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Gynae-Oncology Research

The Gynae-Oncology Department provide care for women with all types and stages of gynaecological cancers. The studies we undertake explore a variety of research directions. These include collecting information regarding registries, tissue collection for biobank and translational research, exploring different clinical, surgical and oncology treatments, effects of conventional and non-conventional pain management, investigating the effects of exercise during chemotherapy and end of life care. We aim to continuously expand our understanding of gynaecological cancers with the research we conduct.

Our Research Team

Associate Professor Rhonda Farrell Director of Gynae-Oncology
Associate Professor Selvan Pather Senior Staff Specialist Gynae-Oncology
Associate Professor Trevor Tedaja-Berges  Senior Staff Specialist Gynae-Oncology
Associate Professor Samir Saidi Senior Staff Specialist Gynae-Oncology
Dr Robyn Sayer Senior Staff Specialist Gynae-Oncology
Dr Michelle Harrison Senior Staff Specialist Medical Oncology
Dr Tahlia Scheinberg Senior Staff Specialist Medical Oncology
Dr Yeh-Lee Chen Senior Staff Specialist Medical Oncology
Dr Angela Pardey Fellow
Dr Harrison Odgers Fellow
Dr Jonathan Sandeford Fellow
Dr Marilyn Boo Fellow
Dr Sadaf Kalam Senior Clinical Trials Manager
Shannon Philp Nurse Practitioner
Belinda Zielony Clinical Nurse Consultant
Pranita Kadlag Data Manager 
Kyra Garland Masters Student (Nursing)
Kathy Roorda Patient Navigator 
Carla Loteria Patient Navigator 
Chen Shi Patient Navigator 

Selected Grants

Amount awarded Grant and project details
$3,700,000 Cancer Institute NSW and Cancer Council NSW, 2021-2024
INOVATe Individualised Ovarian Cancer Treatment through Integration of Genomic Pathology into Multidisciplinary Care.
RPA Investigator: Beale P
$3,158,864 NHMRC, 2024-2028
Endo-3, phase III randomised trial comparing sentinel node biopsy with no node dissection in early-stage endometrial cancer.
Investigator: Farrell R
$40,000 Chris O'Brien Lifehouse Research Grant, 2022-2025
Diagnostic performance of diffusion-weighted MRI compared to laparoscopy in predicting feasibility of complete cytoreduction in advanced ovarian, fallopian tube and primary peritoneal cancer. 
Investigators: Farrell R, McGauran M, YuXuan Y, Lam K,  McNally O, Shadbolt C, Kouloyan-Ilic S. 
$33,520 Gynae-Oncology Research Advisory Group (GORAG) Research Grants, 2022-2024
Endo-3, phase III randomised trial comparing sentinel node biopsy with no node dissection in early-stage endometrial cancer.
Investigator: Farrell R.
$21,060 Gynae-Oncology Research Advisory Group (GORAG) Research Grants, 2022-2024
The role of virtual reality in reducing perioperative anxiety in Gynaecologic Oncology patients, a prospective randomized controlled study.
Investigator: Pather S.

Our Publications

2023

Algera MD, Morton R, Sundar SS, Farrell R, van Driel WJ, Brennan D, Rijken MJ, Sfeir S, Allen L, Eiken M, Coleman RL; collaborators of the Global Equality in Ovarian Cancer Care project group. Exploring international differences in ovarian cancer care: a survey report on global patterns of care, current practices, and barriers. Int J Gynecol Cancer. 2023 Oct 2;33(10):1612-1620. doi: 10.1136/ijgc-2023-004563.
Coates HW, Capell-Hattam IM, Olzomer EM, Du X, Farrell R, Yang H, Byrne FL, Brown AJ. Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase. Elife. 2023 Jan 19;12:e82843. doi: 10.7554/eLife.82843.
Farrell R. The current and potential future role of peritonectomy and hyperthermic intraperitoneal chemotherapy (HIPEC) for treatment of advanced epithelial ovarian cancer in Australia. PhD Thesis. July 2023 doi.org/10.26190/unsworks/25081
Kang EY, Weir A, Meagher NS, Farrington K, Nelson GS, Ghatage P, Lee CH, Riggan MJ, Bolithon A, Popovic G, Leung B, Tang K, Lambie N, Millstein J, Alsop J, Anglesio MS, Ataseven B, Barlow E, Beckmann MW, Berger J, Bisinotto C, Bösmüller H, Boros J, Brand AH, Brooks-Wilson A, Brucker SY, Carney ME, Casablanca Y, Cazorla-Jiménez A, Cohen PA, Conrads TP, Cook LS, Coulson P, Courtney-Brooks M, Cramer DW, Crowe P, Cunningham JM, Cybulski C, Darcy KM, El-Bahrawy MA, Elishaev E, Erber R, Farrell R, Fereday S, Fischer A, García MJ, Gayther SA, Gentry-Maharaj A, Gilks CB; AOCS Group; Grube M, Harnett PR, Harrington SP, Harter P, Hartmann A, Hecht JL, Heikaus S, Hein A, Heitz F, Hendley J, Hernandez BY, Polo SH, Heublein S, Hirasawa A, Høgdall E, Høgdall CK, Horlings HM, Huntsman DG, Huzarski T, Jewell A, Jimenez-Linan M, Jones ME, Kaufmann SH, Kennedy CJ, Khabele D, Kommoss FKF, Kruitwagen RFPM, Lambrechts D, Le ND, Lener M, Lester J, Leung Y, Linder A, Loverix L, Lubiński J, Madan R, Maxwell GL, Modugno F, Neuhausen SL, Olawaiye A, Olbrecht S, Orsulic S, Palacios J, Pearce CL, Pike MC, Quinn CM, Mohan GR, Rodríguez-Antona C, Ruebner M, Ryan A, Salfinger SG, Sasamoto N, Schildkraut JM, Schoemaker MJ, Shah M, Sharma R, Shvetsov YB, Singh N, Sonke GS, Steele L, Stewart CJR, Sundfeldt K, Swerdlow AJ, Talhouk A, Tan A, Taylor SE, Terry KL, Tołoczko A, Traficante N, Van de Vijver KK, van der Aa MA, Van Gorp T, Van Nieuwenhuysen E, van-Wagensveld L, Vergote I, Vierkant RA, Wang C, Wilkens LR, Winham SJ, Wu AH, Benitez J, Berchuck A, Candido Dos Reis FJ, DeFazio A, Fasching PA, Goode EL, Goodman MT, Gronwald J, Karlan BY, Kommoss S, Menon U, Sinn HP, Staebler A, Brenton JD, Bowtell DD, Pharoah PDP, Ramus SJ, Köbel M. CCNE1 and survival of patients with tubo-ovarian high-grade serous carcinoma: An Ovarian Tumor Tissue Analysis consortium study. Cancer. 2023 Mar 1;129(5):697-713. doi: 10.1002/cncr.34582. Epub 2022 Dec 26.
Li T, Timmins HC, Trinh T, Mizrahi D, Harrison M, Horvath LG, Grimison P, Friedlander M, Kiernan MC, King MT, Rutherford C, Goldstein D, Park SB. Patient-Reported Outcome Measures in Chemotherapy-Induced Peripheral Neurotoxicity: Defining Minimal and Clinically Important Changes. J Natl Compr Canc Netw. 2023 Feb;21(2):125-132.e3. doi: 10.6004/jnccn.2022.7074.
Mizrahi D, Goldstein D, Trinh T, Li T, Timmins HC, Harrison M, Marx GM, Hovey EJ, Lewis CR, Friedlander M, Park SB. Physical activity behaviors in cancer survivors treated with neurotoxic chemotherapy. Asia Pac J Clin Oncol. 2023 Feb;19(1):243-249. doi: 10.1111/ajco.13834. Epub 2022 Jul 25.
Odgers H, Anderson L, Kok PS, Farrell R. Dedifferentiated umbilical metastases from low grade endometrioid endometrial adenocarcinoma complicated by super-obesity: A case report. Int J Surg Case Rep. 2023 Jul;108:108449. doi: 10.1016/j.ijscr.2023.108449. Epub 2023 Jul 1.
Pitiyarachchi O, Lee YC, Sim HW, Srirangan S, Mapagu C, Kirk J, Harnett PR, Balleine RL, Bowtell DDL, Samimi G, Brand AH, Marsh DJ, Beale P, Anderson L, Bouantoun N, Provan P; INOVATe Investigators; Ramus SJ, DeFazio A, Friedlander M. Older age should not be a barrier to testing for somatic variants in homologous recombination DNA repair-related genes in patients with high-grade serous ovarian carcinoma. Transl Oncol. 2023 May;31:101638. doi: 10.1016/j.tranon.2023.101638. Epub 2023 Feb 18.
Raichurkar P, Denehy L, Solomon M, Koh C, Pillinger N, Hogan S, McBride K, Carey S, Bartyn J, Hirst N, Steffens D; Prehabilitation Expert Collaborative. Research Priorities in Prehabilitation for Patients Undergoing Cancer Surgery: An International Delphi Study. Ann Surg Oncol. 2023 Nov;30(12):7226-7235. doi: 10.1245/s10434-023-14192-x. Epub 2023 Aug 24.
Takenaka K, Olzomer EM, Hoehn KL, Curry-Hyde A, Jun Chen B, Farrell R, Byrne FL, Janitz M. Investigation of circular RNA transcriptome in obesity-related endometrial cancer. Gene. 2023 Mar 1;855:147125. doi: 10.1016/j.gene.2022.147125. Epub 2022 Dec 19.