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Centre for Education and Research on Ageing Research

The Centre for Education and Research on Ageing (CERA) and its members undertake basic science, epidemiological and clinical research.

CERA is part of the Department of Geriatric Medicine at Concord Hospital. CERA is a multidisciplinary hub to foster collaboration between clinical and academic health professionals and facilitate the translation of research findings into clinical practice. The research objectives of CERA are:

  • To improve the health and productivity of older people through research into the ageing process
  • To improve the well-being and quality of life of older people, especially those with frailty or dementia, through research into health care
  • To provide leadership in the education and training of people involved in the care of older people and those involved in ageing research.

Our current research programs include:

  • Oral Health
  • Ageing liver and nanomedicines
  • Novel mechanisms for dementia
  • Surgical liaison and older people in hospital
  • Advanced care directives
  • Polypharmacy and deprescribing
  • Identification and management of delirium in older inpatients
  • Falls prevention in hospital
  • Geriatric Medicine Services in Australia and New Zealand
  • Emergency Hospital in the Home
  • Enhanced Education of Junior Doctors to Improve the Care and Outcomes of Hospitalised Older Adults.

Our Key Achievements

The Biogerontology group continues to explore the targeted use of medicines and other therapeutics. The group is collaborating with the Institut d'Investigacions Biomèdiques in Barcelona in the use of our nanotechnology for microRNA delivery for the prevention of liver failure.
Treating diabetes with nano insulin: positive mouse and primate studies now completed. Commercialisation with an Australian Biotech company underway in preparation for first in human clinical trials.
Preventing diabetes in an immune model of diabetes with nano insulin: mouse studies currently underway.
Amyloid- beta clearance in the liver, a novel target for preventing Alzheimer's Disease: currently underway by PhD candidate Glen Lockwood.
Targeted nanodelivery of gene therapy: currently underway by PhD candidate Lara Westwood.
Effectiveness, cost-effectiveness and implementation of Emergency Hospital in the Home (EHITH) model of care for older people: In 2022 a new model of care, EHITH, was launched within SLHD.
Collaboration with SLHD AHCC&R Disability Inclusion & Advice Service (DIAS) on development of their project, 'COVID-19 outbreaks in disability group homes within Sydney Local Health District (SLHD)'.
Professor David Le Couteur has a long-term collaboration with Professor of Geriatric Pharmacology, Sarah Hilmer, at the Kolling Institute Royal North Shore Hospital. CERA research pharmacist Sarita Lo is also a member of Professor Hilmer's research team. Their research collaborations include:
  • Optimising quality use of medicines in hospital to improve outcomes in older people (current)
  • 'TO HOME' research project (Towards Optimising Hospitalised Older adults' MEdications) (recently completed and in publication phase)
  • Evaluation of an Intervention Bundle to Reduce Inappropriate Polypharmacy in Older Inpatients: A Pilot Study (recently completed /and in publication phase)
  • Designing decision support to reduce inappropriate polypharmacy in older inpatients - Understanding user perceptions and workflows (completed).
Professor David Le Couteur is a member of the University of Sydney's Charles Perkins Centre (CPC). The CPC is a multidisciplinary research centre committed to improving global health. The projects examine the impact of nutrition on longevity and later life health.
Understanding and reducing falls in the inpatient hospital setting. Charlotte McLennan (PhD). Lead Supervisor Professor Cathie Sherrington (Institute of Musculoskeletal Health). Professor Vasi Naganathan is in the supervisory team.
The TOP UP Trial - A physiotherapy led telehealth and exercise intervention to improve mobility in older people receiving aged care services: an effectiveness and implementation randomised controlled trial. Rik Dawson (PhD) Lead Supervisor Professor Cathie Sherrington (Institute of Musculoskeletal Health), Vasi Naganathan (investigator).
Investigating a psychological strategy to support older adults in making informed cancer screening decisions. Jenna Smith (PhD). Primary Supervisor Professor Kirsten McCaffery, School of Public Health The University of Sydney. Professor Vasi Naganathan on supervisor team.
Intensive Care Unit (ICU) Protocols Influenza Pandemics Public's view. Dr Winston Cheung (PhD). Professor Vasi Naganathan (Lead Supervisor).

Our Research Team

CERA Co-Directors

Professor Vasi Naganathan Professor of Geriatric Medicine, University of Sydney and Consultant Geriatrician, Concord Hospital
Professor Victoria Cogger Associate Dean (Research Education), The University of Sydney / Co-leader Biogerontology laboratory

Department of Geriatric Medicine, Concord Hospital

Professor Vasi Naganathan Consultant Geriatrician
Professor David Le Couteur Senior Staff Specialist in Geriatric Medicine and Professor of Geriatric Medicine, The University of Sydney

Clinical Associate Professor John Cullen


Stream Director Sydney Local Health District Aged Health Care, Rehabilitation, General Medicine, Chronic Care, Disability, Endocrinology, Andrology and Ambulatory Care

Clinical Associate Professor, Concord Clinical School, The University of Sydney

Clinical Associate Professor Louise Waite

Senior Staff Specialist Geriatrician. Head of Department of Geriatric Medicine. Clinical Associate Professor, Concord Clinical School, University of Sydney

Dr Janani Thillainadesan Staff Specialist Geriatrician and Conjoint Lecturer, Concord Clinical School, University of Sydney
Clinical Associate Professor Deborah Cockrell Lead for Oral Health, CERA and Clinical Associate Professor, Concord Clinical School, University of Sydney
Dr Natasha Spalding Staff Specialist Geriatrician and Director of RACF Outreach Service
Dr Cameron Korb-Wells Geriatrician
Steven Chu Oral Health PhD student

Biogerontology Lab, ANZAC Research Institute

Professor Victoria Cogger Co-leader Biogerontology laboratory
Professor David Le Couteur Co-leader Biogerontology laboratory
Dr Nicholas Hunt Post-doctoral researcher
Glen Lockwood Laboratory Manager
Lara Westwood PhD Candidate

CERA Research Support Staff

Leanne Kearney CERA Research Project Officer
Sarita Lo CERA Research Pharmacist
Linda Koria EHITH Project Officer

Higher Degree Students

Winston Cheung PhD Candidate
Steven Chu PhD Candidate
Glen Lockwood PhD Candidate
Charlotte McLennan PhD Candidate
Jenna Smith PhD Candidate
Lara Westwood PhD Candidate
Eleni Azarias Masters (MPhil) student
Joshua Makary Masters (MPhil) student
Ganeshwaran Shivapathasundram Masters (MPhil) student
Bethany Stavert Masters (MPhil) student
Atul Wagh Masters (MPhil) student

Selected Grants

Amount awarded Project and investigator details
$12,981,420 NHMRC Program Grant, 2019-2023
Nutrition and complexity
Investigators: Simpson S, George J, Le Couteur D, Gunton J, Raubenheimer D, Durrant-Whyte H.
$2,800,000 MRFF, 2022-2025
Reshaping low back pain management in the emergency department.
Investigators: Maher C (CIA), Naganathan V (CIJ).
$2,500,000 NHMRC Centres of Research Excellence Scheme, 2020-2024
NHMRC Centre of Research Excellence in the Prevention of Fall-related Injuries
Associate Investigator: Naganathan V.
$1,989,324 ARC Centres of Excellence, 2017-2023
ARC Centre of Excellence in Population Ageing Research 2 (CEPAR 2), University of Sydney Node
Investigators: Baird M, Blyth F, Cumming R, Piggott J, McDonald P, Anstey K, Keane M, Parker S, Sherris M, Bateman H, Clarke P, McKibbin W, Woodland A.
$750,000 MRFF, 2022
Bringing oral insulin to phase I clinical studies using a novel quantum dot drug delivery platform.
Investigator: Hunt N.
$468,879 HCF Research Foundation, 2022-2024
Effectiveness, cost-effectiveness and implementation of Emergency Hospital in the Home model of care for older people
Investigators: Naganathan V, Cullen J, Blyth F, Cunich M.
$50,000 Therapeutic Innovations Australia, 2021-2022
Synthesis and characterisation of Ag2S quantum dots and conjugation to insulin at CSIRO.
Investigator: Hunt N.

Our Publications


Cheyne S, Lindley R, Smallwood N, Tendal B, Chapman M, Navarro DF, Good PD, McDonald S, Morgan D, Murano M, Millard T, Naganathan V, Srikanth V, Tuffin P, Vogel J, White H, Chakrabothy SP, Whiting E, William L, Yates PM, Callary M, Elliott J and Agar MR for the National COVID-19 Clinical Evidence Taskforce. Care of older people and people requiring palliative care with COVID-19: guidance from the Australian National COVID-19 Clinical Evidence Taskforce. The Medical Journal of Australia. 2022 Mar;216(4):203-208. doi.org/10.5694/mja2.51353
Chow EPF, Hsu B, Waite LM, Blyth FM, Handelsman DJ, Couteur DG, Naganathan V, Stanaway F. Diagnostic accuracy of linked administrative data for dementia diagnosis in community-dwelling older men in Australia. BMC Geriatrics. 2022 Nov; 22: 858 doi.org/10.1186/s12877-022-03579-2
Dai Z, Hirani V, Sahni S, Felson DT, Naganathan V, Blyth F, Le Couteur D, Handelsman D, Seibel MJ, Waite L, Kiel DP, Cumming R. Association of dietary fiber and risk of hip fracture in men from the Framingham Osteoporosis Study and the Concord Health and Ageing in Men Project. Nutrition and Health. 2022 Jun;28(2):229-238. 10.1177/02601060211011798.
Das A, Cumming RG, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Ribeiro RV, Simpson JS, Hirani V. Associations between dietary intake of total protein and sources of protein (plant vs. animal) and risk of all-cause and cause-specific mortality in older Australian men: The Concord Health and Ageing in Men Project. Journal of Human Nutrition and Dietetics. 2022 Oct; 35 (5), 845-860. 10.1111/jhn.12965
de Cabo R, Le Couteur DG. (2022) Biology of Aging. In: Harrisons Principles of Internal Medicine (21st Ed). Editors: Loscalzo J, Fauci AS, Kasper DL, Longo DL, Jameson JL, McGraw Hill. Columbus. https://accessmedicine.mhmedical.com/content.aspx?bookid=3095&sectionid…
Djekovic K, Clowes K, Spalding N, Waite L. A retrospective study of the behavioural and psychological symptoms of dementia in patients admitted to a Specialist Dementia Care Unit. Australasian Journal on Ageing. 2022 Mar. doi:10.1111/ajag.13060 (Epub ahead of print)
Eberhard, J., Ruiz, K., Tan, J., Jayasinghe, T.N., Khan, S., Eroglu, E., Adler, C., Simpson, S.J., Le Couteur, D.G., Raubenheimer, D., Macia, L., Gosby, A.K., Ribeiro, R.V. A randomized clinical trial to investigate the effect of dietary protein sources on periodontal health. Journal of Clinical Periodontology. 2022 Apr; 49 (4):388-400. DOI: 10.1111/jcpe.13587
Gnanenthiran, S.R., Ng, A.C.C., Cumming, R.G., Brieger, D.B., le Couteur, D.G., Waite, L.M., Seibel, M., Handelsman, D.J., Naganathan, V., Kritharides, L., Blyth, F.M. Hemoglobin, Frailty, and Long-term Cardiovascular Events in Community-Dwelling Older Men Aged ≥ 70 Years. Canadian Journal of Cardiology. 2022 Jun: 38 (6):745-753. doi.org/10.1016/j.cjca.2022.01.024
Hunt, N.J., McCourt, P.A.G., Kuncic, Z., Le Couteur, D.G., Cogger, V.C. Opportunities and Challenges for Nanotherapeutics for the Aging Population. Frontiers in Nanotechnology, 2022 Jan; 4, art. no. 832524. doi.org/10.3389/fnano.2022.832524
Hunt, N.J., Wahl, D., Westwood, L.J., Lockwood, G.P., Le Couteur, D.G., Cogger, V.C. Targeting the liver in dementia and cognitive impairment: Dietary macronutrients and diabetic therapeutics. Advanced Drug Delivery Reviews. 2022 Nov; 190: article 114537. doi.org/10.1016/j.addr.2022.114537
Ischia L., Naganathan V., Waite L.M., Le Couteur D.G., Thillainadesan J. COVID-19 and Geriatric Medicine in Australia and New Zealand. Australasian Journal on Ageing. 2022 Jun;41(2):301-308 doi.org/10.1111/ajag.13027.
Kiely, K.M., Khalatbari-Soltani, S., Blyth, F.M., Naganathan, V., Handelsman, D.J., Waite, L.M., Le Couteur, D.G., Mortby, M.E., Cumming, R.G., Anstey, K.J. Mixed Evidence of an Association between Self-Rated Hearing Difficulties and Falls: Prospective Analysis of Two Longitudinal Studies. Gerontology. 2022 May:1-11. doi: 10.1159/000524311 (Epub ahead of print)
Le Couteur DG, Anderson RM, de Cabo R. Can we make drug discovery targeting fundamental mechanisms of aging a reality? (invited editorial) Expert Opinion on Drug Discovery, 2022; 17(2):97-100. 10.1080/17460441.2022.1993818.
Le Couteur DG, Flicker L, Hilmer SN. Geriatric medicine and health care for older people in Australia. Age and Ageing 2022 March; 51(3):afac001. doi.org/10.1093/ageing/afac001
Le Couteur DG, Thillainadesan J. What is an aging-related disease? An epidemiological perspective. Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2022 Feb; doi: 10.1093/gerona/glac039. (Epub ahead of print)
Le Couteur, D.G., Raubenheimer, D., Solon-Biet, S., de Cabo, R., Simpson, S.J. Does diet influence aging? Evidence from animal studies. Journal of Internal Medicine. 2022 Jun.  doi.org/10.1111/joim.13530 (Epub ahead of print)
Lin A, Shaheen N, Ganda K, Cullen, Waite LM, Seibel M. Improving osteoporosis treatment rates in inpatients admitted with hip fracture: a healthcare improvement initiative in a tertiary referral hospital. Aging Medicine. 2022 Nov. doi.org/10.1002/agm2.12229 (Epub ahead of print)
Luong, R., Ribeiro., R.V., Rangan, A., Naganathan, V., Blyth, F., Waite, L.M., Handelsman, D.J., Cumming, R.G., Le Couteur, D.G., Hirani, V. Changes in Dietary Total and Nonheme Iron Intake Is Associated With Incident Frailty in Older Men: The Concord Health and Aging in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2022 Sept;77(9):1853-1865. doi: 10.1093/gerona/glac077
Mach, J., Allore, H., Gnjidic, D., Gemikonakli, G., Kane, A.E., Howlett, S.E., de Cabo, R., Le Couteur, D., Hilmer, S.N. Preclinical frailty assessments: Phenotype and frailty index identify frailty in different mice and are variably affected by chronic medications. Experimental Gerontology. 2022 May; 161:111700. doi.org/10.1016/j.exger.2022.111700
Page AT, Potter K, Naganathan V, Hilmer S, McLachlan AJ, Lindley RI, Coman T, Mangin D, Etherton- Beer C. Polypharmacy and medicine regimens in older adults in residential aged care. Archives of Gerontology and Geriatrics. 2022 Nov 4;105:104849. doi: 10.1016/j.archger.2022.104849 (Epub ahead of print)
Raubenheimer, D., Senior, A.M., Mirth, C., Cui, Z., Hou, R., Le Couteur, D.G., Solon-Biet, S.M., Léopold, P., Simpson, S.J. An integrative approach to dietary balance across the life course. iScience. 2022 Apr; 25(5):104315. doi: 10.1016/j.isci.2022.104315
Senior, A.M., Legault, V., Lavoie, F.B., Presse, N., Gaudreau, P., Turcot, V., Raubenheimer, D., Le Couteur, D.G., Simpson, S.J., Cohen, A.A. Multidimensional associations between nutrient intake and healthy ageing in humans. BMC Biology. 2022 Sep 1; 20(1):196. DOI: 10.1186/s12915-022-01395-z
Shi H, Tsai KH, Ma D, Wang X, Desai R, Parungao RJ, Hunt NJ, Cheng YY, Zhang H, Xu Y, Simanainen U, Tan Q, Cooper MS, Handelsman DJ, Maitz PK, Wang, Y. Controlled dual release of dihydrotestosterone and flutamide from polycaprolactone electrospun scaffolds accelerate burn wound healing. The FASEB Journal. 2022 May;36(5):e22310. doi: 10.1096/fj.202101803R.
Shu CC, Wright FAC, Naganathan V, Blyth M, Le Couteur DG, Handelsman D.J, Stanaway FF. Does social support predict increased use of dental services in older men? Australian Dental Journal. 2022 Sept; 67(3):262-270. https://doi.org/10.1111/adj.12911
Sirimanna, P., Boyce, S., Gunanayagam, P., Gladman, M.A. and Naganathan, V. Development of a rating scale for objective assessment of performance in laparoscopic appendicectomy surgery. ANZ Journal of Surgery. 2022 Jul-Aug;92(7-8):1724-1730. https://doi.org/10.1111/ans.17601
Sirimanna, P., Ravindran, P., Smigielski, M., Gladman, M.A., Naganathan, V. Validation and reliability testing of a rating scale for objective assessment of performance in laparoscopic appendicectomy surgery. ANZ Journal of Surgery. 2022 Jul-Aug; 92(7-8):1731-1736. DOI: 10.1111/ans.17862
Solon-Biet, S.M., Griffiths, L., Fosh, S., Le Couteur, D.G., Simpson, S.J., Senior, A.M. Meta-analysis links dietary branched-chain amino acids to metabolic health in rodents. BMC Biology. 2022 Jan; 20 1): 19. DOI: doi.org/10.1186/s12915-021-01201-2
Stavert B, Monaro S, Naganathan V, Aitken S. Frailty predicts increased risk of reintervention in the 2 years after arteriovenous fistula creation. The Journal of Vascular Access. 2022 Apr 21;11297298221088756. doi:10.1177/11297298221088756 (Epub ahead of print)
Stavert, B.M., Monaro, S., Tienstra, L., Naganathan, V., Aitken, S.J. Protocol for a qualitative study exploring haemodialysis dependent patients' arteriovenous fistula experience, values and concerns in Sydney, Australia. BMJ Open. 2022 June; 12(6):e058152. DOI: 10.1136/bmjopen-2021-058152
Thillainadesan J, Hilmer SN, Fleury AM, Naganathan V. New horizons in the perioperative care of older adults. Age and Ageing. 2022 Feb 2;51(2):afab245. doi: 10.1093/ageing/afab245
Thillainadesan J., Monaro S., Aitken S., Kerdic R., Cullen J., Naganathan V. Geriatric Comanagement of Older Vascular Surgery Inpatients Reduces Hospital-Acquired Geriatric Syndromes. Journal of the American Medical Directors Association. 2022 Apr;23(4):589-595.e6. doi: 10.1016/j.jamda.2021.09.037. Epub 2021 Oct 29.
Thillainadesan, J., Charlton, G., Wang, J. Targeted microlearning: Teaching geriatric medicine to Gen Y and Gen Z junior doctors. Australasian Journal on Ageing. 2022 Aug. doi: 10.1111/ajag.13130. (Epub ahead of print)
Thillainadesan, J., Le Couteur, D.G., Haq, I., Wilkinson, T.J. When I say ... microlearning. Medical Education. 2022 Jun; 56 (8):791-792. doi.org/10.1111/medu.14848
Vardy, J.L., Pond, G.R., Cysique, L.A., Gates, T.M., Lagopoulos, J., Renton, C., Waite, L.M., Tannock, I.F., Dhillon, H.M. Lack of cognitive impairment in long-term survivors of colorectal cancer. Supportive Care in Cancer. 2022 Jul; 30(7): 6123-6133. DOI: 10.1007/s00520-022-07008-3
Wright, F.A.C., Shu, E.C.C., Cumming, R.G., Naganathan, V., Blyth, F.M., Hirani, V., Le Couteur, D.G., Handelsman, D.J., Seibel, M.J., Waite, L.M., Stanaway, F.F. Oral health-related quality of life of older Australian men. Community Dentistry and Oral Epidemiology. 2022 May:1-11. doi.org/10.1111/cdoe.12754 (Epub ahead of print)
Wu, H., Mach, J., Gnjidic, D., Naganathan, V., Blyth, F., Waite, L., Handelsman, D., Le Couteur, D., Hilmer, S. Comparing Effects of Polypharmacy on Inflammatory Profiles in Older Adults and Mice: Implications for Translational Ageing Research. Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2022 Jul; 77(7):1295-1303. glac061, /doi.org/10.1093/gerona/glac061
Xu P, Blyth F.M, Naganathan V, Cumming R.G, Handelsman D.J, Seibel M.J, Le Couteur D.G, Waite L.M, and Khalatbari-Soltani S: Socioeconomic inequalities in elective and non-elective hospitalizations in older men. JAMA Network Open. 2022 Apr 1;5(4):e226398. doi:10.1001/jamanetworkopen.2022.6398

Our Presentations


Blyth F. Populations and patients - are they two sides of the same coin? Sydney Health Partners Geriatric Clinical Academic Group (CAG) Launch. Sydney. 2022.
Cogger V. The Biology of the Ageing Liver. The 2022 Liver Sinusoid Meeting, China.
Hunt N. Oral nanoformulations of Insulin. British Pharmacological Society. 2022.
Kawamura J. Prevalence and association of antipsychotic drugs with falls in hospitalised older adults. APSA-ASCEPT. 2022 Joint Conference (Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists). (Second year medical student project - supervisor Dr Janani Thillainadesan).
Lin J. Pharmacist consultations in hospitalised older surgical patients. APSA-ASCEPT 2022 Joint Conference (Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists). (First year medical student project - supervisor Dr Janani Thillainadesan).
Naganathan V. Gerontology training programs and research projects in Australia. The 3rd Vietnam National Geriatric Conference Program, Hanoi, Vietnam. 2022.
Naganathan V. How does research influence everyday clinical practice? Sydney Health Partners Geriatric Clinical Academic Group (CAG) Launch. Sydney. 2022.
Naganathan V. Perspectives on the teaching of Geriatric Medicine. Professor Vasi Naganathan, ANZSGM State Meeting in South Australia. 2022.
Naganathan V. Research does (and does not) influence everyday Geriatric Medicine Practice and Service Development. Professor Vasi Naganathan, ANZSGM State Meetings in QLD and South Australia. 2022.
Thillainadesan J. A collaborative model of proactive geriatrician care and education of junior doctors improves hospital care of older surgical patients (oral presentation). Australian and New Zealand Society for Geriatric Medicine (ANZSGM) Virtual Annual Scientific Meeting. 2022.
Thillainadesan J. A shared model of care on vascular surgery wards. 2022 Princess Alexandria Hospital Health Symposium.
Thillainadesan J. CGA delivery and education to improve clinician practice and patient outcomes. John A. Burns School of Medicine Geriatric Fellows, Hawaii, USA. 2022.
Thillainadesan J. Collaborative model of care. Sydney Health Partners Geriatric Clinical Academic Group (CAG) Launch. Sydney. 2022.
Thillainadesan J. Frailty and the surgical patient. COALFACE GERIATRICS: Managing Comorbidity in an Older Person (Hunter Postgraduate Medical Institute). 2022.
Thillainadesan J. Geriatric Surgical Services around Australia and New Zealand. Virtual roadshow by Australian and New Zealand Society for Geriatric Medicine. 2022.
Thillainadesan J. Geriatrician co-management and education of junior doctors improve the care of hospitalized older surgical patients. Gerontological Society of America (GSA) Annual Scientific Meeting, USA. 2022.
Thillainadesan J. Health Professions Education Research Micro-Conference (virtual). 2022.
Thillainadesan J. How to manage quality of life and life expectancy - frailty and co-morbidities in urology management. 19th Urological Association of Asia Congress. 2022.
Thillainadesan J. Perioperative care in vascular wards. ANZCA 2022 Perioperative Medicine Special Interest Group meeting. 2022.
Thillainadesan J. The Role of Frailty and Resilience in Surgery'. Evidence-Based Perioperative Medicine. Asia Congress. Singapore. 2022.
Thillainadesan J. What matters to older surgical patients and their carers during hospitalisation? Australian and New Zealand Society for Geriatric Medicine (ANZSGM) Virtual Annual Scientific Meeting. 2022.
Thillainadesan J. What matters to older surgical patients and their carers during their hospitalization? Gerontological Society of America (GSA) Annual Scientific Meeting, USA. 2022.