becker KG, Egan JM, Lakatta EG, O'Sullivan J, Larance M, LeCouteur DG, Cogger VC, Gao B, Fernandez-Hernando C, Cuervo AM, de Cabo R. Disulfiram Treatment Normalizes Body Weight in Obese Mice. Cell metabolism. 2020. 32(2), 203-214.e4. 10.1016/j.cmet.2020.04.019 |
| Bertoldo MJ, Listijono DR, Ho WJ, Riepsamen AH, Goss DM, Richani D, Jin XL, Mahbub S, Campbell JM, Habibalahi A, Loh WN, Youngson NA, Maniam J, Wong ASA, Selesniemi K, Bustamante S, Li C, Zhao Y, Marinova MB, Kim LJ, Lau L, Wu RM, Mikolaizak AS, Araki T, Le Couteur DG, Turner N, Morris MJ, Walters KA, Goldys E, O'Neill C, Gilchrist RB, Sinclair DA, Homer HA, Wu LE. NAD+ Repletion Rescues Female Fertility during Reproductive Aging. Cell reports. 2020;30(6):1670-81.e7. 10.1016/j.celrep.2020.01.058 |
| Cervo MMC, Scott D, Seibel MJ, Cumming RG, Naganathan V, Blyth FM, Le Couteur DG, Handelsman DJ, Ribeiro RV, Waite LM, Shivappa N, Hebert JR, Hirani V. Proinflammatory Diet Increases Circulating Inflammatory Biomarkers and Falls Risk in Community-Dwelling Older Men. The Journal of nutrition. 2020;150(2):373-81. 10.1093/jn/nxz256 |
| Chen R, Irving M, Clive Wright FA, Cunich M. An evaluation of health workforce models addressing oral health in residential aged care facilities: A systematic review of the literature. Gerodontology. 2020; 37(3): 222-232. 10.1111/ger.12475 |
| Cumming R, Khalatbari-Soltani S, Blyth F, Naganathan V, Le Couteur D. Not all older men have the chronic diseases associated with severe COVID-19. Australasian Journal on Ageing. 2020;39(4): 381-382. 10.1111/ajag.12839 |
| Das A, Cumming RG, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Ribeiro RV, Simpson JS, Hirani V. Dietary and supplemental antioxidant intake and risk of major adverse cardiovascular events in older men: The Concord Health and Ageing in Men Project. Nutrition, Metabolism and Cardiovascular Diseases 31: 1102-1112, 2021. 10.1016/j.numecd.2020.11.032 |
| Das A, Cumming RG, Naganathan V, Blyth F, Ribeiro RV, Le Couteur DG, Handelsman DJ, Waite LM, Simpson SJ, Hirani V. Prospective Associations Between Dietary Antioxidant Intake and Frailty in Older Australian Men: The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(2):348-56. 10.1093/gerona/glz054 |
| Ford GA, Lord JM, Ferguson MAJ, Bountra C, Le Couteur DG. Organizational Innovation for Developing New Medicines That Target Aging and Age-Related Conditions. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(1):87-8. 10.1093/gerona/glz062 |
| Freire T, Senior AM, Perks R, Pulpitel T, Clark X, Brandon AE, Wahl D, Hatchwell L, Le Couteur DG, Cooney GJ, Larance M, Simpson SJ, Solon-Biet SM. Sex-specific metabolic responses to 6 hours of fasting during the active phase in young mice. The Journal of physiology. 2020;598(11):2081-92. 10.1113/JP278806 |
| Gnanenthiran SR, Ng ACC, Cumming R, Brieger DB, Le Couteur D, Waite L, Handelsman D, Naganathan V, Kritharides L, Blyth F. Low total cholesterol is associated with increased major adverse cardiovascular events in men aged ≥70 years not taking statins. Heart (British Cardiac Society). 2020;106(9):698-705. 10.1136/heartjnl-2019-315449 |
| Handelsman DJ, Desai R, Seibel MJ, Le Couteur DG, Cumming RG. Circulating Sex Steroid Measurements of Men by Mass Spectrometry Are Highly Reproducible after Prolonged Frozen Storage. The Journal of steroid biochemistry and molecular biology. 2020;197:105528. 10.1016/j.jsbmb.2019.105528 |
| Hew JJ, Parungao RJ, Tsai KH, Shi H, Ma D, Nicholls C, Li Z, Solon-Biet SM, D'Souza M, Le Couteur DG, Simpson SJ, Jeschke MG, Maitz PK, Wang Y. Geometric framework reveals that a moderate protein, high carbohydrate intake is optimal for severe burn injury in mice. The British journal of nutrition. 2020;123(9):1056-67. 10.1017/S0007114520000276 |
| Hide D, Warren A, Fernández-Iglesias A, Maeso-Díaz R, Peralta C, Le Couteur DG, Bosch J, Cogger VC, Gracia-Sancho J. Ischemia/Reperfusion Injury in the Aged Liver: The Importance of the Sinusoidal Endothelium in Developing Therapeutic Strategies for the Elderly. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(2):268-77. 10.1093/gerona/glz012 |
| Hsu B, Naganathan V, Blyth FM, Hirani V, Le Couteur DG, Waite LM, Seibel MJ, Handelsman DJ, Cumming RG. Frailty and Cause-Specific Hospitalizations in Community-Dwelling Older Men. The journal of nutrition, health & aging. 2020;24(6):563-9. 10.1007/s12603-020-1352-1 |
| Hubbard RE, Maier AB, Hilmer SN, Naganathan V, Etherton-Beer C, Rockwood K. Frailty in the face of COVID-19. Age and ageing. 2020;49(4):499-500. 10.1093/ageing/afaa095 |
| Hunt NJ, Lockwood GP, Kang SWS, Pulpitel T, Clark X, Mao H, McCourt PAG, Cooney GJ, Wali JA, Le Couteur FH, Le Couteur DG, Cogger VC. The Effects of Metformin on Age-Related Changes in the Liver Sinusoidal Endothelial Cell. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(2):278-85. 10.1093/gerona/glz153 |
| Hunt NJ, Lockwood GP, Le Couteur FH, McCourt PAG, Singla N, Kang SWS, Burgess A, Kuncic Z, Le Couteur DG, Cogger VC. Rapid Intestinal Uptake and Targeted Delivery to the Liver Endothelium Using Orally Administered Silver Sulfide Quantum Dots. ACS nano. 2020;14(2):1492-507. 10.1021/acsnano.9b06071 |
| Johnson George, Blinkhorn Anthony, Byun Roy, Foster Kirsty, Wright Fredrick A Clive. The workforce outcomes of dental graduates from a metropolitan school ‘Rural Clinical Placement Program’ versus a ‘Rural Clinical School’. International Dental Journal. 2020;70(3):214-226. 10.1111/idj.12541 |
| Khalatbari-Soltani S, Blyth FM, Naganathan V, Handelsman DJ, Le Couteur DG, Seibel MJ, Waite LM, Cvejic E, Cumming RG. Socioeconomic status, health-related behaviours, and death among older people: the Concord health and aging in men project prospective cohort study. BMC geriatrics. 2020;20(1):261. 10.1186/s12877-020-01648-y |
| Khalatbari-Soltani S, Stanaway F, Cvejic E, Blyth F, Naganathan V, Handelsman D, Le Couteur D, Seibel M, Waite L, and Cumming R. Contribution of psychosocial factors to socioeconomic inequalities in mortality among older Australian men: a population-based cohort study. International Journal for Equity in Health. 2020. 19, 177. 10.1186/s12939-020-01277-2 |
| Le Couteur DG, Anderson RM, Newman AB. COVID-19 Through the Lens of Gerontology. The journals of gerontology Series A, Biological sciences and medical sciences. 2020 Sep 16;75(9):e119-e120. 10.1093/gerona/glaa077 |
| Le Couteur DG, Anderson RM, Newman AB. Erratum to: COVID-19 Through the Lens of Gerontology. The journals of gerontology Series A, Biological sciences and medical sciences. 2020. doi.org/10.1093/gerona/glaa080 |
| Le Couteur DG, Ribeiro R, Senior A, Hsu B, Hirani V, Blyth FM, Waite LM, Simpson SJ, Naganathan V, Cumming RG, Handelsman DJ. Branched chain amino acids, cardiometabolic risk factors and outcomes in older men: the Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2020 Sep 25;75(10):1805-1810. 10.1093/gerona/glz192 |
| Le Couteur DG, Stanaway F, Waite LM, Cullen J, Lindley RI, Blyth FM, Naganathan V, Cumming RG, Handelsman DJ. Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2020 Sep 25;75(10):1858-1862. 10.1093/gerona/glaa105 |
| Le Couteur, D., Solon-Biet, S., Cogger, V., Ribeiro, R., De Cabo, R., Raubenheimer, D., Cooney, G., Simpson, S. Branched chain amino acids, aging and age-related health.Ageing Research Reviews, 2020;64, 1-11. 10.1016/j.arr.2020.101198 |
| Li J, Zhao Y, Choi J, Ting KK, Coleman P, Chen J, Cogger VC, Wan L, Shi Z, Moller T, Zheng X, Vadas MA, Gamble JR. Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice. PLoS biology. 2020;18(6):e3000734. 10.1371/journal.pbio.3000734 |
| Moth EB, Blinman P, Stefanic N, Naganathan V, Grimison P, Stockler MR, Beale P, Martin A, Kiely BE. Estimating survival time in older adults receiving chemotherapy for advanced cancer. Journal of geriatric oncology. 2020;11(4):617-25. 10.1016/j.jgo.2019.08.013 |
| Moth EB, Kiely BE, Martin A, Naganathan V, Della-Fiorentina S, Honeyball F, Zielinski R, Steer C, Mandaliya H, Ragunathan A, Blinman P. Older adults' preferred and perceived roles in decision-making about palliative chemotherapy, decision priorities and information preferences. Journal of geriatric oncology. 2020;11(4):626-32. 10.1016/j.jgo.2019.07.026 |
| Ortega-Ribera M, Hunt NJ, Gracia-Sancho J, Cogger VC. The Hepatic Sinusoid in Aging and Disease: Update and Advances From the 20th Liver Sinusoid Meeting. Hepatology communications. 2020;4(7):1087-98. 10.1002/hep4.1517 |
| Scott D, Seibel MJ, Cumming R, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Hsu B, Waite LM, Hirani V. Associations of Body Composition Trajectories with Bone Mineral Density, Muscle Function, Falls, and Fractures in Older Men: The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(5):939-45. 10.1093/gerona/glz184 |
| Scott D, Seibel MJ, Cumming R, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Hsu B, Waite LM, Hirani V. Comparison of clinical risk factors for incident fracture in obese and non-obese community-dwelling older men. Bone. 2020;137:115433. 10.1016/j.bone.2020.115433 |
| Simpkins DM, Hohenberg MI, Naganathan V, White K. Help, I'm a specialist! Perspectives of recently qualified geriatricians on the experiences and challenges of working as a consultant geriatrician. Australasian journal on ageing. 2020;39(1):73-80. 10.1111/ajag.12670 |
| Solon-Biet SM, McMahon AC, Ballard JWO, Ruohonen K, Wu LE, Cogger VC, Warren A, Huang X, Pichaud N, Melvin RG, Gokarn R, Khalil M, Turner N, Cooney GJ, Sinclair DA, Raubenheimer D, Le Couteur DG, Simpson SJ. Published Erratum: The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. Cell metabolism. 2020;31(3):654. 10.1016/j.cmet.2020.01.010 |
| Stanaway FF, Blyth FM, Naganathan V, Le Couteur DG, Ribeiro R, Hirani V, Waite LM, Handelsman DJ, Seibel MJ, Cumming RG. Mortality Paradox of Older Italian-Born Men in Australia: The Concord Health and Ageing in Men Project. Journal of immigrant and minority health. 2020;22(1):102-9. 10.1007/s10903-019-00874-w |
| Takehara S, Wright FAC, Waite LM, Naganathan V, Hirani V, Blyth FM, Le Couteur DG, Seibel MJ, Handelsman DJ, Cumming RG. Oral health and cognitive status in the Concord Health and Ageing in Men Project: A cross-sectional study in community-dwelling older Australian men. Gerodontology. 2020;37(4):353-360. DOI: 10.1111/ger.12469 |
| Teng Claris, Loy Clement T, Sellars Marcus, Pond Dimity, Latt Mark D, Waite Louise M, Sinka Victoria, Logeman Charlotte, Tong Allison. Making Decisions About Long-Term Institutional Care Placement Among People With Dementia and Their Caregivers: Systematic Review of Qualitative Studies. The Gerontologist. 2020;60(4): e329–e346. 10.1093/geront/gnz046 |
| Thillainadesan J, Scott IA, Le Couteur DG. Frailty, a multisystem ageing syndrome. Age and ageing. 2020 Aug 24;49(5):758-763. 10.1093/ageing/afaa112 |
| Thillainadesan J, Yumol MF, Hilmer S, Aitken SJ, Naganathan V. Interventions to Improve Clinical Outcomes in Older Adults Admitted to a Surgical Service: A Systematic Review and Meta-analysis. Journal of the American Medical Directors Association. 2020 Dec;21(12):1833-1843.e20. 10.1016/j.jamda.2020.03.023 |
| Valdez E, Wright FAC, Naganathan V, Milledge K, Blyth FM, Hirani V, Le Couteur DG, Handelsman DJ, Waite LM, Cumming RG. Frailty and oral health: Findings from the Concord Health and Ageing in Men Project. Gerodontology. 2020;37(1):28-37. doi: 10.1111/ger.12438 |
| Wahl, D., Anderson, R. M., Le Couteur, D. G. Antiaging therapies, cognitive impairment, and dementia. Journals of Gerontology Series A-Biological Sciences & Medical Sciences. 2020; 75(9), 1643-1652. 10.1093/gerona/glz135 |
| Wang H, Burke LJ, Patel J, Tse BW, Bridle KR, Cogger VC, Li X, Liu X, Yang H, Crawford DHG, Roberts MS, Gao W, Liang X. Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury. Theranostics. 2020;10(15):6715-27. 10.7150/thno.44900 |
| Weir KR, Naganathan V, Bonner C, McCaffery K, Rigby D, McLachlan AJ, Jansen J. Pharmacists' and older adults' perspectives on the benefits and barriers of Home Medicines Reviews - a qualitative study. Journal of health services research & policy. 2020;25(2):77-85. 10.1177/1355819619858632 |
| Wright FAC, Takehara S, Stanaway FF, Naganathan V, Blyth FM, Hirani V, Le Couteur DG, Handelsman DJ, Waite LM, Seibel MJ, Cumming RG. Associations between oral health and depressive symptoms: Findings from the Concord Health and Ageing in Men Project. Australasian journal on ageing. 2020;39(3): e306-e314. doi.org/10.1111/ajag.12763 |
| Wu, H., Mach, J., Le Couteur, D. G., Hilmer, S. N. Fall-related mortality trends in Australia and the United Kingdom: implications for research and practice. Maturitas. 2020;142, 68-72. 10.1016/j.maturitas.2020.07.008 |
| Baysari MT, Duong M, Zheng WY, Nguyen A, Lo S, Ng B, Ritchie A, Le Couteur D, McLachlan A, Bennett A, Hilmer S. Delivering the right information to the right person at the right time to facilitate deprescribing in hospital: a mixed methods multisite study to inform decision support design in Australia. BMJ open. 2019;9(9):e030950. 10.1136/bmjopen-2019-030950 |
| Gaddam RR, Chambers S, Fraser R, Cogger VC, Le Couteur DG, Ishii I, Bhatia M. Cystathionine-Gamma-Lyase-Derived Hydrogen Sulfide-Regulated Substance P Modulates Liver Sieve Fenestrations in Caecal Ligation and Puncture-Induced Sepsis. International journal of molecular sciences. 2019;20(13). 10.3390/ijms20133191 |
| Gibney JM, Wright FA, D'Souza M, Naganathan V. Improving the oral health of older people in hospital. Australasian journal on ageing. 2019 Mar;38(1):33-38. doi: 10.1111/ajag.12588 |
| Hsu B, Hirani V, Cumming RG, Naganathan V, Blyth FM, Wright FC, Waite LM., Seibel MJ., Handelsman DJ., Le Couteur DG.. Cross-Sectional and Longitudinal Relationships Between Inflammatory Biomarkers and Frailty in Community-dwelling Older Men: The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2019;74(6):835-41. 10.1093/gerona/glx142 |
| Hunt NJ, Kang SWS, Lockwood GP, Le Couteur DG, Cogger VC. Hallmarks of Aging in the Liver. Computational and structural biotechnology journal. 2019;17:1151-61. 10.1016/j.csbj.2019.07.021 |
| Hunt NJ, Lockwood GP, Warren A, Mao H, McCourt PAG, Le Couteur DG, Cogger V. Manipulating fenestrations in young and old liver sinusoidal endothelial cells. American journal of physiology Gastrointestinal and liver physiology. 2019;316(1):G144-g54. 10.1152/ajpgi.00179.2018 |
| Johnson G, Byun R, Foster K, Wright F, Blinkhorn A. A longitudinal workforce analysis of a Rural Clinical Placement Program for final year dental students. Australian Dental Journal. 2019 Jun;64(2):181-192. doi: 10.1111/adj.12691. PMID: 30929266. |
| Jokanovic N, Aslani P, Carter S, Duong M, Gnjidic D, Jansen J, Le Couteur D, Hilmer S. Development of consumer information leaflets for deprescribing in older hospital inpatients: a mixed-methods study. BMJ open. 2019;9(12):e033303. 10.1136/bmjopen-2019-033303 |
| Kang SWS, Cogger VC, Le Couteur DG, Fu D. Multiple cellular pathways regulate lipid droplet homeostasis for the establishment of polarity in collagen sandwich-cultured hepatocytes. American journal of physiology Cell physiology. 2019;317(5):C942-c52. 10.1152/ajpcell.00051.2019 |
| Kashyap M, Thuermann P, Le Couteur DG, Abernethy DR, Hilmer SN. IUPHAR International geriatric clinical pharmacology curriculum for medical students. Pharmacological research. 2019;141:611-5. 10.1016/j.phrs.2019.01.032 |
| Koay YC, Wali JA, Luk AWS, Macia L, Cogger VC, Pulpitel TJ, Wahl D, Solon-Biet SM, Holmes A, Simpson SJ, O'Sullivan JF. Ingestion of resistant starch by mice markedly increases microbiome-derived metabolites. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019;33(7):8033-42. 10.1096/fj.201900177R |
| Mach J., Huizer-Pajkos A., Cogger V., McKenzie C., Le Couteur D., de Cabo R., Jones B., Hilmer S.. Corrigendum to: The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats. The journals of gerontology Series A, Biological sciences and medical sciences. 2019;74(3):332. 10.1093/gerona/gly160 |
| Maeso-Díaz R, Ortega-Ribera M, Lafoz E, Lozano JJ, Baiges A, Francés R, Albillos A, Peralta C, García-Pagán JC, Bosch J, Cogger VC, Gracia-Sancho J. Aging Influences Hepatic Microvascular Biology and Liver Fibrosis in Advanced Chronic Liver Disease. Aging and disease. 2019;10(4):684-98. 10.14336/AD.2019.0127 |
| Mao H, Diekmann R, Liang HPH, Cogger VC, Le Couteur DG, Lockwood GP, Hunt NJ, Schüttpelz M, Huser TR, Chen VM and McCourt PAG. Cost-efficient nanoscopy reveals nanoscale architecture of liver cells and platelets. Nanophotonics;8(7): 1299-1313. doi.org/10.1515/nanoph-2019-0066 |
| Morimoto J., Senior A., Ruiz K., Wali J., Pulpite, T., Solon-Biet S., Cogger V., Raubenheimer D., Le Couteur D., Simpson S., Eberhard J.. Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis. PloS one. 2019;14(3):e0212796. 10.1371/journal.pone.0212796 |
| Moth EB, Kiely BE, Stefanic N, Naganathan V, Martin A, Grimison P, StocklerMR, Beale P, Blinman P. Predicting chemotherapy toxicity in older adults: Comparing the predictive value of the CARG Toxicity Score with oncologists' estimates of toxicity based on clinical judgement. Journal of geriatric oncology. 2019;10(2):202-9. 10.1016/j.jgo.2018.08.010 |
| Moth, E., Kiely, B., Stefanic, N., Naganathan, V., Martin, A., Grimison, P., Stockler, M., Beale, P., Blinman, P.. Oncologists' perceptions on the usefulness of geriatric assessment measures and the CARG toxicity score when prescribing chemotherapy for older patients with cancer. Journal of geriatric oncology. 2019;10(2):210-5. 10.1016/j.jgo.2018.11.004 |
| Naganathan V. Prescribing to the Oldest Old. In: Nagaratnam N., Nagaratnam K., Cheuk G., editors. Advanced Age Geriatric Care: A Comprehensive Guide. Springer, Cham; 2019. p 297-304. doi.org/10.1007/978-3-319-96998-5 |
| Naganathan V., Nagaratnam K. Managing Osteoporosis in Oldest of Old. In: Nagaratnam N., Nagaratnam K., Cheuk G., editors. Advanced Age Geriatric Care: A Comprehensive Guide. Springer, Cham; 2019. p 217-221. doi.org/10.1007/978-3-319-96998-5 |
| Narayan SW, Pearson SA, Litchfield M, Le Couteur DG, Buckley N, McLachlan AJ, Zoega H. Anticholinergic medicines use among older adults before and after initiating dementia medicines. British journal of clinical pharmacology. 2019;85(9):1957-63. 10.1111/bcp.13976 |
| Rhee J, Meller A, Krysinska K, Gonski P, Naganathan V, Zwar N, Hayen A, Cullen J, O’Keefe JA, McDonald J, Harris-Roxas B, Caplan GA. Advance care planning for patients with advanced illnesses attending hospital outpatient clinics study: a study protocol for a randomised controlled trial. BMJ open. 2019;9(1):e023107. 10.1136/bmjopen-2018-023107 |
| Ribeiro R.V., Solon-Biet S.M., Pulpitel T., Senior A.M., Cogger V.C., Clark X., O’Sullivan J., Koay Y.C., Hirani V., Blyth F.M., Seibel M.J., Waite L.M., Naganathan V., Cumming R.G., Handelsman D.J., Simpson S.J., Couteur D.G.L. Of Older Mice and Men: Branched-Chain Amino Acids and Body Composition. Nutrients. 2019;11(8). 10.3390/nu11081882 |
| Ribeiro RV, Simpson SJ, Le Couteur DG, Raubenheimer D, Eberhard J, Ruiz K, Macia L, Todorova Y, Gosby AK. The nutrition for healthy living study: A randomised clinical trial assessing the effect of protein sources on healthy ageing Nutrition and Healthy Aging 2019;5(1): 43-51. 10.3233/NHA-180055 |
| Scott IA, Hilmer SN, Le Couteur DG. Going Beyond the Guidelines in Individualising the Use of Antihypertensive Drugs in Older Patients. Drugs & aging. 2019;36(8):675-85. 10.1007/s40266-019-00683-8 |
| Scott, D., Seibel M., Cumming R., Naganathan V., Blyth F., Le Couteur D., Handelsman D., Waite L., Hirani V. Does Combined Osteopenia/Osteoporosis and Sarcopenia Confer Greater Risk of Falls and Fracture Than Either Condition Alone in Older Men? The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2019;74(6):827-34. 10.1093/gerona/gly162 |
| Senior AM, Solon-Biet SM, Cogger VC, Le Couteur DG, Nakagawa S, Raubenheimer D, Simpson SJ. Dietary macronutrient content, age-specific mortality and lifespan. Proceedings Biological sciences. 2019;286(1902):20190393. 10.1098/rspb.2019.0393 |
| Shu CC, Hsu B, Cumming RG, Blyth FM, Waite LM, Le Couteur DG, Handelsman DJ, Naganathan V. Caregiving and all-cause mortality in older men 2005-15: the Concord Health and Ageing in Men Project. Age and ageing. 2019;48(4):571-6. doi.org/10.1093/ageing/afz039 |
| Simpson SJ, Le Couteur DG. The diet and the damage done. Nature metabolism. 2019;1(11):1030-1. 10.1038/s42255-019-0128-6 |
| Solon-Biet SM, Cogger VC, Pulpitel T, Wahl D, Clark X, Bagley E, Gregoriou GC, Senior AM, Wang QP, Brandon AE, Perks R, O'Sullivan J, Koay YC, Bell-Anderson K, Kebede M, Yau B, Atkinson C, Svineng G, Dodgson T, Wali JA, Piper MDW, Juricic P, Partridge L, Rose AJ, Raubenheimer D, Cooney GJ, Le Couteur DG, Simpson SJ. Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nature metabolism. 2019;1(5):532-45. 10.1038/s42255-019-0059-2 |
| Solon-Biet SM, Wahl D, Raubenheimer D, Cogger V., Le Couteur DG, Simpson SJ. The geometric framework: An approach for studying the impact of nutrition on healthy aging. Drug Discovery Today: Disease Models 2019; 27; 61-68. doi.org/10.1016/j.ddmod.2019.03.002 |
| Thillainadesan J, Hilmer SN, Close J, Kearney L, Naganathan V Geriatric medicine services for older surgical patients in acute hospitals: Results from a binational survey Australasian Journal on Ageing 2019; 38(4):278-283. 10.1111/ajag.12675 |
| Thomas R, Sims R, Beller E, Scott A., Doust J, Le Couteur DG, Pond D, Loy C, Forlini C., Glasziou P. An Australian community jury to consider case-finding for dementia: Differences between informed community preferences and general practice guidelines. Health Expectations, 2019 22(3), 475-484. 10.1111/hex.12871 |
| Toyama T, van den Broek-Best O, Ohkuma T, Handelsman D, Waite LM, Seibel MJ, Cumming R, Naganathan V, Sherrington C, Hirani V, Wang AY. Associations of Impaired Renal Function With Declines in Muscle Strength and Muscle Function in Older Men: Findings From the CHAMP Study. The journals of gerontology Series A, Biological sciences and medical sciences. 2019;74(11):1812-20. 10.1093/gerona/glz100 |
| Tran J, Wright FAC, Takehara S, Chu C-C, Naganathan V., Hirani V., Blyth FM, Le Couteur DG, Waite L, Handelsman DJ, Seibel M, Milledge K, Cumming RG. Oral health behaviours of older Australian men: the Concord Health and Ageing in Men Project. Australian dental journal. 2019;64(3):246-55. 10.1111/adj.12694 |
| Wahl D, Gokarn R, Mitchell SJ, Solon-Biet SM, Cogger VC, Simpson SJ, Le Couteur DG., de Cabo R. Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice. Nutrition and healthy aging. 2019;5(2):111-7. 10.3233/NHA-180059 |
| Wahl D, Solon-Biet SM, Cogger VC, Fontana L, Simpson SJ, Le Couteur DG, Ribeiro RV. Aging, lifestyle and dementia. Neurobiology of disease. 2019;130:104481. 10.1016/j.nbd.2019.104481 |
| Weir KR, Bonner C, McCaffery K, Naganathan V, Carter SM, Rigby D, Trevena L, Mclachlan A, Jansen J. Pharmacists and patients sharing decisions about medicines: Development and feasibility of a conversation guide. Research in social & administrative pharmacy : RSAP. 2019;15(6):682-90. 10.1016/j.sapharm.2018.08.009 |
| Weir KR, Naganathan V, Rigby D, McCaffery K, Bonner C, Trevena L, McLachlan A, Jansen J. Home medicines reviews: a qualitative study of GPs’ experiences. Australian journal of primary health. 2019;26(1) 24-30 https://doi.org/10.1071/PY19072. |
| Wright FAC, Law GG, Milledge KL, Chu SK, Hsu B, Valdez E, Naganathan V, Hirani V, Blyth FM, LeCouteur DG, Waite LM, Handelsman DJ, Seibel MJ, Cumming RG. Chewing function, general health and the dentition of older Australian men: The Concord Health and Ageing in Men Project. Community dentistry and oral epidemiology. 2019;47(2):134-41. 10.1111/cdoe.12435 |
Our Presentations
2021
| Hunt N. 2021 Annual CPC EMCR Symposium. Nanotherapeutics improve metabolism in aging mice. Australia. 2021. |
| Hunt N. Australasian Diabetes Congress 2021. Nanomedicines formulations of metformin and nicotinamide mononucleotide dramatically improve metabolic properties in aging mice. Australia. 2021 |
| Hunt N. Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists 55th Annual Scientific Meeting. Nanoformulations of Insulin. Australia. 2021 |
| Hunt N. Liver Seminars: Young Investigators Edition, Online. Nanotechnology for cell specific drug delivery in the liver. Australia. 2021 |
| Hunt N. Sydney Nano: Meet the Author Series, Online. Targeted hepatic drug delivery using nanotechnology for metabolic and age-associated conditions. Australia. 2021 |
| Ischia L. (supervisor Dr Thillainadesan). ANZSGM Virtual Annual Scientific Meeting. 1 oral presentation. Australia. 2021 |
| Le Couteur DG. Nathan Shock Center Birmingham University. A geometric view of nutrition and aging. USA, 2021 |
| Le Couteur DG. National Geriatric Conference. Geriatric Medicine in health care of older people. Vietnam. 2021 |
| Thillainadesan J. 16th Annual Academic Surgical Congress (virtual). 2 oral presentations. USA. 2021 |
| Thillainadesan J. Age Anaesthesia Association Virtual Annual Scientific Meeting. 2 oral presentations. UK. 2021 |
| Thillainadesan J. ANZSGM Virtual Annual Scientific Meeting. 1 oral presentation. Australia. 2021 |
Centre for Education and Research on Ageing Research
Centre for Education and Research on Ageing (CERA)
Professor Vasi Naganathan and Professor Victoria Cogger