Centre for Education and Research on Ageing Research

The Centre for Education and Research on Ageing (CERA) and its members undertake basic science, epidemiological and clinical research.

CERA is part of the Department of Geriatric Medicine at Concord Hospital. CERA is a multidisciplinary hub to foster collaboration between clinical and academic health professionals and facilitate the translation of research findings into clinical practice. The research objectives of CERA are:

To improve the health and productivity of older people through research into the ageing process
To improve the well-being and quality of life of older people, especially those with frailty or dementia, through research into health care
To provide leadership in the education and training of people involved in the care of older people and those involved in ageing research.

Our current research programs include:

Oral Health
Ageing liver and nanomedicines
Novel mechanisms for dementia
Surgical liaison and older people in hospital
Advanced care directives
Polypharmacy and deprescribing
Identification and management of delirium in older inpatients
Falls prevention in hospital
Geriatric Medicine Services in Australia and New Zealand
Emergency Hospital in the Home
Enhanced Education of Junior Doctors to Improve the Care and Outcomes of Hospitalised Older Adults.

Our Key Achievements

The Biogerontology group continues to explore the targeted use of medicines and other therapeutics. The group is collaborating with the Institut d'Investigacions Biomèdiques in Barcelona in the use of our nanotechnology for microRNA delivery for the prevention of liver failure.

Treating diabetes with nano insulin: positive mouse and primate studies now completed. Commercialisation with an Australian Biotech company underway in preparation for first in human clinical trials.

Preventing diabetes in an immune model of diabetes with nano insulin: mouse studies currently underway.

Amyloid- beta clearance in the liver, a novel target for preventing Alzheimer's Disease: currently underway by PhD candidate Glen Lockwood.

Targeted nanodelivery of gene therapy: currently underway by PhD candidate Lara Westwood.

Effectiveness, cost-effectiveness and implementation of Emergency Hospital in the Home (EHITH) model of care for older people: In 2022 a new model of care, EHITH, was launched within SLHD.

Collaboration with SLHD AHCC&R Disability Inclusion & Advice Service (DIAS) on development of their project, 'COVID-19 outbreaks in disability group homes within Sydney Local Health District (SLHD)'.

Professor David Le Couteur has a long-term collaboration with Professor of Geriatric Pharmacology, Sarah Hilmer, at the Kolling Institute Royal North Shore Hospital. CERA research pharmacist Sarita Lo is also a member of Professor Hilmer's research team. Their research collaborations include:

Optimising quality use of medicines in hospital to improve outcomes in older people (current)
'TO HOME' research project (Towards Optimising Hospitalised Older adults' MEdications) (recently completed and in publication phase)
Evaluation of an Intervention Bundle to Reduce Inappropriate Polypharmacy in Older Inpatients: A Pilot Study (recently completed /and in publication phase)
Designing decision support to reduce inappropriate polypharmacy in older inpatients - Understanding user perceptions and workflows (completed).

Professor David Le Couteur is a member of the University of Sydney's Charles Perkins Centre (CPC). The CPC is a multidisciplinary research centre committed to improving global health. The projects examine the impact of nutrition on longevity and later life health.

Understanding and reducing falls in the inpatient hospital setting. Charlotte McLennan (PhD). Lead Supervisor Professor Cathie Sherrington (Institute of Musculoskeletal Health). Professor Vasi Naganathan is in the supervisory team.

The TOP UP Trial - A physiotherapy led telehealth and exercise intervention to improve mobility in older people receiving aged care services: an effectiveness and implementation randomised controlled trial. Rik Dawson (PhD) Lead Supervisor Professor Cathie Sherrington (Institute of Musculoskeletal Health), Vasi Naganathan (investigator).

Investigating a psychological strategy to support older adults in making informed cancer screening decisions. Jenna Smith (PhD). Primary Supervisor Professor Kirsten McCaffery, School of Public Health The University of Sydney. Professor Vasi Naganathan on supervisor team.

Intensive Care Unit (ICU) Protocols Influenza Pandemics Public's view. Dr Winston Cheung (PhD). Professor Vasi Naganathan (Lead Supervisor).

Our Research Team

CERA Co-Directors
Professor Vasi Naganathan	Professor of Geriatric Medicine, University of Sydney and Consultant Geriatrician, Concord Hospital
Professor Victoria Cogger	Associate Dean (Research Education), The University of Sydney / Co-leader Biogerontology laboratory
Department of Geriatric Medicine, Concord Hospital
Professor Vasi Naganathan	Consultant Geriatrician
Professor David Le Couteur	Senior Staff Specialist in Geriatric Medicine and Professor of Geriatric Medicine, The University of Sydney
Clinical Associate Professor John Cullen	Stream Director Sydney Local Health District Aged Health Care, Rehabilitation, General Medicine, Chronic Care, Disability, Endocrinology, Andrology and Ambulatory Care Clinical Associate Professor, Concord Clinical School, The University of Sydney
Clinical Associate Professor Louise Waite	Senior Staff Specialist Geriatrician. Head of Department of Geriatric Medicine. Clinical Associate Professor, Concord Clinical School, University of Sydney
Dr Janani Thillainadesan	Staff Specialist Geriatrician and Conjoint Lecturer, Concord Clinical School, University of Sydney
Clinical Associate Professor Deborah Cockrell	Lead for Oral Health, CERA and Clinical Associate Professor, Concord Clinical School, University of Sydney
Dr Natasha Spalding	Staff Specialist Geriatrician and Director of RACF Outreach Service
Dr Cameron Korb-Wells	Geriatrician
Steven Chu	Oral Health PhD student
Biogerontology Lab, ANZAC Research Institute
Professor Victoria Cogger	Co-leader Biogerontology laboratory
Professor David Le Couteur	Co-leader Biogerontology laboratory
Dr Nicholas Hunt	Post-doctoral researcher
Glen Lockwood	Laboratory Manager
Lara Westwood	PhD Candidate
CERA Research Support Staff
Leanne Kearney	CERA Research Project Officer
Sarita Lo	CERA Research Pharmacist
Linda Koria	EHITH Project Officer
Higher Degree Students
Winston Cheung	PhD Candidate
Steven Chu	PhD Candidate
Glen Lockwood	PhD Candidate
Charlotte McLennan	PhD Candidate
Jenna Smith	PhD Candidate
Lara Westwood	PhD Candidate
Eleni Azarias	Masters (MPhil) student
Joshua Makary	Masters (MPhil) student
Ganeshwaran Shivapathasundram	Masters (MPhil) student
Bethany Stavert	Masters (MPhil) student
Atul Wagh	Masters (MPhil) student

Selected Grants

Amount awarded	Project and investigator details
$12,981,420	NHMRC Program Grant, 2019-2023 Nutrition and complexity Investigators: Simpson S, George J, Le Couteur D, Gunton J, Raubenheimer D, Durrant-Whyte H.
$2,800,000	MRFF, 2022-2025 Reshaping low back pain management in the emergency department. Investigators: Maher C (CIA), Naganathan V (CIJ).
$2,500,000	NHMRC Centres of Research Excellence Scheme, 2020-2024 NHMRC Centre of Research Excellence in the Prevention of Fall-related Injuries Associate Investigator: Naganathan V.
$1,989,324	ARC Centres of Excellence, 2017-2023 ARC Centre of Excellence in Population Ageing Research 2 (CEPAR 2), University of Sydney Node Investigators: Baird M, Blyth F, Cumming R, Piggott J, McDonald P, Anstey K, Keane M, Parker S, Sherris M, Bateman H, Clarke P, McKibbin W, Woodland A.
$750,000	MRFF, 2022 Bringing oral insulin to phase I clinical studies using a novel quantum dot drug delivery platform. Investigator: Hunt N.
$468,879	HCF Research Foundation, 2022-2024 Effectiveness, cost-effectiveness and implementation of Emergency Hospital in the Home model of care for older people Investigators: Naganathan V, Cullen J, Blyth F, Cunich M.
$50,000	Therapeutic Innovations Australia, 2021-2022 Synthesis and characterisation of Ag2S quantum dots and conjugation to insulin at CSIRO. Investigator: Hunt N.

Previous Grants

Amount awarded	Grant and project details
$586,840	NHMRC Boosting Dementia Research Grant Scheme, 2018-2020 (extended) Team Approach to Polypharmacy Evaluation and Reduction for General Practice patients with dementia: the Australian TAPERdem study Investigators: Etherton-Beer C, Parkinson L, Naganathan V, Caughey G, Redfern J, Clifford R, Page A, Mangin D
$560,241	NHMRC, 2018-2020 A targeted approach to age related disease: nanomedicines and the liver sinusoidal endothelium Investigators: Cogger V, Le Couteur D, Kuncic Z, McCourt P
$510,580	ARC, 2018-2020 A life-course approach to the nutrition-lifespan-reproduction nexus Investigators: Raubenheimer D, Solon-Biet S, Walters K, Le Couteur D
$437,000	NSW Ministry of Health, 2018-2021 Advance Care Planning in outpatient clinics – extension Investigators: Caplan G, Meller A, Naganathan V, Cullen J
$325,000	ARC Discovery Project Grant, 2017-2019 Properties of nanomaterials determine their disposal by liver cells Investigators: Cogger V, Xu Z, Roberts M
$85,000	Australian Diabetes Society, 2021 Skip Martin Postdoctoral Fellowship Investigator: Hunt N
$80,000	University of Sydney DVC Research / Thompson Fellowships, 2018 A targeted approach to age related disease: nanomedicines and the liver sinusoidal endothelium Investigator: Cogger V.
$25,000	Sydney Health Partners, 2021 HIPFFIT: HIP Fracture and Frailty Improvement Translational project Clinical PI: Cullen J
$10,000	ANZ Musculoskeletal Clinical Trials Network, 2019 Safe mobility to prevent falls in acute hospitals: adaptation of the successful Safe Recovery rehabilitation unit program Naganathan V.

Our Publications

2022

Cheyne S, Lindley R, Smallwood N, Tendal B, Chapman M, Navarro DF, Good PD, McDonald S, Morgan D, Murano M, Millard T, Naganathan V, Srikanth V, Tuffin P, Vogel J, White H, Chakrabothy SP, Whiting E, William L, Yates PM, Callary M, Elliott J and Agar MR for the National COVID-19 Clinical Evidence Taskforce. Care of older people and people requiring palliative care with COVID-19: guidance from the Australian National COVID-19 Clinical Evidence Taskforce. The Medical Journal of Australia. 2022 Mar;216(4):203-208. doi.org/10.5694/mja2.51353

Chow EPF, Hsu B, Waite LM, Blyth FM, Handelsman DJ, Couteur DG, Naganathan V, Stanaway F. Diagnostic accuracy of linked administrative data for dementia diagnosis in community-dwelling older men in Australia. BMC Geriatrics. 2022 Nov; 22: 858 doi.org/10.1186/s12877-022-03579-2

Dai Z, Hirani V, Sahni S, Felson DT, Naganathan V, Blyth F, Le Couteur D, Handelsman D, Seibel MJ, Waite L, Kiel DP, Cumming R. Association of dietary fiber and risk of hip fracture in men from the Framingham Osteoporosis Study and the Concord Health and Ageing in Men Project. Nutrition and Health. 2022 Jun;28(2):229-238. 10.1177/02601060211011798.

Das A, Cumming RG, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Ribeiro RV, Simpson JS, Hirani V. Associations between dietary intake of total protein and sources of protein (plant vs. animal) and risk of all-cause and cause-specific mortality in older Australian men: The Concord Health and Ageing in Men Project. Journal of Human Nutrition and Dietetics. 2022 Oct; 35 (5), 845-860. 10.1111/jhn.12965

de Cabo R, Le Couteur DG. (2022) Biology of Aging. In: Harrisons Principles of Internal Medicine (21^st Ed). Editors: Loscalzo J, Fauci AS, Kasper DL, Longo DL, Jameson JL, McGraw Hill. Columbus. https://accessmedicine.mhmedical.com/content.aspx?bookid=3095&sectionid…

Djekovic K, Clowes K, Spalding N, Waite L. A retrospective study of the behavioural and psychological symptoms of dementia in patients admitted to a Specialist Dementia Care Unit. Australasian Journal on Ageing. 2022 Mar. doi:10.1111/ajag.13060 (Epub ahead of print)

Eberhard, J., Ruiz, K., Tan, J., Jayasinghe, T.N., Khan, S., Eroglu, E., Adler, C., Simpson, S.J., Le Couteur, D.G., Raubenheimer, D., Macia, L., Gosby, A.K., Ribeiro, R.V. A randomized clinical trial to investigate the effect of dietary protein sources on periodontal health. Journal of Clinical Periodontology. 2022 Apr; 49 (4):388-400. DOI: 10.1111/jcpe.13587

Gnanenthiran, S.R., Ng, A.C.C., Cumming, R.G., Brieger, D.B., le Couteur, D.G., Waite, L.M., Seibel, M., Handelsman, D.J., Naganathan, V., Kritharides, L., Blyth, F.M. Hemoglobin, Frailty, and Long-term Cardiovascular Events in Community-Dwelling Older Men Aged ≥ 70 Years. Canadian Journal of Cardiology. 2022 Jun: 38 (6):745-753. doi.org/10.1016/j.cjca.2022.01.024

Hunt, N.J., McCourt, P.A.G., Kuncic, Z., Le Couteur, D.G., Cogger, V.C. Opportunities and Challenges for Nanotherapeutics for the Aging Population. Frontiers in Nanotechnology, 2022 Jan; 4, art. no. 832524. doi.org/10.3389/fnano.2022.832524

Hunt, N.J., Wahl, D., Westwood, L.J., Lockwood, G.P., Le Couteur, D.G., Cogger, V.C. Targeting the liver in dementia and cognitive impairment: Dietary macronutrients and diabetic therapeutics. Advanced Drug Delivery Reviews. 2022 Nov; 190: article 114537. doi.org/10.1016/j.addr.2022.114537

Ischia L., Naganathan V., Waite L.M., Le Couteur D.G., Thillainadesan J. COVID-19 and Geriatric Medicine in Australia and New Zealand. Australasian Journal on Ageing. 2022 Jun;41(2):301-308 doi.org/10.1111/ajag.13027.

Kiely, K.M., Khalatbari-Soltani, S., Blyth, F.M., Naganathan, V., Handelsman, D.J., Waite, L.M., Le Couteur, D.G., Mortby, M.E., Cumming, R.G., Anstey, K.J. Mixed Evidence of an Association between Self-Rated Hearing Difficulties and Falls: Prospective Analysis of Two Longitudinal Studies. Gerontology. 2022 May:1-11. doi: 10.1159/000524311 (Epub ahead of print)

Le Couteur DG, Anderson RM, de Cabo R. Can we make drug discovery targeting fundamental mechanisms of aging a reality? (invited editorial) Expert Opinion on Drug Discovery, 2022; 17(2):97-100. 10.1080/17460441.2022.1993818.

Le Couteur DG, Flicker L, Hilmer SN. Geriatric medicine and health care for older people in Australia. Age and Ageing 2022 March; 51(3):afac001. doi.org/10.1093/ageing/afac001

Le Couteur DG, Thillainadesan J. What is an aging-related disease? An epidemiological perspective. Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2022 Feb; doi: 10.1093/gerona/glac039. (Epub ahead of print)

Le Couteur, D.G., Raubenheimer, D., Solon-Biet, S., de Cabo, R., Simpson, S.J. Does diet influence aging? Evidence from animal studies. Journal of Internal Medicine. 2022 Jun. doi.org/10.1111/joim.13530 (Epub ahead of print)

Lin A, Shaheen N, Ganda K, Cullen, Waite LM, Seibel M. Improving osteoporosis treatment rates in inpatients admitted with hip fracture: a healthcare improvement initiative in a tertiary referral hospital. Aging Medicine. 2022 Nov. doi.org/10.1002/agm2.12229 (Epub ahead of print)

Luong, R., Ribeiro., R.V., Rangan, A., Naganathan, V., Blyth, F., Waite, L.M., Handelsman, D.J., Cumming, R.G., Le Couteur, D.G., Hirani, V. Changes in Dietary Total and Nonheme Iron Intake Is Associated With Incident Frailty in Older Men: The Concord Health and Aging in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2022 Sept;77(9):1853-1865. doi: 10.1093/gerona/glac077

Mach, J., Allore, H., Gnjidic, D., Gemikonakli, G., Kane, A.E., Howlett, S.E., de Cabo, R., Le Couteur, D., Hilmer, S.N. Preclinical frailty assessments: Phenotype and frailty index identify frailty in different mice and are variably affected by chronic medications. Experimental Gerontology. 2022 May; 161:111700. doi.org/10.1016/j.exger.2022.111700

Page AT, Potter K, Naganathan V, Hilmer S, McLachlan AJ, Lindley RI, Coman T, Mangin D, Etherton- Beer C. Polypharmacy and medicine regimens in older adults in residential aged care. Archives of Gerontology and Geriatrics. 2022 Nov 4;105:104849. doi: 10.1016/j.archger.2022.104849 (Epub ahead of print)

Raubenheimer, D., Senior, A.M., Mirth, C., Cui, Z., Hou, R., Le Couteur, D.G., Solon-Biet, S.M., Léopold, P., Simpson, S.J. An integrative approach to dietary balance across the life course. iScience. 2022 Apr; 25(5):104315. doi: 10.1016/j.isci.2022.104315

Senior, A.M., Legault, V., Lavoie, F.B., Presse, N., Gaudreau, P., Turcot, V., Raubenheimer, D., Le Couteur, D.G., Simpson, S.J., Cohen, A.A. Multidimensional associations between nutrient intake and healthy ageing in humans. BMC Biology. 2022 Sep 1; 20(1):196. DOI: 10.1186/s12915-022-01395-z

Shi H, Tsai KH, Ma D, Wang X, Desai R, Parungao RJ, Hunt NJ, Cheng YY, Zhang H, Xu Y, Simanainen U, Tan Q, Cooper MS, Handelsman DJ, Maitz PK, Wang, Y. Controlled dual release of dihydrotestosterone and flutamide from polycaprolactone electrospun scaffolds accelerate burn wound healing. The FASEB Journal. 2022 May;36(5):e22310. doi: 10.1096/fj.202101803R.

Shu CC, Wright FAC, Naganathan V, Blyth M, Le Couteur DG, Handelsman D.J, Stanaway FF. Does social support predict increased use of dental services in older men? Australian Dental Journal. 2022 Sept; 67(3):262-270. https://doi.org/10.1111/adj.12911

Sirimanna, P., Boyce, S., Gunanayagam, P., Gladman, M.A. and Naganathan, V. Development of a rating scale for objective assessment of performance in laparoscopic appendicectomy surgery. ANZ Journal of Surgery. 2022 Jul-Aug;92(7-8):1724-1730. https://doi.org/10.1111/ans.17601

Sirimanna, P., Ravindran, P., Smigielski, M., Gladman, M.A., Naganathan, V. Validation and reliability testing of a rating scale for objective assessment of performance in laparoscopic appendicectomy surgery. ANZ Journal of Surgery. 2022 Jul-Aug; 92(7-8):1731-1736. DOI: 10.1111/ans.17862

Solon-Biet, S.M., Griffiths, L., Fosh, S., Le Couteur, D.G., Simpson, S.J., Senior, A.M. Meta-analysis links dietary branched-chain amino acids to metabolic health in rodents. BMC Biology. 2022 Jan; 20 1): 19. DOI: doi.org/10.1186/s12915-021-01201-2

Stavert B, Monaro S, Naganathan V, Aitken S. Frailty predicts increased risk of reintervention in the 2 years after arteriovenous fistula creation. The Journal of Vascular Access. 2022 Apr 21;11297298221088756. doi:10.1177/11297298221088756 (Epub ahead of print)

Stavert, B.M., Monaro, S., Tienstra, L., Naganathan, V., Aitken, S.J. Protocol for a qualitative study exploring haemodialysis dependent patients' arteriovenous fistula experience, values and concerns in Sydney, Australia. BMJ Open. 2022 June; 12(6):e058152. DOI: 10.1136/bmjopen-2021-058152

Thillainadesan J, Hilmer SN, Fleury AM, Naganathan V. New horizons in the perioperative care of older adults. Age and Ageing. 2022 Feb 2;51(2):afab245. doi: 10.1093/ageing/afab245

Thillainadesan J., Monaro S., Aitken S., Kerdic R., Cullen J., Naganathan V. Geriatric Comanagement of Older Vascular Surgery Inpatients Reduces Hospital-Acquired Geriatric Syndromes. Journal of the American Medical Directors Association. 2022 Apr;23(4):589-595.e6. doi: 10.1016/j.jamda.2021.09.037. Epub 2021 Oct 29.

Thillainadesan, J., Charlton, G., Wang, J. Targeted microlearning: Teaching geriatric medicine to Gen Y and Gen Z junior doctors. Australasian Journal on Ageing. 2022 Aug. doi: 10.1111/ajag.13130. (Epub ahead of print)

Thillainadesan, J., Le Couteur, D.G., Haq, I., Wilkinson, T.J. When I say ... microlearning. Medical Education. 2022 Jun; 56 (8):791-792. doi.org/10.1111/medu.14848

Vardy, J.L., Pond, G.R., Cysique, L.A., Gates, T.M., Lagopoulos, J., Renton, C., Waite, L.M., Tannock, I.F., Dhillon, H.M. Lack of cognitive impairment in long-term survivors of colorectal cancer. Supportive Care in Cancer. 2022 Jul; 30(7): 6123-6133. DOI: 10.1007/s00520-022-07008-3

Wright, F.A.C., Shu, E.C.C., Cumming, R.G., Naganathan, V., Blyth, F.M., Hirani, V., Le Couteur, D.G., Handelsman, D.J., Seibel, M.J., Waite, L.M., Stanaway, F.F. Oral health-related quality of life of older Australian men. Community Dentistry and Oral Epidemiology. 2022 May:1-11. doi.org/10.1111/cdoe.12754 (Epub ahead of print)

Wu, H., Mach, J., Gnjidic, D., Naganathan, V., Blyth, F., Waite, L., Handelsman, D., Le Couteur, D., Hilmer, S. Comparing Effects of Polypharmacy on Inflammatory Profiles in Older Adults and Mice: Implications for Translational Ageing Research. Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2022 Jul; 77(7):1295-1303. glac061, /doi.org/10.1093/gerona/glac061

Xu P, Blyth F.M, Naganathan V, Cumming R.G, Handelsman D.J, Seibel M.J, Le Couteur D.G, Waite L.M, and Khalatbari-Soltani S: Socioeconomic inequalities in elective and non-elective hospitalizations in older men. JAMA Network Open. 2022 Apr 1;5(4):e226398. doi:10.1001/jamanetworkopen.2022.6398

2021

Cervo M, Scott D, Seibel MJ, Cumming RG, Naganathan V, Blyth FM, Le Couteur DG, Handelsman DJ, Ribeiro RV, Waite LM, Hirani V. Adherence to Mediterranean Diet and its Associations with Circulating Cytokines, Musculoskeletal Health and Incident Falls in Community-Dwelling Older Men: The Concord Health and Ageing in Men Project. Clinical Nutrition 2021 Oct 23;40(12):5753-5763. 10.1016/j.clnu.2021.10.010

Chu KY, Cockrell D,Naganathan V, Stanaway F, Wright FAC. Oral health status of newly admitted residents living in residential aged care. Australian Dental Journal. 2021 December;66(4):391-396 10.1111/adj.12864

Das A, Cumming RG, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Ribeiro RV, Simpson SJ, Hirani V. Associations between nutrient intakes and dietary patterns with different sarcopenia definitions in older Australian men: the concord health and ageing in men project. Public Health Nutrition. 2021 Oct;24(14):4490-4505. doi: 10.1017/S1368980020003547. Epub 2020 Oct 7. Erratum in: Public Health Nutr. 2021 Feb;24(2):378-383. PMID: 33023717.

Das A, Cumming RG, Naganathan V, Ribeiro RV, Le Couteur DG, Handelsman DJ, Waite LM, Hirani V. The association between antioxidant intake, dietary pattern and depressive symptoms in older Australian men: the Concord Health and Ageing in Men Project. European journal of nutrition. 2021 Feb;60(1):443-454. 10.1007/s00394-020-02255-8

Duong, M. H., McLachlan, A. J., Bennett, A. A., Jokanovic, N., Le Couteur, D. G., Baysari, M. T., Gnjidic, D., Blyth, F., Hilmer, S. N. Iterative development of clinician guides to support deprescribing decisions and communication for older patients in hospital: a novel methodology. Drugs & Aging 2021,38, 75-87. 10.1007/s40266-020-00820-8

Fotheringham AK, Solon-Biet SM. Bielefeldt-Ohmann H, McCarthy DA, McMahon AC, Ruohonen K, Li I, Sullivan MA, Whiddett RO, Borg DJ, Cogger VC, Ballard WO, Turner N, Melvin RG, Raubenheime D, Le Couteur DG, Simpson SJ, Forbes JM. Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure. iScience, 2021 Oct 16;24(11):103308 10.1016/j.isci.2021.103308

Gibney JM, Naganathan V, Lim MAWT. Oral health is Essential to the Well-Being of Older People. The American Journal of Geriatric Psychiatry. 2021 Oct;29(10):1053-1057. doi: 10.1016/j.jagp.2021.06.002. Epub 2021 Jun 11. PMID: 34246517.

Hew JJ , Parungao RJ, Mooney CP, Smyth JK, Kim S, Tsai KHY, Shi H, Chong C, Chan RCF, Attia B, Nicholls D, Li Z, Solon-Biet SM, Le Couteur DG, Simpson SJ, Jeschke MG, Maitz PK, Wang Y. Low-protein diet accelerates wound healing in mice post-acute injury. Burns & Trauma 2021 Aug 9;9:tkab010. 10.1093/burnst/tkab010

Hilmer SN, Mirko P, Le Couteur DG, Schwartz J, Thuermann P. Development, evaluation and use of COVID-19 vaccines in older adults: preliminary principles for the pandemic and beyond. British Journal of Clinical Pharmacology 2021; 87(9) 3459-3461. 10.1111/bcp.14967

Hsu B, Korda R, Naganathan V, Lewis P, Ooi S, Brieger D, Jorm L. Burden of cardiovascular diseases in older adults using aged care services. Age and Ageing. 2021;50(5): 1845–1849. 10.1093/ageing/afab083

Hunt N, Lockwood G, Kang S, Westwood L, Limantoro C, Chrzanowski W, McCourt P, Kuncic Z, Le Couteur D, Cogger V. Quantum Dot Nanomedicine Formulations Dramatically Improve Pharmacological Properties and Alter Uptake Pathways of Metformin and Nicotinamide Mononucleotide in Aging Mice. ACS Nano 2021 23;15(3):4710-4727. 10.1021/acsnano.0c09278

Khalatbari-Soltani S, Blyth FM, Naganathan V, Le Couteur DG, Handelsman DJ, Seibel MJ, Hirani V, Wright FAC, Waite LM, Cumming RG. Cohort Profile update: The Concord Health and Ageing in Men Project (CHAMP). International Journal of Epidemiology. 2021 October; 51(1):31-32h. 10.1093/ije/dyab171

Khalatbari-Soltani S, Cumming R.G, Chomik R, Blyth F.M, Naganathan V, Handelsman D.J, Le Couteur D.G, Waite L.M, and Stanaway F. The association between home ownership and the health of older men: cross-sectional analysis of the Australian Concord Health and Ageing in Men Project. Australasian Journal on Ageing. 2021 Sep;40(3):e199-e206. 10.1111/ajag.12896

Khalatbari-Soltani S, Stanaway F, Sherrington C, Blyth FM, Naganathan V, Handelsman DJ, Seibel MJ, Waite LM, Le Couteur DG, Cumming RG. The prospective association between socioeconomic status and falls among community-dwelling older men. Journal of Gerontology Medical Science. 2021;76(10):1821-1828. 10.1093/gerona/glab038

Krishnan A, Waite LM, Stanaway FF. Representation of racial and ethnic minority groups in cohort studies evaluating risk factors for dementia: protocol for a scoping review. BMJ Open. 2021 May 13;11(5):e044404. 10.1136/bmjopen-2020-044404.

Le Couteur DG, Handelsman DJ, Stanaway F, Waite LM, Blyth FM, Naganathan V, Cumming RG, Hirani V. Sarcopenic obesity and amino acids: Concord Health and Ageing in Men Project. Journal of Gerontology Biological Science 2021 May 22;76(6):1000-1004. 10.1093/gerona/glab076

Le Couteur DG, Solon-Biet SM, Parker BL, Pulpitel T, Brandon AE, Hunt NJ, Wali JA, Gokarn R, Senior AM, Cooney GJ, Raubenheimer D, Cogger VC, James DE, Simpson SJ. Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol and rapamycin. Cell Metabolism. 2021 Nov 6;S1550-4131(21)00528-3. doi: 10.1016/j.cmet.2021.10.016.

Mach J, Gemikonakli G, Logan C, Vander Wyk B, Allore H, Ekambareshwar S, Kane AE, Howlett SE, de Cabo R, Le Couteur DG, Hilmer SN. Chronic polypharmacy with increasing Drug Burden Index (DBI) exacerbates frailty and impairs physical function, with effects attenuated by deprescribing, in aged mice. The journals of gerontology Series A, Biological sciences and medical sciences. 2021 May 22;76(6):1010-1018. 10.1093/gerona/glaa060

Mesinovic J, Scott D, Seibel MJ, Cumming RG, Naganathan V, Blyth FM, Le Couteur DG, Waite LM, Handelsman DJ, Hirani V. Risk Factors for Incident Falls and Fractures in Older Men with and without Type 2 Diabetes Mellitus: The Concord Health and Ageing in Men Project, Journals Gerontology Medical Science. 2021 May 22;76(6):1090-1100. 10.1093/gerona/glab062

Milledge K, Cumming R, Wright F, Naganathan V, Blyth F, Le Couteur D, Waite L, Handelsman D, Hirani, V. Associations between the composition of Functional Tooth Units and nutrient intake in older men: The Concord Health and Ageing in Men Project. Public Health Nutrition 2021; 24(18), 6335-6345. 10.1017/S1368980021003566.

Ng B, Duong M, Lo S, Le Couteur D, Hilmer S. Deprescribing perceptions and practice: reported by multidisciplinary hospital clinicians after, and by medical students before and after, viewing an e-learning module. Research in Social and Administrative Pharmacy 2021 17(11):1997-2005. 10.1016/j.sapharm.2021.03.002

Parkinson L, Magin P, Etherton-Beer C, Naganathan V and Mangin D. Engaging General Practice and patients with AusTAPER, a pharmacist facilitated web-based deprescribing tool. Journal of Pharmacy Practice and Research 2021: 51(2): 154-159. 10.1002/jppr.1713

Scott D, Blyth F, Naganathan V, Le Couteur DG, Handelsman DJ, Seibel MJ, Waite LM, Hirani V. Prospective associations of chronic and intrusive pain with sarcopenia and physical disability among older Australian men: The Concord Health and Ageing in Men Project. Experimental Gerontology 2021 Oct 1;153:111501. 10.1016/j.exger.2021.111501.

Smith J, Dodd RH, Gainey KM, Naganathan V, Cvejic E, Jansen J and McCaffery KJ. Patient-reported factors associated with older adults’ cancer screening decision-making: A systematic review. JAMA Network Open 2021 Nov 1;4(11):e2133406. 10.1001/jamanetworkopen.2021.33406

Smith J, Dodd RH, Hersch J, McCaffery KJ, Naganathan V, Cvejic E and Jansen J. Psychosocial and clinical predictors of continued cancer screening in older adults. Patient Education and Counseling. 2021 Dec;104(12):3093-3096. 10.1016/j.pec.2021.04.027

Stanaway FF, Ribeiro RV, Khalatbari-Soltani S, Cvejic E, Blyth FM, Naganathan V, Handelsman DJ, Le Couteur DG, Simpson SJ, Waite LM, Cumming RG, Hirani V. Diet quality in an ethnically diverse population of older men in Australia. European Journal of Clinical Nutrition. 2021 Dec;75(12):1792-1800. 10.1038/s41430-021-00893-7

Takehara S, Wright FAC, Naganathan V, Hirani V, Blyth FM, Le Couteur DG, Waite LM, Seibel MJ, Handelsman DJ, Cumming RG. A cross-sectional study of perceived dental treatment needs and oral health status in community-dwelling older Australian men: The Concord Health and Ageing in Men Project. International Dental Journal. 2021 Jun;71(3):224-232. 10.1111/idj.12623

Thillainadesan J, Hilmer SN, Mudge AM, Aitken SJ, Kearney L, Monaro SR, Li SJ, Schasser S, Kerdic R, Tang R, Naganathan V. Understanding the role and value of process quality indicators in older vascular surgery inpatients. The Journal of Surgical Research. 2021 Jun 23;267:91-101. 10.1016/j.jss.2021.05.003

Thillainadesan J, Jansen J, Close J, Hilmer S, Naganathan V. Geriatrician perspectives on perioperative care: a qualitative study. BMC Geriatrics. 2021; 68. 10.1186/s12877-021-02019-x

Thillainadesan Janani, Mudge Alison, Aitken Sarah, Cullen John, Yumol Minna, Close Jacqueline, Norris C, Kerdic Richard, Naganathan Vasikaran. The prognostic performance of frailty for delirium and functional decline in vascular surgery patients. Journal of the American Geriatrics Society. 2021;69(3): 688-695. 10.1111/jgs.16907

Thillainadesan Janani, Yumol Minna F., Suen Michael, Hilmer Sarah, Naganathan Vasi. Enhanced Recovery After Surgery in Older Adults Undergoing Colorectal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Diseases of the Colon and Rectum. 2021;64(8):1020-1028. doi:10.1097/DCR.0000000000002128

Wahl, D., Gokarn, R., Solon-Biet, S., Cogger, V., LaRocca, T., Raubenheimer, D., Simpson, S., Le Couteur, D. (2021). Modeling nutrition and brain aging in rodents. In Martin CR, Preedy VR, Rajendram R (Eds.), Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging, (pp. 517-526). London: Academic Press. 10.1016/C2018-0-02036-8

Wali JA, Milner A, Luk A, Pulpitel T, Dodgson T, Facey H, Wahl D, Kebede M, Senior AM, Sullivan M, Brandon A, Yau B, Lockwood G, Koay YC, Ribeiro R, Solon-Biet SM1, Bell-Anderson K, O’ Sullivan J, Macia L, Forbes J, Cooney GJ, Cogger VC, Holmes A, Raubenheimer D, Le Couteur DG, Simpson SJ. Impact of dietary carbohydrate type and protein-carbohydrate interaction on metabolic health. Nature Metabolism 2021; 3:810-828. 10.1038/s42255-021-00393-9

Wali JA, Raubenheimer D, Senior AM, Le Couteur DG, Simpson SJ. Cardio-metabolic consequences of dietary carbohydrates: reconciling contradictions using nutritional geometry. Cardiovascular research. 2021 Jan 21;117(2):386-401. 10.1093/cvr/cvaa136

Weir KR, Naganathan V, Carter SM, Tam CWM, McCaffery K, Bonner C, Rigby D, McLachlan AJ, Jansen J. The role of older patients’ goals in GP decision-making about medicines: A qualitative study. BMC Family Practice 2021; 22:13 10.1186/s12875-020-01347-y

Wu H, Le Couteur DG, Hilmer SN. Mortality trends of stroke and dementia: changing landscapes and new challenges. Journal of American Geriatrics Society 2021; 69(10) 2888-2898. 10.1111/jgs.17322

Wu H, Mach J, Le Couteur DG, Hilmer SN. Nationwide mortality trends of delirium in Australia and the United States from 2006 to 2016. Australasian Journal on Ageing. Published online Mar 2021. 10.1111/ajag.12926

Wu, H, Mach J, Gemikonakli G, Tran T, Allore H, Gnjidic D, Howlett SE, de Cabo R, Le Couteur DG, Hilmer SN. Polypharmacy Results in Functional Impairment in Mice: Novel Insights into Age and Sex Interactions. J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):1748-1756. 10.1093/gerona/glab088

Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. (November 2021) 3rd Revised Edition. Editors: Lord SR, Sherrington S and Naganathan V. Cambridge University Press. https://doi.org/10.1017/9781108594455

Chapters

a. Noguchi N and Naganathan V. Medical Risk Factors for Falls. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 172–91.

b. Ma L and Naganathan V. Medications as Risk Factors for Falls. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 192–201.

c. Lord SR, Sherrington C and Naganathan V. The Relative Importance of Fall Risk Factors: Analysis and Summary. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 237–48.

d. Latt MD and Naganathan V. The Medical Management of Older People at Risk of Falls. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 322–40.

e. Lord SR, Sherrington C and Naganathan V. Bringing It All Together. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 469–80.

2020

Aitken SJ, Randall DA, Noguchi N, Blyth FM, Naganathan V. Multiple Peri-Operative Complications are Associated with Reduced Long Term Amputation Free Survival Following Revascularisation for Lower Limb Peripheral Artery Disease: A Population Based Linked Data Study. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. 2020;59(3):437-45. 10.1016/j.ejvs.2019.11.014

Aitken S. J.,Lujic S.,Randall D. A.,Noguchi N.,Naganathan V.,Blyth F. M. Predicting outcomes in older patients undergoing vascular surgery using the Hospital Frailty Risk Score. British Journal of Surgery. 2020 Oct online: 10.1002/bjs.12043

Aitken SJ, Thillainadesan T, Monaro S, Naganathan Vasi. Collaborative models of care for older vascular surgery patients admitted to hospital. ANZ Journal of Surgery. 2020;90(7-8): 1232-1233. 10.1111/ans.16086

Bernier M, Harney D, Koay YC, Diaz A, Singh A, Wahl D, Pulpitel T, Ali A, Guiterrez V, Mitchell SJ, Kim EY, Mach J, Price NL, Aon MA, LeCouteur DG, Cogger VC, Fernandez-Hernando C, O'Sullivan J, Larance M, Cuervo AM, de Cabo R. Elucidating the mechanisms by which disulfiram protects against obesity and metabolic syndrome. NPJ aging and mechanisms of disease. 2020;6:8. 10.1038/s41514-020-0046-6

Bernier M, Mitchell SJ, Wahl D, Diaz A, Singh A, Seo W, Wang M, Ali A, Kaiser T, Price NL, Aon MA, Kim EY, Petr MA, Cai H, Warren A, Di Germanio C, Di Francesco A, Fishbein K, Guiterrez V, Harney D, Koay YC, Mach J, Enamorado IN, Pulpitel T, Wang Y, Zhang J, Zhang L, Spencer RG, Becker KG, Egan JM, Lakatta EG, O'Sullivan J, Larance M, LeCouteur DG, Cogger VC, Gao B, Fernandez-Hernando C, Cuervo AM, de Cabo R. Disulfiram Treatment Normalizes Body Weight in Obese Mice. Cell metabolism. 2020. 32(2), 203-214.e4. 10.1016/j.cmet.2020.04.019

Bertoldo MJ, Listijono DR, Ho WJ, Riepsamen AH, Goss DM, Richani D, Jin XL, Mahbub S, Campbell JM, Habibalahi A, Loh WN, Youngson NA, Maniam J, Wong ASA, Selesniemi K, Bustamante S, Li C, Zhao Y, Marinova MB, Kim LJ, Lau L, Wu RM, Mikolaizak AS, Araki T, Le Couteur DG, Turner N, Morris MJ, Walters KA, Goldys E, O'Neill C, Gilchrist RB, Sinclair DA, Homer HA, Wu LE. NAD+ Repletion Rescues Female Fertility during Reproductive Aging. Cell reports. 2020;30(6):1670-81.e7. 10.1016/j.celrep.2020.01.058

Cervo MMC, Scott D, Seibel MJ, Cumming RG, Naganathan V, Blyth FM, Le Couteur DG, Handelsman DJ, Ribeiro RV, Waite LM, Shivappa N, Hebert JR, Hirani V. Proinflammatory Diet Increases Circulating Inflammatory Biomarkers and Falls Risk in Community-Dwelling Older Men. The Journal of nutrition. 2020;150(2):373-81. 10.1093/jn/nxz256

Chen R, Irving M, Clive Wright FA, Cunich M. An evaluation of health workforce models addressing oral health in residential aged care facilities: A systematic review of the literature. Gerodontology. 2020; 37(3): 222-232. 10.1111/ger.12475

Cumming R, Khalatbari-Soltani S, Blyth F, Naganathan V, Le Couteur D. Not all older men have the chronic diseases associated with severe COVID-19. Australasian Journal on Ageing. 2020;39(4): 381-382. 10.1111/ajag.12839

Das A, Cumming RG, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Ribeiro RV, Simpson JS, Hirani V. Dietary and supplemental antioxidant intake and risk of major adverse cardiovascular events in older men: The Concord Health and Ageing in Men Project. Nutrition, Metabolism and Cardiovascular Diseases 31: 1102-1112, 2021. 10.1016/j.numecd.2020.11.032

Das A, Cumming RG, Naganathan V, Blyth F, Ribeiro RV, Le Couteur DG, Handelsman DJ, Waite LM, Simpson SJ, Hirani V. Prospective Associations Between Dietary Antioxidant Intake and Frailty in Older Australian Men: The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(2):348-56. 10.1093/gerona/glz054

Ford GA, Lord JM, Ferguson MAJ, Bountra C, Le Couteur DG. Organizational Innovation for Developing New Medicines That Target Aging and Age-Related Conditions. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(1):87-8. 10.1093/gerona/glz062

Freire T, Senior AM, Perks R, Pulpitel T, Clark X, Brandon AE, Wahl D, Hatchwell L, Le Couteur DG, Cooney GJ, Larance M, Simpson SJ, Solon-Biet SM. Sex-specific metabolic responses to 6 hours of fasting during the active phase in young mice. The Journal of physiology. 2020;598(11):2081-92. 10.1113/JP278806

Gnanenthiran SR, Ng ACC, Cumming R, Brieger DB, Le Couteur D, Waite L, Handelsman D, Naganathan V, Kritharides L, Blyth F. Low total cholesterol is associated with increased major adverse cardiovascular events in men aged ≥70 years not taking statins. Heart (British Cardiac Society). 2020;106(9):698-705. 10.1136/heartjnl-2019-315449

Handelsman DJ, Desai R, Seibel MJ, Le Couteur DG, Cumming RG. Circulating Sex Steroid Measurements of Men by Mass Spectrometry Are Highly Reproducible after Prolonged Frozen Storage. The Journal of steroid biochemistry and molecular biology. 2020;197:105528. 10.1016/j.jsbmb.2019.105528

Hew JJ, Parungao RJ, Tsai KH, Shi H, Ma D, Nicholls C, Li Z, Solon-Biet SM, D'Souza M, Le Couteur DG, Simpson SJ, Jeschke MG, Maitz PK, Wang Y. Geometric framework reveals that a moderate protein, high carbohydrate intake is optimal for severe burn injury in mice. The British journal of nutrition. 2020;123(9):1056-67. 10.1017/S0007114520000276

Hide D, Warren A, Fernández-Iglesias A, Maeso-Díaz R, Peralta C, Le Couteur DG, Bosch J, Cogger VC, Gracia-Sancho J. Ischemia/Reperfusion Injury in the Aged Liver: The Importance of the Sinusoidal Endothelium in Developing Therapeutic Strategies for the Elderly. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(2):268-77. 10.1093/gerona/glz012

Hsu B, Naganathan V, Blyth FM, Hirani V, Le Couteur DG, Waite LM, Seibel MJ, Handelsman DJ, Cumming RG. Frailty and Cause-Specific Hospitalizations in Community-Dwelling Older Men. The journal of nutrition, health & aging. 2020;24(6):563-9. 10.1007/s12603-020-1352-1

Hubbard RE, Maier AB, Hilmer SN, Naganathan V, Etherton-Beer C, Rockwood K. Frailty in the face of COVID-19. Age and ageing. 2020;49(4):499-500. 10.1093/ageing/afaa095

Hunt NJ, Lockwood GP, Kang SWS, Pulpitel T, Clark X, Mao H, McCourt PAG, Cooney GJ, Wali JA, Le Couteur FH, Le Couteur DG, Cogger VC. The Effects of Metformin on Age-Related Changes in the Liver Sinusoidal Endothelial Cell. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(2):278-85. 10.1093/gerona/glz153

Hunt NJ, Lockwood GP, Le Couteur FH, McCourt PAG, Singla N, Kang SWS, Burgess A, Kuncic Z, Le Couteur DG, Cogger VC. Rapid Intestinal Uptake and Targeted Delivery to the Liver Endothelium Using Orally Administered Silver Sulfide Quantum Dots. ACS nano. 2020;14(2):1492-507. 10.1021/acsnano.9b06071

Johnson George, Blinkhorn Anthony, Byun Roy, Foster Kirsty, Wright Fredrick A Clive. The workforce outcomes of dental graduates from a metropolitan school ‘Rural Clinical Placement Program’ versus a ‘Rural Clinical School’. International Dental Journal. 2020;70(3):214-226. 10.1111/idj.12541

Khalatbari-Soltani S, Blyth FM, Naganathan V, Handelsman DJ, Le Couteur DG, Seibel MJ, Waite LM, Cvejic E, Cumming RG. Socioeconomic status, health-related behaviours, and death among older people: the Concord health and aging in men project prospective cohort study. BMC geriatrics. 2020;20(1):261. 10.1186/s12877-020-01648-y

Khalatbari-Soltani S, Stanaway F, Cvejic E, Blyth F, Naganathan V, Handelsman D, Le Couteur D, Seibel M, Waite L, and Cumming R. Contribution of psychosocial factors to socioeconomic inequalities in mortality among older Australian men: a population-based cohort study. International Journal for Equity in Health. 2020. 19, 177. 10.1186/s12939-020-01277-2

Le Couteur DG, Anderson RM, Newman AB. COVID-19 Through the Lens of Gerontology. The journals of gerontology Series A, Biological sciences and medical sciences. 2020 Sep 16;75(9):e119-e120. 10.1093/gerona/glaa077

Le Couteur DG, Anderson RM, Newman AB. Erratum to: COVID-19 Through the Lens of Gerontology. The journals of gerontology Series A, Biological sciences and medical sciences. 2020. doi.org/10.1093/gerona/glaa080

Le Couteur DG, Ribeiro R, Senior A, Hsu B, Hirani V, Blyth FM, Waite LM, Simpson SJ, Naganathan V, Cumming RG, Handelsman DJ. Branched chain amino acids, cardiometabolic risk factors and outcomes in older men: the Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2020 Sep 25;75(10):1805-1810. 10.1093/gerona/glz192

Le Couteur DG, Stanaway F, Waite LM, Cullen J, Lindley RI, Blyth FM, Naganathan V, Cumming RG, Handelsman DJ. Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2020 Sep 25;75(10):1858-1862. 10.1093/gerona/glaa105

Le Couteur, D., Solon-Biet, S., Cogger, V., Ribeiro, R., De Cabo, R., Raubenheimer, D., Cooney, G., Simpson, S. Branched chain amino acids, aging and age-related health.Ageing Research Reviews, 2020;64, 1-11. 10.1016/j.arr.2020.101198

Li J, Zhao Y, Choi J, Ting KK, Coleman P, Chen J, Cogger VC, Wan L, Shi Z, Moller T, Zheng X, Vadas MA, Gamble JR. Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice. PLoS biology. 2020;18(6):e3000734. 10.1371/journal.pbio.3000734

Moth EB, Blinman P, Stefanic N, Naganathan V, Grimison P, Stockler MR, Beale P, Martin A, Kiely BE. Estimating survival time in older adults receiving chemotherapy for advanced cancer. Journal of geriatric oncology. 2020;11(4):617-25. 10.1016/j.jgo.2019.08.013

Moth EB, Kiely BE, Martin A, Naganathan V, Della-Fiorentina S, Honeyball F, Zielinski R, Steer C, Mandaliya H, Ragunathan A, Blinman P. Older adults' preferred and perceived roles in decision-making about palliative chemotherapy, decision priorities and information preferences. Journal of geriatric oncology. 2020;11(4):626-32. 10.1016/j.jgo.2019.07.026

Ortega-Ribera M, Hunt NJ, Gracia-Sancho J, Cogger VC. The Hepatic Sinusoid in Aging and Disease: Update and Advances From the 20th Liver Sinusoid Meeting. Hepatology communications. 2020;4(7):1087-98. 10.1002/hep4.1517

Scott D, Seibel MJ, Cumming R, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Hsu B, Waite LM, Hirani V. Associations of Body Composition Trajectories with Bone Mineral Density, Muscle Function, Falls, and Fractures in Older Men: The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(5):939-45. 10.1093/gerona/glz184

Scott D, Seibel MJ, Cumming R, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Hsu B, Waite LM, Hirani V. Comparison of clinical risk factors for incident fracture in obese and non-obese community-dwelling older men. Bone. 2020;137:115433. 10.1016/j.bone.2020.115433

Simpkins DM, Hohenberg MI, Naganathan V, White K. Help, I'm a specialist! Perspectives of recently qualified geriatricians on the experiences and challenges of working as a consultant geriatrician. Australasian journal on ageing. 2020;39(1):73-80. 10.1111/ajag.12670

Solon-Biet SM, McMahon AC, Ballard JWO, Ruohonen K, Wu LE, Cogger VC, Warren A, Huang X, Pichaud N, Melvin RG, Gokarn R, Khalil M, Turner N, Cooney GJ, Sinclair DA, Raubenheimer D, Le Couteur DG, Simpson SJ. Published Erratum: The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. Cell metabolism. 2020;31(3):654. 10.1016/j.cmet.2020.01.010

Stanaway FF, Blyth FM, Naganathan V, Le Couteur DG, Ribeiro R, Hirani V, Waite LM, Handelsman DJ, Seibel MJ, Cumming RG. Mortality Paradox of Older Italian-Born Men in Australia: The Concord Health and Ageing in Men Project. Journal of immigrant and minority health. 2020;22(1):102-9. 10.1007/s10903-019-00874-w

Takehara S, Wright FAC, Waite LM, Naganathan V, Hirani V, Blyth FM, Le Couteur DG, Seibel MJ, Handelsman DJ, Cumming RG. Oral health and cognitive status in the Concord Health and Ageing in Men Project: A cross-sectional study in community-dwelling older Australian men. Gerodontology. 2020;37(4):353-360. DOI: 10.1111/ger.12469

Teng Claris, Loy Clement T, Sellars Marcus, Pond Dimity, Latt Mark D, Waite Louise M, Sinka Victoria, Logeman Charlotte, Tong Allison. Making Decisions About Long-Term Institutional Care Placement Among People With Dementia and Their Caregivers: Systematic Review of Qualitative Studies. The Gerontologist. 2020;60(4): e329–e346. 10.1093/geront/gnz046

Thillainadesan J, Scott IA, Le Couteur DG. Frailty, a multisystem ageing syndrome. Age and ageing. 2020 Aug 24;49(5):758-763. 10.1093/ageing/afaa112

Thillainadesan J, Yumol MF, Hilmer S, Aitken SJ, Naganathan V. Interventions to Improve Clinical Outcomes in Older Adults Admitted to a Surgical Service: A Systematic Review and Meta-analysis. Journal of the American Medical Directors Association. 2020 Dec;21(12):1833-1843.e20. 10.1016/j.jamda.2020.03.023

Valdez E, Wright FAC, Naganathan V, Milledge K, Blyth FM, Hirani V, Le Couteur DG, Handelsman DJ, Waite LM, Cumming RG. Frailty and oral health: Findings from the Concord Health and Ageing in Men Project. Gerodontology. 2020;37(1):28-37. doi: 10.1111/ger.12438

Wahl, D., Anderson, R. M., Le Couteur, D. G. Antiaging therapies, cognitive impairment, and dementia. Journals of Gerontology Series A-Biological Sciences & Medical Sciences. 2020; 75(9), 1643-1652. 10.1093/gerona/glz135

Wang H, Burke LJ, Patel J, Tse BW, Bridle KR, Cogger VC, Li X, Liu X, Yang H, Crawford DHG, Roberts MS, Gao W, Liang X. Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury. Theranostics. 2020;10(15):6715-27. 10.7150/thno.44900

Weir KR, Naganathan V, Bonner C, McCaffery K, Rigby D, McLachlan AJ, Jansen J. Pharmacists' and older adults' perspectives on the benefits and barriers of Home Medicines Reviews - a qualitative study. Journal of health services research & policy. 2020;25(2):77-85. 10.1177/1355819619858632

Wright FAC, Takehara S, Stanaway FF, Naganathan V, Blyth FM, Hirani V, Le Couteur DG, Handelsman DJ, Waite LM, Seibel MJ, Cumming RG. Associations between oral health and depressive symptoms: Findings from the Concord Health and Ageing in Men Project. Australasian journal on ageing. 2020;39(3): e306-e314. doi.org/10.1111/ajag.12763

Wu, H., Mach, J., Le Couteur, D. G., Hilmer, S. N. Fall-related mortality trends in Australia and the United Kingdom: implications for research and practice. Maturitas. 2020;142, 68-72. 10.1016/j.maturitas.2020.07.008

2019

Baysari MT, Duong M, Zheng WY, Nguyen A, Lo S, Ng B, Ritchie A, Le Couteur D, McLachlan A, Bennett A, Hilmer S. Delivering the right information to the right person at the right time to facilitate deprescribing in hospital: a mixed methods multisite study to inform decision support design in Australia. BMJ open. 2019;9(9):e030950. 10.1136/bmjopen-2019-030950

Gaddam RR, Chambers S, Fraser R, Cogger VC, Le Couteur DG, Ishii I, Bhatia M. Cystathionine-Gamma-Lyase-Derived Hydrogen Sulfide-Regulated Substance P Modulates Liver Sieve Fenestrations in Caecal Ligation and Puncture-Induced Sepsis. International journal of molecular sciences. 2019;20(13). 10.3390/ijms20133191

Gibney JM, Wright FA, D'Souza M, Naganathan V. Improving the oral health of older people in hospital. Australasian journal on ageing. 2019 Mar;38(1):33-38. doi: 10.1111/ajag.12588

Hsu B, Hirani V, Cumming RG, Naganathan V, Blyth FM, Wright FC, Waite LM., Seibel MJ., Handelsman DJ., Le Couteur DG.. Cross-Sectional and Longitudinal Relationships Between Inflammatory Biomarkers and Frailty in Community-dwelling Older Men: The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2019;74(6):835-41. 10.1093/gerona/glx142

Hunt NJ, Kang SWS, Lockwood GP, Le Couteur DG, Cogger VC. Hallmarks of Aging in the Liver. Computational and structural biotechnology journal. 2019;17:1151-61. 10.1016/j.csbj.2019.07.021

Hunt NJ, Lockwood GP, Warren A, Mao H, McCourt PAG, Le Couteur DG, Cogger V. Manipulating fenestrations in young and old liver sinusoidal endothelial cells. American journal of physiology Gastrointestinal and liver physiology. 2019;316(1):G144-g54. 10.1152/ajpgi.00179.2018

Johnson G, Byun R, Foster K, Wright F, Blinkhorn A. A longitudinal workforce analysis of a Rural Clinical Placement Program for final year dental students. Australian Dental Journal. 2019 Jun;64(2):181-192. doi: 10.1111/adj.12691. PMID: 30929266.

Jokanovic N, Aslani P, Carter S, Duong M, Gnjidic D, Jansen J, Le Couteur D, Hilmer S. Development of consumer information leaflets for deprescribing in older hospital inpatients: a mixed-methods study. BMJ open. 2019;9(12):e033303. 10.1136/bmjopen-2019-033303

Kang SWS, Cogger VC, Le Couteur DG, Fu D. Multiple cellular pathways regulate lipid droplet homeostasis for the establishment of polarity in collagen sandwich-cultured hepatocytes. American journal of physiology Cell physiology. 2019;317(5):C942-c52. 10.1152/ajpcell.00051.2019

Kashyap M, Thuermann P, Le Couteur DG, Abernethy DR, Hilmer SN. IUPHAR International geriatric clinical pharmacology curriculum for medical students. Pharmacological research. 2019;141:611-5. 10.1016/j.phrs.2019.01.032

Koay YC, Wali JA, Luk AWS, Macia L, Cogger VC, Pulpitel TJ, Wahl D, Solon-Biet SM, Holmes A, Simpson SJ, O'Sullivan JF. Ingestion of resistant starch by mice markedly increases microbiome-derived metabolites. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019;33(7):8033-42. 10.1096/fj.201900177R

Mach J., Huizer-Pajkos A., Cogger V., McKenzie C., Le Couteur D., de Cabo R., Jones B., Hilmer S.. Corrigendum to: The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats. The journals of gerontology Series A, Biological sciences and medical sciences. 2019;74(3):332. 10.1093/gerona/gly160

Maeso-Díaz R, Ortega-Ribera M, Lafoz E, Lozano JJ, Baiges A, Francés R, Albillos A, Peralta C, García-Pagán JC, Bosch J, Cogger VC, Gracia-Sancho J. Aging Influences Hepatic Microvascular Biology and Liver Fibrosis in Advanced Chronic Liver Disease. Aging and disease. 2019;10(4):684-98. 10.14336/AD.2019.0127

Mao H, Diekmann R, Liang HPH, Cogger VC, Le Couteur DG, Lockwood GP, Hunt NJ, Schüttpelz M, Huser TR, Chen VM and McCourt PAG. Cost-efficient nanoscopy reveals nanoscale architecture of liver cells and platelets. Nanophotonics;8(7): 1299-1313. doi.org/10.1515/nanoph-2019-0066

Morimoto J., Senior A., Ruiz K., Wali J., Pulpite, T., Solon-Biet S., Cogger V., Raubenheimer D., Le Couteur D., Simpson S., Eberhard J.. Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis. PloS one. 2019;14(3):e0212796. 10.1371/journal.pone.0212796

Moth EB, Kiely BE, Stefanic N, Naganathan V, Martin A, Grimison P, StocklerMR, Beale P, Blinman P. Predicting chemotherapy toxicity in older adults: Comparing the predictive value of the CARG Toxicity Score with oncologists' estimates of toxicity based on clinical judgement. Journal of geriatric oncology. 2019;10(2):202-9. 10.1016/j.jgo.2018.08.010

Moth, E., Kiely, B., Stefanic, N., Naganathan, V., Martin, A., Grimison, P., Stockler, M., Beale, P., Blinman, P.. Oncologists' perceptions on the usefulness of geriatric assessment measures and the CARG toxicity score when prescribing chemotherapy for older patients with cancer. Journal of geriatric oncology. 2019;10(2):210-5. 10.1016/j.jgo.2018.11.004

Naganathan V. Prescribing to the Oldest Old. In: Nagaratnam N., Nagaratnam K., Cheuk G., editors. Advanced Age Geriatric Care: A Comprehensive Guide. Springer, Cham; 2019. p 297-304. doi.org/10.1007/978-3-319-96998-5

Naganathan V., Nagaratnam K. Managing Osteoporosis in Oldest of Old. In: Nagaratnam N., Nagaratnam K., Cheuk G., editors. Advanced Age Geriatric Care: A Comprehensive Guide. Springer, Cham; 2019. p 217-221. doi.org/10.1007/978-3-319-96998-5

Narayan SW, Pearson SA, Litchfield M, Le Couteur DG, Buckley N, McLachlan AJ, Zoega H. Anticholinergic medicines use among older adults before and after initiating dementia medicines. British journal of clinical pharmacology. 2019;85(9):1957-63. 10.1111/bcp.13976

Rhee J, Meller A, Krysinska K, Gonski P, Naganathan V, Zwar N, Hayen A, Cullen J, O’Keefe JA, McDonald J, Harris-Roxas B, Caplan GA. Advance care planning for patients with advanced illnesses attending hospital outpatient clinics study: a study protocol for a randomised controlled trial. BMJ open. 2019;9(1):e023107. 10.1136/bmjopen-2018-023107

Ribeiro R.V., Solon-Biet S.M., Pulpitel T., Senior A.M., Cogger V.C., Clark X., O’Sullivan J., Koay Y.C., Hirani V., Blyth F.M., Seibel M.J., Waite L.M., Naganathan V., Cumming R.G., Handelsman D.J., Simpson S.J., Couteur D.G.L. Of Older Mice and Men: Branched-Chain Amino Acids and Body Composition. Nutrients. 2019;11(8). 10.3390/nu11081882

Ribeiro RV, Simpson SJ, Le Couteur DG, Raubenheimer D, Eberhard J, Ruiz K, Macia L, Todorova Y, Gosby AK. The nutrition for healthy living study: A randomised clinical trial assessing the effect of protein sources on healthy ageing Nutrition and Healthy Aging 2019;5(1): 43-51. 10.3233/NHA-180055

Scott IA, Hilmer SN, Le Couteur DG. Going Beyond the Guidelines in Individualising the Use of Antihypertensive Drugs in Older Patients. Drugs & aging. 2019;36(8):675-85. 10.1007/s40266-019-00683-8

Scott, D., Seibel M., Cumming R., Naganathan V., Blyth F., Le Couteur D., Handelsman D., Waite L., Hirani V. Does Combined Osteopenia/Osteoporosis and Sarcopenia Confer Greater Risk of Falls and Fracture Than Either Condition Alone in Older Men? The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2019;74(6):827-34. 10.1093/gerona/gly162

Senior AM, Solon-Biet SM, Cogger VC, Le Couteur DG, Nakagawa S, Raubenheimer D, Simpson SJ. Dietary macronutrient content, age-specific mortality and lifespan. Proceedings Biological sciences. 2019;286(1902):20190393. 10.1098/rspb.2019.0393

Shu CC, Hsu B, Cumming RG, Blyth FM, Waite LM, Le Couteur DG, Handelsman DJ, Naganathan V. Caregiving and all-cause mortality in older men 2005-15: the Concord Health and Ageing in Men Project. Age and ageing. 2019;48(4):571-6. doi.org/10.1093/ageing/afz039

Simpson SJ, Le Couteur DG. The diet and the damage done. Nature metabolism. 2019;1(11):1030-1. 10.1038/s42255-019-0128-6

Solon-Biet SM, Cogger VC, Pulpitel T, Wahl D, Clark X, Bagley E, Gregoriou GC, Senior AM, Wang QP, Brandon AE, Perks R, O'Sullivan J, Koay YC, Bell-Anderson K, Kebede M, Yau B, Atkinson C, Svineng G, Dodgson T, Wali JA, Piper MDW, Juricic P, Partridge L, Rose AJ, Raubenheimer D, Cooney GJ, Le Couteur DG, Simpson SJ. Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nature metabolism. 2019;1(5):532-45. 10.1038/s42255-019-0059-2

Solon-Biet SM, Wahl D, Raubenheimer D, Cogger V., Le Couteur DG, Simpson SJ. The geometric framework: An approach for studying the impact of nutrition on healthy aging. Drug Discovery Today: Disease Models 2019; 27; 61-68. doi.org/10.1016/j.ddmod.2019.03.002

Thillainadesan J, Hilmer SN, Close J, Kearney L, Naganathan V Geriatric medicine services for older surgical patients in acute hospitals: Results from a binational survey Australasian Journal on Ageing 2019; 38(4):278-283. 10.1111/ajag.12675

Thomas R, Sims R, Beller E, Scott A., Doust J, Le Couteur DG, Pond D, Loy C, Forlini C., Glasziou P. An Australian community jury to consider case-finding for dementia: Differences between informed community preferences and general practice guidelines. Health Expectations, 2019 22(3), 475-484. 10.1111/hex.12871

Toyama T, van den Broek-Best O, Ohkuma T, Handelsman D, Waite LM, Seibel MJ, Cumming R, Naganathan V, Sherrington C, Hirani V, Wang AY. Associations of Impaired Renal Function With Declines in Muscle Strength and Muscle Function in Older Men: Findings From the CHAMP Study. The journals of gerontology Series A, Biological sciences and medical sciences. 2019;74(11):1812-20. 10.1093/gerona/glz100

Tran J, Wright FAC, Takehara S, Chu C-C, Naganathan V., Hirani V., Blyth FM, Le Couteur DG, Waite L, Handelsman DJ, Seibel M, Milledge K, Cumming RG. Oral health behaviours of older Australian men: the Concord Health and Ageing in Men Project. Australian dental journal. 2019;64(3):246-55. 10.1111/adj.12694

Wahl D, Gokarn R, Mitchell SJ, Solon-Biet SM, Cogger VC, Simpson SJ, Le Couteur DG., de Cabo R. Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice. Nutrition and healthy aging. 2019;5(2):111-7. 10.3233/NHA-180059

Wahl D, Solon-Biet SM, Cogger VC, Fontana L, Simpson SJ, Le Couteur DG, Ribeiro RV. Aging, lifestyle and dementia. Neurobiology of disease. 2019;130:104481. 10.1016/j.nbd.2019.104481

Weir KR, Bonner C, McCaffery K, Naganathan V, Carter SM, Rigby D, Trevena L, Mclachlan A, Jansen J. Pharmacists and patients sharing decisions about medicines: Development and feasibility of a conversation guide. Research in social & administrative pharmacy : RSAP. 2019;15(6):682-90. 10.1016/j.sapharm.2018.08.009

Weir KR, Naganathan V, Rigby D, McCaffery K, Bonner C, Trevena L, McLachlan A, Jansen J. Home medicines reviews: a qualitative study of GPs’ experiences. Australian journal of primary health. 2019;26(1) 24-30 https://doi.org/10.1071/PY19072.

Wright FAC, Law GG, Milledge KL, Chu SK, Hsu B, Valdez E, Naganathan V, Hirani V, Blyth FM, LeCouteur DG, Waite LM, Handelsman DJ, Seibel MJ, Cumming RG. Chewing function, general health and the dentition of older Australian men: The Concord Health and Ageing in Men Project. Community dentistry and oral epidemiology. 2019;47(2):134-41. 10.1111/cdoe.12435

Our Presentations

2022

Blyth F. Populations and patients - are they two sides of the same coin? Sydney Health Partners Geriatric Clinical Academic Group (CAG) Launch. Sydney. 2022.

Cogger V. The Biology of the Ageing Liver. The 2022 Liver Sinusoid Meeting, China.

Hunt N. Oral nanoformulations of Insulin. British Pharmacological Society. 2022.

Kawamura J. Prevalence and association of antipsychotic drugs with falls in hospitalised older adults. APSA-ASCEPT. 2022 Joint Conference (Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists). (Second year medical student project - supervisor Dr Janani Thillainadesan).

Lin J. Pharmacist consultations in hospitalised older surgical patients. APSA-ASCEPT 2022 Joint Conference (Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists). (First year medical student project - supervisor Dr Janani Thillainadesan).

Naganathan V. Gerontology training programs and research projects in Australia. The 3rd Vietnam National Geriatric Conference Program, Hanoi, Vietnam. 2022.

Naganathan V. How does research influence everyday clinical practice? Sydney Health Partners Geriatric Clinical Academic Group (CAG) Launch. Sydney. 2022.

Naganathan V. Perspectives on the teaching of Geriatric Medicine. Professor Vasi Naganathan, ANZSGM State Meeting in South Australia. 2022.

Naganathan V. Research does (and does not) influence everyday Geriatric Medicine Practice and Service Development. Professor Vasi Naganathan, ANZSGM State Meetings in QLD and South Australia. 2022.

Thillainadesan J. A collaborative model of proactive geriatrician care and education of junior doctors improves hospital care of older surgical patients (oral presentation). Australian and New Zealand Society for Geriatric Medicine (ANZSGM) Virtual Annual Scientific Meeting. 2022.

Thillainadesan J. A shared model of care on vascular surgery wards. 2022 Princess Alexandria Hospital Health Symposium.

Thillainadesan J. CGA delivery and education to improve clinician practice and patient outcomes. John A. Burns School of Medicine Geriatric Fellows, Hawaii, USA. 2022.

Thillainadesan J. Collaborative model of care. Sydney Health Partners Geriatric Clinical Academic Group (CAG) Launch. Sydney. 2022.

Thillainadesan J. Frailty and the surgical patient. COALFACE GERIATRICS: Managing Comorbidity in an Older Person (Hunter Postgraduate Medical Institute). 2022.

Thillainadesan J. Geriatric Surgical Services around Australia and New Zealand. Virtual roadshow by Australian and New Zealand Society for Geriatric Medicine. 2022.

Thillainadesan J. Geriatrician co-management and education of junior doctors improve the care of hospitalized older surgical patients. Gerontological Society of America (GSA) Annual Scientific Meeting, USA. 2022.

Thillainadesan J. Health Professions Education Research Micro-Conference (virtual). 2022.

Thillainadesan J. How to manage quality of life and life expectancy - frailty and co-morbidities in urology management. 19th Urological Association of Asia Congress. 2022.

Thillainadesan J. Perioperative care in vascular wards. ANZCA 2022 Perioperative Medicine Special Interest Group meeting. 2022.

Thillainadesan J. The Role of Frailty and Resilience in Surgery'. Evidence-Based Perioperative Medicine. Asia Congress. Singapore. 2022.

Thillainadesan J. What matters to older surgical patients and their carers during hospitalisation? Australian and New Zealand Society for Geriatric Medicine (ANZSGM) Virtual Annual Scientific Meeting. 2022.

Thillainadesan J. What matters to older surgical patients and their carers during their hospitalization? Gerontological Society of America (GSA) Annual Scientific Meeting, USA. 2022.

2021

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