Clinical Immunology Research

The Clinical Immunology and Allergy Department at RPA has an extensive research program across several areas including basic immunology sciences, autoimmune diseases, and designing novel assays for diagnosis of immune-mediated disorders.

In 2024 we established a biobanking repository for serum and cells from patients with autoimmune and inflammatory diseases to assist in our future studies. The department at Royal Prince Alfred, in conjunction its sister department at Concord Hospital, have established the Sydney Translational Immunology and Allergy Centre and this has been recognised as an international Centre of Excellence of the Federation of Clinical Immunology Societies (FOCiS).

Selected Grants

Amount awarded	Grant and project details
$2,752,967	MRFF, 2023-2025 Comparing Immunisation-boosting Regimens for COVID-19 Upon Initiation of immunosuppressive Therapies (CIRCUIT Study). Investigators: Lee FJ
$135,000	NHMRC, 2023-2025 Postgraduate Research Scholarship. Investigator: Stoyanov A
$995,867	NSW Health COVID-19 Vaccine Acceleration Research Grant, 2023-2024 Nasal delivered COVID vaccine to block transmission of SARS-CoV-2. Investigators: Britton WJ, Ashhurst A, Johansen M, Payne RP, Young P, Hansbro P Triccas JA. Steain N, Byrne S, Turville S.
$352,879	NSW Dust Diseases Board, 2023-2024 Defining new and effective therapies against the pathogenesis of accelerated silicosis. Investigators: Hansbro P, Britton WJ, Chambers D, Quan D, Troy L, Corte T, Hansbro N, Gang L.
US$13,100,000	NIH, 2022-2027 Advancing Vaccine Adjuvant Research for Tuberculosis Contract. Investigators: Britton WJ, Izzo A, Triccas JA
€200,023	Leprosy Research Initiative (Holland), 2022-2025 The COMBINE study: Defining the impact of combined community-wide screening and mass chemoprophylaxis for leprosy in Kiribati: a prospective community implementation study. Investigators: Chambers S, Britton WJ, Tomlinson J, Marais B, Marks GB, Priest P, Ioteba N, Maribo, Cunanan A, Hill J, Coleman M.
$896,784	NHMRC Ideas Grant, 2022-2024 Defining the impact of chronic lung disease on COVID-19 and developing effective therapies Investigators: Britton WJ, Hansbro N, Johansen M, Idrees S.
$4,248,555	MRFF, 2020-2024 Pathway to the Elimination of Antibiotic-Resistant and Latent Tuberculosis in the Pacific: the PEARL study Investigators: Marais B, Britton WJ, Marks GB, Fox G, Saunders BM, Trauer J, Viney K

Our Publications

2024

Heynemann S, Vanguru V, Adelstein S, Kao S. Hemophagocytic lymphohistiocytosis (HLH) and cytokine release syndrome (CRS) in a patient with oncogene-addicted metastatic non-small cell lung cancer (NSCLC) following combination chemotherapy-immunotherapy. Asia Pac J Clin Oncol. 2024 Apr;20(2):315-318. doi: 10.1111/ajco.13906. Epub 2022 Dec 23.

Bosi I, Singh-Grewal D. Child with swollen fingers associated with recent SARS-CoV-2 infection. J Paediatr Child Health. 2024 Jan;60(1):32-33. doi: 10.1111/jpc.16350. Epub 2023 Jan 31.

Sutton KM, Wiggins M, Zaragoza R, Swamy S. Chronic spontaneous urticaria as the presenting feature in a paediatric case of chronic myeloid leukaemia. Pediatr Blood Cancer. 2024 Mar;71(3):e30846. doi: 10.1002/pbc.30846. Epub 2024 Jan 7.

Wright K, Han DJ, Song R, de Silva K, Plain KM, Purdie AC, Shepherd A, Chin M, Hortle E, Wong JJ, Britton WJ, Oehlers SH. Zebrafish tsc1 and cxcl12a increase susceptibility to mycobacterial infection. Life Sci Alliance. 2024 Feb 2;7(4):e202302523. doi: 10.26508/lsa.202302523.

Marinelli T, Masters J, Buckland ME, Lee M, Rawlinson W, Kim KW, Urriola N, van Hal S. Chronic and Neurotropic: A Paradigm-Challenging Case of Dengue Virus Encephalitis in a Patient With Advanced HIV Infection. Clin Infect Dis. 2024 Aug 16;79(2):498-501. doi: 10.1093/cid/ciae061.

Chu GJ, Bailey CG, Nagarajah R, Liang O, Metierre C, Sagnella SM, Castelletti L, Yeo D, Adelstein S, Rasko JEJ. Mesothelin antigen density influences anti-mesothelin chimeric antigen receptor T cell cytotoxicity. Cytotherapy. 2024 Apr;26(4):325-333. doi: 10.1016/j.jcyt.2024.01.011. Epub 2024 Feb 13.

Stewart EL, Counoupas C, Quan DH, Wang T, Petrovsky N, Britton WJ, Triccas JA. Lung IL-17A-Producing CD4+ T Cells Correlate with Protection after Intrapulmonary Vaccination with Differentially Adjuvanted Tuberculosis Vaccines. Vaccines (Basel). 2024 Jan 26;12(2):128. doi: 10.3390/vaccines12020128.

Bosi I, Ford LS. Erythritol allergy. J Paediatr Child Health. 2024 Jun;60(6):248-249. doi: 10.1111/jpc.16565. Epub 2024 May 13.

Stewart EL, Counoupas C, Steain M, Ashley C, Alca S, Hartley-Tassell L, von Itzstein M, Britton WJ, Petrovsky N, Triccas JA. Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is a cellular receptor for delta inulin adjuvant. Immunol Cell Biol. 2024 Aug;102(7):593-604. doi: 10.1111/imcb.12774. Epub 2024 May 17.

Goh DSL, Yuson R, Gounder P, Yun J, Limaye S. Strategic testing following toxic epidermal necrolysis allows reintroduction of chemotherapy in a patient with progressive myeloma. Asia Pac Allergy. 2024 Jun;14(2):90-92. doi: 10.5415/apallergy.0000000000000125. Epub 2023 Dec 18.

Lee E, Bosi I, Peacock K, Lau C, Ford LS, Wong M, Hsu P. Novel infantile presentations of chronic granulomatous disease. Pediatr Allergy Immunol. 2024 Jul;35(7):e14190. doi: 10.1111/pai.14190.

Bradhurst P, Stoyanov A, Nithichanon A, Bundell C, Urriola N. A homogeneous bioluminescent inhibition immunoassay to detect anti-interferon gamma antibodies. Clin Exp Immunol. 2024 Nov 12;218(3):283-290. doi: 10.1093/cei/uxae055.

King JM, Giallonardo FD, Shaik A, McGregor S, Yeung JYK, Sivaruban T, Lee FJ, Cunningham P, Dwyer DE, Nigro SJ, Grulich AE, Kelleher AD. Low HIV drug resistance prevalence among recently diagnosed HIV-positive men who have sex with men in a setting of high PrEP use. J Int AIDS Soc. 2024 Jul;27(7):e26308. doi: 10.1002/jia2.26308.

Maxwell JWC, Stockdale S, Stewart EL, Ashley CL, Smith LJ, Steain M, Triccas JA, Byrne SN, Britton WJ, Ashhurst AS, Payne RJ. Intranasal Self-Adjuvanted Lipopeptide Vaccines Elicit High Antibody Titers and Strong Cellular Responses against SARS-CoV-2. ACS Infect Dis. 2024 Sep 13;10(9):3419-3429. doi: 10.1021/acsinfecdis.4c00544. Epub 2024 Aug 28.

Sprogyte L, Park M, Nureen L, Tedla N, Richardson A, Di Girolamo N. Development and characterization of a preclinical mouse model of alkali-induced limbal stem cell deficiency. Ocul Surf. 2024 Oct;34:329-340. doi: 10.1016/j.jtos.2024.08.015. Epub 2024 Aug 29.

Torres-Robles A, Baysari M, Allison K, Shaw M, Hutchings O, Britton WJ, Wilson A, Poon SK. Assessment of health technology acceptability for remote monitoring of patients with COVID-19: A measurement model for user perceptions of pulse oximeters. Digit Health. 2024 Sep 11;10:20552076241269513. doi: 10.1177/20552076241269513.

Nisa A, Pinto R, Britton WJ, Triccas JA, Counoupas C. Immunogenicity and Protective Efficacy of a Multi-Antigen <i>Mycobacterium tuberculosis</i> Subunit Vaccine in Mice. Vaccines (Basel). 2024 Aug 30;12(9):997. doi: 10.3390/vaccines12090997.

Quan DH, Wang T, Martinez E, Kim HY, Sintchenko V, Britton WJ, Triccas JA, Alffenaar JC. Synergistic oral beta-lactam combinations for treating tuberculosis. J Appl Microbiol. 2024 Oct 3;135(10):lxae255. doi: 10.1093/jambio/lxae255.

Shrestha LB, Tungatt K, Aggarwal A, Stubis A, Fewings NL, Fichter C, Akerman A, Rodrigo C, Tedla N, Lee S, Lloyd AR, Brilot F, Britton WJ, Kelleher A, Caterson ID, Douglas MW, Rockett R, Tangye SG, Triccas JA, Turville SG, Sandgren KJ, Bull RA, Cunningham AL; VIIM Collaborative Research Group of NSW. Bivalent Omicron BA.1 vaccine booster increases memory B cell breadth and neutralising antibodies against emerging SARS-CoV-2 variants. EBioMedicine. 2024 Dec;110:105461. doi: 10.1016/j.ebiom.2024.105461. Epub 2024 Nov 28.

Bedding MJ, Forster BC, Giltrap AM, Stevens MT, Corcilius L, Britton WJ, Payne RJ. Modular Total Synthesis and Antimycobacterial Activity of Rufomycins. Org Lett. 2024 Dec 20;26(50):10993-10998. doi: 10.1021/acs.orglett.4c04163. Epub 2024 Dec 9.

2023

Akerman A, Milogiannakis V, Jean T, Esneau C, Silva MR, Ison T, Fichter C, Lopez JA, Chandra D, Naing Z, Caguicla J, Li D, Walker G, Amatayakul-Chantler S, Roth N, Manni S, Hauser T, Barnes T, Condylios A, Yeang M, Wong M, Foster CSP, Sato K, Lee S, Song Y, Mao L, Sigmund A, Phu A, Vande More AM, Hunt S, Douglas M, Caterson I, Britton W, Sandgren K, Bull R, Lloyd A, Triccas J, Tangye S, Bartlett NW, Darley D, Matthews G, Stark DJ, Petoumenos K, Rawlinson WD, Murrell B, Brilot F, Cunningham AL, Kelleher AD, Aggarwal A, Turville SG. Emergence and antibody evasion of BQ, BA.2.75 and SARS-CoV-2 recombinant sub-lineages in the face of maturing antibody breadth at the population level. EBioMedicine. 2023 Apr;90:104545. doi: 10.1016/j.ebiom.2023.104545. Epub 2023 Mar 30.

Armitage E, Quan D, Flórido M, Palendira U, Triccas JA, Britton WJ. CXCR3 Provides a Competitive Advantage for Retention of Mycobacterium tuberculosis-Specific Tissue-Resident Memory T Cells Following a Mucosal Tuberculosis Vaccine. Vaccines (Basel). 2023 Sep 29;11(10):1549. doi: 10.3390/vaccines11101549.

Baird S, Ashley CL, Marsh-Wakefield F, Alca S, Ashhurst TM, Ferguson AL, Lukeman H, Counoupas C, Post JJ, Konecny P, Bartlett A, Martinello M, Bull RA, Lloyd A, Grey A, Hutchings O, Palendira U, Britton WJ, Steain M, Triccas JA. A unique cytotoxic CD4+ T cell-signature defines critical COVID-19. Clin Transl Immunology. 2023 Aug 28;12(8):e1463. doi: 10.1002/cti2.1463.

Bosi I, O'Mara D, Clark T, Patabendige NS, Kennedy SE, Gunasekera H. Associations between item characteristics and statistical performance for paediatric medical student multiple choice assessments. MedEdPublish (2016). 2023 Nov 8;13:270. doi: 10.12688/mep.19764.1.

Bosi I, Wong WK, Mohammad S, Britton P, Hsu P. Unusual Manifestations of APECED. J Clin Immunol. 2023 Dec 27;44(1):33. doi: 10.1007/s10875-023-01647-9.

Chen R, Wei X, Yang C, Nguyen K. A novel magnetic bead-based immunoprecipitation method for anti-dense fine speckled 70 antibodies. Pathology. 2023 Oct;55(6):843-849. doi: 10.1016/j.pathol.2023.04.002. Epub 2023 May 29.

Chu GJ, Bailey CG, Nagarajah R, Sagnella SM, Adelstein S, Rasko JEJ. The 4-1BBζ costimulatory domain in chimeric antigen receptors enhances CD8+ T-cell functionality following T-cell receptor stimulation. Cancer Cell Int. 2023 Dec 18;23(1):327. doi: 10.1186/s12935-023-03171-7.

Chu GJ, Linton A, Kao S, Klebe S, Adelstein S, Yeo D, Rasko JEJ, Cooper WA. High mesothelin expression by immunohistochemistry predicts improved survival in pleural mesothelioma. Histopathology. 2023 Aug;83(2):202-210. doi: 10.1111/his.14916. Epub 2023 Apr 11.

Coleman M, Hill J, Timeon E, Rimon E, Bauro T, Ioteba N, Cunanan A, Douglas NM, Islam T, Tomlinson J, Campbell PO, Williman J, Priest P, Marais BJ, Britton WJ, Chambers ST. Effectiveness of population-wide screening and mass drug administration for leprosy control in Kiribati: the COMBINE protocol. BMJ Open. 2023 Jun 29;13(6):e065369. doi: 10.1136/bmjopen-2022-065369.

Daniel L, Counoupas C, Bhattacharyya ND, Triccas JA, Britton WJ, Feng CG. L-selectin-dependent and -independent homing of naïve lymphocytes through the lung draining lymph node support T cell response to pulmonary Mycobacterium tuberculosis infection. PLoS Pathog. 2023 Jul 5;19(7):e1011460. doi: 10.1371/journal.ppat.1011460.

Deng L, Tapper K, Thosar D, Goeman E, Baker L, Adelstein S, Boyle M, Brown DA, Evans L, Katelaris C, Lee F, Li J, Swaminathan S, Taylor MS, Wong M, Wood N. Use of adrenaline to manage suspected anaphylaxis following COVID-19 vaccination: An Australian retrospective cohort study. Vaccine. 2023 Sep 22;41(41):5987-5993. doi: 10.1016/j.vaccine.2023.08.024. Epub 2023 Aug 24.

Jee AS, Stewart I, Youssef P, Adelstein S, Lai D, Hua S, Stevens W, Proudman S, Ngian GS, Glaspole IN, Moodley YP, Bleasel JF, Macansh S, Nikpour M, Sahhar J, Corte TJ; Australian Scleroderma Cohort Study, Australian Scleroderma Interest Group, Australian Idiopathic Pulmonary Fibrosis Registry, and associated investigators. A Composite Serum Biomarker Index for the Diagnosis of Systemic Sclerosis-Associated Interstitial Lung Disease: A Multicenter, Observational Cohort Study. Arthritis Rheumatol. 2023 Aug;75(8):1424-1433. doi: 10.1002/art.42491. Epub 2023 May 15.

Jenkins F, Le T, Farhat R, Pinto A, Anzari A, Bonsall D, Golubchik T, Bowden R, Lee FJ, van Hal SJ. Validation of an HIV whole genome sequencing method for HIV drug resistance testing in an Australian clinical microbiology laboratory. J Med Virol. 2023 Dec;95(12):e29273. doi: 10.1002/jmv.29273.

Ramsay JA, Jones M, Vande More AM, Hunt SL, Williams PCM, Messer M, Wood N, Macartney K, Lee FJ, Britton WJ, Snelling TL, Caterson ID. A single blinded, phase IV, adaptive randomised control trial to evaluate the safety of coadministration of seasonal influenza and COVID-19 vaccines (The FluVID study). Vaccine. 2023 Nov 22;41(48):7250-7258. doi: 10.1016/j.vaccine.2023.10.050. Epub 2023 Oct 29.

Sawyer AJ, Patrick E, Edwards J, Wilmott JS, Fielder T, Yang Q, Barber DL, Ernst JD, Britton WJ, Palendira U, Chen X, Feng CG. Spatial mapping reveals granuloma diversity and histopathological superstructure in human tuberculosis. J Exp Med. 2023 Jun 5;220(6):e20221392. doi: 10.1084/jem.20221392. Epub 2023 Mar 15.

Stewart E, Ashhurst A, Britton W. Arming the airways: An update on the clinical status of intranasal vaccines and the role of mucosal adjuvants. Vaccine Insights. 2023;2:213-228. doi:10.18609/vac.2023.033.

Torres-Robles A, Allison K, Poon SK, Shaw M, Hutchings O, Britton WJ, Wilson A, Baysari M. Patient and Clinician Perceptions of the Pulse Oximeter in a Remote Monitoring Setting for COVID-19: Qualitative Study. J Med Internet Res. 2023 Sep 5;25:e44540. doi: 10.2196/44540.

Wang Y, Khanal D, Alreja AB, Yang H, Yk Chang R, Tai W, Li M, Nelson DC, Britton WJ, Chan HK. Bacteriophage endolysin powders for inhaled delivery against pulmonary infections. Int J Pharm. 2023 Mar 25;635:122679. doi: 10.1016/j.ijpharm.2023.122679. Epub 2023 Feb 3.

2022

Albariqi AH, Wang Y, Chang RYK, Quan DH, Wang X, Kalfas S, Drago J, Britton WJ, Chan H-K. (2022) Pharmacokinetics and Safety of Inhaled Ivermectin in Mice as a Potential COVID-19 Treatment. International Journal of Pharmaceutics May 10; 619:121688. Doi;10.1089/jamp.2021.0059. PMID 35314278.

Albariqi AH, Wei-Ren, Khanal D, Kalfas S, Tang P, Britton WJ, Drago J, Chan HK. Preparation and characterization of inhalable ivermectin powders for potential COVID-19 Treatment. (2022) J. Aerosol Medicine & Pulmonary Drug Delivery 35(5): 239-251.

Ashhurst AS, Johansen MD, Maxwell JWC, Stockdale S, Ashley CL, Aggarwal A, Siddiquee R, Mackay JP, Counoupas C, Byrne SN, Turville S, Steain M, Triccas JA, Hansbro PM, Payne RJ, Britton WJ. (2022) Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice. Nature Communications 13 (1):1-18. Pub 22/11/2022. Research Square doi.org/10.21203/rs.3.rs-1179181/v1.

Bradhurst, P. & Urriola, N. Arthritis Mutilans in Jo1 Antisynthetase Syndrome. J Rheumatology jrheum.220885 (2022) doi:10.3899/jrheum.220885.

Callum J, Nguyen PTB, Martinez E, Van-Anh T. Nguyen, Frances Garden, Nhung V. Nguyen, Thu-Anh Nguyen, Hoa B. Nguyen, Son V. Nguyen, Khanh B. Luu, Jennifer Ho, Nguyen N. Linh, Britton WJ, Sintchecnko V, Fox G, Marks GB. Prevalence and genetic basis of first line drug resistance of Mycobacterium tuberculosis in Ca Mau, Vietnam (2022) ERJ Open Research Oct 1, 8(3):00122-2022. DOI: 10.1183/23120541.00122-2022.

Caterson, H. C., Xu, G., Adelstein, S. & Puranik, R. A Diagnosis That a Cardiologist Should Not MIS: Multisystem Inflammatory Syndrome in Adults. Hear Lung Circulation (2022) doi:10.1016/j.hlc.2022.08.014.

Chan DKY, Braidy N, Chen RF, Xu YH, Bentley S, Lubomski M, Davis RL, Chen J, Sue CM, Mellick GD. Strong Predictive Algorithm of Pathogenesis-Based Biomarkers Improves Parkinson's Disease Diagnosis. Mol Neurobiol. 2022 Mar; 59(3):1476-1485. doi: 10.1007/s12035-021-02604-6. Epub 2022 Jan 7 PMID: 34993845.

Chan DKY; Chen J; Chen RF; Parikh J; Xu YH; Silburn PA; Mellick GD, 2022, 'Plasma biomarkers inclusive of α-synuclein/amyloid-beta40 ratio strongly correlate with Mini-Mental State Examination score in Parkinson’s disease and predict cognitive impairment', Journal of Neurology, vol. 269, pp. 6377 -6385,

Chen R, Luo I, Rae M, Huang S. A cost-effective sample pooling strategy for line blot assay in detecting onconeural antibodies. J Immunol Methods. 2022 Feb 10;503:113235. doi: 10.1016/j.jim.2022.113235. Epub 2022 Feb 10. PMID: 35151664.

Chen S, Quan DH, Sam G, Wang XT, Ozberk V, Halfmann P, Pandey M, Good MF, Kawaoka Y, Britton WJ, Rehm BHA. (2022) Engineered CRM197 particles as versatile vaccine platform technology. Small. Dec 23, 2022; e2205819.  doi:

Coleman M, Hill, J, Timeon E, Tonganibeia A, Eromanga B, Islam T,^]Trauer JM, Christensen A, Fox GF, Marks GB, Britton WJ, Marais BJ. (2022) Population-wide active case finding and prevention for tuberculosis and leprosy elimination in Kiribati - the PEARL study protocol. BMJ Open April 1; 12 (4): e055295.

Coleman, M, Christensen, A. Hill, J. Temareti, M. Timeon, E, Fox, GJ; Britton, WJ, Marais, B. (2022). Maximising the sharing and reuse of project-specific resources. International Journal of Tuberculosis and Lung Disease Oct 1, 26(10): 910-913. doi.org/10.5588/ijtld.22.0360

Counoupas C, Pino P, Stella AO, Ashley C, Lukeman H, Bhattacharyya ND, Tada T, Anchisi S, Metayer C, Martinis J, Aggarwal A, Kint J, Britton WJ, D’costa BM, Wurm MJ, Landau NR, Steain M, Turville SG, Wurm F, David SA, Triccas JA. (2022) High-titre neutralizing antibodies against the SARS-CoV-2 Delta variant induced by Alhydroxyquim-II-adjuvanted trimeric spike antigens. Microbiology Spectrum Feb 16; 10(1):e0169521. doi: 10.1128/spectrum.01695-21.

Daniel L, Bhattacharyya N, Counoupas C, Cai Y, Chen X, Triccas JA, Britton WJ, Feng CG. (2022) Stromal structure remodelling by B lymphocytes limits T cell activation in lymph node of Mycobacterium tuberculosis-infected mice. J. Clinical Investigation Nov 1; 2022; 132(21):e157873. https://doi.org/10.1172/JCI157873. 

Hanna CC, Maxwell JWC, Ismanto HS, Ashhurst AS, Artner LM, Rudrawar S, Britton WJ, Yamasaki S, Payne RJ.^. (2022) Synthetic Vaccines Targeting Mincle Through Conjugation of Trehalose Dibehenate. Chemical Communications 2022 Jun 16;58(49):6890-6893. doi: 10.1039/d2cc02100e.PMID: 35638863

Hawkins PME, , Hoi DM, Cheung C-Y, Quan D, Wang T, Sasi VN, Liu DY, Linington RG, Jackson CJ, Oehlers SH, Cook GM, Britton WJ, Clausen T, Payne RJ. (2022) Potent Antimycobacterials Targeting the Chaperone ClpC1 Based on the Depsipeptide Natural Products Ecumicin and Ohmyungsamycin A. Journal of Medicinal Chemistry, Mar 16, 65 (6) 4893-4908. doi: 10.1021/acs.jmedchem.1c02122. PMID: 35293761.

Heynemann, S, Vanguru, V, Adelstein, S, Kao, S. Hemophagocytic lymphohistiocytosis (HLH) and cytokine release syndrome (CRS) in a patient with oncogene-addicted metastatic non-small cell lung cancer (NSCLC) following combination chemotherapy-immunotherapy. Asia-Pac J Clin Oncol. 2022; 1- 4. https://doi.org/10.1111/ajco.13906

Hortle E, Tran LV, Fontaine ARM, Pinello N, Wong JJ-L, Britton WJ, Oehlers SH. (2022) OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection. Life Science Alliance May 11;5(9):e202201476. doi: 10.26508/lsa.202201476. Print 2022 Sep. PMID: 35545295.

Johansen M; Mahbub R; Idrees S; Nguyen D; Pathinayake P; Nichol K; Hansbro N; Gearing L; Hertzog P; Gallego-Ortega D; Britton W; Saunders B; Wark P; Faiz A; Hansbro P. (2022). Increased SARS-CoV-2 infection, protease and inflammatory responses in COPD primary bronchial epithelial cells defined with single cell RNA-sequencing. American Journal of Respiratory and Critical Care Medicine May 12. doi: 10.1164/rccm.202108-1901OC. Online ahead of print. PMID: 35549656.

Kam JK, Wright K, Britton WJ, Oehlers SH (2022) Treatment of infection-induced vascular pathologies is protective against persistent rough morphotype Mycobacterium abscessus infection in zebrafish. Microbial Pathogenesis May 16;167:105590. doi: 10.1016/j.micpath.2022.105590. PMID: 35588967.

Kam JY, Cheng T, Garland DC, Britton WJ, Tobin DM, Oehlers SH. (2022) Inhibition of infection-induced vascular permeability modulates host leukocyte recruitment to Mycobacterium marinum granulomas in zebrafish. Pathogens and Disease Apr 29; 80(1):009. doi: 10.1093/femspd/ftac009.PMID: 35438161.

Kam JY, Hortle E, Krogman E, Warner SE, Cholan PM, Kikuch Ki, Triccas JA, Britton WJ, Johansen MD, Kremer L, Oehlers SH. (2022). Rough and smooth variant Mycobacterium abscessus infections are differentially controlled by host immunity during chronic infection. Nature Communications Feb 17, 13(1):1-11. doi:10.1038/s41467-022-28638-5. PMID: 35177649 

Luo I, Bradhurst P, Chen R. Intravenous immunoglobulin infusion contributes to a high incidence of false reactive screen results for human T-lymphotropic virus. Pathology. 2022 Oct;54(6):768-771. doi: 10.1016/j.pathol.2022.02.003. Epub 2022 May 6. PMID: 35534285.

Luo KY, Ogawa M; Ayer A, Britton WJ, Stocker R, Kikuchi K, Oehlers SH. (2022) Zebrafish heme oxygenase 1a is necessary for normal development and macrophage migration. Zebrafish Feb 2, 19(1):7-17. doi: 10.1089/zeb.2021.0058. PMID: 35108124

Luo, K, Stocker R, Britton WJ, Kikuchi K, Oehlers SH.(2022) Heme oxygenase limits Mycobacterium marinum infection-induced detrimental ferrostatin-sensitive cell death in zebrafish. FEBS Journal Feb. 289 (3):671-678. doi: 10.1111/febs.16209. PMID: 34544203. Editors’s choice paper.

Nisa A, Counoupas C, Pinto R, Britton WJ, Triccas JA. (2022) Characterization of the protective immune responses conferred by recombinant BCG overexpressing components of Mycobacterium tuberculosis Sec protein export system. Vaccines 2022, 10(6): 945; https://doi.org/10.3390/vaccines10060945 PMID: 35746553 (epub 14/6/2022).

Pittet LF, Fritschi N, Tebruegge M, Dutta B, Donath S, Messin NK, Casalaz D, Hanekom WA, Britton WJ, Robins-Browne R, Curtis N, Ritz R^,*and the BCG Immune Response Study (BIRS) group. (2022) To scar or not to scar? Scar formation following infant immunisation with bacille Calmette-Guérin is associated with enhanced Mycobacterium-specific T-cell responses. Am J Respir Crit Care Med (pub 10/1/2022). 205(7):830-8. doi.org/10.1164/rccm.202108-1892OC. PubMed: 35007188.

Quan D, Kwong AJ, Hansbro P, Britton WJ. (2022) No smoke without fire. Impact of cigarette smoking on the immune control of tuberculosis European Respiratory Reviews. 2022 Jun 7;31(164):210252. doi: 10.1183/16000617.0252-2021. PMID: 35675921  IF 12.34

Raubinger S, Lee FJ, Pinto AN. HIV: the changing paradigm. Intern Med J. 2022;52:542-549.

Richardson A, Chu S, Agapides M, Adelstein S, Wallman L, Wienholt L. Gluten - free diet adherence and implications for the diagnosis of coeliac disease. Pathology. 2022; (https://doi.org/10.1016/j.pathol.2021.12.297)

Rowe, S., Spies, J. M. & Urriola, N. Severe treatment-refractory antibody positive autoimmune autonomic ganglionopathy after mRNA COVID19 vaccination. Autoimmun Rev 103201 (2022) doi:10.1016/j.autrev.2022.103201

Stewart E, Counoupas C, Johansen MD, Nguyen DH, Miemczyk S, Hansbro NG, Ferrell K, Ashhurst A, Sibel Alca S, Steain M, Ashley C, Britton WJ, Hansbro PM, Petrovsky N, Triccas JA. (2022) Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2. Mucosal Immunology 15(6):1405-1415. Pub online 22/11/2022 DOI: 10.1038/s41385-022-00578-9 PMID: 36411332

Stoyanov, A., Toong, C., Kong, Y., Chen, R. & Urriola, N. Serum protein electrophoresis and rheumatoid factor analysis is an effective screening strategy for cryoglobulinaemia. Pathology (2022) doi:10.1016/j.pathol.2022.09.004.

Urriola, N., Blazek, K., Adelstein, S. (2022) Subunit - specific autoantibodies in autoimmune autonomic ganglionopathy. Journal of Neuroimmunology, 363, art. no. 57780 https://doi.org/10.1016/j.jneuroim.2021.577805

Vanka KS, Shukla S, Gomez H, Kumar V, James C, Palanisami T, Williams K, Chambers DC, Britton WJ, Ilic D, Hansbro PM*, Horvat J*. (2022) Understanding the Pathogenesis of Occupational Dust Diseases; Resurgence of An Historic Problem. European Respiratory Reviews. Jul 12;31(165):210250. doi: 10.1183/16000617.0250-2021. PMID: 35831008 

Velan K, Nguyen,VN, Nguyen BH, Dang T, Nguyen HA, Vu DH, Do TT Duc CP, Nguyen HL, Pham HT, Marais BJ, Johnston J, Britton W, Beardsley J, Negin J, Wiseman V, Marks, GB, Nguyen TA, Fox GF. (2022). Harnessing new mHealth technologies to Strengthen the Management of Drug-resistant Tuberculosis in Vietnam (V-SMART trial): a protocol for a randomized controlled trial. BMJ Open 2022; June 8, 12: e052633. doi:10.1136/bmjopen-2021-052633.

Wang Y, Chang YK, Britton WJ, Chan H-K. (2022) Inhalational delivery of antimicrobial proteins and peptides to treat lung infections. Advanced Drug Delivery Reviews. 2021, Nov 20; 180: 114066. PMID 34813794. doi.org/10.1016/j.addr.2021.114066. IF 13.3.

Wei X, ChenR, YangC, NguyenK, Wakefield D. Improved diagnostic performance of confirmatory assays for detecting dense fine speckled (DFS) 70 antibodies. Pathology. 2022 Dec;54(7):904-909. doi: 10.1016/j.pathol.2022.05.010. Epub 2022 Jul 19. PMID: 35995618.

2021

Aiyer A, Visser S, Bye P, Britton WJ, Whiteley GS, Glasbey TO, Kriek FH, Farrell J, Das T, Manos J. (2021) Effect of N-acetylcysteine in combination with antibiotics on the biofilms of three cystic fibrosis pathogens of emerging importance. Antibiotics 10(10): 1176. PMID: 34680757. doi.org/10.3390/antibiotics10101176. . IF 4.74.

Ashhurst AS*, Hanna CC, Payne RJ*, Britton WJ*. Immunological assessment of lung responses to inhalational lipoprotein vaccines against bacterial pathogens. In Bacterial Vaccines, Edited Bidmos F, Bosse J, Langford P. 2022. Pg 301-323. Humana, New York, USA. Methods in Molecular Biology 2022; 2414:301-323. PMID 33542494. doi: 10.1007/978-1-0716-1900-1.

Bhattacharyya N, Counoupas C, Daniel L, Zhang G, Cook S, Cootes T, Stifter S, Bowen D, Triccas JA, Bertolino P, Britton WJ, Feng CG (2021). TCR affinity does not specify effector function but controls the emergence and size of T-helper populations. J. Immunology May 28: 206(12):2875-2887. doi: 10.4049/jimmunol.2001271. PMID: 34049970

Burnett DL, Jackson KJL, Langley DB, Aggrawal A, Stella AO, Balachandran H, Johansen MD, Lenthall H, Rouet R, Walker G, Saunders BM, Singh M, Henry JY, Jackson J, Stewart AG, Schofield P, Milthorpe C, Martinello M, Schulz S, Roth E, Kelleher A, Emery S, Britton W, Rawlinson WD, Brink R, Bull R, Hansbro PM, Jaeck H-K, Turville S, Christ D, Goodnow CC. (2021) Immunization to elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability of the receptor binding domain. Immunity 54(12) 2908-2921.

Chan DKY, Braidy N, Chen RF, Xu YH, Bentley S, Lubomski M, Davis RL, Chen J, Sue CM, Mellick GD. Strong Predictive Algorithm of Pathogenesis-Based Biomarkers Improves Parkinson's Disease Diagnosis. Mol Neurobiol. 2022 Jan 7. doi: 10.1007/s12035-021-02604-6. Epub ahead of print. PMID: 34993845.

Chen RF, Braidy N, Xu YH, Tan S, Chan DKY. Macrophage- and Microglia-Related Chemokines Are Associated with Small Vessel (White Matter) Vascular Dementia: A Case-Control Study. Dement Geriatr Cogn Disord. 2021;50(5):454-459. doi: 10.1159/000519885. Epub 2021 Nov 12. PMID: 34775383.

Chen RF, Luo I, Rae M, Huang S. A cost-effective sample pooling strategy for line blot assay in detecting onconeural antibodies. J Immunol Methods. 2022 Feb 10;503:113235. doi: 10.1016/j.jim.2022.113235. Epub ahead of print. PMID: 35151664.

Chen RF, Wei XM. The interference of laboratory tests by immunoglobulin infusion: Problems and solutions. J Clin Images Med Case Rep. 2021; 2(2): 1047. DOI:10.52768/2766-7820/1047

Chen S, Quan DH, Wang XT, Sandford S, Kirman JR, Britton WJ, Rehm BHA. (2021) Particulate mycobacterial vaccines induce protective immunity against tuberculosis in mice. Nanoparticles 2021 Aug 13; 11(b):2060. PMID 34443891. doi: org/10.3390/nano11082060. IF 5.07.

Cholan PM, Morris S, LuoK, Chen J, BolandJ, McCaughan GW, Britton WJ, Oehlers SH. (2021) Transplantation of high fat fed mouse microbiota into zebrafish larvae identifies MyD88-dependent acceleration of hyperlipidaemia by Gram positive cell wall components. BioFactors (epub 19/10/2021). doi.org/10.1002/biof.1796 PMID: 34665899. IF 4.73.

Counoupas C, Stella AO, Bhattacharyya ND, Alice Grey, Karishma Patel, Angela L Ferguson, Owen Hutchings, Carl G Feng, Megan Steain, Anupriya Aggarwal, Jason KK Low, Joel P Mackay, Anthony D Kelleher, Britton WJ, Turville SG, Triccas JA. (2021) A single dose, BCG-adjuvanted SARS-CoV-2 vaccine induces Th1-polarized immunity and high-titre neutralizing antibodies in mice. NPJ Vaccines 2021 Nov 30;6(1):1-10. doi: 10.1038/s41541-021-00406-4.PMID: 34848711

Di Giallonardo, F., Pinto, A., Keen, P., Shaik, A., Carrera, A., Salem, H., Selvey, C., Nigro, S., Fraser, N., Price, K., Lee, F., Dwyer, D., et al (2020). Increased HIV Subtype Diversity Reflecting Demographic Changes in the HIV Epidemic in New South Wales, Australia. Viruses, 12(12), 1402

Dinh MH, Hutchings O, Bein KJ, Shaw J, Raut A, Russell SB, Jagers D, Fox GJ, Edwards J, Britton WJ. (2021). Emergency Department presentations from quarantine hotels in Sydney, Australia, during the COVID-19 outbreak - an analysis of clinical patterns and outcomes. Med J Aust 214 (10), 473. doi: 10.5694/mja2.51046 PMID: 33908054

Ferrell KC*, Stewart EL*, Counoupas C, Ashhurst RM, Britton WJ, Petrovsky N, Triccas JA. (2021) Intrapulmonary vaccination with delta-inulin adjuvant stimulates non-polarised chemotactic signalling and diverse cellular interaction. Mucosal Immunology Feb 5, 4:1-12. PMID 33542494. doi: 10.1038/s41385-021-00379-6.

Hanna CC*, Ashhurst AS*, Quan D, Maxwell J, Britton WJ*, Payne RJ*. (2021) Synthetic protein conjugate vaccines provide protection against Mycobacterium tuberculosis in mice. PNAS (USA) Jan 26; 118 (4) e2013730118. PMID: 33468674. doi: 10.1073/pnas. 2013730118

Hewavisenti T*, Ferguson SA*, Gasparini G, Ohashi T, Braun A, Miles J, Elliott M, Sierro F, Feng CG, Britton WJ, Gebhardt T, Tangye S, Palendira U. (2021) Tissue-resident regulatory T cells accumulate at human barrier lymphoid organs. Immunology and Cell Biology 99(8):894-906 (epub 3/6/2021). doi.org/10.1111/imcb.12481. PMID: 34080230.

Jee, A., Parker, M., Bleasel, J., Troy, L., Lau, E., Jo, H., Teoh, A., Adelstein, S., Webster, S., Corte, T. (2021). Baseline Characteristics and Survival of an Australian Interstitial Pneumonia with Autoimmune Features Cohort. Respiration, 100(9), 853-864.

Jee, A., Parker, M., Bleasel, J., Troy, L., Lau, E., Jo, H., Teoh, A., Webster, S., Adelstein, S., Corte, T. (2021). Diagnosis of myositis-associated interstitial lung disease: Utility of the myositis autoantibody line immunoassay. Respiratory Medicine, 187, 106581.

Johansen MD, Shalini S, Kuma S, Raynaud C, Quan D, Britton WJ, Hansbro PM, Kumar V, Kremer L. (2021) Biological and biochemical evaluation of isatin-isoniazid hybrids as bactericidal candidates against Mycobacterium tuberculosis. Antimicrobial Agents & Chemotherapy July 16: 65(8): e0001121. doi: 10.1128/AAC.00011-21. PMID: 33972252.

Krummenacher, M., Lee, F., Wienholt, L., Hissaria, P. (2021). Lack of standardisation in interpretation and reporting of autoantibody assays: a survey analysis of Australasian laboratories with focus on line immunoassays. Pathology, 53(7), 883-888.

Lin Y, Quan D, Chang YK, Chow M, Wang Y, Li M, Morales S, Britton WJ, Kutter E, Li J, Chan H-K. (2021). Synergistic activity of phage PEV20-ciprofloxacin combination powder formulation-A proof-of-principle study in a P. aeruginosa lung infection model. European Journal Pharmaceutics Biopharmaceutics. Jan, 158:166-171. doi: org/10.1016/ j.ejpb.2020.11.019. PMID: 33253892.

Luo I, Bradhurst P, Chen RF. Intravenous Immunoglobulin infusion contributes to a high incidence of false reactive screen results for Human T-Lymphotropic Virus. Pathology (accepted for publication on 07/02/2022)

Morris S, Cholan P, Britton WJ, Oehlers SH. (2021). Glucose inhibits haemostasis and accelerates diet-induced hyperlipidaemia in zebrafish embryos. Scientific Reports 2021, Sept 24; 11: 19049. PMID: 34561530. doi.org/10.1038/s41598-021-98566-9. IF 5.54

Morris S, Wright K, Malyla V, Britton WJ, Hansbro PM, Cholan PM, Oehlers SH. (2021). Exposure to the gut microbiota from cigarette smoke-exposed mice exacerbates cigarette smoke extract-induced inflammation in zebrafish larvae. Current Research in Immunology 2021 Dec 6;2:229-236. doi: 10.1016/j.crimmu.2021.12.001. PMID: 35492390.

Muflihah H, Flórido M, Lin LCW, Xia Y, Triccas JA, Stambas J, Britton WJ. (2021) Boosting BCG with recombinant Influenza A virus tuberculosis vaccines increases pulmonary T cell responses but not protection against Mycobacterium tuberculosis infection. PLoS ONE 2021 Nov 18;16(11):e0259829. PMID: 34793507. doi: 10.1371/journal.pone.0259829.

Pedersen JL, Barry SE, Bokil NJ, Ellis M, Yang YR, Guan G, Wang X, Faiz A, Britton WJ, Saunders BM. (2021) High sensitivity and specificity of a 5-analyte protein and microRNA biosignature for identification of active tuberculosis. Clinical Translational Immunology Jun 22, 10 (6), e1298. PMID: 34188917. DOI: 10.1002/cti2.1298.

Pittet LF, Tebruegge M, Dutta B, Donath S, Messina N, Casalaz D, Hanekom WA, Britton WJ, Robins-Browne R, Curtis N,* Ritz N*. (2021) Mycobacterium ulcerans-specific immune response after immunisation with Bacillus Calmette-Guérin (BCG) vaccine. Vaccine Jan 22; 39(4):652-657. doi:10.1016/j.vaccine.2020.11.045. PMID: 33371993

Quan DH, Counoupas C, Nagalingam G, Pinto R, Petrovsky N, Britton WJ, Triccas JA. (2021). Advax adjuvant vaccine formulations promote protective immunity against aerosol Mycobacterium tuberculosis in the absence of deleterious inflammation and reactogenicity. Vaccine Apr 1; 39(14):1990-1996. doi: 10.1016/j.vaccine.2021.02.041. PMID: 33714652

Raubinger S, Lee FJ, Pinto AN. HIV: the changing paradigm. Intern Med J. 2022 Apr;52(4):542-549. doi: 10.1111/imj.15739. PMID: 35419962.

Stevens MT, Nagaria BD, Britton WJ, Saunders BM. (2021) Tissue origin influences macrophage response to mycobacterial infection. Immunology and Cell Biology. 2021 Nov; 99(10):1085-1092. PMID: 34273196. doi: 10.1111/imcb.12493.

Tran V, Hortle E, Britton WJ, Oehlers SH (2021) Common anti-hemostatic medications increase the severity of uropathogenic Escherichia coli sepsis. Microbiological Research 2021, Nov 12; 254:126918. PMID 34798538. doi.org/10.1016/j.micres.2021.126918.

Tran W, Kusay AS, Hawkins PME, Chen-Yi Cheung C-Y, Nagalingam G, Pujari V, Ford DJ, Stoye A, Ochoa JL, Audette RE, Hortle E, Oehlers SH, Charman SA, Linington RG, Rubin EJ, Dowson CG, Roper DI, Crick DC, Balle T, Cook GM, Britton WJ, Payne RJ. (2021) Synthetic Sansanmycin Analogues as Potent Mycobacterium tuberculosis Translocase I Inhibitors. J. Medicinal Chemistry 2021 Dec 9;64(23):17326-17345 doi: 10.1021/acs.jmedchem.1c01407. PMID: 34845906.

Trewin, B., Adelstein, S., Spies, J., Beadnall, H., Barton, J., Ho, N., Gallagher, K., Barnett, M. (2020). Precision therapy for neuromyelitis optica spectrum disorder: A retrospective analysis of the use of class-switched memory B-cells for individualised rituximab dosing schedules. Multiple Sclerosis and Related Disorders, 43, 1-4.

Urriola, N. Autoimmune Autonomic Ganglionopathy: antibodies to the alpha3 ganglionic acetylcholine receptor and flow cytometric methods for their detection. University of Sydney Library (2022).

Urriola, N., Adelstein, S. (2022). Autoimmune autonomic ganglionopathy: Ganglionic acetylcholine receptor autoantibodies. Autoimmunity reviews, 21(2), 102988.

Urriola, N., Blazek, K., Adelstein, S. (2022). Subunit-specific autoantibodies in autoimmune autonomic ganglionopathy. Journal of Neuroimmunology, 363, 577805.

Urriola, N., Lang, B. & Adelstein, S. Evaluation of commercially available antibodies and fluorescent conotoxins for the detection of surface ganglionic acetylcholine receptor on the neuroblastoma cell line, IMR-32 by flow cytometry. J Immunol Methods 498, 113124 (2021).

Urriola, N., Spies, J., Blazek, K., Lang, B., Adelstein, S. (2021). A Flow Cytometric Assay to Detect Functional Ganglionic Acetylcholine Receptor Antibodies by Immunomodulation in Autoimmune Autonomic Ganglionopathy. Frontiers in Immunology, 12, 705292.

Verma, R., Balaraju, V., Seneviratne, M., Garsia, R., Adelstein, S., Puranik, R., Dennis, M. (2020). A decade follow-up: On the prevalence, distribution and clinical correlates of myocardial fibrosis, as detected by cardiac magnetic resonance, in systemic lupus erythematosus. Lupus, 29(14), 1981-1983.

Wei XM, Chen RF, Yang C, Nguyen K, Wakefield D. Improved diagnostic performance of confirmatory assays for detecting dense fine speckled (DFS) 70 antibodies. Pathology (abstract published, full article under review)

Wienholt, L., Dawson, E., Khan, L., Hughes, T., Lee, F. (2020). The impact of indirect immunofluorescence screening dilution on the positivity of gastric parietal cell antibodies. Pathology, 52(5), 589-590.

Wienholt, L., Kane, A., Adelstein, S., Richardson, A., Kothur, K., Brilot-Turville, F., Dale, R. (2021). Cerebrospinal fluid free light chain quantitation is a specific biomarker for inflammatory neurological disorders in a paediatric patient cohort. Pathology, 56(6), 753-758.

Wright K, de Silva K, Plain KM, Purdie AC, Duggin IG, Blair TA, Britton WJ, Oehlers SH. (2021) Mycobacterial infection-induced miR-206 inhibits protective neutrophil recruitment via the CXCL12/CXCR4 signalling axis. PLoS Pathogens Apr 7,17(4):e1009186. doi: 10.1371/journal.ppat.1009186. PMID: 33826679

2020

Anderson S, Sasson SC, Lee FJ, Cooper W, Larsen S, Garsia R. Episodic fevers and vasodilatory shock mimicking urosepsis in a patient with HIV-associated multicentric Castleman's Disease: a case report. BMC Infect Dis. 2016;16:53

Cholan PM, Han A, Woodie BR, Kurz ARM, Britton WJ, Ye L, Rawls JF, Oehlers SH. (2020) Conserved anti-inflammatory effects and sensing of butyrate in zebrafish. Gut Microbes Nov 9;12(1):1-11. doi:10.1080/19490976.2020.1824563. PMID: 33064972

Counoupas C, Ferrell K, Ashhurst A, Bhattacharyya N, Nagalingam G, Feng CG, Petrovsky N, Britton WJ, Triccas JA. (2020) Mucosal delivery of a multistage subunit vaccine promotes development of lung-resident memory T cells and affords interleukin-17-dependant protection against pulmonary tuberculosis. NPJ Vaccines Nov 12, 5(1):105. doi: 10.1038/s41541-020-00255-7. PMID: 33298977.

Di Giallonardo F, Pinto AN, Keen P, Shaik A, Carrera A, Salem H, Telfer B, Cooper C, Price K, Selvey C, Holden J, Bachmann N, Lee FJ, Dwyer DE, Duchêne S, Holmes EC, Grulich AE, Kelleher AD. Limited sustained local transmission of HIV-1 CRF01_AE in New South Wales, Australia. Viruses. 2019;11:E482

Fox GJ, Nguyen CB, Nguyen TA, Tran PT, Marais BM, Graham SG, Nguyen BH, Dowdy D, Mason P, Britton WJ, Behr MA, Menzies D, Nguyen VN, Marks GB. (2020) Levofloxacin versus placebo for the treatment of latent tuberculosis among contacts of patients with multidrug-resistant tuberculosis (The VQUIN MDR Trial): a protocol for a randomized controlled trial. BMJ Open Jan 2;10(1):e033945. doi: 10.1136/bmjopen-2019-033945. PMID: 31900274

Hawkins PME, Giltrap AM, Nagalingam G, Cheung C-Y, Cook GM, Britton WJ, Payne RJ (2020). Total Synthesis and Anti-mycobacterial Activity of Ohmyungsamycin A, Deoxyecumicin and Ecumicin. Chemistry-a European Journal Nov 26;26(66):15200-15205. https://doi.org/10.1002/chem.202002408. PMID: 32567168

Hewavisenti T, Ferguson A, Wang K, Jones D, Gebhardt T, Edwards J, Mei Zhang, Britton WJ, Yang J, Hong A, Palendira U. (2020) CD103+ tumour-resident CD8+ T cell numbers underlie improved patient survival in oropharyngeal squamous cell carcinoma. J. ImmunoTherapy Cancer 8 (1):e000452. doi:10.1136/jitc-2019-000452

Ho J, Bokil N, Nguyen PTB, Nguyen TA, Liu MY, Fox GJ, Saunders BM, Guy B Marks GB, Britton WJ. (2020) A Transcriptional Blood Signature Distinguishes Early Tuberculosis Disease from Latent Tuberculosis Infection and Uninfected Individuals in a Vietnamese Community-based cohort. Journal of Infection Jul; 81(1):72-80. PMID: 32330522. doi.org/10.1016/ j.jinf.2020.03.066.

Hu HQ, Lee FJ, Garsia R. Sirolimus for systemic lupus erythematosus: questionable efficacy. Lancet. 2018;392:733-734

Hu, H., Reddell, S., Riminton, S., Chan, C. & Urriola, N. Refractory chronic spontaneous urticaria after the use of alemtuzumab in multiple sclerosis. Neurology, Neuroimmunol &Neuroinflammation. 2020; 7, e661

Johansen MD, Irving A, Montagutelli X, Tate MD, Rudloff I, Nold MF, Hansbro NG, Kim RY, Donovan C, Liu G, Faiz A, Short KR, Lyons G, McCaughan GW, Gorrell MD, Cole A, Moreno C, Le Couteur D, Hesselson D, Triccas J, Neely GG, Gamble JR, Simpson SJ, Saunders BM, Oliver BG, Britton WJ, Wark PA, Nold-Petry CA, Hansbro PM. (2020) Animal and translational models of SARS-CoV-2 infection and COVID-19. Mucosal Immunology Nov 13(6):877-891. doi: 10.1038/s41385-020-00340-z. PMID: 32820248

Lee FJ, Amin J, Carr A. Limited reporting of major harms in studies of initial combination antiretroviral therapy: a systematic review. AIDS. 2015;29:921-929

Lee FJ, Carr A. Dyslipidemia in HIV-infected patients. In: Garg, A (ed). Dyslipidemias: pathophysiology, evaluation and management. New York: Springer Publishing Company, New York, USA; 2015. ISBN 978-1-60761-424-1

Lee FJ, Marriott D, Bloch M, Richardson R, Mackenzie N, Carr A. Post-prandial lipid effects of raltegravir vs. darunavir/ritonavir in HIV-1-infected adults commencing combination antiretroviral therapy. J Antimicrob Chemother. 2016;71:1127-1129

Lee FJ, Monteiro P, Baker D, Bloch M, Roth N, Finlayson R, Moore R, Hoy J, Martinez E, Carr A. Rosuvastatin versus protease inhibitor switching for hypercholesterolaemia: a randomised trial. HIV Med. 2016;17:605-614

Lee FJ. Approaches to the management of antiretroviral therapy toxicity. In: HIV Management in Australasia - a guide for clinical care. Sydney: Australasian Society for HIV Medicine, Sydney, Australia; 2016. (http://www.hivmanagement.ashm.org.au)

Lee FJ. Measurement of soluble glycoprotein VI in studies of abacavir-based therapy: concerns about test precision. AIDS. 2018;32:2263-2264

Lee G, Robosa R, Fong G, Lee FJ, Lowe P, Pinto AN. Adult cervicofacial nocardiosis with IL-12/23 blockade. Australas J Dermatol. 2019;60:323-324

Lin Y, Chang YK, Britton WJ, Morales S, Kutter E, Li J, Chan H-K. (2020) Storage stability of phage-ciprofloxacin combination powders for the treatment of Pseudomonas aeruginosa respiratory infections. International Journal of Pharmaceutics Oct 12;591:119952. https://doi.org/10.1016/j.ijpharm.2020.119952. PMID: 33059012

Lin Y, Quan D, Chang YK, Chow M, Wang Y, Li M, Morales S, Britton WJ, Kutter E, Li J, Chan H-K. 2020. Efficacy of co-spray dried phage and ciprofloxacin combination in an acute neutropenic mouse lung infection model caused by Pseudomonas aeruginosa. European Journal of Pharmaceutics and Biopharmaceutics Nov 27:S0939-6411. doi.org/10.1016/j.ejpb.2020.11.019. PMID: 33253892.

Moynihan GV, Teo PCK, Lee FJ, Zoeller MR. Case report: capillary leak syndrome with cardiac tamponade. Anaesth Intensive Care. 2019;47:305-306

Qiu J, Helou J, Urriola N, Welgampola M, Parratt J, Wong T, et al. 076 The expanding clinical phenotype of NMDAR encephalitis. J Neurol Neurosurg Psychiatry 2018;89:A31-A31.

Urriola N, Helou J, Maamary J, Pogson J, Lee F, Parratt K, et al. NMDA receptor antibody in teratoma-related opsoclonus-myoclonus syndrome. J Clin Neurosci 2018.

Urriola N, Paganini L, Riminton S, Limaye S. Oral amoxicillin-associated anaphylaxis, 1 year after negative penicillin testing and oral amoxicillin challenge. J Allergy Clin Immunol Pract 2016;4:763-4.

Urriola N, Soosapilla K, Drummond J, et al. Fulminant thymomatous AMPAR-antibody limbic encephalitis with hypertonic coma, bruxism, an isoelectric electroencephalogram and temporal cortical atrophy, with recovery. BMJ Case Reports CP 2019;12:e227893

Urriola N, Soosapilla K, Herkes G, et al. Heidenhain variant sporadic Creutzfeldt-Jakob disease diagnosed as an autoimmune encephalitis due to a false-positive GAD autoantibody. BMJ Case Reports CP 2019;12:e229018.

Urriola N, Williams A, Keat K. Macrophage activation syndrome/haemophagocytic lymphohistiocytosis secondary to Burkholderia cepacia complex septicaemia in an elderly female carrier of X-linked chronic granulomatous disease with extreme lyonisation: 'cepacia syndrome' revisited. BMJ Case Reports CP 2019;12:e230434.

Urriola NX, Helou J, Maamary J, Pogson J, Lee F, Parratt K, Gillis D, Fulham MJ, Halmágyi GM. NMDA receptor antibody in teratoma-related opsoclonus-myoclonus syndrome. J Clin NeuroSci. 2018;58:203-204

Velem K, Nhung NV, Anh NT, Cuong PD, Hoa NB, Cuong NK, Dung NH, Sy DN, Britton WJ. Marks GB, Fox GJ. (2020) Risk factors for TB among household contacts of patients with smear- positive TB in eight provinces of Vietnam: a nested case-control study. Clinical Infectious Diseases (accepted 11/11/2020). doi: org/10.1093/cid/ciaa1742.

Wang Y, Khanal D, Chang YK, Shang X, Yang H, Britton WJ, Nelson D, Chan H-K. (2020) Can bacteriophage endolysins be nebulised for inhalation delivery against Streptococcus pneumoniae? (2020) International Journal of Pharmaceutics Oct 14, 591:119982. https://doi.org/10.1016/j.ijpharm.2020.119982. PMID: 33068693

Wienholt L, Dawson E, Khan L, Hughes T, Lee F. The impact of indirect immunofluorescence screening dilution on the positivity of gastric parietal cell antibodies. Pathology. 2020;52:589-590

Wienholt LA, Richardson A, Wong RC, Chapman K, Lee FJ. A review of 10 years of data from an external quality assurance program for antiphospholipid antibodies: no evidence for improved aCL and β2GPI assay standardization. Ann Blood. 2019;4;27e

Wightman F, Solomon A, Kumar S, Urriola N, Gallagher K, Hiener B, et al. Effect of ipilimumab on the HIV reservoir in an HIV-infected individual with metastatic melanoma.Aids 2015;29:504.

Yun J, Cai F, Lee FJ, Pichler WJ. T-cell-mediated drug hypersensitivity: immune mechanisms and their clinical relevance. Asia Pac Allergy. 2016;6:77-89

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