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Anaesthetics Research

The Royal Prince Alfred Hospital Department of Anaesthetics is dedicated to improving patient outcomes in perioperative care through their ongoing participation in clinical research and quality assurance activities.

The department proudly supports staff members who initiate their own innovative research projects and those who commit time and expertise towards larger multi-centre trials. Our primary contributions to clinical research include investigating the mechanisms of anaesthesia, exploring the concept of consciousness, closing the gap between research in males and females undergoing anaesthesia, improving perioperative brain health, and enhancing training for the safe provision of anaesthesia.

In 2020, the Department of Anaesthetics welcomed Professor Robert Sanders, Nuffield Chair of Anaesthetics at the University of Sydney. Since his commencement in the role, Professor Sanders has re-invigorated research within the department, attracted grant funding for ongoing projects and formed a research team in collaboration with the University of Sydney.

The research projects under Professor Sanders are primarily focused on reducing postoperative delirium, a state of sudden confusion that can occur after surgery and is associated with worse outcomes for the patient. Continuing research in this area will become increasingly relevant following the recognition of delirium as an actual and potential Hospital Acquired Complication (HAC) by the Australian Commission on Safety and Quality in Health Care in 2021.

The research team consists of Clinical Nurse Consultants Kaitlin Kramer and Belinda Anderson, many consultant and fellow anaesthetic doctors who are PrincipaI or Associate Investigators on local or multi-site projects, junior doctors and nurses who reach out to assist with trials and a hospital scientist. 

Selected Grants

Amount awarded Grant and project details
$70,000 Australian and New Zealand College of Anaesthetics, 2025-2030
DEARS Trial (2025 Patron Emerging Investigator Grant).
Investigator: Braithwaite H.
$4,057,466 NHMRC, 2024-2029
DECIDE Trial.
Investigator: Sanders RD (CIA).
$120,000 Australian and New Zealand College of Anaesthetics, 2023-2025
PRIORITY: Sub Study.
Investigator: Pillinger N.
$4,910,000 NIH, 2020-2025
Clarifying the overlapping pathology of delirium and dementia.
Investigators: Sanders RD, Pearce RA.
$1,970,000 NIH, 2020-2025
Receptors, microcircuits and hierarchical connectivity in predictive coding and sensory awareness.
Investigators: Saalamnn Y, Sanders RD.

Our Publications

2024

Aldecoa C, Bettelli G, Bilotta F, Sanders RD, Aceto P, Audisio R, Cherubini A, Cunningham C, Dabrowski W, Forookhi A, Gitti N, Immonen K, Kehlet H, Koch S, Kotfis K, Latronico N, MacLullich AMJ, Mevorach L, Mueller A, Neuner B, Piva S, Radtke F, Blaser AR, Renzi S, Romagnoli S, Schubert M, Slooter AJC, Tommasino C, Vasiljewa L, Weiss B, Yuerek F, Spies CD. Update of the European Society of Anaesthesiology and Intensive Care Medicine evidence-based and consensus-based guideline on postoperative delirium in adult patients. Eur J Anaesthesiol. 2024 Feb 1;41(2):81-108. doi: 10.1097/EJA.0000000000001876. Epub 2023 Aug 30.
Gjini K, Casey C, Kunkel D, Her M, Banks MI, Pearce RA, Lennertz R, Sanders RD. Delirium is associated with loss of feedback cortical connectivity. Alzheimers Dement. 2024 Jan;20(1):511-524. doi: 10.1002/alz.13471. Epub 2023 Sep 11. 
Moi D, Olesnicky B, Zanjani N, Wang A, Mulligan M. Validation of the American College of Surgeons National Surgical Quality Improvement Program risk predictor in an Australian general surgical cohort. ANZ J Surg. 2024 Feb;94(1-2):108-116. doi: 10.1111/ans.18710. Epub 2023 Oct 4. 
Casey CP, Tanabe S, Farahbakhsh ZZ, Parker M, Bo A, White M, Ballweg T, Mcintosh A, Filbey W, Banks MI, Saalmann YB, Pearce RA, Sanders RD. Evaluation of putative signatures of consciousness using specific definitions of responsiveness, connectedness, and consciousness. Br J Anaesth. 2024 Feb;132(2):300-311. doi: 10.1016/j.bja.2023.09.031. Epub 2023 Oct 31. 
Chalitsios CV, Luney MS, Lindsay WA, Sanders RD, McKeever TM, Moppett I. Risk of Mortality Following Surgery in Patients With a Previous Cardiovascular Event. JAMA Surg. 2024 Feb 1;159(2):140-149. doi: 10.1001/jamasurg.2023.5951.
Sanders RD, McCulloch TJ. Depth of amnesia monitoring. Response to Br J Anaesth 2023; 131: e145-7. Br J Anaesth. 2024 Feb;132(2):421-422. doi: 10.1016/j.bja.2023.11.010. Epub 2023 Dec 4.
Cao C, Fulham M, Irons J, Cooper W, Zhang O. Robotic Anatomical Pulmonary Resections: An Australian Experience. Heart Lung Circ. 2024 Jan;33(1):86-91. doi: 10.1016/j.hlc.2023.10.014. Epub 2023 Dec 7.
Staquet C, Vanhaudenhuyse A, Kandeepan S, Sanders RD, Ribeiro de Paula D, Brichant JF, Laureys S, Bonhomme V, Soddu A. Changes in Intrinsic Connectivity Networks Topology Across Levels of Dexmedetomidine-Induced Alteration of Consciousness. Anesth Analg. 2024 Oct 1;139(4):798-811. doi: 10.1213/ANE.0000000000006799. Epub 2024 Jan 30.
Payne T, Loadsman JA. Inside the black box: Random effects meta-analysis with zero heterogeneity. J Crit Care. 2024 Jun;81:154529. doi: 10.1016/j.jcrc.2024.154529. Epub 2024 Feb 8.
Tran A, Wang A, Mickaill J, Strbenac D, Larance M, Vernon ST, Grieve SM, Figtree GA, Patrick E, Yang JYH. Construction and optimization of multi-platform precision pathways for precision medicine. Sci Rep. 2024 Feb 21;14(1):4248. doi: 10.1038/s41598-024-54517-8.
Cornall G, Zhao E, Luckett T, Erciyas E, Monck D, Glare P, Wang A, Lee YC. Management of pain in cancer patients- lessons from practices during the COVID-19: a qualitative study of cancer care providers' perspectives. BMC Health Serv Res. 2024 Feb 22;24(1):232. doi: 10.1186/s12913-024-10710-z.
Cecconi B, Montupil J, Mortaheb S, Panda R, Sanders RD, Phillips C, Alnagger N, Remacle E, Defresne A, Boly M, Bahri MA, Lamalle L, Laureys S, Gosseries O, Bonhomme V, Annen J. Study protocol: Cerebral characterization of sensory gating in disconnected dreaming states during propofol anesthesia using fMRI. Front Neurosci. 2024 Feb 13;18:1306344. doi: 10.3389/fnins.2024.1306344.
Antcliffe DB, Mi Y, Santhakumaran S, Burnham KL, Prevost AT, Ward JK, Marshall TJ, Bradley C, Al-Beidh F, Hutton P, McKechnie S, Davenport EE, Hinds CJ, O'Kane CM, McAuley DF, Shankar-Hari M, Gordon AC, Knight JC. Patient stratification using plasma cytokines and their regulators in sepsis: relationship to outcomes, treatment effect and leucocyte transcriptomic subphenotypes. Thorax. 2024 May 20;79(6):515-523. doi: 10.1136/thorax-2023-220538.
Payne T, Lennertz RC, Sanders RD. Brain Injury in Postoperative Delirium: Lessons from Neurofilament Light. Anesthesiology. 2024 May 1;140(5):884-886. doi: 10.1097/ALN.0000000000004921.
Lee YC, Brake T, Zhao E, Dumitrescu A, Lee W, Tassie B, Khor KE, Wang AY. The use of interventional procedures for cancer pain. A brief review. Support Care Cancer. 2024 Apr 12;32(5):285. doi: 10.1007/s00520-024-08467-6.
McBride KE, Torzillo J, Davis R, Steffens D, Wand T, Sanders RD, Glozier N, Solomon MJ. Mental illness comorbidity significantly impacts surgical outcomes for emergency surgical patients. ANZ J Surg. 2024 Jul-Aug;94(7-8):1341-1348. doi: 10.1111/ans.19008. Epub 2024 Apr 25.
Safa B, Trinh H, Lansdown A, McHardy PG, Gollish J, Kiss A, Kaustov L, Choi S. Ultrasound-guided suprainguinal fascia iliaca compartment block and early postoperative analgesia after total hip arthroplasty: a randomised controlled trial. Br J Anaesth. 2024 Jul;133(1):146-151. doi: 10.1016/j.bja.2024.04.019. Epub 2024 May 18. 
Goh SSN, Zhao J, Drakeford PA, Chen Q, Lim WW, Li AL, Chan KS, Ong MW, Goo JTT. Assessing the impact of frailty in elderly patients undergoing emergency laparotomies in Singapore. Ann Acad Med Singap. 2024 Jun 28;53(6):352-360. doi: 10.47102/annals-acadmedsg.2023155.
Sanders RD, Watne L, Roberson SW, Kimchi EY, Slooter AJC, Cunningham C, Nourski KV, Palanca BJA, Lennertz R, Banks MI. International Delirium Pathophysiology & Electrophysiology Network for Data sharing (iDEPEND). BJA Open. 2024 Jul 30;11:100304. doi: 10.1016/j.bjao.2024.100304.
Taylor J, Robledo KP, Medel V, Heller G, Payne T, Wehrman J, Casey C, Yang PF, Krause BM, Lennertz R, Naismith S, Teixeira-Pinto A, Sanders RD. Association between surgical admissions, cognition, and neurodegeneration in older people: a population-based study from the UK Biobank. Lancet Healthy Longev. 2024 Sep;5(9):100623. doi: 10.1016/j.lanhl.2024.07.006. Epub 2024 Sep 5.
Payne T, Taylor J, Kunkel D, Konieczka K, Ingram F, Blennow K, Zetterberg H, Pearce RA, Meyer-Franke A, Terrando N, Akassoglou K, Sanders RD, Lennertz RC. Association of preoperative to postoperative change in cerebrospinal fluid fibrinogen with postoperative delirium. BJA Open. 2024 Oct 5;12:100349. doi: 10.1016/j.bjao.2024.100349.
Cordina R, Ratwatte S, Khor L, Plunkett B, Irons J, Baker D, Nicholson I, McGuire M, Simmons L, Ng M. Transcatheter Edge-to-Edge Repair of Common Atrioventricular Valve Regurgitation in the Setting of a Lateral Tunnel Fontan Circulation. Struct Heart. 2024 Jul 26;8(6):100348. doi: 10.1016/j.shj.2024.100348.
Kramer K, Payne T, Brooks M, Barry J, Mahajan N, Malcolm S, Braithwaite H, Wang A, Thompson C, Liyanagama K, Sanders RD. Noradrenergic suppression to reduce electroencephalographic arousal after intubation: a randomised, placebo-controlled trial. BJA Open. 2024 Dec 16;13:100359. doi: 10.1016/j.bjao.2024.100359.
Mohanta S, Cleveland DM, Afrasiabi M, Rhone AE, Górska U, Cooper Borkenhagen M, Sanders RD, Boly M, Nourski KV, Saalmann YB. Traveling waves shape neural population dynamics enabling predictions and internal model updating. bioRxiv. Preprint posted online January 10, 2024. doi:10.1101/2024.01.09.574848.
Payne E, Gonzalez Ortiz F, Kramer K, Sanders RD, et al. Umbilical cord blood pTau217 and BD-tau are associated with markers of neonatal hypoxia: a prospective cohort study. medRxiv. Preprint posted online December 2024. doi:10.1101/2024.12.20.24319360.