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Bone Biology

The Bone Research Program pursues basic, applied and clinical research in bone health and biology. Our basic research focuses on the actions of steroid hormones in bone, covering emerging and exciting areas such as the links between bone and systemic fuel metabolism, or the complex regulatory functions of glucocorticoids in inflammatory arthritis.

Our applied and clinical research focuses on the assessment of bone metabolism, the implementation of secondary fracture prevention programs, and male ageing. Our research has been continuously supported by competitive grants from the NHMRC and other agencies.

Our group is well represented at national and international scientific meetings, including the American Society for Bone and Mineral Research (ASBMR), the Australian and New Zealand Bone and Mineral Society (ANZBMS), the Australian & New Zealand Obesity Society (ANZOS), European Association for the study of Diabetes Annual Meeting; European Calcified Tissue Society (ECTS); Endocrine Society’s Annual Meeting and Expo (ENDO2017) and others). At all of these meetings, our group has had multiple oral presentations and awards, reflecting the high standard and international recognition of our research.

Our Research Team

Professor Markus Seibel Head of Department
Professor Hong Zhou Head of Department
Dr Eugenie Mcfarlane Research Staff
Colette Fong-Yee Research Staff
Lauryn Cavanagh Research Staff
Andrew Auwyang Research Staff

Our Research Projects

Chronic Disruption of Circadian Rhythm Accelerates Cartilage Degeneration: The Role Of Endogenous Glucocorticoids
E Macfarlane, L Cavanagh, C Fong-Yee, C Little, QJ Meng, MJ Seibel, H Zhou

Chronic Disruption of Circadian Rhythm Induces Bone Loss: The role of Endogenous Glucocorticoids
E Macfarlane, L Cavanagh, C Fong-Yee, QJ Meng, MJ Seibel, H Zhou

Endogenous Glucocorticoids in Osteoarthritis
E Macfarlane, L Cavanagh, C Fong-Yee, C Little, MJ Seibel, H Zhou
Endogenous Glucocorticoids and Diet-induced Bone, Fat and Metabolic Dysregulation
S Kim, L Cavanagh, E Macfarlane, C Fong-Yee, M Swarbrick, MJ Seibel, H Zhou
The Concord Fracture Liaison Service: A world-class research and clinical program for secondary fracture prevention
K Ganda, MJ Seibel
Make the first fracture the last! Secondary Fracture Prevention in Primary Care
MJ Seibel (Chief Investigator) with Alice Knight, Anne Redman and Cate D’Este (Sax Institute)
Zoledronate in the Prevention of Paget's  (ZiPP) Study – A Randomised Trial of Genetic Testing and Targeted Zoledronic acid Therapy to Prevent SQSTM1 Mediated Paget’s Disease
S Ralston (Chief Investigator, Univ of Edinburgh) with MJ Seibel, K Ganda and collaborators around the world
Concord Health in Ageing Men Project (CHAMP)
with R Cumming, D Handelsman, MJ Seibel and others

Selected Grants

Amount awarded Grant and project details
$1,500,000 National Health and Medical Research Council (NHMRC), 2021-25
“The first osteoporotic fracture the last - Implementation and analysis of an evidence-based, integrated model of care for secondary fracture prevention”
Investigators: Seibel