Our Research Team
| Amy Lonergan | Scientific Officer |
| Patrick Tang | Data Manager |
On
Neurosurgery Research
The Department of Neurosurgery at Royal Prince Alfred Hospital provides care and a full range of neurosurgical services for adult patients with acute and chronic conditions.
The Department's research focus includes neurooncology (including brain tumour banking "Glionet"), spinal surgery and cerebrovascular surgery.
Our Publications
2023
| Kyle K, Maamary J, Jonker B, Peters J, Barnett Y, Barnett M, D'Souza A, Maller J, Wang C, Tisch S. Consistency is key: influence of skull density ratio distribution on the formation of clinically effective lesions and long-term tremor suppression following treatment with MR-guided focused ultrasound. J Neurosurg. 2023 Sep 1;140(3):648-656. doi: 10.3171/2023.6.JNS231153. PMID: 37657096. |
| Kyle K, Maller J, Barnett Y, Jonker B, Barnett M, D'Souza A, Calamante F, Maamary J, Peters J, Wang C, Tisch S. Tremor suppression following treatment with MRgFUS: skull density ratio consistency and degree of posterior dentatorubrothalamic tract lesioning predicts long-term clinical outcomes in essential tremor. Front Neurol. 2023 Apr 25;14:1129430. doi: 10.3389/fneur.2023.1129430. PMID: 37181561; PMCID: PMC10166854. |
| Lim SY, Shklovskaya E, Lee JH, Pedersen B, Stewart A, Ming Z, Irvine M, Shivalingam B, Saw RPM, Menzies AM, Carlino MS, Scolyer RA, Long GV, Rizos H. The molecular and functional landscape of resistance to immune checkpoint blockade in melanoma. Nat Commun. 2023 Mar 18;14(1):1516. doi: 10.1038/s41467-023-36979-y. PMID: 36934113; PMCID: PMC10024679. |
| Maamary J, Peters J, Kyle K, Barnett Y, Jonker B, Tisch S. Effective Subthalamic Nucleus Deep Brain Stimulation Following MRgFUS for Tremor Dominant Parkinson's Disease. Mov Disord Clin Pract. 2023 Jan 30;10(3):486-492. doi: 10.1002/mdc3.13662. PMID: 36949789; PMCID: PMC10026293. |
| Maamary J, Peters J, Kyle K, Ruge D, Jonker B, Barnett Y, Tisch S. Evaluation of the efficacy and safety of MRI-guided focused ultrasound (MRgFUS) for focal hand dystonia: study protocol for an open-label non-randomised clinical trial. BMJ Neurol Open. 2023 Oct 25;5(2):e000522. doi: 10.1136/bmjno-2023-000522. PMID: 37900622; PMCID: PMC10603452. |
| Peters J, Maamary J, Kyle K, Olsen N, Jones L, Bolitho S, Barnett Y, Jonker B, Tisch S. Outcomes of Focused Ultrasound Thalamotomy in Tremor Syndromes. Mov Disord. 2024 Jan;39(1):173-182. doi: 10.1002/mds.29658. Epub 2023 Nov 14. PMID: 37964429. |
| Shaw R, Jukes AK, Allan RS. High-flow bypass for giant dolichoectatic vertebrobasilar aneurysms: illustrative cases. J Neurosurg Case Lessons. 2023 Dec 11;6(24):CASE23613. doi: 10.3171/CASE23613. PMID: 38079625; PMCID: PMC10718280. |
| Shaw R, Wong J, Andrade H, Radovanovic I. Disconnection of a jugular foramen dural arteriovenous fistula with cortical venous reflux via an intradural retrosigmoid approach: illustrative case. J Neurosurg Case Lessons. 2023 Dec 11;6(24):CASE23549. doi: 10.3171/CASE23549. PMID: 38079627; PMCID: PMC10718279. |
| Shepherd CE, Lewis SJG, Tisch S, McCann H, Jonker B, Halliday GM. Effects of STN/SNr deep brain stimulation in a case of progressive supranuclear palsy with a Parkinson disease phenotype. J Neuropathol Exp Neurol. 2023 Aug 21;82(9):821-823. doi: 10.1093/jnen/nlad052. PMID: 37418010. |
| Wilmott JS, Tawbi H, Engh JA, Amankulor NM, Shivalingam B, Banerjee H, Vergara IA, Lee H, Johansson PA, Ferguson PM, Saiag P, Robert C, Grob JJ, Butterfield LH, Scolyer RA, Kirkwood JM, Long GV, Davies MA. Clinical Features Associated with Outcomes and Biomarker Analysis of Dabrafenib plus Trametinib Treatment in Patients with BRAF-Mutant Melanoma Brain Metastases. Clin Cancer Res. 2023 Feb 1;29(3):521-531. doi: 10.1158/1078-0432.CCR-22-2581. PMID: 36477181; PMCID: PMC9898142. |
| Zhang AS, Jonker BP, Morris CL, Campbell RG, Alvarado R, Winder M, Sacks R, Seresirikachorn K, Harvey RJ. Endoscopic Endonasal Biopsy for Diagnosis of Undifferentiated Lesions of the Cavernous Sinus. World Neurosurg. 2023 Jul;175:e391-e396. doi: 10.1016/j.wneu.2023.03.103. Epub 2023 Mar 31. PMID: 37004883. |
| Conway JW, Rawson RV, Lo S, Ahmed T, Vergara IA, Gide TN, Attrill GH, Carlino MS, Saw RPM, Thompson JF, Spillane AJ, Shannon KF, Shivalingam B, Menzies AM, Wilmott JS, Long GV, Scolyer RA, Pires da Silva I. Unveiling the tumor immune microenvironment of organ-specific melanoma metastatic sites. J Immunother Cancer. 2022 Sep;10. |
| Halmagyi GM, Parker GD, Chen L, Welgampola MS, Watson JDG, Barnett MH, Todd MJ, El-Wahsh S, Rose V, Stoodley MA, Brennan JW. Progressive loss of hearing and balance in superficial siderosis due to occult spinal dural defects. European Archives of Oto-Rhino-Laryngology. 2022. |
| Li A, Yip M, Choski H, London K, Potter AJ, Lo SN, Saw RPM, Shannon KF, Pires da Silva I, Varey AHR, Menzies AM, Long GV, Shivalingam B, Scolyer RA, Thompson J, Ch'ng S. Lack of association between anatomical sites of scalp melanomas and brain metastases does not support direct vascular spread. Melanoma Research 2022; 32:4. |
| Morrison T, Datta R, Masters L, Boggild M, Reddel S, Brennan J. MR 'Scalpel sign' of spinal arachnoid web. Practical Neurology 2002; 22:3 |
| Newell F, Johansoson PA, Wilmott JS, Nones K, Lakis V, Pritchard AL, LO SN, Rawson RV, Kazakoff SH, Colebatch AJ, Koufariotis LT, Ferguson PM, Wood S, Leonard C, Law MH, Brooks KM, Broit N, Palmer JM, Couts KL, Vergara IA, Long GV, Barbour AP, Nieweg OE, Shivalingam B, Robinson WA, Stretch JR, Spillane AJ, Saw RPM, Shannon KF, Thompson JF, Mann GJ, Pearson JV, Scolyer RA, Waddell N, Hayward NK. Comparative genomics provides etiological and biological insights into melanoma subtypes. Cancer Discovery 2022. |
| Pogson JM, Taylor RL, Bradshaw AP, McGarvie L, D'Souza M, Flanagan S, Kong J, Biggs N, Shivalingam B, Greenberg S, Croxson G, Halmagyi GM, Welgampola MS. The human vestibulo-ocular reflex and compensatory saccades in schwannoma patients before and after vestibular nerve section. Clinical Neurophysiology. 2022. Vol. 138. |
| Pudsey L, Haworth A, White P, Moutrie Z, Jonker B, Foote M, Poder J. Current status of intra-cranial stereotactic radiotherapy and sterotactic radiosurgery in Australia and New Zealand: key considerations froma workshop and surveys. Physical and Engineering Sciences in Medicine 2022. 45.1 |
| Sinclair KZ, Yip JM, Aggarwal S, Jukes A, Clark J, Shivalingam B, Ch'ng S. Microsurgical scalp reconstruction and cranioplasty refined. Australian Journal of Plastic Surgery 2022. 5:1. |
| Stroud A, Dhaliwal P, Harvey RJ, Jonker BP. Low but not undetectable early postoperatigve nadir serum cortisol predicts sustained remission in Cushing's disease. Endocr oncol 2022. 2: 19-31. |
| Stroud A, Tisch S, Joknker BP. Cerebellar Cortex Stimulation for Acquired Dystonia: A case report and review of its role in modern surgical practice. Stereotactic and Functional Neurosurgery. 2022. |
| Watson CJG, Lawlor M, Sy J, Krishnaswamy M, Buckland ME, Brennan JW, Satgunaseelan L. Anaplasia and age of onset in desmoplastic infantile ganglioglioma: Case report and review of the literature. Paediatric Blood and Cancer. 2002 |
| Wilmott JS, Tawbi H, Engh JA, Amankulor NM, Shivalingam B, Banerjee H, Vergara IA, Lee H, Johansson PA, Ferguson PM, Saiag P, Robert C, Grob JJ, Butterfield LH, Scolyer RA, Kirkwood JM, Long GV, Davies MA. Clinical features associated wtih outcomes and biomarker analysis of dabrafenib plus trametinib treatment in patients with BRAF-mutant melanoma brain metastases. Clin Cancer Res. 2022 Dec 7. |
| Xian E, Morrison T, Wong J. Hyperacute in-stent thrombosis causing large vessel occlusion after stent-assisted aneurysm coiling secondary to complete clopidogrel and prasugrel resistance: A case report. J Neurol Surg A Cent Eur Neurosurg 2022 |
| Askenase MH, Goods BA, Beatty HE, Steinschneider AF, Velazquez SE, Osherov A, Landreneau MJ, Carroll SL, Tran TB, Avram VS, Drake RS, Gatter GJ, Massey JA, Karuppagounder SS, Ratan RR, Matouk CC, Sheth KN, Ziai WC, Parry-Jones AR, Awad IA, Zuccarello M, Thompson RE, Dawson J, Hanley DF, Love JC, Shalek AK, Sansing LH; MISTIE III Consortium; ICHseq investigators; ICHseq Investigators MISTIE III Investigators. Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage. Sci Immunol. 2021 Feb 19;6(56):eabd6279. doi: 10.1126/sciimmunol.abd6279. Epub 2021 Feb 19. PMID: 33891558. |
| Chang N, Grayson JW, Mangussi-Gomes J, Jonker BP et al. Assessment of magnetic resonance imaging criteria for the diagnosis of cavernous sinus invasion by pituitary tumors. J Clin Neurosci 2021; 90: 262-7. |
| Choi S, Hong A, Wang T, Lo S, Chen B, Silva I, Kapoor R, Hsiao E, Fogarty GB, Carlino MS, Menzies AM, Long GV, Shivalingam BS. Risk of radiation necrosis after stereotactic radiosurgery for melanoma brain metastasis by anatomical location. Strahlenther Onkol. 2021 Dec;197(12):1104-1112. doi: 10.1007/s00066-021-01798-x. Epub 2021 Jun 10. PMID: 34114045. |
| Grayson, J., Nayak, A., Winder, M., Jonker, B., Alvarado, R., Barham, H., ... Harvey, R. (2021). Multidisciplinary Team Care in the Surgical Management of Pituitary Adenoma. Journal of Neurological Surgery Part B: Skull Base. 2021 Jun;82(3):295-302 https://doi.org/10.1055/s-0039-1700498 |
| Hong AM, Waldstein C, Shivalingam B, Carlino MS, Atkinson V, Kefford RF, McArthur GA, Menzies AM, Thompson JF, Long GV. Management of melanoma brain metastases: Evidence-based clinical practice guidelines by Cancer Council Australia. Eur J Cancer. 2021 Jan;142:10-17. doi: 10.1016/j.ejca.2020.10.013. Epub 2020 Nov 15. PMID: 33207293. |
| Jonker, B. Neuroablative procedures. Video. [NOVEL]. 2021. Available at: https://collections.lib.utah.edu/ark:/87278/s6qz82z3. March 29, 2021 |
| Lewin A, Fearnside M, Kuru R, Jonker B et al. Rates, costs, return to work and reoperation following spinal surgery in a workers' compensation cohort in New South Wales, 2010-2018: a cohort study using administrative data. Bmc Health Serv Res 2021; 21: 955. |
| Rabbie R, Ferguson P, Wong K, Couturier DL, Moran U, Turner C, Emanuel P, Haas K, Saunus JM, Davidson MR, Lakhani SR, Shivalingam B, Long GV, Parkinson C, Osman I, Scolyer RA, Corrie P, Adams DJ. The mutational landscape of melanoma brain metastases presenting as the first visceral site of recurrence. Br J Cancer. 2021 Jan;124(1):156-160. doi: 10.1038/s41416-020-01090-2. Epub 2020 Oct 7. PMID: 33024263; PMCID: PMC7782512. |
| Wilson DN, Barnett Y, Kyle K, Tisch S, Jonker BP. Predictors of thermal response and lesion size in patients undergoing magnetic resonance-guided focused ultrasound thalamotomy. J Clin Neurosci 2021; 91: 75-9. |
| Young AS, Reddel SW, Jonker B, Thompson E, Welgampola MS. A dorsolateral medullary lesion causing persistent down-beating nystagmus. J Neurol 2021; 268: 4371-3. |
| Fish, C., Sy, J., Wong, J., High mitotic activity in a capillary hemangioma of the cauda equina: Case report and review of the literature. Clinical Neuropathology, 2020, 39(3): 135-138. |
| Hallal S, Azimi A, Wei H, Ho N, Lee MYT, Sim HW, et al. A Comprehensive Proteomic SWATH-MS Workflow for Profiling Blood Extracellular Vesicles: A New Avenue for Glioma Tumour Surveillance. Int J Mol Sci. 2020;21(13). |
| Hallal S, Ebrahim Khani S, Wei H, Lee MYT, Sim HW, Sy J, et al. Deep Sequencing of Small RNAs from Neurosurgical Extracellular Vesicles Substantiates miR-486-3p as a Circulating Biomarker that Distinguishes Glioblastoma from Lower-Grade Astrocytoma Patients. Int J Mol Sci. 2020;21(14). |
| Hong AM, Waldstein C, Shivalingam B, Carlino MS, Atkinson V, Kefford RF, et al. Management of melanoma brain metastases: Evidence-based clinical practice guidelines by Cancer Council Australia. Eur J Cancer. 2020;142:10-7. |
| Morrison, T., Jukes, A., Wong, J., Rupture from cavernous internal carotid artery pseudoaneurysm 11 years after transsphenoidal surgery. Journal of Clinical Neurosciences, 2020, 79: 266-268 |
| Orgain CA, Kuan EC, Alvarado R, Adappa ND, Jonker BP, Lee JYK, et al. (2020). Smell Preservation following Unilateral Endoscopic Transnasal Approach to Resection of Olfactory Groove Meningioma: A Multi-institutional Experience. Journal of Neurological Surgery Part B Skull Base, 81, 263-267. https://doi.org/10.1055/s-0039-1688794, 10.1055/s-0039-1688794 |
| Ovens C, Dean B, Gzell C, Patanjali N, Jonker B, O'Connor M, et al. (2020). Optimal management in optic nerve sheath meningioma - A multicentre study and pooled data analysis. Journal of Clinical Neuroscience, 80, 162-168. https://doi.org/10.1016/j.jocn.2020.08.017, 10.1016/j.jocn.2020.08.017 |
| Rabbie R, Ferguson P, Wong K, Couturier DL, Moran U, Turner C, et al. The mutational landscape of melanoma brain metastases presenting as the first visceral site of recurrence. Br J Cancer. 2020. |
| Shklovskaya E, Lee JH, Lim SY, Stewart A, Pedersen B, Ferguson P, et al. Tumor MHC Expression Guides First-Line Immunotherapy Selection in Melanoma. Cancers (Basel). 2020;12(11). |
| Stroud A, Dhaliwal P, Alvarado R, Winder MJ, Jonker BP, Grayson JW, et al. (2020). Outcomes of pituitary surgery for Cushing's disease: a systematic review and meta-analysis. Pituitary, 23, 595-609. https://doi.org/10.1007/s11102-020-01066-8, 10.1007/s11102-020-01066-8 |
| Wang M, Jonker B, Killen L, Bogum Y, McCormack A, Bishay RH. Fatal high-grade skull osteosarcoma 30 years following radiotherapy for Cushing's disease. Endocrinol Diabetes Metab Case Rep. 2020;2020. doi:10.1530/EDM-20-0062, 10.1530/EDM-20-0062 |
| Wilson K, Shivalingam B, Sayasneh A. Vaginal discharge: leaking cerebrospinal fluid? J Obstet Gynaecol. 2020;40(2):279-80. |
| Allison S. Young, Benjamin Jonker and Miriam S. Welgampola (2019) Neurology 92;723-724 Vestibular paroxysmia presenting with irritative nystagmus |
| Fish C, Sy J, Wong J. (2020) Clin Neuropath, 2020 Feb 12, High mitotic activity in a capillary hemangioma of the cauda equine: Case report and review of the literature. https://doi.org/10.5414/NP301227 |
| Grayson, J., Nayak, A., Winder, M., Jonker, B., Alvarado, R., Barham, H., Harvey, R. (2019). Multidisciplinary Team Care in the Surgical Management of Pituitary Adenoma. Journal of Neurological Surgery Part B: Skull Base. https://doi.org/10.1055/s-0039-1700498 |
| Hanley, D. F., Thompson, R. E., Rosenblum, M., Yenokyan, G., Lane, K., McBee, N., Zomorodi, A. (2019). Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial. The Lancet, 393(Lancet Glob Health 1 2013), 1021-1032. https://doi.org/10.1016/s0140-6736(19)30195-3 - Participated as a MISTIE III investigator |
| Kirsty R. Hamilton, Sharon SI Lee, James C. Urquhart, Benjamin P. Jonker (2019), A systematic review of outcome in intramedullary ependymoma and astrocytoma, Journal of Clinical Neuroscience, Volume 63, 2019, Pages 168-175 |
| Minh-Son To and Alistair Jukes (2019), Reporting trends of p values in the neurosurgical literature, Journal of Neurosurgery, Feb 8 2019 https://doi.org/10.3171/2018.8.JNS172897 |
| Vediappan RS, Mascarenhas A, Nguyen-Hoang A, Anne Fong S, Jukes A, Richter K, Bassiouni A, Patel S, Chryssidis S, Otto S, Moratti S, James Psaltis A, Vreugde S, Wormald PJ. J Clin Neurosci. 2020 Feb;72:378-385. Prevention of peridural adhesions in spinal surgery: Assessing safety and efficacy of Chitogel with Deferiprone in a sheeo model. doi: 10.1016/j.jocn.2019.12.042.. |
Our Presentations
2023
| Madani, D., et al. ROR1 mRNA expression in glioma: a novel prognostic biomarker. COGNO Annual Scientific Meeting, Sydney 2023. |
| Shivalingam, B. Low Grade Glioma Surgical Techniques Review. Neurosurgical Society of Australasia Annual Scientific Meeting 2023. |
| Madani D, Shivalingam B. ROR1 mRNA expression in glioma - a novel prognostic biomarker. Society of Neuro-oncology Annual Scientific Meeting, Miami 2022. |
| Xian, E, Mulcahy M, Elalingam T, Wong J. Middle meningeal arteyr embolisation for chronic subdural haematomas - first Australian single-centre experinece. Neurosurgical Society of Australasia Annual Scientific Meeting, Sydney 2022. |
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Xian E, Hallal S, Satunaseelan L, Mason S, Patanjali N, Sim HW, Buckland ME, McGee-Collett M, Brennan J, Allan R, Jonker B, Wong J, Shivalingam B, Alexander K. GlioNET: a multi-centre, observational study for newly diagnosed glioma patients. Poster Presentation at Neurosurgical Society of Australasia Annual Scientific Meeting 2021. |
| Jonker BP, MR Guided Focused Ultrasound for Tremor - The Australian Experience - Presented at: Scientific Meeting for the Asian Australasian Society of Stereotactic and Functional Neurosurgery, South Korea -Presentation Online - September 18, 2020. |
| Shivalingam B. WFNS-AASNS webinar 20/10/20 : "Managing CSF leak after lateral and posterior skull base surgery". |
Neurosurgery Research
Neurosurgery Research