Colorectal Surgery Research

The Colorectal Department has created a foundation in evidence-based practice through their close ties to the Surgical Outcomes Research Centre (SOuRCe), established in 2002. Through this multidisciplinary collaboration within the Sydney Local Health District and the University of Sydney, the Department's research agenda addresses diverse aspects of surgical outcomes, including surgical effectiveness, patient reported outcomes and quality of life, patterns of care and evidence-based practice, health economic evaluation, assessment of patient preferences, surgical decision-making and other methodological studies.

Over many years, the Department has become one of the major research-focused units. With support from over $30 million in competitive funding (including major funding bodies such as the NHMRC, MRFF, CINSW, NIHR and others) and a multi-disciplinary approach, the Department has published in many of the top surgical and medical journals, including NATURE, BMJ, JAMA surgery, Annals of Surgery, The British Journal of Surgery, Journal of Surgical Oncology and other high impact journals. Additionally, the Department is supportive of young academic surgeons, having assisted in the supervision of PhD and MPhil and MD students. These achievements have contributed significantly to the enhancement of patient outcomes and have changed clinical practice at RPA, Australia and Internationally.

Our Research Team

Associate Professor Chris Byrne	Head of Department
Professor Michael Solomon	Research Lead
Associate Professor Cherry Koh	Research Lead
Dr Peter Lee	Colorectal Surgeon, Masters Student
Dr Nabila Ansari	Colorectal Surgeon
Dr Kirk Austin	Colorectal Surgeon
Dr Kheng-Seong Ng	Colorectal Surgeon
Associate Professor Jonathan Hong	Colorectal Surgeon
Associate Professor Daniel Steffens	SOuRCe Director
Sascha Karunaratne	Advanced GI Surgery Program Manager
Mollie Pieniazek	Pelvic Exenteration Research Officer
Jessica El-Hayek	Pelvic Exenteration Research Officer
Henna Solanki	Peritoneal Malignancy Research Officer
Lylee Ye	Retroperitoneal Sarcoma Research Officer
Nicholas Hirst	PRIORITY Research Officer
Ruby Cole	PRIORITY Research Officer
Zirong Bai	PhD Candidate
Dr Kilian Brown	PhD Candidate
Dr Elizabeth Connolly	PhD Candidate
Dr Celine Garrett	Masters Student
Dr Hugh Giddings	Masters Student
Dr Yeqian Huang	PhD Candidate
Dr Charlotte Johnstone	Masters Student
Dr Peter Lee	Masters Student
Dr Pratik Raichurkar	Masters Student
Dr Hang Yue Siu	Masters Student
Dr Jacob Waller	Masters Student
Kate Wilson	PhD Candidate
Dr Philip Yang	Masters Student

Selected Grants

Amount awarded	Grant and project details
$4,995,331	Medical Research Future Fund (MRFF), 2024-2029 Virtual Multimodal Hub for Patients Undergoing Major Gastrointestinal Cancer Surgery – PRIORITY-CONNECT 2 Randomised Type I Hybrid Effectiveness-Implementation Trial Investigator: Steffens D (CI)
$1,119,877	NHMRC, 2020-2024 PRIORITY TRIAL - Preoperative exercise for patients undergoing major abdominal cancer surgery: A Multicentre Randomised Controlled Trial. Investigators: Young J, Solomon MJ, Riedel B, Steffens D, Morton R, Denehy L, Heriot A, Koh C, Li Q, Bauman A.

Previous Grants

Amount awarded	Grant and project details
$41,600	The University of Sydney DVC Research Covid-19 Support Scheme, 2022 PRIORITY TRIAL - Preoperative exercise for patients undergoing major abdominal cancer surgery: A Multicentre Randomised Controlled Trial. Additional funds to support research project following the pandemic. Investigators: Young J, Solomon MJ, Riedel B, Steffens D, Morton R, Denehy L, Heriot A, Koh C, Li Q, Bauman A.
$10,000	Royal Australasian College of Surgeons, 2021-2023 Hugh Johnston Travel Grant. Investigator: Coker D

Our Publications

2023

Brown K, Solomon M, Ng KS, Sutton P, Koh C, White K, Steffens D; EviSurg Research Group. Development of a risk prediction tool for patients with locally advanced and recurrent rectal cancer undergoing pelvic exenteration: protocol for a mixed-methods study. BMJ Open. 2023 Aug 30;13(8):e075304. doi: 10.1136/bmjopen-2023-075304.

Brown KGM, D'Souza N, Solomon MJ. How to access the presacral space using a posterior trans-sacral approach. ANZ J Surg. 2023 Dec;93(12):2993-2994. doi: 10.1111/ans.18750. Epub 2023 Oct 23.

Brown KGM, McBride KE, Anderson T, Solomon MJ. Delivering complex surgical services: lessons learned from the evolution of a specialised pelvic exenteration centre. Aust Health Rev. 2023 Dec;47(6):735-740. doi: 10.1071/AH23186.

Brown KGM, Risbey C, Solomon MJ, Austin KKS, Lee PJ, Byrne CM. Pelvic exenteration for chronic fistulating pelvic sepsis after multimodal treatment of pelvic malignancy. Eur J Surg Oncol. 2023 Dec;49(12):107124. doi: 10.1016/j.ejso.2023.107124. Epub 2023 Oct 20.

Brown KGM, Solomon MJ, Heriot A, Frizelle F. Treatment of locally advanced and recurrent rectal cancer in Australia and New Zealand: recent progress and future challenges. ANZ J Surg. 2023 Oct;93(10):2291-2292. doi: 10.1111/ans.18635. Epub 2023 Jul 26.

Brown KGM, Solomon MJ, Steffens D, Ng KS, Byrne CM, Austin KKS, Lee PJ. Pelvic Exenteration for Squamous Cell Carcinoma of the Anus: Oncological, Morbidity, and Quality-of-Life Outcomes. Dis Colon Rectum. 2023 Nov 1;66(11):1427-1434. doi: 10.1097/DCR.0000000000002919. Epub 2023 Jul 26.

Fitzsimmons T, Thomas M, Tonkin D, Murphy E, Hollington P, Solomon M, Sammour T, Luck A. Establishing a state-wide pelvic exenteration multidisciplinary team meeting in South Australia. ANZ J Surg. 2023 May;93(5):1227-1231. doi: 10.1111/ans.18220. Epub 2022 Dec 25.

Fullard K, Steffens D, Solomon M, Shin JS, Koh C. Measuring the impact of the COVID-19 pandemic on colorectal cancer presentation: a retrospective comparative study. ANZ J Surg. 2023 Dec;93(12):2951-2957. doi: 10.1111/ans.18701. Epub 2023 Oct 17.

Giddings HL, Ng KS, Solomon MJ, Steffens D, Van Buskirk J, Young J. Population outcomes, trends and the future of pouch surgery for ulcerative colitis: a 19-year New South Wales data linkage study. ANZ J Surg. 2023 Nov;93(11):2686-2696. doi: 10.1111/ans.18588. Epub 2023 Jul 14.

Giddings HL, Ng KS, Solomon MJ, Steffens D, Van Buskirk J, Young J. Reducing rate of total colectomies for ulcerative colitis but higher morbidity in the biologic era: an 18-year linked data study from New South Wales Australia. ANZ J Surg. 2023 Dec;93(12):2928-2938. doi: 10.1111/ans.18713. Epub 2023 Oct 5.

Greijdanus NG, Wienholts K, Ubels S, Talboom K, Hannink G, Wolthuis A, de Lacy FB, Lefevre JH, Solomon M, Frasson M, Rotholtz N, Denost Q, Perez RO, Konishi T, Panis Y, Rutegård M, Hompes R, Rosman C, van Workum F, Tanis PJ, de Wilt JHW; TENTACLE-Rectum Collaborative Group. Stoma-free Survival After Rectal Cancer Resection With Anastomotic Leakage: Development and Validation of a Prediction Model in a Large International Cohort. Ann Surg. 2023 Nov 1;278(5):772-780. doi: 10.1097/SLA.0000000000006043. Epub 2023 Jul 27.

Harji DP, Koh C, McKigney N, Solomon MJ, Griffiths B, Evans M, Heriot A, Sagar PM, Velikova G, Brown JM. Development and validation of a patient reported outcome measure for health-related quality of life for locally recurrent rectal cancer: a multicentre, three-phase, mixed-methods, cohort study. EClinicalMedicine. 2023 May 17;59:101945. doi: 10.1016/j.eclinm.2023.101945.

Jiang W, Koh C, Solomon M, Karunaratne S, Beckenkamp PR, Clifford K, Woodfield J, Steffens D. Time to Prioritise Quality Over Quantity in Prehabilitation Trials: A Literature Review. Eurasian Journal of Medicine and Oncology. 2023;7(3):287–303. DOI: 10.14744/ejmo.2023.14880.

Johnstone CS, Koh CE, Britton GJ, Solomon MJ, McLachlan AJ. Implementation of a peri-operative pain-management algorithm reduces the use of opioid analgesia following pelvic exenteration surgery. Colorectal Dis. 2023 Apr;25(4):631-639. doi: 10.1111/codi.16442. Epub 2022 Dec 28.

Johnstone CSH, Roberts D, Mathieson S, Steffens D, Koh CE, Solomon MJ, McLachlan AJ. Pain, pain management and related outcomes following pelvic exenteration surgery: a systematic review. Colorectal Dis. 2023 Apr;25(4):562-572. doi: 10.1111/codi.16462. Epub 2023 Jan 8.

Lim CYS, Laidsaar-Powell RC, Young JM, Steffens D, Ansari N, Joshy G, Butow P; advanced-CRC survivorship authorship group. Healthcare experiences of people with advanced colorectal cancer: A qualitative study. Eur J Oncol Nurs. 2023 Apr;63:102265. doi: 10.1016/j.ejon.2022.102265. Epub 2023 Jan 2.

Makker PGS, Koh C, Steffens D. ASO Author Reflections: Pre-operative Function Status Predicts Post-operative Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intra-peritoneal Chemotherapy. Ann Surg Oncol. 2023 Jan;30(1):459-460. doi: 10.1245/s10434-022-12750-3. Epub 2022 Oct 28.

Makker PGS, Koh CE, Ansari N, Gonzaga N, Bartyn J, Solomon M, Steffens D. Functional Outcomes Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Prospective Cohort Study. Ann Surg Oncol. 2023 Jan;30(1):447-458. doi: 10.1245/s10434-022-12691-x. Epub 2022 Oct 28.

Palma CA, van Kessel CS, Solomon MJ, Leslie S, Jeffery N, Lee PJ, Austin KKS. Bladder preservation or complete cystectomy during pelvic exenteration of patients with locally advanced or recurrent rectal cancer, what should we do? Eur J Surg Oncol. 2023 Jul;49(7):1250-1257. doi: 10.1016/j.ejso.2023.01.002. Epub 2023 Jan 10.

PelvEx Collaborative. Empty pelvis syndrome: PelvEx Collaborative guideline proposal. Br J Surg. 2023 Nov 9;110(12):1730-1731. doi: 10.1093/bjs/znad301.

Raichurkar P, Denehy L, Solomon M, Koh C, Pillinger N, Hogan S, McBride K, Carey S, Bartyn J, Hirst N, Steffens D; Prehabilitation Expert Collaborative. Research Priorities in Prehabilitation for Patients Undergoing Cancer Surgery: An International Delphi Study. Ann Surg Oncol. 2023 Nov;30(12):7226-7235. doi: 10.1245/s10434-023-14192-x. Epub 2023 Aug 24.

Raichurkar P, Koh C, Steffens D. ASO Author Reflections: Future Directions in Prehabilitation Research. Ann Surg Oncol. 2023 Dec;30(13):8755-8756. doi: 10.1245/s10434-023-14304-7. Epub 2023 Sep 29.

Rajendran S, Brown KGM, Solomon MJ. Oncovascular surgery for advanced pelvic malignancy. Br J Surg. 2023 Jan 10;110(2):144-149. doi: 10.1093/bjs/znac414.

Rajendran S, Nguyen CL, Brown KGM, Solomon MJ. The evolution of oncovascular pelvic surgery: A historical perspective. Eur J Surg Oncol. 2023 Jul;49(7):1314-1316. doi: 10.1016/j.ejso.2023.01.018. Epub 2023 Jan 18.

Risbey C, Fielder T, Steffens D, Shin JS, Solomon M. Patterns of DNA mismatch repair protein expression for primary and recurrent colorectal cancer at an advanced surgical unit: A retrospective audit. Colorectal Dis. 2023 Mar;25(3):369-374. doi: 10.1111/codi.16391. Epub 2022 Nov 21.

Risbey CWG, Brown KGM, Solomon MJ, Koh C, Karunaratne S, Steffens D. Impact of geographical health disparities on outcomes following pelvic exenteration at a centralised quaternary referral centre. Eur J Surg Oncol. 2023 Nov;49(11):107082. doi: 10.1016/j.ejso.2023.107082. Epub 2023 Sep 14.

Siu AHY, Holyland M, Carey S, Steffens D, Ansari N, Koh CE. Is the measurement of sarcopenia associated with oncological disease in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy? ANZ J Surg. 2023 Sep;93(9):2186-2191. doi: 10.1111/ans.18645. Epub 2023 Jul 31.

Steffens D, Denehy L, Solomon M, Koh C, Ansari N, McBride K, Carey S, Bartyn J, Lawrence AS, Sheehan K, Delbaere K. Consumer Perspectives on the Adoption of a Prehabilitation Multimodal Online Program for Patients Undergoing Cancer Surgery. Cancers (Basel). 2023 Oct 18;15(20):5039. doi: 10.3390/cancers15205039.

Steffens D, Makker PGS, Ansari N, Solomon MJ, Solanki H, Moran B, Koh C. The influence of postoperative morbidity on medium to long-term quality of life trajectories following cytoreductive surgery for peritoneal malignancy - A prospective cohort study. Surgical Oncology Insight. 2023;100004. ISSN 2950-2470. DOI: 10.1016/j.soi.2023.100004.

Steffens D, Pocovi NC, Bartyn J, Delbaere K, Hancock MJ, Koh C, Denehy L, van Schooten KS, Solomon M, On Behalf Of The Priority Trial Collaboration. Feasibility, Reliability, and Safety of Remote Five Times Sit to Stand Test in Patients with Gastrointestinal Cancer. Cancers (Basel). 2023 Apr 24;15(9):2434. doi: 10.3390/cancers15092434.

Steffens D, Solomon MJ, Lee P, Austin K, Koh C, Byrne C, Karunaratne S, Hatcher S, Taylor K, McBride K. Surgical, survival and quality of life outcomes in over 1000 pelvic exenterations: lessons learned from a large Australian case series. ANZ J Surg. 2023 May;93(5):1232-1241. doi: 10.1111/ans.18356. Epub 2023 Mar 3.

van Kessel CS, Waller J, Steffens D, Lee PJ, Austin KKS, Stalley PD, Solomon MJ. Improving Surgical Outcomes in Pelvic Exenteration Surgery: Comparison of Prone Sacrectomy With Anterior Cortical Sacrectomy Techniques. Ann Surg. 2023 Dec 1;278(6):945-953. doi: 10.1097/SLA.0000000000006040. Epub 2023 Jul 24.

2022

Chang KH, Solomon MJ. The role of surgery in the palliation of advanced pelvic malignancy. European Journal of Surgical Oncology 2022; 48:2323-2329: 10.1016/j.ejso.2022.01.019.

Chetwood JD, Volovets A, Sivam S, Koh C. Surgical considerations in cystic fibrosis: what every general surgeon needs to know. ANZ Journal of Surgery 2022; 92:2425-2432.

Clark DA, Yeoh E, Edmundson A, Harris C, Stevenson A, Steffens D, Solomon M. A Development Study of Drain Fluid Gastrografin as a Biomarker of Anastomotic Leak. Annals of coloproctology 2022; 38(2):124-132; DOI: 10.3393/ac.2020.12.24.

Clark DA, Edmundson A, Steffens D, Radford-Smith G, Solomon S. Multi-center study of drain fluid amylase as a biomarker for the detection of anastomotic leakage after ileal pouch surgery without a diverting ileostomy. Diseases of the Colon and Rectum. 2022; DOI:10.1097/DCR.0000000000002376.

Clark D, Edmundson A, Steffens D, Harris C, Stevenson A, Solomon M. Drain fluid amylase as a biomarker for the detection of anastomotic leakage after rectal resection without a diverting ileostomy. ANZ Journal of Surgery. 2022; 92:813-818. doi: 10.1111/ans.17461.

Clark DA, Stevenson A, Lumley J, Peterson D, Harris C, Steffens D, Solomon M. Does an ileostomy cover the surgeon or the anastomosis? (Perspective) ANZ Journal of Surgery 2022; 92:19-20.

Fitzsimmons T, Thomas M, Tonkin D, Murphy E, Hollington P, Solomon M, Sammour T, Luck A. Establishing a State-wide Pelvic Exenteration Multidisciplinary Team Meeting in South Australia. ANZ Journal of Surgery 2022; DOI: 10.1111/ans.18220.

Garret C, Steffens D, Solomon M, Koh C. Early-onset colorectal cancer: why it should be high on our list of differentials. ANZ Journal of Surgery. 2022; 92:1638-1643.

Harji D, Koh C, McKigney M, Solomon MJ, Griffiths B, Evan M, Heriot A, Sargar PM, Velikova G, Brown JM. Short term outcomes of Health-Related Quality of Life in Patients with Locally Recurrent Rectal Cancer: a multi-centre, international, cross-sectional cohort study. British Journal of Surgery 2022; DOI: 10.1093/bjsopen/zrac168.

Hogan S, Reece L, Solomon M, R A, Carey S. Early enteral feeding is beneficial for patients after pelvic exenteration surgery - A randomised controlled trial. Journal of Parenteral and Enteral Nutrition 2022; 46(2):411-421: DOI: 10.1002/jpen.2120.

Hogan S, Steffens D, Vuong K, Rangan A, Solomon M, Carey S. Preoperative nutritional status impacts clinical outcome and hospital length of stay in pelvic exenteration patients - a retrospective study. Nutrition and Health 2022; 28(1):41-48; DOI: 10.1177/02601060211009067.

Huang Y, Wang X, Steffens D, Young JM, Solomon MJ, Koh CE. Grading Complications in Pelvic Exenteration: Limitations of Current Classification Systems. Diseases of the Colon & Rectum 2022; doi: 10.1097/DCR.0000000000002396.

Huang Y, Steffens D, Koh CE, Young JM, Solomon MJ. Differences in Surgical Outcomes and Quality of Life outcomes in Pelvic Exenteration Between Locally Advanced versus Locally Recurrent Rectal Cancer. Diseases of the Colon & Rectum 2022; 65: 1475-1482.

Johnstone J, Koh C, Britton GJ, Solomon MJ, McLachlan A. Implementation of a perioperative pain management algorithm reduces the use of opioid analgesia following pelvic exenteration surgery. Colorectal Disease 2022; Dec 2: DOI: 10.1111/codi.16442.

Johnstone C, Roberts D, Mathieson S, Steffens D, Koh C, Solomon M, McLachlan A, Pain, pain management and related outcomes following pelvic exenteration surgery: A systematic review. Colorectal Disease 2022; DOI: 10.1111/codi.16462.

Keane CR, O'Grady G, Bissett IP, Hayes J, Hulme-Moir M, Eglinton TW, Solomon MJ, Lumley JW, Simes J, Stevenson ARL. Functional Outcome of Laparoscopic Assisted Resection vs Open Resection of Rectal Cancer: A secondary analysis of the Australasian Laparoscopic Cancer of the Rectum Trial (ALaCaRT). Diseases of the Colon & Rectum 2022; 65(7): e698-e706 DOI: 10.1097/DCR.0000000000002166.

Khaw CW, Ebrahimi N, Lee P, McCarthy ASE, Solomon M. Long‐term results of mesh pelvic floor reconstruction to address the empty pelvis syndrome. Colorectal Disease 2022; 24:1211-1215.

Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Nancy L. Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao Jr MM, MD; MacLean AB, Maher IA, Mittal BB, Nehal KS, MD; Ozog DM, MD; Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M. Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease. (Clinical Review) JAMA Oncology 2022; 8:618-628.

Koh CE, Brown KGM, Steffens D, Young J, Salkeld G, Solomon MJ. What constitutes a clear margin in patients with locally recurrent rectal cancer undergoing pelvic exenteration? Annals of Surgery 2022; 275(1):157-165: 10.1097/SLA.0000000000003834.

Koh CE. The long road to gender equity in surgery. British Journal of Surgery. 2022; 378:o2263; DOI: 10.1136/bmj.o2263.

Koh CE. Resecting the primary in unresectable stage IV colorectal cancer: Should we or shouldn't we? (Editorial). Colorectal Disease 2022; 24:809-810.

Law CK, Stevenson ARL, Solomon M, Hague W, Wilson K, Simes JR, Morton RL, the Australasian Gastro-Intestinal Trials Group (AGITG) ALaCaRT investigators. ASO Author Reflections: Is Laparoscopic-Assisted Surgery More Costly than Traditional Open Resection for Rectal Cancer Treatment? Annals of Surgical Oncology 2022; 29:1935-1936.

Law CK, Stevenson ARL, Solomon M, Wilson K, Simes JR, Morton RL and the Australasian GastroIntestinal Trials Group (AGITG) ALaCaRT Investigators. ASO Visual Abstract: Health Care Costs of Laparoscopic Versus Open Surgery for Rectal Cancer Patients in the First 12 Months: A Secondary End-Point Analysis of the Australasian Laparoscopic Cancer of the Rectum Trial (ALaCaRT). Annals of Surgery 2022; 29:1923-1934.

Lim C, Laidsaar-Powell R, Young J, Solomon M, Steffens D, Yeo D, Blinman P, Koczwara B, Joshy G, Butow P. The advanced-CRC survivorship authorship group, & Butow, P. (2022). The long haul: Lived experiences of survivors following different treatments for advanced colorectal cancer: A qualitative study. European Journal of Oncology Nursing. 2022; 58:102123.

Lim C, Laidsaar-Powell R, Young J, Solomon M, Steffens D, Blinman P, O'Loughlin S, Zhang Y, Butow P. Fear of cancer progression and death anxiety in survivors of advanced colorectal cancer: A qualitative study exploring coping strategies and quality of life. OMEGA - Journal of Death and Dying. 2022; DOI: 10.1177/00302228221121493.

Lim CYS, Laidsaar-Powell RC, Young JM, Steffens D, Koczwara B, Zhang Y. The advanced-CRC survivorship authorship group, & Butow, P. Work: Saviour or struggle? A qualitative study examining employment and finances in colorectal cancer survivors living with advanced cancer. Supportive Care in Cancer. DOI: 10.1007/s00520-022-07307-9.

Mackay I, Clark DA, Nicholson J, Edmundson A, Steffens D, Solomon M. Risk taking propensity: Nurse, surgeon and patient preferences for diverting ileostomy. Colorectal Disease 2022; 24;1073-1079; DOI: 10.1111/codi.16149.

Makker PGS, Koh C, Solomon M, Steffens D. Preoperative functional capacity and postoperative outcomes following abdominal and pelvic cancer surgery - a systematic review and meta-analysis. (Review article) ANZ Journal of Surgery. 2022; 92:1658-1667.

Makker PGS, Koh CE, Ansari N, Gonzaga N, Bartyn J, Solomon M, Steffens D. ASO Visual Abstract: Functional outcomes of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy - a prospective cohort study. Annals of Surgical Oncology. 2022: DOI: 10.1245/s10434-022-12691-x.

Makker PGS, Koh CE, Steffens D. ASO Author Reflections: Pre-operative Function Status Predicts Post-operative Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intra-peritoneal Chemotherapy. Annals of Surgical Oncology. 2022: DOI: 10.1245/s10434-022-12750-3.

Makker PGS, Steffens D. ASO Visual Abstract: Functional Outcomes of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy-A Prospective Cohort Study. Annals of Surgical Oncology. 2022: 10.1245/s10434-022-12801-9.

McGiffin T, Clark DA, Edmundson A, Steffens D, Stevenson A, Solomon M. Surgical management and long-term functional outcomes after anastomotic leak in patients undergoing minimally invasive restorative rectal resection and without a diverting ileostomy. ANZ Journal of Surgery 2022; 92:806-812.

Mercieca-Bebber R et al. Patient-reported bowel, urinary and sexual outcomes after Laparoscopic-assisted Resection or Open Resection for Rectal Cancer: The Australasian Laparoscopic Cancer of the Rectum Randomized Clinical Trial (ALaCart). Annals of Surgery 2022; DOI: 10.1097/SLA.0000000000005412.

Ng K-S, Lee PJM. (Erratum) Pelvic exenteration: Pre-, intra-, and post-operative considerations. Surgical Oncology 2022; 43,101787.

Oswald A, McBride K, Seif S, Koh C, Ansari N, Steffens D. Depression, anxiety, stress and distress following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: Results of a prospective cohort study. Journal of Clinical Psychology in Medical Settings. 2022; DOI: 10.1007/s10880-022-09918-0.

PelvEx Collaborative. Minimum standards of pelvic exenterative practice: PelvEx Collaborative guideline. British Journal of Surgery 2022; 109:1251-1263.

Pillinger N, Koh C, Ansari N, Munoz P, McNamara S, Steffens D. Preoperative cardiopulmonary exercise testing improves risk assessment of morbidity and length of stay following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy. Anaesthesia and Intensive Care. 2022; DOI: 10.1177/0310057X211064904.

Risbey C, Fielder T, Steffens D, Joo-Shik S, Solomon M. Patterns of DNA mismatch repair protein expression for primary and recurrent colorectal cancer at an advanced surgical unit: a retrospective audit. Colorectal Disease 2022; 00:1-6; DOI: 10.1111/codi.16391.

Siu AHY, Carey S, Jones LH, Morton R, Koh C. Detailed analysis of in-hospital costs for adult patients with Type III intestinal failure. A single centre study with global implications. Journal of Parenteral and Enteral Nutrition 2022; 46:685-692; DOI:10.1002/jpen.2136.

Solomon MJ, Alamadi R, Lee PJ, Austin KKS. En-Bloc Partial Pubic Bone Excision with Complete Soft Tissue Pelvic Exenteration. (Research Letter & Video) British Journal of Surgery 2022; 109:640-641; DOI:10.1093/bjs/znac122.

Steffens D, Solomon MJ, Beckenkamp PR, Koh CE, Yeo D, Sandroussi C, Toms C, Blyth H, Murray S, Venchiarutti R, Fox O , Benicio K, Bartyn J, Stanislaus C, O'Connor L, Bourrigan L, Ha C, Kirpichnikov A, Plunkett J, Laurence J, Joseph D, Pulitano C, Crawford M, Hancock M. Individualised, targeted step count intervention following gastrointestinal cancer surgery: The Fit-4-Home randomised clinical trial. ANZ Journal of Surgery. 2022; 92:703-711; DOI: 10.1111/ans.17212.

Steffens D, Young J, Riedel B, Morton R, Denehy L, Heriot A, Koh C, Li Q, Bauman A, Sandroussi C, Ismail H, Dieng M, Ansari N, Pillinger N, O'Shannassy S, Mckeown S, Cunningham D, Sheehan K, Iori G, Bartyn J, Solomon M. PRehabIlitatiOn with pReoperatIve exercise and educaTion for patients undergoing major abdominal cancer surgerY: Protocol for a multicentre randomised controlled TRIAL (PRIORITY TRIAL). BMC Cancer 2022; 22:443: DOI: 10.1186/s12885-022-09492-6.

Steinberg J, Chan P, Hogden E, Tiernan G, Morrow A, Kang Y-J, He E, Venchiarutti R, Titterton L, SankeyL, Pearn A, Nichols C, McKay S, Hayward A, Egoroff N, Engel A, Gibbs P, Goodwin A, Harris M, Kench J, Pachter N, Parkinson B, Pockney P, Ragunathan A, Smyth C, Solomon M, Steffens D, Toh J, Wallace M, Canfell K, Gill A, Macrae F, Tucker K, Taylor N. Lynch syndrome testing of colorectal cancer patients in a high-income country with universal healthcare: a retrospective study of current practice and gaps in seven Australian hospitals. Hereditary Cancer in Clinical Practice. 2022; DOI:10.1186/s13053-022-00225-1.

Sutton PA, Brown KGM, Ebrahimi N, Solomon MJ. Long term surgical complications following pelvic exenteration - operative management of the empty pelvis syndrome. Colorectal Disease 2022; DOI: 10.1111/codi.16238.

Van Kessel CS, Solomon MJ. Understanding the Philosophy, Anatomy, and Surgery of the Extra-TME Plane of Locally Advanced and Locally Recurrent Rectal Cancer; Single Institution Experience with International Benchmarking. (Review) Cancers 2022; 14:5058: doi.org/10.3390/cancers14205058.

Zhou DDX, King D, Thomson K, Grimison P. Trabectedin for metastatic liposarcoma and leiomyosarcoma: Comparison of real-world experience in an Australian sarcoma specialist center to pivotal clinical trial results. Asia-Pac J Clin Oncol, 18: e526-e528.

2021

Alahmadi RH, Solomon MJ, Steffens D. ASO Author Reflections: Quality of Life and Survival Outcomes in Elderly Patients Undergoing Pelvic Exenteration. [Editorial] Annals of Surgical Oncology 2021; 28:5236-37.

Alahmadi RH, Steffens D, Solomon MJ, Lee PJ, Austin KS, Koh CE. Elderly Patients Have Better Quality of Life but Worse Survival Following Pelvic Exenteration: A 25-Year Single Center Experience. Annals of Surgical Oncology 2021; 28:5226-35.

Brown KGM, Ansari N, Solomon MJ, Austin KKS, Hamilton AER, Young CJ. Pelvic exenteration combined with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for advanced primary or recurrent colorectal cancer with peritoneal metastases. Colorectal Dis. 2021 Jan;23(1):186-191. doi: 10.1111/codi.15378. Epub 2020 Oct 16.

Brown KGM, Solomon MJ, Lau YC, Steffens D, Austin KKS, Lee PJ. Sciatic and femoral nerve resection during extended radical surgery for advanced pelvic tumours: long-term survival, functional and quality of life outcomes. Ann Surg 2021; 273:982-988.

Brown KGM, Solomon MJ. Managing the primary tumour in patients with incurable metastatic rectal cancer. [Editorial] Diseases of the Colon & Rectum 2021; 64: 5-6.

Chang KH, Brown KGM, Lau YC, Solomon MJ. Excellent outcomes after extended radical pelvic resection for locally advanced and recurrent inflammatory bowel disease-associated anorectal cancer. Diseases of the Colon & Rectum 2021; 2021:64:209-216.

Chen MZ, Austin KKS, Solomon MJ, Brown KGM, Steffens D. Outcomes of metastasectomy and pelvic exenteration for patients with metastatic advanced primary or recurrent rectal cancer. ANZ J Surg. 2021 Mar;91(3):231-232. doi: 10.1111/ans.16294.

Däster Silvio, Shin J-S, Loizides S, Steffens D, Koh C, Solomon MJ. Pathology reporting of pelvic exenteration specimens for locally recurrent rectal cancer. European Journal of Surgical Oncology 2021; 47:2100-2107.

Garrett C, Steffens D, Ansari N, Koh C. A phase I, non-randomised controlled trial demonstrating the novel technique of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy utilising warm humidified carbon dioxide insufflation. Colorectal Disease. 2021; 23:1573-1578: DOI: https://doi.org/10.1111/codi.15588.

Hong JSY, De Robles MS, Brown C, Brown KGM, Young CJ, Solomon MJ. Can MRI pelvimetry predict the technical difficulty of laparoscopic rectal cancer surgery. International Journal of Colorectal Disease 2021; DOI: 10.1007/s00384-021-04000-x.

Keane CR, O'Grady G, Bissett IP, Hayes J, Hulme-Moir M, Eglinton TW, Solomon MJ, Lumley JW, Simes J, Stevenson ARL. Functional Outcome of Laparoscopic Assisted Resection vs Open Resection of Rectal Cancer: A secondary analysis of the Australasian Laparoscopic Cancer of the Rectum Trial. Diseases of the Colon & Rectum 2021; DOI: 10.1097/DCR.0000000000002166.

Law CK, Brewer K, Brown C, Wilson K, Bailey L, Hague W, Simes R, Stevenson A, Solomon M, Morton RL. Return to work following laparoscopic-assisted resection or open resection for rectal cancer: findings from ALaCaRT - Australasian Laparoscopic Cancer of the Rectum Trial. Cancer Medicine 2021; 10:552-562.

Lee PJ , Meshkat B, Sasidharan P, Zahid A, Coker DJ, Solomon MJ. Survival and Morbidity Outcomes after Pelvic Exenteration for Pelvic Sarcoma: An Institutional Series. ANZ Journal of Surgery 2021; DOI: 10.1111/ans.17275.

Makker PGS, Koh CE, Solomon MJ, Ratcliffe J, Steffens D. Functional outcomes following pelvic exenteration: results from a prospective cohort study. Colorectal Disease 2021; 23:2647-2658.

Ng KS, Lee PJM. Pelvic exenteration: Pre-, intra-, and post-operative considerations. Surg Oncol. 2021 Jun;37:101546. doi: 10.1016/j.suronc.2021.101546. Epub 2021 Mar 19.

PelvEx Collaboration. Induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as neoadjuvant treatment for locally recurrent rectal cancer: study protocol of a multicentre, open-label, parallel-arms, randomized controlled study (PelvEx II). British Journal of Surgery Open 2021; 5(3):zrab029.

Rajendran S, Brown KGM, Solomon MJ, Austin KKS, Lee PJ, Robinson D, Steffens D. Complete resection of the iliac vascular system during pelvic exenteration: an evolving surgical approach to lateral compartment excision. British Journal of Surgery 2021; 108:885-887.

Sharp G, Steffens D, Koh C. Evidence of negative pressure therapy for anastomotic leak: A systematic review. ANZ Journal of Surgery 2021; 91; 537-545.

Siu AHY, Carey S, Jones LH, Morton R, Koh C. Detailed analysis of in-hospital costs for patients with Type III intestinal failure. A single centre study with global implications. Journal of Parenteral and Enteral Nutrition 2021; DOI:10.1002/jpen.2136.

Solomon M, Sutton PA, Lee P, Austin K. Perineal urethrectomy in the anterior compartment for pelvic exenteration. [Research Letter & Video] British Journal of Surgery 2021; 108:e364: DOI: 10.1093/bjs/znab286.

Solomon MJ. Redefining the boundaries of advanced pelvic oncology surgery. (Editorial, Leading article). British Journal of Surgery 2021; DOI: 10.1093/bjs/znab047.

Solomon MJ. Access to the anterior pelvic compartment in pelvic exenteration in women-the interlabial approach: video vignette. British Journal of Surgery 2021; 108:e268-269.

Solomon MJ. Expert Commentary on the Evaluation and Management of Ischiorectal Fossa Tumors. Diseases of the Colon and Rectum 2021; 64:1176-1177.

Steffens D, Ismail H, Denehy L, Beckenkamp PR, Solomon M, Koh C, Bartyn J, Pillinger N. Preoperative Cardiopulmonary Exercise Test Associated with Postoperative Outcomes in Patients Undergoing Cancer Surgery: A Systematic Review and Meta-Analyses. Annals of Surgical Oncology 2021; DOI:10.1245/s10434- 021-10251-3.

Steffens D, Pillinger N, Solomon M. ASO Author Reflections: The importance of preoperative cardiopulmonary exercise test in patients undergoing cancer surgery. Annals of Surgical Oncology 2021; DOI: doi.org/10.1245/s10434-021-10266-w.

Steffens D, Solomon M, Denehy L. Is Preoperative Exercise Training the New Holy Grail for Patients Undergoing Major Surgery? [Editorial] Annals American Thoracic Society 2021; 587-589.

Steffens D, Young J, Solomon MJ, Cunningham D. Feasibility and acceptability of pre-operative exercise to improve patient outcomes after major cancer surgery: A pilot randomised controlled trial. Pilot and Feasibility Studies 2021; DOI: 10.1186/s40814-021-00765-8.

Steffens D. Preoperative exercise for patients undergoing major abdominal cancer surgery. Physiotherapy InMotion. APA. March 2021. 54-55. https://australian.physio/inmotion#2021.

Sutton PA, Solomon M, Sasidharan P, Lee P, Austin K. Abdominolithotomy sacrectomy for the management of locally recurrent rectal cancer: video vignette. British Journal of Surgery 2021; 108:e257 ; DOI: 10.1093/bjs/znab105.

The Royal Marsden Group (C Kontovounisios, Aik Yong Chok, P Tekkis, A Oliver and R Shahnawaz) & The PelvEx Collaborative. Perioperative Management and Anaesthetic Considerations in Pelvic Exenteration using Delphi methodology: Results from the PelvEx Collaborative. British Journal of Surgery 2021; 5(1):1-10: doi.org/10.1093/bjsopen/zraa055.

Van Ramshorst GH, Young JM, Solomon MJ. Reply to Comment on, "Complications and Impact on Quality of Life of Vertical Rectus Abdominis Myocutaneous Flaps for Reconstruction in Pelvic Exenteration Surgery". Diseases of the Colon and Rectum 2021; 64: e100-e101.

Van Workum F, Talboom K, Hannink G, Wolthuis A, de Lacy BF, Lefevre JH, Solomon M, Frasson M, Rotholtz N, Denost Q, Perez RO, Konishi T, Panis Y, Rosman C, Hompes R, Tanis PJ. TreatmENT of AnastomotiC LeakagE after rectal cancer resection: the TENTACLE - Rectum study. Colorectal Disease 2021; 23:982-988.

Vuong K, Alchin LM, Solomon MJ, Koh CE, Steffens D. A prospective investigation of pain and fatigue following pelvic exenteration. European Journal of Surgical Oncology 2021; DOI: 10.1016/j.ejso.2021.07.022.

Yu XQ, Goldsbury D, Feletto E, Koh CE, Canfell K, O'Connell DL. Socioeconomic disparities in colorectal cancer survival: contributions of prognostic factors in a large Australian cohort. Journal of Cancer Research and Clinical Oncology 2021; DOI:10.1007/s00432-021-03856-4.

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